scholarly journals Comparative Evaluation of the Antimicrobial Efficacy of Octenidine Dihydrochloride with Contemporary Root Canal Disinfectants: A Systematic Review

2020 ◽  
pp. 64-76
Author(s):  
Rukhsaar Akbar Gulzar ◽  
P. Ajitha ◽  
Haripriya Subbaiyan
Keyword(s):  
Systematic Review ◽  
Root Canal ◽  
Primary Outcome Measure ◽  
Antimicrobial Efficacy ◽  
Antibacterial Efficacy ◽  
Human Teeth ◽  
Root Canal Irrigants ◽  
Octenidine Dihydrochloride ◽  
Wide Range

Octenidine is a cationic disinfectant that has been tested for its wide range of antibacterial efficacy and biocompatibility. It finds its application in the medical field as an antiseptic for wounds and mucous membranes. The present systematic review aims to compare the antimicrobial efficacy of Octenidine Dihydrochloride with various root canal irrigants and medicaments. An electronic search strategy was planned to search the database of PUBMED CENTRAL and MEDLINE using the search terms alone and in combination using PUBMED search builder till September 2019 for related studies. In Vitro studies that compared the antibacterial efficacy of Octenidine Dihydrochloride to other irrigants and medicaments against Enterococcus faecalis and Candida albicans using extracted human teeth were included in the review. The primary outcome measure was the reduction in the microbial load which was assessed through either CFU or the percentage of viable and dead bacteria. A total of 7 studies that matched the inclusion criteria were included in the systematic review. The studies indicated that Octenidine Dihydrochloride was highly effective in eliminating E faecalis and C albicans and could be a more biocompatible potential alternative or an adjunct to the existing irrigants and medicaments.

scholarly journals Effect of exposure to etidronic acid on the bond strength of calcium silicate-based cements after 1 and 21 days: an in vitro study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Elena Rebolloso de Barrio ◽  
Juan José Pérez-Higueras ◽  
Ernesto García-Barbero ◽  
Lucía Gancedo-Caravia
Keyword(s):  
Bond Strength ◽  
Root Canal ◽  
Calcium Silicate ◽  
Ethylenediaminetetraacetic Acid ◽  
Setting Time ◽  
Etidronic Acid ◽  
Human Teeth ◽  
Root Canal Irrigants ◽  
Push Out

Abstract Background After reparation of root perforations with calcium silicate-based cements (CSBC), the surface of the material is expected to be exposed to root canal irrigants (RCI) while resuming the root canal treatment. Methods The aim of this study was to compare the effect of exposure to a mixture of sodium hypochlorite (NaOCl) and etidronic acid (HEBP) or other irrigants on the Push Out Bond Strength (POBS) of CSBC after two different setting times. 240 root slices 1 mm thick were obtained from single-rooted human teeth. A 1.4 mm diameter perforation was performed on each slice and filled with Biodentine (BD) or ProRoot MTA (PMTA). After 1 or 21 days they were exposed to 17% ethylenediaminetetraacetic acid, 5.25% NaOCl, a mixture of 5.25% NaOCl and 9% HEBP (NaOCl + HEBP) or saline (n = 15) and submitted to a push-out test. POBS results were analysed with ANOVA and Tukey tests. Results BD showed higher POBS than PMTA after 1 day (p < .05). After 21 days no differences were found between materials. After 1 day exposure to NaOCl + HEBP resulted in higher POBS, compared to the other irrigants (p < .05). Conclusion POBS results are influenced by the cement, the setting time and the exposure to irrigants.

Antimicrobial Efficacy of Octenidine Dihydrochloride and Artemisia Annua Plant Extract as Root Canal Irrigants – An In Vivo Study

2021 ◽  
Author(s):  
Tejinderpal Singh
Keyword(s):  
Plant Extract ◽  
Root Canal ◽  
Artemisia Annua ◽  
Saline Group ◽  
In Vivo Study ◽  
Antimicrobial Efficacy ◽  
Root Canal Irrigants ◽  
Octenidine Dihydrochloride ◽  
Group A

Objectives: The study aimed to evaluate and compare the antimicrobial efficacy of two root canal irrigantsOctenidine dihydrochloride and herbal Artemisia annua plant extract. Methods: Forty-two maxillary central incisors teeth were selected which were divided into four groups – group A (Octenidine dihydrochloride with saline), group B (only Octenidine dihydrochloride), group C (Artemisia annua with saline), group D (only Artemisia annua). Samples for microbiological culturing were collected after access preparation, after biomechanical preparation, and after final irrigation in each group with the help of paper points. CFU count was observed for both aerobic and anaerobic bacteria. The results were collected and subjected to a Student t-test. Results: After statistical analysis, it was observed that bacterial reduction was seen in all the groups but the maximum reduction was observed in group A. Conclusion: The results of the present study imply that a highly significant reduction in CFU/ml count was found in subgroup A1. Therefore, within the limitations of the present in-vivo study, Octenidine dihydrochloride can be recommended as an effective root canal irrigant than Artemisia annua plant extract.

scholarly journals An in vitro comparison of Antimicrobial Efficacy of Three Root Canal Irrigants—BioPure MTAD, 2% Chlorhexidine Gluconate and 5.25% Sodium Hypochlorite as a Final Rinse against E. faecalis

2013 ◽  
Vol 14 (5) ◽  
pp. 842-847 ◽  
Author(s):  
MS Rama Rao ◽  
Vinod Agrawal ◽  
Kanupriya Dhingra ◽  
V Rajesh Gopal ◽  
Abhijita Mohapatra
Keyword(s):  
Sodium Hypochlorite ◽  
Root Canal ◽  
Antibacterial Activities ◽  
Chlorhexidine Gluconate ◽  
Antimicrobial Efficacy ◽  
Pulp Tissue ◽  
Root Canal Irrigants ◽  
Significant Difference ◽  
In Vitro Comparison

ABSTRACT Aim This study was conducted to evaluate the antimicrobial activity of 5.25% sodium hypochlorite (NaOCl), 2% chlorhexidine (CHX) and BioPure MTAD when used as a final rinse against Enterococcus faecalis. Materials and methods Sixty single-rooted premolars were biomechanically prepared, inoculated with E. faecalis and divided into various groups. These were then irrigated with the test irrigants and tested microbiologically for growth of E. faecalis immediately after irrigation and after 48 hours. Results Statistical analysis showed that there was a significant difference between the antibacterial activities of BioPure MTAD, 2% CHX and 5.25% NaOCl at 5 minutes; however, the antibacterial activities of the three irrigants were comparable after 2 days of irrigation Conclusion The present study concludes that BioPure MTAD is as effective against E. faecalis as 5.25% NaOCl and more effective than 2% CHX. Clinical significance E. faecalis is one of the most resistant intracanal species and a possible cause of root canal failure. Many authors have stressed the importance of using antimicrobial irrigants during chemomechanical preparation to ensure complete disinfection. Therefore, various irrigating solutions have been used during and immediately after root canal preparation to remove debris and necrotic pulp tissue and to eliminate microorganisms that cannot be reached by mechanical instrumentation. How to cite this article Agrawal V, Rao MSR, Dhingra K, Gopal VR, Mohapatra A, Mohapatra A. An in vitro comparison of Antimicrobial Efficacy of Three Root Canal Irrigants—BioPure MTAD, 2% Chlorhexidine Gluconate and 5.25% Sodium Hypochlorite as a Final Rinse against E. faecalis. J Contemp Dent Pract 2013;14(5):842-847.

Effect of root canal irrigants on push-out bond strength of endodontic sealers: a systematic review

2020 ◽  
pp. 1-21
Author(s):  
Lara Dotto ◽  
Gabriel Kalil Rocha Pereira ◽  
Alvin Tomm ◽  
Ataís Bacchi ◽  
Rafael Sarkis-Onofre
Keyword(s):  
Systematic Review ◽  
Bond Strength ◽  
Root Canal ◽  
Root Canal Irrigants ◽  
Endodontic Sealers ◽  
Push Out

The in vitro evaluation of antibacterial efficacy optimized with cellular apoptosis on multi-functional polyurethane sealers for the root canal treatment

2021 ◽  
Vol 9 (5) ◽  
pp. 1370-1383
Author(s):  
Xiaoyu Lei ◽  
Jian Wang ◽  
Jie Chen ◽  
Jing Gao ◽  
Jinzheng Zhang ◽  
...  
Keyword(s):  
Root Canal ◽  
Evaluation System ◽  
Root Canal Treatment ◽  
Antibacterial Efficacy ◽  
Apoptotic Pathway ◽  
In Vitro Evaluation ◽  
Cellular Apoptosis ◽  
Genetic Assessment

Combined with a series of antibacterial tests and the genetic assessment of the apoptotic pathway, an evaluation system has been rationalized to govern the fate of the different compositions of PU-based sealers.

scholarly journals The Antibacterial Efficacy of Biopure MTAD in Root Canal Contaminated with Enterococcus faecalis

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Blerim Kamberi ◽  
Donika Bajrami ◽  
Miranda Stavileci ◽  
Shuhreta Omeragiq ◽  
Fatmir Dragidella ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Sodium Hypochlorite Solution ◽  
Antibacterial Efficacy ◽  
Human Teeth ◽  
Exact Test ◽  
Hypochlorite Solution ◽  
Root Canals ◽  
Significant Difference ◽  
Level Of Significance

Aim. The purpose of this in vitro study was to assess the antimicrobial efficacy of Biopure MTAD against E. faecalis in contaminated root canals. Materials and Methods. Forty-two single rooted extracted human teeth were inoculated with E. faecalis and incubated for four weeks. The samples were divided in two control and five experimental groups irrigated with 1.5% sodium hypochlorite solution (NaOCl); 3% NaOCl; BioPure MTAD; 1.5% NaOCl/17% EDTA; or 3% NaOCl/17% EDTA. After a one-week incubation, complete disinfection was confirmed by the absence of turbidity in the incubation media. Dentin shavings were taken from samples with no turbidity to verify whether E. faecalis was present in dentin tubules. Results were analyzed statistically using Fisher's exact test, with the level of significance set at . Results. Statistical analysis of the data obtained at Day 7 and after dentin shaving analysis showed that BioPure MTAD had significantly greater antibacterial activity than 1.5% NaOCl, 1.5% NaOCl/17% EDTA and 3% NaOCl/17% EDTA. No significant difference was detected between MTAD and 3% NaOCl. Conclusions. These findings suggest that BioPure MTAD possesses superior bactericidal activity compared with NaOCl and EDTA against E. faecalis.

scholarly journals Effectiveness of a silicon-based root canal sealer for filling of simulated lateral canals

2007 ◽  
Vol 18 (1) ◽  
pp. 20-23 ◽  
Author(s):  
João Vicente Baroni Barbizam ◽  
Matheus Souza ◽  
Doglas Cecchin ◽  
Jakob Dabbel
Keyword(s):  
Root Canal ◽  
In Vitro Study ◽  
Root Canal Sealer ◽  
Human Teeth ◽  
Significance Level ◽  
Working Length ◽  
Group 3 ◽  
Group 2 ◽  
Silicon Based

The purpose of this in vitro study was to evaluate the ability of a silicon-based root canal sealer, compared to zinc oxide and eugenol and an epoxy resin-based sealers, for filling of simulated lateral canals. Thirty extracted single-rooted human teeth were selected, conventional access was made and the working length was established 1 mm from the apical foramen. Three simulated lateral canals, one in each root third (coronal, middle and apical) were prepared in both the mesial and distal surfaces of each tooth using a size 15 reamer adapted to a low-speed handpiece. Each root canal was instrumented using ProTaper rotary files up to file F3 at the working length, and then irrigated with 2.5% NaOCl followed by EDTA. The teeth were assigned to 3 groups (n=10), according to the root canal sealer: Roeko Seal (Group 1), Sealer 26 (group 2) and Grossman's sealer (Group 3). Gutta-percha cold lateral condensation technique was performed in all groups. Postoperative radiographs were taken and the images were projected for evaluation of the quality of lateral canal filling. Data were submitted to statistical analysis by Kruskal Wallis test at 5% significance level. The results showed that Grossman's sealer filled a larger number of lateral canals than Roeko Seal (p<0.05) and Sealer 26 (p<0.01). It may be concluded that Roeko Seal silicone-based root canal sealer was not as effective as the Grossman's sealer for filling of simulated lateral canals. The lateral canals localized in the apical third of the root were more difficult to be filled.

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