scholarly journals Prevalence of Tuberculosis among Children with Severe Acute Malnutrition at Ola during Children’s Hospital in Freetown Sierra Leone

Author(s):  
Lucy Eberechukwu Yaguo Ide

Prevalence of Tuberculosis among Children with Severe Acute Malnutrition at Ola during Children’s Hospital in Freetown Sierra Leone. Worldwide, pediatric tuberculosis account for about 1million cases, annually, accounting for 10-15% of all tuberculosis; with more than 100,000 estimated mortality annually, it is also one of the 10 most common causes of childhood mortality. Aim of this study was to determine the prevalence of tuberculosis among children with severe acute malnutrition at Ola During Children’s Hospital in Freetown Sierra Leone. It was a descriptive cross-sectional study, carried out at the therapeutic feeding center (TFC) of Ola During Children’s Hospital in 2018. An opportunistic sampling method in which every next patient whose mother gave consent was recruited until the number 74 was reached. Patients who met the World Health Organisation (WHO) criteria for diagnosis of severe acute malnutrition were admitted into the TFC and consecutively selected and interviewed using a structured questionnaire after obtaining written informed consent, from their mothers or caregivers. All the mothers approached during the study period consented for the study. Diagnosis of tuberculosis was both clinically and by laboratory investigations, 74 children whose mothers/caregivers consented for the study were recruited. Data was entered into an excel spread sheet and analyzed using Epi info version 7. There were 74 children with a median age of 11 months ± 9.9SD. Forty (54.1%) Males and 34(45.9%) Females, with a M:F ratio of 1.18:1. Prevalence of tuberculosis was 20%. Diagnosis of Tuberculosis was based on clinical findings of extreme weight loss or failure to gain weight, Chest x-ray findings of perihilar infiltrates. Gene Xpert MTB RIF results were all negative 0(0%). Most of the mothers 59 (79.7%) were aged between 20-29 years, 45(60.9%) of them were petty traders, while 15(20.3%) had no formal education. The chi square was used to determine the statistical difference, there was no statistically significant difference between gender and TB, P= 0.3415, there is a statistically significant difference between no formal education and occurrence of tuberculosis in their children P= 0.0467. Conclusions/Recommendations: Prevalence of Tuberculosis is still high among children with severe acute malnutrition. Gene Xpert MTB RIF was unable to make a bacteriological confirmation. There are difficulties with making bacteriological confirmation of tuberculosis in resource poor settings. Guidelines requiring mainly clinical parameters need to be developed for use in resource limited countries.

2021 ◽  
Vol 29 (01) ◽  
pp. 116-120
Author(s):  
Saadia Khan ◽  
Waqas Imran Khan ◽  
Ayesha Fayyaz ◽  
Ibad Ali ◽  
Asad Abbas ◽  
...  

Objective: To determine the percentage of Hypothyroidism in children with severe acute malnutrition. Study Design: Cross Sectional study. Setting: Nutrition Rehabilitation Center, Children’s Hospital and Institute of Child Health Multan. Period: January 2019 to December 2019. Material & Methods: A total of 255 malnourished patients (as per inclusion criteria) were included in current study. A written Performa was designed to collect history, anthropometric measurements and systemic examination. Taking aseptic measures venous blood was sent for baseline tests as well as for T3, T4 and TSH, total serum protein albumin and total ferritin levels to hospital laboratory. Correlation between serum thyroid concentrations and total protein, albumin, hemoglobin and serum ferritin were estimated by using t-test and p-vlaue less than 0.05 was considered as significant. Total collected data was entered and analyzed in SPSS version 21.0. Results: A total of 255 malnourished children were included in this study. Majority of studied subjects were male (52.5%) with 83.92%, 3-5 years of age. Amongst the 255 children mean values of T3 in MAM and SAM patients were 105.4 ng/dl and 89.7 ng/dl respectively. There was a statistically significant (p <0.001) association between decreased T3 and type of malnutrition. Similarly, mean values of T4 in MAM and SAM patients were 6.3 ug/dl and 5.7 ug/dl respectively that was statistically significant (p <0.05). Lower values of T4 were higher among SAM children in 1 to 3 years age group compared to respective MAM children with p value .0.05 and high T4 value in 3-5 years age group of MAM children were both statistically insignificant. Higher mean Values of TSH was found in SAM compared to MAM children both age groups. Conclusion: Severe acute malnutrition (SAM) is associated with reduction in T3 and T4 levels and higher levels of TSH in SAM children as compared to MAM. The altered thyroid hormone status in children with PEM is perhaps a protective phenomenon to limit protein catabolism and lower energy requirements.


2020 ◽  
Author(s):  
Amira M. Shalaby ◽  
Amira F. EL-Gazzar

Abstract Background: Congenital anomalies (CA) are common causes of infant’s and childhood deaths and disability. Objectives: The aim of the study is to determine the prevalence, describe the types and risk factors of congenital anomalies among newborns admitted to Neonatal Intensive Care Unit (NICU) of a Children's Hospital. Study design: It is a prospective observational study(analytic cross sectional study) was performed and screening of the newborn admitted at NICU of a Children's Hospital during the period of 6 months from 1 to 12-2017 to the end of 5-2018. The sample was 346 newborns, 173 cases and 173 control. We collected data using a record checklist and an interviewing questionnaire.Results: There were a significant difference between cases and control concerning gestational age (P=0.001), single or multiple babies (P=0.002), residence (P=0.001), consanguineous marriage (P=0.01) and family history of unfavorable outcome (P=0.001). We also found that the most common type of congenital anomalies was gastrointestinal anomalies 63 cases (36.4%) with tracheoesophageal fistula 17 cases (27%) being the most common GIT anomalies. Then the musculoskeletal anomalies being the second common anomalies 14.5% with diaphragmatic hernia 10 cases being the most common in musculoskeletal anomalies followed by other anomalies (22 multiple +1Conjoined Twins 23 cases (13.3%) followed by circulatory anomalies 22 cases (12.7%), followed by CNS anomalies 18 cases (10%). Conclusion: The prevalence of congenital anomalies was 22.97%. The most common anomalies were gastrointestinal anomalies (GIT), musculoskeletal anomalies, multiple anomalies and circulatory system anomalies. The risk factors were consanguineous marriage, positive family history, urban areas, full-term and singleton pregnancies.


2021 ◽  
Vol 62 (4) ◽  
Author(s):  
Nguyen Van Dung ◽  
Nguyen Thi Thinh ◽  
Pham Van Phu

A cross-sectional survey on 523 pairs of mother and suffered from acute respiratory infections child6-23 months old treated at the Maternity and Children’s Hospital of Ha Nam provine in 2016-2018to assess the nutritional status of children and describe some mother’s child-feeding practices. Theresults showed that: The rates of stunting and wasting of children were high: 21.2% and 11.1%(respectively); the rate of underweight was 14.0%. The rates of mothers who breastfeed their babieslate after the first hour after birth and of mothers who give complementary foods too early or too late(before 6 months or after 8 months of age) were quite high: 62.5% and 53.0% (respectively); the rateof mothers squeezed colostrum before first breastfeeding was 24.3%. Children who were started oncomplementary feeding at the wrong time compared with those who were fed at the right time hadhigher rates of stunting: 24.2% and 18.8% (respectively) (OR=1, 4; 95%CI 0.9-2.3) but no statisticallysignificant difference (p=0.1075); the rate of underweight malnutrition was also higher: 19.5% and7.8% (respectively) statistically significant difference (OR=2.9; 95%CI 1.6-5.3; p=0.0001).


2021 ◽  
Vol 62 (2) ◽  
Author(s):  
Bùi Đặng Lan Hương ◽  
Bùi Đặng Phương Chi ◽  
Trần Thị Kiều Trinh

Objective: To evaluate the appropriateness in using drugs of hand, foot and mouth disease treatment at the Children’s Hospital of Can Tho city in 2019. Subjects and methods: Retrospective cross-sectional descriptive study on 400 medical records of inpatients at Can Tho Children’s Hospital during the period from January 2019 to December 2019. Results: There was a statistically significant difference between the group of patients using the dose appropriate to the prescribed dose (P = 0.000 <0.005). Drugs with the most suitable delivery rhythm were Paracetamol, Midazolam, Diazepam, Adrenalin, Dobutamim, Immunoglobulin G, Cefuroxim with 100% as recommended. The lowest rate of used drugs compared to the recommendations was Cefotaxim (89.9%) and Ceftriaxon (83.3%). The most used oral medications: Paracetamol, Ibuprofen, Phenobarbital, Chlorpheniramine, Diazepam, Adrenalin, Dobutamim, Immunoglobulin G were suitable to the 100% recommendation. The lowest appropriate rate compared with the recommendation was Cefuroxime, which accounted for 6.7%, using the injection route in accordance with the recommendation. The more common pair of interactions was Paracetamol and Phenobabital concomitantly accounted for 90.6% of the total 149 of the recorded interactions and a lower proportion was the pair of Midazolam with Phenobabital, accounting for 9.4%. Conclusion: Most drugs with highly suitable indications for use, of which the highest were Paracetamol, Diazepam, Adrenalin, Dobutamim, Immunoglobulin G. Antibiotics had the lowest appropriate utilization rate.


2019 ◽  
Vol 31 (4) ◽  
pp. 238-243
Author(s):  
Allison I Daniel

BackgroundInpatient treatment at nutritional rehabilitation units (NRUs) is needed for children who have severe acute malnutrition (SAM) and acute illness, loss of appetite, or severe oedema. World Health Organization guidelines state that nutritional counselling should be done with primary caregivers at NRUs. These recommendations also include psychosocial stimulation interventions to improve developmental outcomes in children with SAM. However, there is limited information about the delivery of these types of interventions for caregivers and children in NRU settings. The primary objective of this research was therefore to obtain data about NRU resources, activities, and protocols relevant to psychosocial stimulation and counselling interventions during inpatient treatment of children with SAM. MethodsA cross-sectional survey was administered by interview at all 16 NRUs in seven districts in Southern Malawi. Participants were health workers, nurses, and nutritionists employed at the respective NRUs. ResultsThe response rate was 100% across NRUs. Half of participants said that psychosocial stimulation interventions are conducted at their respective NRUs, yet none of the NRUs have protocols for delivery of these interventions. Furthermore, 7/16 (44%) NRUs have no resources for psychosocial stimulation including play materials. Thirteen of 16 (81%) participants said that they feel this type of intervention is very important and 3/16 (19%) participants said that this somewhat important for children with SAM. All NRUs provide counselling to caregivers about breastfeeding and nutrition; 15/16 (94%) also give counselling about water, sanitation and hygiene. ConclusionsUltimately, results from this survey highlighted that there is a need to invest in comprehensive interventions to improve developmental and nutritional outcomes in these vulnerable children requiring admission to NRUs. 


2020 ◽  
Vol 189 (12) ◽  
pp. 1623-1627
Author(s):  
Francisco M Barba ◽  
Lieven Huybregts ◽  
Jef L Leroy

Abstract Child acute malnutrition (AM) is an important cause of child mortality. Accurately estimating its burden requires cumulative incidence data from longitudinal studies, which are rarely available in low-income settings. In the absence of such data, the AM burden is approximated using prevalence estimates from cross-sectional surveys and the incidence correction factor $K$, obtained from the few available cohorts that measured AM. We estimated $K$ factors for severe acute malnutrition (SAM) and moderate acute malnutrition (MAM) from AM incidence and prevalence using representative cross-sectional baseline and longitudinal data from 2 cluster-randomized controlled trials (Innovative Approaches for the Prevention of Childhood Malnutrition—PROMIS) conducted between 2014 and 2017 in Burkina Faso and Mali. We compared K estimates using complete (weight-for-length z score, mid-upper arm circumference (MUAC), and edema) and partial (MUAC, edema) definitions of SAM and MAM. $K$ estimates for SAM were 9.4 and 5.7 in Burkina Faso and in Mali, respectively; K estimates for MAM were 4.7 in Burkina Faso and 5.1 in Mali. The MUAC and edema–based definition of AM did not lead to different $K$ estimates. Our results suggest that $K$ can be reliably estimated when only MUAC and edema-based data are available. Additional studies, however, are required to confirm this finding in different settings.


Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 681
Author(s):  
Ritu Rana ◽  
Marie McGrath ◽  
Ekta Sharma ◽  
Paridhi Gupta ◽  
Marko Kerac

Small and nutritionally at-risk infants under six months, defined as those with wasting, underweight, or other forms of growth failure, are at high-risk of mortality and morbidity. The World Health Organisation 2013 guidelines on severe acute malnutrition highlight the need to effectively manage this vulnerable group, but programmatic challenges are widely reported. This review aims to inform future management strategies for small and nutritionally at-risk infants under six months in low- and middle-income countries (LMICs) by synthesising evidence on existing breastfeeding support packages for all infants under six months. We searched PubMed, CINAHL, Cochrane Library, EMBASE, and Global Health databases from inception to 18 July 2018. Intervention of interest were breastfeeding support packages. Studies reporting breastfeeding practices and/or caregivers’/healthcare staffs’ knowledge/skills/practices for infants under six months from LMICs were included. Study quality was assessed using NICE quality appraisal checklist for intervention studies. A narrative data synthesis using the Synthesis Without Meta-analysis (SWiM) reporting guideline was conducted and key features of successful programmes identified. Of 15,256 studies initially identified, 41 were eligible for inclusion. They were geographically diverse, representing 22 LMICs. Interventions were mainly targeted at mother–infant pairs and only 7% (n = 3) studies included at-risk infants. Studies were rated to be of good or adequate quality. Twenty studies focused on hospital-based interventions, another 20 on community-based and one study compared both. Among all interventions, breastfeeding counselling (n = 6) and education (n = 6) support packages showed the most positive effect on breastfeeding practices followed by breastfeeding training (n = 4), promotion (n = 4) and peer support (n = 3). Breastfeeding education support (n = 3) also improved caregivers’ knowledge/skills/practices. Identified breastfeeding support packages can serve as "primary prevention" interventions for all infants under six months in LMICs. For at-risk infants, these packages need to be adapted and formally tested in future studies. Future work should also examine impacts of breastfeeding support on anthropometry and morbidity outcomes. The review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO 2018 CRD42018102795).


2020 ◽  
Vol 5 (1) ◽  
pp. 466-484
Author(s):  
Bashiru Mansaray ◽  
Shaosheng Jin

AbstractThe Sierra Leonean government has implemented the improved rice varieties directed at enhancing more rice production to reduce food insecurity. This paper evaluates the food security effect of improved rice variety adoption using cross-sectional data collected in 2017 from a randomly selected sample of 624 rice farmers in Sierra Leone. The analysis uses the endogenous switching regression and propensity score matching (PSM) approach. The results revealed that the adoption of improved rice varieties has a significant positive effect on food security. That confirms the crucial role of improved rice variety adoption in increasing food production and food security. Therefore, the study recommended the intensification of policies that promote improved rice variety adoption, if more food production and food security are to be realized. Further, the government should continue the lead in rice variety promotion and dissemination and in enhancing an enabling environment for the effective adoption of farmers. Given the preponderant evidence of the different factors of food security, appropriate policies that seek to promote formal education, more income generation for farmers, and easy and credible access to farmland for landless farmers would enhance food security.


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