Characterization and Biological Activities of an Alkali Soluble Exopolysaccharide from Acetobacter

Natural polysaccharides have received much attention due to the plethora of their applications. Acetobacter sp. MRL 5A (KX082688) produced an alkali soluble exopolysaccharide (20.39 g/L) on sucrose based media during the late log and early stationary phases. The exopolysaccharide was insoluble in water with high moisture-retention ability and produced viscous solutions and gels. The exopolysaccharide contained 40.3% glucose, 34.4% galactose, 22.2% mannose and 3.1% of arabinose monomers revealed by GC. The exopolysaccharide showed emulsifying, flocculating and in-vitro antioxidant activity similar to standard exopolysaccharides like dextran and xanthan. This EPS can be of potential use in food, cosmetic, pharmaceutical and biomedical fields.

Download Full-text

To perform phytochemical screening and study the antioxidant potential of isolated compound from Hemidesmus indicus

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i2.2401 ◽

2019 ◽

Vol 9 (2) ◽

pp. 188-191

Author(s):

, Nutan ◽

Manas Kr Das ◽

Gaurav Saxena ◽

Nitin Kumar

Keyword(s):

Antioxidant Activity ◽

Bioactive Compounds ◽

Biological Activities ◽

Phytochemical Screening ◽

Good Source ◽

Physicochemical Composition ◽

Hemidesmus Indicus ◽

Isolated Compound ◽

In Vitro Antioxidant Activity

“Anantmul” is an important and widely used medicinal plant. The study aimed to determine the physicochemical composition, bioactive compounds and antioxidant activity of Hemidesmus indicus (Asclepiadaceae). The roots of the plant were collected and sequentially extracted using petroleum ether, ethyl acetate, and methanol. The preliminary phytochemical screening of extracts was carried out and found to be a good source of bioactive compounds. Biological activities of flavonoid and phenolic compounds have been discovered in several latest studies. Further phytochemical isolation was carried out, and Lupeol was isolated. Phenols are shown to be multifunctional antioxidants which will perform as singlet oxygen quenchers. Lupeol was evaluated for in-vitro antioxidant activity. It showed a correlation with antioxidant activity by DPPH (IC50 = 0.52, P 6 0.05) and H2O2 (IC50 = 0.43, P 6 0.05). The results show promising perspectives for the exploitation and use of anantmul rhizome as a constituent of anti-aging as well as anticancer diet. Keywords: Anantmul, Lupeol, Antioxidant, DPPH

Download Full-text

Phenolic Isomers from Plantago Catharinea Leaves: Isolation, Identification, Quantification and in Vitro Antioxidant Activity

Natural Product Communications ◽

10.1177/1934578x1701200326 ◽

2017 ◽

Vol 12 (3) ◽

pp. 1934578X1701200

Author(s):

Leonardo Mendes De Souza Mesquita ◽

Claudia Quintino Da Rocha ◽

Luiz Henrique Lima Affonso ◽

Antonietta Cerulli ◽

Sonia Piacente ◽

...

Keyword(s):

Antioxidant Activity ◽

High Performance ◽

Chemical Structure ◽

Biological Activities ◽

Bioactive Molecules ◽

Good Source ◽

Rare Sugar ◽

Polyphenolic Acids ◽

In Vitro Antioxidant Activity

In this study we isolated two polyphenolic acids of m/z 639, called catharinol A and catharinol B, from Plantago catharinea L. (Plantaginaceae) leaves. Although presenting very similar structures, catharinol A showed higher antioxidant activity when compared with gallic acid and quercetin standards. These compounds are position isomers and present in their chemical structure the rare sugar D-allose. Molecules with similar constitution are known to have important biological activities such as antitumor and immunosuppressive. These compounds were isolated by high-performance liquid chromatography (HPLC) and characterized by mass spectrometry (FIA-ESI-IT-MS/MS) and nuclear magnetic resonance (NMR). This work is the first study on the chemical composition of P. catharinea and encourages the production of Plantago species as a good source of bioactive molecules.

Download Full-text

Chemical composition and biological activities of essential oils of endemic Thymus leucostomus Hausskn. et Velen

Bangladesh Journal of Botany ◽

10.3329/bjb.v49i4.52505 ◽

2020 ◽

Vol 49 (4) ◽

pp. 957-965

Author(s):

Omer Elkiran ◽

Cumhur Avsar

Keyword(s):

Antioxidant Activity ◽

Chemical Composition ◽

Essential Oil ◽

Essential Oils ◽

Biological Activities ◽

Antioxidant Properties ◽

Antimicrobial Activities ◽

Gram Positive Bacteria ◽

In Vitro Antioxidant Activity

The chemical composition, antimicrobial and antioxidant properties of the essential oils from the leaves of endemic Thymus leucostomus naturally grown in Turkey were investigated and chemical differences were discussed by means of chemotaxonomy. Twenty-six components were identified representing 98.8% of the oils. The main compounds in the essential oil of T. leucostomus were: o-cymene (30.6%), carvacrol (9.6%), thymol methyl ether (7.2%), limonene (6.8%). Essential oil was screened for their antimicrobial activities against 7 bacteria and 2 yeast species by using disc-diffusion and MIC procedure. The essential oil showed higher effectiveness against all the tested bacteria and yeast. The extract was observed to be much more effective in Gram-positive bacteria (especially, S. aureus ATCC 6538). In vitro antioxidant activity based on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical was evaluated for the essential oil, and it was found that the essential oil had good antioxidant activity in the range of the IC50= 5.42 ±0.8 μg/ml.

Download Full-text

SYNTHESIS AND ANTIOXIDANT ACTIVITY OF SOME NEW SULFONAMIDE DERIVATIVES

10.46793/iccbi21.351m ◽

2021 ◽

Author(s):

Jovana M. Muškinja ◽

◽

Jelena S. Katanić Stanković ◽

Zoran R. Ratković

Keyword(s):

Antioxidant Activity ◽

Antioxidant Activities ◽

Biological Activities ◽

Point Of View ◽

Important Class ◽

Dpph Radical ◽

Sulfa Drugs ◽

Nmr Methods ◽

In Vitro Antioxidant Activity

Sulfonamide derivatives are a very important class of compounds with pronounced biological activities and, for this reason, they have very useful pharmaceutical applications. They are the basis of several groups of drugs and are known as sulfa-drugs. From this point of view, the present study focuses on the synthesis of some novel structural hybrids incorporating two very important groups, sulfonamide, and pyrazoline. The new sulfonamide-based pyrazolines were synthesized in very good yields. The structures of the sulfonamide compounds were confirmed by IR and NMR methods. Synthesized compounds were tested for their antioxidant activities using two different methods, DPPH radical and ABTS radical cation scavenging assays. The results showed relatively good in vitro antioxidant activity.

Download Full-text