scholarly journals Female Sexual Dysfunction in Patients Treated with Antidepressants: A Comparison between Agomelatine and Escitalopram

2021 ◽  
pp. 196-204
Author(s):  
Virinder Kaur ◽  
Ng Chong Guan ◽  
Jesjeet Singh Gill ◽  
Low Sue-Yin
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Desire ◽  
Female Sexual Dysfunction ◽  
Rating Scale ◽  
Psychiatric Clinic ◽  
Depression Severity ◽  
Cross Sectional ◽  
Care Clinic ◽  
Significant Difference ◽  
Desire Disorder

Aim: This study aims to determine and compare the prevalence of Female Sexual Dysfunction (FSD) between patients on escitalopram and agomelatine, as well as to investigate possible factors associated with their usage. Study Design: Cross-sectional. Place and Duration of Study: Psychiatric Day Care Clinic, Department of Psychological Medicine, University Malaya Medical Centre (UMMC), Malaysia, between November 1, 2020 until February 1, 2021. Methodology: This study is a cross-sectional study involving 66 women with depression from the outpatient psychiatric clinic of a university hospital; 35 of whom were prescribed with escitalopram and 31 with agomelatine. The subjects were in remission and had no significant signs or symptoms of depression for at least 2 months. The prevalence of FSD between the two groups were compared after adjusting for underlying depression severity. Results: This study showed that the overall prevalence rate of FSD was 33.3%, with the prevalence being higher for those on escitalopram (42.9%) than those on agomelatine (22.6%), but did not achieve statistical significance (P=0.081). Out of the six domains of FSD, multivariate analyses revealed that there was a significant reduction of 69% in sexual desire disorder (95% CI:0.110, 0.855), P=0.022 for those on agomelatine compared to escitalopram. Controlling for drug dosage and depression severity (as measured using Montgomery-Asberg Depression Rating Scale), the odds for patients on agomelatine developing sexual desire disorder was 0.267 (95% CI:0.091, 0.783), P=0.016. Conclusion: There was no significant difference in FSD risk between patients on agomelatine and those on escitalopram. Patients on agomelatine were however less likely to develop sexual desire disorder, which demonstrates a slightly better sexual acceptability profile of agomelatine in women in this respect compared to escitalopram.

scholarly journals Quality of Life and Female Sexual Dysfunction in Croatian Women with Stress-, Urgency- and Mixed Urinary Incontinence: Results of a Cross-Sectional Study

Medicina ◽  
2019 ◽  
Vol 55 (6) ◽  
pp. 240
Author(s):  
Ivan Radoja ◽  
Dunja Degmečić
Keyword(s):  
Quality Of Life ◽  
Urinary Incontinence ◽  
Sexual Dysfunction ◽  
Female Sexual Dysfunction ◽  
Cross Sectional Study ◽  
Mixed Urinary Incontinence ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference

Background and objectives: Urinary incontinence is defined as the involuntary leakage of urine. Studies have reported that the severity of urinary incontinence symptoms can cause decreased quality of life and female sexual dysfunction in women, but the association between the duration of the incontinence and the aforementioned disturbances has not been evaluated. The objective of this study was to evaluate the differences in the occurrence of decreased quality of life and female sexual dysfunction in Croatian women with urinary incontinence, with regard to the duration and subtype of urinary incontinence. Materials and Methods: We conducted a cross-sectional study from March 2017 to July 2018 at our neurourology and urodynamics outpatient clinic, among 120 women with urinary incontinence symptoms. Based on medical history, physical exam and urodynamic assessment, participants were divided into groups with stress-, urgency- and mixed urinary incontinence. Several quality of life and female sexual dysfunction questionnaires were used for evaluation. The differences between the three UI groups were tested by the Kruskal–Wallis test. All p values were two-sided. The level of significance was set to Alpha = 0.05. Results: The mixed urinary incontinence group had a significantly inferior quality of life (p = 0.003) and lower scores on the female sexual dysfunction questionnaires (p = 0.02). The longer the duration of incontinence King’s Health Questionnaire total score was worse (p = 0.003) and Female Sexual Function Index total score was worse (p < 0.001). Conclusions: Our results showed that there was a statistically significant difference in the occurrence of decreased quality of life and female sexual dysfunction considering the duration and subtype of incontinence in Croatian women.

scholarly journals Prevalence of female sexual dysfunction in allied health workers: a cross-sectional pilot study in a tertiary hospital in Singapore

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Farah Safdar ◽  
Chui Lee Julia Eng ◽  
Khin Lay Wai ◽  
Wan Shi Tey ◽  
Seng Bin Ang
Keyword(s):  
Risk Factors ◽  
Pilot Study ◽  
Sexual Dysfunction ◽  
Female Sexual Dysfunction ◽  
Allied Health ◽  
Health Workers ◽  
Significant Risk ◽  
Tertiary Hospital ◽  
Cross Sectional ◽  
Significant Difference

Abstract Background Female sexual dysfunction (FSD) is increasingly being identified as a problem around the world. Women can have problems in various parts of the sexual cycle - desire, arousal, lubrication, orgasm or they may experience pain related to sexual activity. The only study involving Singapore with regard to sexual dysfunction in women, the Asian Global Studies of Sexual Attitudes and Behaviours in 2002, reported that Singapore had one of the lowest age-standardised sexual dysfunction rates of 32% compared with other Asian countries. This pilot study aims to evaluate the prevalence of female sexual dysfunction and to investigate the independent significant risk factors among allied health workers in a tertiary hospital in Singapore. Methods A cross-sectional study where an anonymous questionnaire which included 19 questions in the FSFI (Female Sexual Function Index) was distributed to all allied health workers in a tertiary hospital in Singapore aged between 18 to 70 years old. Results Three hundred thirty completed questionnaires were involved in analysis. 56.0% of women were found to have sexual dysfunction. A significant difference was found in the prevalence of FSD when comparing nurses to other allied health staff, where nurses had a decreased risk of developing FSD. Age was not found to be a significant risk factor in our study. Respondents below 40 years of age had significantly lower satisfaction scores than those above 40. Indians and Filipinos were found to have lower scores than the Chinese and Malay respondents in the lubrication (p = 0.02) and pain domains (p = 0.02). Conclusion A significant proportion our female allied health workers suffer from sexual dysfunction. In this study, we found that the overall prevalence was independent of age, race and marital status. Nurses had a lower risk of developing FSD. We will need further studies to assess the prevalence of female sexual dysfunction in the general population, to evaluate the independent significant risk factors for developing FSD, in addition to classical risk factors, as well as to assess the psychological impact of this condition and whether people would be willing to seek help for such problems.

scholarly journals Cross Sectional Survey of Priapism and Sexual Dysfunction in 353 Men with Sickle Cell Disease

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 2302-2302
Author(s):  
Ibrahim Musa Idris ◽  
Jamil Aliyu Galadanci ◽  
Akib Abba ◽  
Sharfuddeen Abbas Mashi ◽  
Anele Uzoma ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Sexual Dysfunction ◽  
Focus Group ◽  
Sexual Function ◽  
Sickle Cell ◽  
Sexual Desire ◽  
Erectile Function ◽  
Clinical Epidemiology ◽  
Cross Sectional ◽  
Significant Difference

Introduction: In both high and low income countries, life span in sickle cell disease (SCD) is increasing and quality of life is improving. Recent research activities have focused on decreasing SCD-related morbidities. However, limited research has been done on clinical epidemiology of priapism, sexual dysfunction and libido in men with SCD. As part of our ongoing Priapism in Nigeria (PIN) cohort to assess knowledge gap in clinical epidemiology of priapism and sexual dysfunction in men with SCD, we tested the hypothesis that sexual dysfunction is high in men with SCD compared to age/race matched men without SCD. Methods: We utilized a mixed method study design (cross-sectional survey and focus group discussions) in men, aged 18-40 years, with confirmed SCD and men without SCD as comparators for the survey. Participants were recruited from the adult sickle cell clinic and general outpatients department of Aminu Kano Teaching Hospital (AKTH) and Murtala Mohammed Specialists Hospital (MMSH) in Kano, Nigeria from February to July 2019. Priapism is defined as a purposeless painful erection, unrelated to sexual desire; and mostly occurs in the stuttering or recurrent ischemic form, which lasts less than 4 hours. We used the validated International Index of Erectile Function (IIEF) questionnaire to assess erectile dysfunction in this population. Additionally, we conducted 6 focus group discussions in Nigeria (3 sessions) and United States (3 sessions), respectively; in which we asked open ended questions about symptoms, experiences, beliefs and life impacts of priapism. Data were presented as means ± standard deviation or proportions with 95% Confidence Intervals. The t-test and Chi square test were used to compare demographic data. Similarly, domain-specific scores, which included: 1) erectile function, 2) sexual desire, 3) orgasmic function, 4) overall satisfaction with sex life, and 5) intercourse satisfaction- were compared between the two groups using t-test; where higher scores indicate better sexual function. Erectile domain was further sub-classified into normal (26-30), mild ED (22-25), mild-moderate ED (17-21), moderate ED (11-16) and severe ED (0-10). We considered alpha level of significance to be <0.05. The focus group data was analyzed using an iterative inductive/deductive approach. Results: A total of 353 men with SCD and 250 men without SCD were evaluated; for the demographic features the only significant difference was in monthly income (p 0.007) with SCD being higher, table 1. The prevalence of any priapism episode (major or stuttering) in men with and without SCD was 31.72% (112 of 353) and 2% (5 of 250). Among men with SCD, 25.9% (29 of 112) and 74.1% (83 of 112) had major and stuttering priapism episodes, respectively. Based on the IIEF, the men with SCD when compared to men without SCD had significantly lower total mean scores (24.9 vs 29.6, p 0.0002), erectile function (9.9 vs 11.5, p 0.005), sexual desire (5.8 vs 7.1, p<0.0001), and overall satisfaction with sex life (2.3 vs 3.5, p<0.0001). No significant difference in orgasmic function (p=0.29) and intercourse satisfaction (p=0.12) was observed. Among the married men with and without SCD, 55% (21 of 38) and 84% (22 of 26) had normal erectile function, and 26.3% (10 of 38) and 11.5% (3 of 26) had severe erectile dysfunction, respectively. Based on the data from our focus groups with a total of 28 and 7 participants (n=35), in Nigeria and United States respectively, we were guided by biopsychosocial and socio-ecological models to develop a conceptual framework (not shown). We identified themes on cultural context, priapism (triggers, schema, episodes and coping strategies), emotional and sexual function impacts, with respective quotes (results not shown). Conclusions: In the largest cross-sectional and qualitative study of priapism in men with SCD to date, we demonstrated that priapism and sexual dysfunction are significant cause of morbidity when compared to men without SCD. Married participants with SCD have 2-fold greater proportion of severe erectile dysfunction than those without SCD. Our qualitative results revealed tremendous impact of priapism and sexual dysfunction in men with SCD. Participants with priapism experience shame, anxiety and depression, and declined sexual function. There was diversity in causal attribution and coping strategies of priapism. Disclosures Idris: Fogarty International Center: Research Funding.

scholarly journals Prevalence of sexual dysfunction in women resident of a capital city in the brazilian western Amazon

2020 ◽  
Vol 12 (12) ◽  
pp. e5359
Author(s):  
Joice Rodrigues Fagundes ◽  
Siglia Sousa De França ◽  
Everton Felipe do Vale Araújo ◽  
Alberto Pereira Firmino Filho ◽  
Charlene Cristine Rodrigues Menezes
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Desire ◽  
National Level ◽  
Cross Sectional Study ◽  
Self Report ◽  
Capital City ◽  
Average Score ◽  
Cross Sectional ◽  
Significant Difference ◽  
Potential Risk Factors

Objective: To determine the prevalence of sexual dysfunction in non-pregnant, pregnant, and postpartum women, and its association with potential risk factors. Methods: Cross-sectional study composed of 419 women, who attend public health units, from April to August 2019, in Rio Branco, Acre. The volunteers were subjected to a self-report questionnaire previously validated at national level: The Sexual Quotient-Female version. Results: Based on the total number of responses, 35.6% of the participants had sexual dysfunction. Of those, almost half of the volunteers (42%) were unemployed (p = 0.003). In the sexual desire and orgasm domains, the average score was higher among women during pregnancy (2.8203) (3,4844) than in the puerperal women (2.3454) (2,0912), respectively (p<0,05). Regarding pain, 30.1% answered "always" for its incidence during sexual intercourse. Age alone does not influence the sexual function of the participants, (r <1 and p> 0.05). Conclusion: The present study unveiled an important percentage of sexual dysfunction, predominantly in the pain subdomain. In addition, a significant difference was found in the sexual desire and orgasm domains, with higher scores found in pregnant women compared to puerperal women. Another fact was the higher percentage of sexual dysfunction in unemployed women.

scholarly journals Evaluation of emotional arousal level and depression severity using voice-derived sound pressure change acceleration

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shuji Shinohara ◽  
Hiroyuki Toda ◽  
Mitsuteru Nakamura ◽  
Yasuhiro Omiya ◽  
Masakazu Higuchi ◽  
...  
Keyword(s):  
Sound Pressure ◽  
Rating Scale ◽  
Characteristic Curve ◽  
Emotional Arousal ◽  
Pressure Change ◽  
Arousal Level ◽  
Depression Severity ◽  
Number Of Patients ◽  
National Defense Medical College ◽  
Significant Difference

AbstractIn this research, we propose a new index of emotional arousal level using sound pressure change acceleration, called the emotional arousal level voice index (EALVI), and investigate the relationship between this index and depression severity. First, EALVI values were calculated from various speech recordings in the interactive emotional dyadic motion capture database, and the correlation with the emotional arousal level of each voice was examined. The resulting correlation coefficient was 0.52 (n = 10,039, p < 2.2 × 10−16). We collected a total of 178 datasets comprising 10 speech phrases and the Hamilton Rating Scale for Depression (HAM-D) score of outpatients with major depression at the Ginza Taimei Clinic (GTC) and the National Defense Medical College (NDMC) Hospital. The correlation coefficients between the EALVI and HAM-D scores were − 0.33 (n = 88, p = 1.8 × 10−3) and − 0.43 (n = 90, p = 2.2 × 10−5) at the GTC and NDMC, respectively. Next, the dataset was divided into “no depression” (HAM-D < 8) and “depression” groups (HAM-D ≥ 8) according to the HAM-D score. The number of patients in the “no depression” and “depression” groups were 10 and 78 in the GTC data, and 65 and 25 in the NDMC data, respectively. There was a significant difference in the mean EALVI values between the two groups in both the GTC and NDMC data (p = 8.9 × 10−3, Cliff’s delta = 0.51 and p = 1.6 × 10−3; Cliff’s delta = 0.43, respectively). The area under the curve of the receiver operating characteristic curve when discriminating both groups by EALVI was 0.76 in GTC data and 0.72 in NDMC data. Indirectly, the data suggest that there is some relationship between emotional arousal level and depression severity.

Perineal Injury and Its Association with Postpartum Sexual Dysfunction among First Delivery Women

2021 ◽  
Vol 2 (3) ◽  
pp. 34-39
Author(s):  
Z. Nusee ◽  
M. N. Ainy ◽  
P. Hafizah
Keyword(s):  
Sexual Dysfunction ◽  
Vaginal Delivery ◽  
Female Sexual Dysfunction ◽  
Family Income ◽  
Mode Of Delivery ◽  
Sexually Active ◽  
Perineal Tear ◽  
Health Clinics ◽  
Perineal Injury ◽  
Significant Difference

Background: Female sexual dysfunction (FSD) following childbirth imposes significant burden to the marital institution around the world. The perineal injury may potentially be one of the main risk factors contributing to postpartum female sexual dysfunction (PPFSD). The study aimed to determine the effect of perineal injury and patients’ characteristics on PPFSD. Methodology: This cross-sectional questionnaire study was conducted in six different health clinics in the district of Kuantan from April 2019 to October 2019. Eligible women who came to the family health clinics at 6 months postpartum were recruited as study population. The participants completed their biodata and socio-demographic form and the Malay-validated Female Sexual Function Index (MVFSFI) questionnaire given. A cut-off point of 26.55 and below on MVFSFI scoring system was used as a measure of the primary outcome of sexual dysfunction. Results: Out of 240 women who delivered vaginally, 34 (14%) had intact perineum, 107 (44.6%) sustained 1st degree perineal tear, 96 (40%) 2nd degree tear and three (1.25%) 3rd degree tear. Among the respondents, 60.9% of the sexually active respondents who had vaginal delivery, reported to have PPFSD. The timing of sexual resumption does not correlate with the severity of perineal tear. The severity of perineal tear is significantly associated with age (p=0.018), duration of marriage (p=0.008), body mass index (BMI) (p=0.019) and instrumental delivery (p=0.025). The level of personnel skill whom performed the repair were also found to have a significant relationship to PPFSD (p= 0.001). The relationship of participants’ mean age (p=0.271), marriage duration (p=0.903), race (p=0.928), religion (p=0.852), education level (p=0.549), employment status (p=0.102), family income (p=0.460) and BMI(p=0.159) with presence of PPFSD were all found to be statistically not significant. Conclusion: Occurrence of PPFSD is high among sexually active women who had vaginal delivery complicated by perineal tear, especially among those requiring instrumentation. The severity of perineal tear is associated with age, duration of marriage, BMI and mode of delivery. However, PPFSD does not significantly relate to the severity of perineal tear. None of the socio-demographic factors show a significant difference to sexual dysfunction.

scholarly journals Alternative Therapies for Male and Female Sexual Dysfunction

2004 ◽  
Vol 32 (02) ◽  
pp. 161-173 ◽  
Author(s):  
Han H. Aung ◽  
Lucy Dey ◽  
Victoria Rand ◽  
Chun-Su Yuan
Keyword(s):  
Chinese Medicine ◽  
Sexual Dysfunction ◽  
Traditional Chinese Medicine ◽  
Sexual Desire ◽  
Female Sexual Dysfunction ◽  
Alternative Therapies ◽  
Men And Women ◽  
Male And Female ◽  
Herbal Medications ◽  
Pharmaceutical Agents

Sexual dysfunction is prevalent in both men and women. Although new pharmaceutical agents have been identified for male erectile problems, sexual desire and orgasm disorders, individuals with sexual dysfunction often seek alternative therapies, including traditional Chinese medicine. This article reviews currently used alternative therapies, such as herbal medications, L-arginine, acupuncture, biofeedback and others. Potential herb-drug interactions are also presented.

scholarly journals A comparison of pain registration by Visual Analog Scale and Numeric Rating Scale – a cross-sectional study of primary triage registration

2020 ◽  
Author(s):  
Jofrid Kollltveit ◽  
Malin Osaland ◽  
Marianne Reimers ◽  
Magnus Berle
Keyword(s):  
Emergency Department ◽  
Visual Analog Scale ◽  
Rating Scale ◽  
Emergency Admission ◽  
Numeric Rating Scale ◽  
University Hospital ◽  
Analog Scale ◽  
Cross Sectional ◽  
Significant Difference ◽  
Numeric Rating

BackgroundPain is a subjective sensation; self-reporting is important for quantifying pain intensity. There are several different validated tools for this, such as Visual Analog Scale and Numeric Rating Scale. In the clinic, these terms are often used as equivalent. The objective of this study was to examine correlation and agreement between the pain registration tools in triage in an emergency department.Materials and MethodsThe study was performed in the Department of Emergency Medicine at Haukeland University Hospital in the period June-August 2019. We registered the pain score with two tools in 200 unselected patients in emergency admission with pain. In addition, we registrered gender, age, triage and general department affiliation.ResultsWe found a strong correlation between the pain registration tools by Spearmans correlation test (rho=0,930, p<0,001). There were no significant difference between the pain registration tools within the subgroups. Bland-Altman analysis show agreement between the two pain registration tools.ConclusionsIn an Emergency Department triage is it acceptable to use Visual Analog Scale and Numeric Rating Scale as equivalent, as long as the correct terminology is used.

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