Clinical Characteristics, Management, and Outcome of the First 19 Patients With Pneumonia Due to the 2019 Novel Coronavirus Disease Treated in an Intensive Care Unit in the Republic of Cyprus

AbstractBackgroundSince December 2019, acute respiratory disease (ARD) due to 2019 novel coronavirus (2019-nCoV) emerged in Wuhan city and rapidly spread throughout China. We sought to delineate the clinical characteristics of these cases.MethodsWe extracted the data on 1,099 patients with laboratory-confirmed 2019-nCoV ARD from 552 hospitals in 31 provinces/provincial municipalities through January 29th, 2020.ResultsThe median age was 47.0 years, and 41.90% were females. Only 1.18% of patients had a direct contact with wildlife, whereas 31.30% had been to Wuhan and 71.80% had contacted with people from Wuhan. Fever (87.9%) and cough (67.7%) were the most common symptoms. Diarrhea is uncommon. The median incubation period was 3.0 days (range, 0 to 24.0 days). On admission, ground-glass opacity was the typical radiological finding on chest computed tomography (50.00%). Significantly more severe cases were diagnosed by symptoms plus reverse-transcriptase polymerase-chain-reaction without abnormal radiological findings than non-severe cases (23.87% vs. 5.20%, P<0.001). Lymphopenia was observed in 82.1% of patients. 55 patients (5.00%) were admitted to intensive care unit and 15 (1.36%) succumbed. Severe pneumonia was independently associated with either the admission to intensive care unit, mechanical ventilation, or death in multivariate competing-risk model (sub-distribution hazards ratio, 9.80; 95% confidence interval, 4.06 to 23.67).ConclusionsThe 2019-nCoV epidemic spreads rapidly by human-to-human transmission. Normal radiologic findings are present among some patients with 2019-nCoV infection. The disease severity (including oxygen saturation, respiratory rate, blood leukocyte/lymphocyte count and chest X-ray/CT manifestations) predict poor clinical outcomes.

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Surveillance of device associated infections and mortality in a major intensive care unit in the Republic of Cyprus

BMC Infectious Diseases ◽

10.1186/s12879-017-2704-2 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 10

Author(s):

Stelios Iordanou ◽

Nicos Middleton ◽

Elizabeth Papathanassoglou ◽

Vasilios Raftopoulos

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

The Republic ◽

Republic Of Cyprus

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Baseline characteristics, level of disease severity and outcomes of patients with COVID-19 admitted to intensive care unit in COVID-19 dedicated Mugda Medical College and Hospital, Dhaka, Bangladesh

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20204347 ◽

2020 ◽

Vol 7 (10) ◽

pp. 3837

Author(s):

Irin Hossain ◽

Manzurul H. Khan ◽

Shah G. Tuhin ◽

M. M. Aktaruzzaman ◽

Shafiur Rahman ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Critically Ill ◽

Critically Ill Patients ◽

Clinical Characteristics ◽

Icu Patients ◽

Ventilator Support ◽

Medical College ◽

Central Oxygen ◽

Novel Coronavirus

Background: Novel coronavirus disease is associated with highly intensive care unit (ICU) mortality. With the dramatic increase of confirmed cases as well as death toll in Bangladesh, timely and effective management of severely and critically ill patients appears to be particularly important. This includes streamlining workflows for rapid diagnosis and isolation, clinical management, and infection prevention. The main objective of this study was identification of the demographic, clinical characteristics, severity and outcome of patients admitted into ICU. Methods: We aimed to describe the demographic and clinical characteristics, severity of disease, management patterns and outcomes of critically ill patients with coronavirus disease 2019 admitted to ICU in a Bangladeshi setting and for this purpose a retro-prospective study of conveniently selected 63 ICU admitted patients with COVID-19 was conducted from May 1 to June 30, 2020. Data were obtained from patient charts and the hospitals’ records using a structured questionnaire. Results: Most of the ICU patients were older male (30, 65.3%) and most of them were 70 or above years of age group (17, 37.0%). ICU patients more likely suffered from comorbidities like hypertension (938, 60.3%); diabetes (36, 57.1%); chronic kidney disease (21, 33.3%). In most cases treatment in ICU included the administration of antibiotics (100.0%) (Meropenem, 20, 31.7%). Forty-Eight patients died (discharge mortality, 76.2%), and fourteen patients were discharged alive from the ICU with a rate of 22.2%. One patient transferred (Palliative discharge, 1.6%) to other facilities for palliative care purpose.Conclusions: Our findings also highlight the importance of planning for mass critical care along with central oxygen supply system as the need for ICU care and ventilator support to treat patients with COVID-19 grows rapidly in Bangladesh.

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A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care

Journal of Biological Rhythms ◽

10.1177/0748730421992587 ◽

2021 ◽

Vol 36 (1) ◽

pp. 55-70

Author(s):

Jeffrey Haspel ◽

Minjee Kim ◽

Phyllis Zee ◽

Tanja Schwarzmeier ◽

Sara Montagnese ◽

...

Keyword(s):

Intensive Care Unit ◽

Human Physiology ◽

Critical Care ◽

Intensive Care ◽

Severe Acute Respiratory Syndrome ◽

Circadian Clock ◽

Clinical Course ◽

Disease Expression ◽

Severe Manifestation ◽

Novel Coronavirus

We currently find ourselves in the midst of a global coronavirus disease 2019 (COVID-19) pandemic, caused by the highly infectious novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we discuss aspects of SARS-CoV-2 biology and pathology and how these might interact with the circadian clock of the host. We further focus on the severe manifestation of the illness, leading to hospitalization in an intensive care unit. The most common severe complications of COVID-19 relate to clock-regulated human physiology. We speculate on how the pandemic might be used to gain insights on the circadian clock but, more importantly, on how knowledge of the circadian clock might be used to mitigate the disease expression and the clinical course of COVID-19.

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Clinical characteristics of non-convulsive status epilepticus diagnosed by simplified continuous electroencephalogram monitoring at an emergency intensive care unit

Acute Medicine & Surgery ◽

10.1002/ams2.221 ◽

2016 ◽

Vol 4 (1) ◽

pp. 31-37 ◽

Cited By ~ 6

Author(s):

Satoshi Egawa ◽

Toru Hifumi ◽

Kenya Kawakita ◽

Arisa Manabe ◽

Ryuta Nakashima ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Status Epilepticus ◽

Clinical Characteristics ◽

Convulsive Status Epilepticus

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Increase in Pediatric Intensive Care Unit Hospitalizations Due to Toxic Ingestions during the COVID-19 Pandemic

Journal of Pediatric Intensive Care ◽

10.1055/s-0041-1727249 ◽

2021 ◽

Author(s):

Jennifer L. van Helmond ◽

Brittany Fitts ◽

Jigar C. Chauhan

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Pediatric Intensive Care Unit ◽

Home Environment ◽

Clinical Characteristics ◽

Pediatric Intensive Care ◽

Cross Sectional Study ◽

Mitigation Measures ◽

Sectional Study ◽

Cross Sectional

AbstractThe coronavirus disease 2019 (COVID-19) pandemic and related community mitigation measures had a significant psychosocial impact. We suspected that more patients were admitted to our pediatric intensive care unit (PICU) for toxic ingestions since the start of the pandemic. We therefore investigated if PICU admissions related to toxic ingestions were higher in 2020 as a result of COVID-19 compared with previous years. We completed a cross-sectional study at a tertiary children's hospital comparing admissions to our PICU between April 2020 and October 2020, during which COVID-19 and community mitigation measures were in place, to those during the same 7-month period in the previous 3 years. Total PICU admissions, admissions for all toxic ingestions (intentional ingestions and accidental ingestions), and demographic and clinical characteristics of patients were compared. Total PICU admissions in 2020 during COVID-19 pandemic months were lower compared with the same months in the preceding 3 years (−16%, p< 0.001), however, admissions for toxic ingestions were higher during COVID-19 (+64%, p< 0.001). When separated by type, intentional (+55%, p = 0.012) and accidental ingestions (+94%, p = 0.021) were higher during COVID-19. COVID-19 with community mitigation measures has led to an increase in PICU admissions for intentional and accidental ingestions, indicating an increase in severity of toxic ingestions in children associated with the pandemic. Mental health of adolescents, and safety of infants and toddlers in their home environment, should be targeted with specific interventions in the ongoing COVID-19 pandemic.

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Clinical characteristics and neonatal outcomes of liveborn newborns with hydrops fetalis treated in a tertiary level neonatal intensive care unit

Birth Defects Research ◽

10.1002/bdr2.1640 ◽

2020 ◽

Vol 112 (6) ◽

pp. 515-522

Author(s):

Nuriye Emiroğlu ◽

Fatma Hilal Yılmaz ◽

Ramazan Keçeci ◽

Mehmet Yücel ◽

Nazlı Dilay Gültekin ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Neonatal Intensive Care Unit ◽

Neonatal Intensive Care ◽

Clinical Characteristics ◽

Hydrops Fetalis ◽

Neonatal Outcomes ◽

Tertiary Level

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CLINICAL CHARACTERISTICS OF 28 PATIENTS WITH DIABETES AND COVID-19 IN WUHAN, CHINA

Endocrine Practice ◽

10.4158/ep-2020-0108 ◽

2020 ◽

Vol 26 (6) ◽

pp. 668-674 ◽

Cited By ~ 33

Author(s):

Feng Wang ◽

Yan Yang ◽

Kun Dong ◽

Yongli Yan ◽

Shujun Zhang ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Clinical Characteristics ◽

Troponin I ◽

Clinical Laboratory ◽

Invasive Mechanical Ventilation ◽

Icu Patients ◽

Patients With Diabetes

Objective: Previous studies on coronavirus disease 2019 (COVID-19) were based on information from the general population. We aimed to further clarify the clinical characteristics of diabetes with COVID-19. Methods: Twenty-eight patients with diabetes and COVID-19 were enrolled from January 29, 2020, to February 10, 2020, with a final follow-up on February 22, 2020. Epidemiologic, demographic, clinical, laboratory, treatment, and outcome data were analyzed. Results: The average age of the 28 patients was 68.6 ± 9.0 years. Most (75%) patients were male. Only 39.3% of the patients had a clear exposure of COVID-19. Fever (92.9%), dry cough (82.1%), and fatigue (64.3%) were the most common symptoms, followed by dyspnea (57.1%), anorexia (57.1%), diarrhea (42.9%), expectoration (25.0%), and nausea (21.4%). Fourteen patients were admitted to the intensive care unit (ICU). The hemoglobin A1c level was similar between ICU and non-ICU patients. ICU patients had a higher respiratory rate, higher levels of random blood glucose, aspartate transaminase, bilirubin, creatine, N-terminal prohormone of brain natriuretic peptide, troponin I, D-dimers, procalcitonin, C-reactive protein, ferritin, interleukin (IL)-2R, IL-6, and IL-8 than non-ICU patients. Eleven of 14 ICU patients received noninvasive ventilation and 7 patients received invasive mechanical ventilation. Twelve patients died in the ICU group and no patients died in the non-ICU group. Conclusion: ICU cases showed higher rates of organ failure and mortality than non-ICU cases. The poor outcomes of patients with diabetes and COVID-19 indicated that more supervision is required in these patients. Abbreviations: COVID-19 = coronavirus disease 2019; ICU = intensive care unit; MERS-CoV = middle East respiratory syndrome-related coronavirus; 2019- nCoV = 2019 novel coronavirus; NT-proBNP = N-terminal prohormone of brain natriuretic peptide; SARS-CoV = severe acute respiratory syndrome-related coronavirus

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