Hepatoprotective Activity of Turmeric and Garlic against 7-12, Dimethylbenzanthracene Induced Liver Damage in Wistar Albino Rats

In order to isolate the main hepatoprotective component of Echinops grijisii, the crude drug was extracted with methanol and subjected to continuous extractions using n-hexane chloroform, ethyl acetate and n-butanol. The hepatoprotective studies of each fraction from the methanol extract of E. grijisii was conducted in Wistar albino rats with CC14-induced liver damage. Hepatoprotective activity was evaluated in terms of the modification of serum transaminase values such as SGOT and SGPT, and histopathological changes of liver biopsy. The results indicated that the main hepatoprotective component was concentrated in n-butanol and aqueous fractions.

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Assessment of the hepatoprotective activity of the seeds of Hunteria umbellata (Hallier F.) on carbon tetrachloride (CCl4) induced liver damage in Wistar albino rats

10.1063/1.5033397 ◽

2018 ◽

Author(s):

Olubanke Olujoke Ogunlana ◽

Oluseyi Ebenezer Ogunlana ◽

Isaacson Bababode Adelani ◽

Angie Osariem Igbinoba Adebayo ◽

Opetoritse Laju David ◽

...

Keyword(s):

Carbon Tetrachloride ◽

Liver Damage ◽

Hepatoprotective Activity ◽

Albino Rats ◽

Wistar Albino Rats

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Hepatoprotective Activity of Calotropis gigantea Root Bark Experimental Liver Damage Induced by D-Galactosamine in Rats

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2008.1.3.12 ◽

1970 ◽

Vol 1 (3) ◽

pp. 281-286

Author(s):

Pradeep Deshmukh ◽

Tanaji Nandgude ◽

Mahendra Singh Rathode ◽

Anil Midha ◽

Nitin Jaiswal

Keyword(s):

Methyl Cellulose ◽

Hepatoprotective Activity ◽

Albino Rats ◽

Root Bark ◽

Significant Activity ◽

Alcoholic Extract ◽

Calotropis Gigantea ◽

Wistar Albino Rats ◽

Experimental Liver ◽

Hepatoprotective Drug

The suspensions of alcoholic extract of root bark of the plant Calotropis gigantea in 0.6% carboxy methyl cellulose (CMC) were evaluated for hepatoprotective activity in Wistar albino rats by inducing hepatic injury with D-galactosamine (400 mg/kg). Alcoholic extract of root bark of the plant Calotropis gigantea at an oral dose of 200 mg/kg and 400 mg/kg exhibited a significant (P<0.001, P<0.01 and P<0.05) protection effect by normalizing the levels of aspartate amino transferase (ASAT/ GOT), alanine amino transferase (ALAT/GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), which were significantly (P<0.001) increased in rats by treatment with 400 mg/kg i.p. of D-galactosamine. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P<0.001).

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The effect of baicalein on endoplasmic reticulum stress and autophagy on liver damage

Human & Experimental Toxicology ◽

10.1177/09603271211003634 ◽

2021 ◽

pp. 096032712110036

Author(s):

MC Üstüner ◽

C Tanrikut ◽

D Üstüner ◽

UK Kolaç ◽

Z Özdemir Köroğlu ◽

...

Keyword(s):

Endoplasmic Reticulum ◽

Transcription Factor ◽

Er Stress ◽

Liver Damage ◽

Albino Rats ◽

Tem Analysis ◽

Stress Markers ◽

Activating Transcription Factor 4 ◽

Activating Transcription Factor ◽

Wistar Albino Rats

Carbon tetrachloride (CCl4) is a toxic chemical that causes liver injury. CCl4 triggers endoplasmic reticulum (ER) stress and unfolded protein response (UPR). UPR triggers autophagy to deal with the damage. The aim of this study was to investigate the effect of baicalein, derived from Scutellaria baicalensis, on CCl4-induced liver damage concerning ER stress and autophagy. Two groups of Wistar albino rats (n = 7/groups) were treated with 0.2 ml/kg CCl4 for 10 days with and without baicalein. Histological and transmission electron microscopy (TEM) analysis, autophagy, and ER stress markers measurements were carried out to evaluate the effect of baicalein. Histological examinations showed that baicalein reduced liver damage. TEM analysis indicated that baicalein inhibited ER stress and triggered autophagy. CCl4-induced elevation of C/EBP homologous protein (CHOP), glucose-regulating protein 78 (GRP78), activating transcription factor 4 (ATF4), activating transcription factor 6 (ATF6), inositol requiring enzyme 1 (IRE1), pancreatic ER kinase (PERK), and active/spliced form of X-box-binding protein 1 (XBP1s) ER stress markers were decreased by baicalein. Baicalein also increased the autophagy-related 5 (ATG5), Beclin1, and Microtubule-associated protein 1A/1B-light chain 3-phosphatidylethanolamine-conjugated form (LC3-II) autophagy marker levels. In conclusion, baicalein reduced the CCl4-induced liver damage by inhibiting ER stress and the trigger of autophagy.

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Protective Effect of Ethanolic Extract ofTabernaemontana divaricata(L.) R. Br. against DEN and Fe NTA Induced Liver Necrosis in Wistar Albino Rats

BioMed Research International ◽

10.1155/2014/240243 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 9

Author(s):

Kannappan Poornima ◽

Palanisamy Chella Perumal ◽

Velliyur Kanniappan Gopalakrishnan

Keyword(s):

Ethanolic Extract ◽

Treated Group ◽

Hepatic Necrosis ◽

Hepatoprotective Activity ◽

Albino Rats ◽

Protective Effects ◽

Liver Necrosis ◽

Standard Drug ◽

Tabernaemontana Divaricata ◽

Wistar Albino Rats

This study is an attempt to evaluate the hepatoprotective activity ofTabernaemontana divaricataagainst DEN and Fe NTA induced liver necrosis in rats. Ethanolic extract of the whole plant ofTabernaemontana divaricataat doses of 200 and 400 mg/kg body weight and 5-fluorouracil (standard drug) was orally administered to male Wistar Albino rats once daily for 24 weeks, simultaneously treated with the carcinogen DEN and Fe NTA. In simultaneously treated animals, the plant extract significantly decreased the levels of uric acid, bilirubin, AST, ALT, and ALP in serum and increased the levels of liver marker enzymes in liver. Treatment with the extracts resulted in a significant increase in the levels of antioxidants accompanied by a marked reduction in the levels of malondialdehyde when compared to DEN and Fe NTA treated group. When compared with 200 mg/kg bw rats, 400 mg/kg bw rats and 5-fluorouracil treated rats showed better results in all the parameters. The histopathological studies confirmed the protective effects of extract against DEN and Fe NTA induced liver necrosis. Thus, it could be concluded that the use ofTabernaemontana divaricataextract in the treatment of carcinogen induced hepatic necrosis.

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Evaluation of anti-hepatotoxic potential of Cassia javanica (L.) methanol extract against paracetamol-induced liver damage in Wistar albino rats

Proceedings of the Mizoram Science Congress 2018 (MSC 2018) - Perspective and Trends in the Development of Science Education and Research ◽

10.2991/msc-18.2018.40 ◽

2018 ◽

Author(s):

Esther Lalhmingliani ◽

Zodinpuii ◽

R.K. Lalremtluangi ◽

Lalramdinthara Chenkual ◽

Lalthansangi

Keyword(s):

Liver Damage ◽

Methanol Extract ◽

Albino Rats ◽

Wistar Albino Rats

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EVALUATION OF HEPATOPROTECTIVE EFFECTS OF SELECTED FRUIT PEEL EXTRACTS AND THEIR POLY HERBAL MIXTURE ON CCL4 INDUCED HEPATOTOXICITY: AN IN VIVO STUDY

INDIAN DRUGS ◽

10.53879/id.57.09.12110 ◽

2020 ◽

Vol 57 (09) ◽

pp. 67-74

Author(s):

Gana Manjusha Kondepudi ◽

Battu Ganga Rao ◽

P Balakrishnaiah

Keyword(s):

Hepatoprotective Activity ◽

Serum Markers ◽

Albino Rats ◽

Dependent Manner ◽

Fruit Peel ◽

Herbal Mixture ◽

Wistar Albino Rats ◽

Dose Dependent ◽

Peel Extract

The main aim of this study was to screen the selected fruit peel extracts and their polyherbal mixture (PHM) for hepatoprotective activity. Male wistar albino rats (180-200 g), divided into 12 groups after induction of hepatotoxicity, were treated with selected fruit peel extracts and PHM and at the end of 14th day blood and liver samples were collected and analysed. The aqueous peel extract of Malus pumila was a better hepatoprotective among the selected peel extracts. The activities might be due to the conditioning of hepatocytes by protecting the integrity of the membrane from CCl4 induced leakage of serum markers into circulation. All the selected plant extracts and PHM were shown to revert back the liver enzymes to the normal values in diseased rats in a dose dependent manner. In conclusion, the selected fruit peel extracts and poly herbal mixture can be a potent hepatoprotective agent due to their antioxidant and anti-inflammatory actions.

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Hepatoprotective Activity on Vitex negundo Linn. (Verbenaceae) by using Wistar Albino Rats in Ibuprofen Induced Model

International Journal of Pharmacology ◽

10.3923/ijp.2010.658.663 ◽

2010 ◽

Vol 6 (5) ◽

pp. 658-663 ◽

Cited By ~ 7

Author(s):

R. Mahalakshm ◽

P. Rajesh ◽

N. Ramesh ◽

V. Balasubram ◽

V. Rajesh Kannan

Keyword(s):

Hepatoprotective Activity ◽

Albino Rats ◽

Vitex Negundo ◽

Wistar Albino Rats

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Antioxidant and Hepatoprotective Potentials of Lasimorpha senegalensis Schott Leaf Extract on Carbon Tetrachloride-induced Liver Damage in Rats

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2020/v32i2130754 ◽

2020 ◽

pp. 70-78

Author(s):

Chinyere Blessing Chigor ◽

Felix Ifeanyi Nwafor ◽

Edith Ugwuja ◽

Chisimdi S. Obi

Keyword(s):

Liver Damage ◽

Leaf Extract ◽

Liver Enzymes ◽

Radical Scavenging Activity ◽

Research Work ◽

Radical Scavenging ◽

Albino Rats ◽

Endogenous Antioxidants ◽

Wistar Albino Rats

Aims: The present study assessed the antioxidant and hepatoprotective potentials of the methanolic leaf extract of Lasimorpha senegalensis – a medicinal plant used by the indigenous people of Nigeria to treat hepatitis and feverish conditions. Place and Duration of Study: The research work was conducted in the Department of Pharmacognosy and Environmental Medicine and Department of Plant Science and Biotechnology, both in the University of Nigeria, Nsukka, from May to August, 2019. Methodology: Phytochemical analyses and acute toxicity study of the sample followed standard procedures. In vitro antioxidant assay was by DPPH and H2O2 models. A total of 25 male Wistar albino rats (120 – 150 g) were grouped into five, each group with five animals. Hepatotoxicity was induced with carbontetrachloride (1 ml/kg). The treatment groups (3-5) received extract (200 and 400 mg/kg) and Silymarin (100 mg/kg). Endogenous antioxidants (superoxide dismutase, catalase, glutathione peroxidase), plasma malondialdehyde and liver enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphate) were determined after treatment. Results: The results showed the leaf extract had appreciable amounts of bioactive phytochemicals and free radical scavenging activity (IC50 of 0.52 mg/ml and 0.71 mg/ml for DPPH and H2O2 respectively) with no toxicity at 5000 mg/kg. The extract also elevated the endogenous antioxidants and significantly (p ≤ .05) reduced lipid peroxidase and liver enzymes. Conclusion: This report justifies the local use of this plant in the management of various diseases related to oxidative stress and liver damage.

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