scholarly journals A comparative analysis of Mean Platelet Volume in COPD patients vs. healthy controls

2016 ◽  
Vol 15 (09) ◽  
pp. 146-150
Author(s):  
Dr. S. Banerjee ◽  
Dr. Anshul Kumar ◽  
Dr. Sujata Ganguly ◽  
Dr. Ravi Shanker ◽  
Dr. Arun Singh ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Mean Platelet Volume ◽  
Healthy Controls ◽  
Platelet Volume ◽  
Copd Patients

scholarly journals RELATIONSHIP OF MEAN PLATELET VOLUME WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS SEVERITY- AN OBSERVATIONAL STUDY

2021 ◽  
Vol 9 (10) ◽  
pp. 423-428
Author(s):  
Kishore Kumar Sharma ◽  
Mani Ram Kumhar ◽  
Mayank Shrivastav ◽  
Harsh Tak
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Body Mass Index ◽  
Acute Exacerbation ◽  
Mean Platelet Volume ◽  
Chronic Obstructive ◽  
Platelet Volume ◽  
Obstructive Pulmonary Disease ◽  
Bode Index ◽  
Copd Patients ◽  
Relationship Of

Background & Objectives: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation and inflammation. Mean platelet volume (MPV) may be used as a marker of inflammation. We aimed to study the association between MPV and COPD patients during acute attack and relationship of MPV with severity of COPD by FEV1 (%predicted), BODE Index, PaO2, mMRC grade and 6MWD test. Methods: 100 patients with COPD (50 with acute exacerbation and 50 with stable COPD) and 30 healthy controls were enrolled in the study. Mean platelet volume (MPV), spirometry, arterial blood gases, body mass index, renal function tests and BODE index (body mass index, airflow obstruction,dyspnoea and exercise) were assessed. Level of MPV was compared between cases and controls. Results: Of 100 COPD patients, 87(87%) were male and 13(13%)were female.MPV was significantly higher in COPD patients than control and also higher in acute exacerbation group than stable COPD (p=0.001). Interpretation & Conclusions: In the present study,MPV remain in normal range in all COPD patients, but MPV values were significantly higher in COPD cases compared with control.Increased MPV was associated with acute exacerbation and also increasing with severity of COPD.

Elevated Concentrations of Soluble Adhesion Molecules and Large Platelets in Diabetic Patients: Are They Markers of Vascular Disease and Diabetic Nephropathy?

2007 ◽  
Vol 13 (4) ◽  
pp. 391-397 ◽  
Author(s):  
N. Bavbek ◽  
A. Kargili ◽  
O. Kaftan ◽  
F. Karakurt ◽  
A. Kosar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Mean Platelet Volume ◽  
Plasma Levels ◽  
Platelet Reactivity ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Platelet Volume ◽  
Soluble Adhesion Molecules ◽  
Protein Excretion

P-selectin, E-selectin, and mean platelet volume are markers associated with platelet reactivity that have been demonstrated to be increased in diabetes. We were particularly interested to see if there was a difference in mean platelet volume and selectins between diabetics and nondiabetics, and in diabetics with and without nephropathy, and whether there was a correlation between mean platelet volume and selectins. One hundred and fourteen diabetic patients and 31 healthy controls were investigated. Plasma levels of P-selectin and E-selectin were higher in the diabetic group than in controls ( P = .001 and P = .007, respectively) and in diabetic patients with proteinuria than in patients without proteinuria ( P = .002 and P = .004, respectively). Protein excretion was lower in patients with low mean platelet volume values ( P = .004). In conclusion, elevated platelet volume and high selectin values may play a role in the development of vasculopathies and complications in diabetes mellitus. Further studies are needed to prove these results.

Mean platelet volume is elevated in exacerbated and convalescent COPD patients

2015 ◽  
Vol 451 ◽  
pp. 227-231 ◽  
Author(s):  
Ming Zhang ◽  
Yali Li ◽  
Jie Zhang ◽  
Qiuhong Zhang ◽  
Xia Yang ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Copd Patients

scholarly journals Does The Mean Platelet Volume (MPV) Have Any Importance In the Evaluation of Cardiovascular Disease In COPD Patients?

2020 ◽  
Vol 20 (3) ◽  
pp. 663-673
Author(s):  
Hatice Kilic ◽  
Funda Karaduman Yalcin ◽  
Cantürk Kaya ◽  
Tuba Öğüt ◽  
Habibe Hezer ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Copd Patients ◽  
The Mean

scholarly journals Platelet aggregation, mean platelet volume and plasma fibrinogen as risk factors for acute myocardial infarction

2018 ◽  
Vol 6 (11) ◽  
pp. 3552 ◽  
Author(s):  
Geeta Yadav ◽  
Rashmi Kushwaha ◽  
Wahid Ali ◽  
Uma S. Singh ◽  
Ashutosh Kumar ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Platelet Aggregation ◽  
Mean Platelet Volume ◽  
Screening Tools ◽  
Plasma Fibrinogen ◽  
Healthy Controls ◽  
Platelet Volume ◽  
Increased Risk ◽  
The Mean

Background: The Aim of this study was to assess the role of platelet aggregation, mean platelet volume (MPV) and plasma fibrinogen levels in the pathogenesis of acute myocardial infarction (AMI).Methods: A prospective case control study was conducted on 30 cases of AMI and 30 normal healthy age and sex matched controls. The cases and controls were investigated for platelet aggregation studies (done in platelet rich plasma (PRP) using light transmission chrono-log optical aggregometer), MPV (measured by automated cell counter) and plasma fibrinogen levels (estimated by Clauss method).Results: The mean platelet aggregation (%) in cases AMI was 57.61±11.91 which was significantly higher compared with 35.00±10.40 for healthy controls (p<0.001). Using Receiver Operating Characteristic (ROC) analysis, most patients of AMI had a platelet aggregability of ≥49% on optical aggregometry (sensitivity = 83.3 % and specificity = 93.7%). The MPV (fL) in cases of AMI was 8.04±0.39 which was significantly larger when compared with 7.67±0.43 for controls (p= 0.001). The mean plasma fibrinogen concentration in cases of AMI was 383.1±48.3mg/dl which was significantly higher when compared with 271.33±57.7mg/dl for healthy controls (p<0.001).Conclusions: Platelet hyperaggregability, elevated MPV and plasma fibrinogen levels are found in patients with AMI and contribute significantly to risk of developing coronary thrombosis. These variables should be considered as additional screening tools to identify individuals at increased risk of developing AMI.

Independent Predictors of Severity and Hospitalization in Acute Bronchiolitis: Neutrophil/Lymphocyte Ratio and Mean Platelet Volume

2018 ◽  
Vol 13 (04) ◽  
pp. 268-273
Author(s):  
Şahin Takçı ◽  
Buket Seyyah ◽  
Resul Yılmaz ◽  
Ali Gul
Keyword(s):  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Mean Platelet Volume ◽  
Clinical Severity ◽  
Healthy Controls ◽  
Acute Bronchiolitis ◽  
Platelet Volume ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

Background and Aim Acute bronchiolitis is the most common cause of hospitalization in the first year of life. The neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV) are readily calculable laboratory markers used to evaluate systemic inflammation. We aim to evaluate the optimal values of these markers for the prediction of severity and hospitalization in infants with acute bronchiolitis. Materials and Methods A total of 105 patients with acute bronchiolitis and 62 healthy controls aged 1 to 12 months were prospectively enrolled to the study. The patients' group was classified into two groups, namely, outpatient and inpatient, also divided into three groups according to clinical scoring: mild, moderate, and severe. The association of NLR and MPV with clinical severity and hospitalization was investigated. Results The mean age was 7.75 ± 2.98 months in patients and 7.69 ± 2.87 months in controls. The means of NLR were 0.47 and 0.64 in controls and patients, respectively (p = 0.032) and of MPV were 9.64 and 8.9 (p < 0.001), respectively. The means of NLR were 0.73 and 0.50 in inpatient and outpatient groups, respectively (p = 0.014) and of MPV were 8.65 and 9.32 (p = 0.046), respectively. NLR of 0.64 value was calculated as a cutoff for the prediction of hospitalization with 45% sensitivity and 83% specificity (positive predictive value = 81%, negative predictive value = 19%). Conclusion We found that blood neutrophil percentage and blood NLR are increased and also weakly predictive—but insufficient to be clinically useful—for the decision of hospitalization in acute bronchiolitis. When the positive predictive value of an NLR of 0.64 is sufficient to decide hospitalization, the negative predictive value is impractical. MPV value was less in infants with acute bronchiolitis than healthy controls and in inpatients than outpatients with acute bronchiolitis. Low MPV might be marker of inflammation in acute bronchiolitis.

scholarly journals Mean Platelet Volume as Marker of Thrombosis Event in Antiphospholipid Syndrome Patients

2019 ◽  
Vol 26 (2) ◽  
Author(s):  
Michael Dwinata ◽  
Jonathan H. Haposan ◽  
Inolyn Pandjaitan
Keyword(s):  
Antiphospholipid Syndrome ◽  
Mean Platelet Volume ◽  
Platelet Reactivity ◽  
Systemic Autoimmune Disease ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Healthy Controls ◽  
Platelet Volume ◽  
The Mean ◽  
Critical Appraisal Skills

Antiphospholipid antibody syndrome (APS) is a systemic autoimmune disease associated with venous and/or arterial thrombosis with the presence and persistence of antiphospholipid antibodies (aPL). One of the currently discussed markers related to a high risk of thromboembolism is increased Mean Platelet Volume (MPV). This study aimed to know whether an association exists between MPV and thrombosis event in APS patients. We systematically searched and reviewed studies from MEDLINE, Science Direct and the Cochrane Controlled Trials registry (CENTRAL) from October until November 2018. We use appraisal tools from Critical Appraisal Skills Programme (CASP-UK) for cohort studies. We found two relevant studies to be included in our review.In total, 389 patients consisting 92 APS patient and 297 APS-negative and healthy controls were included. In two studies, the mean of MPV in APS group with thrombosis ranged from 7.85 to 9.22 fl. MPV in APS group with thrombosis was higher than in the APS group without thrombosis and in healthy controls. The platelet size, measured as MPV, reflects platelet reactivity, including aggregation, glycoprotein IIb-IIIa expression and production of more thrombogenic factors. In summary, MPV has a positive correlation with thrombosis event in APS patient. MPV may also be a potential clinical predictor for recurrence of thrombosis in APS patient. We urge that more future prospective studies with larger sample size to be done in order to validate this potential marker.Keywords : Mean platelet volume, thrombosis, antiphospholipid syndrome

Impact of mean platelet volume on the occurrence and severity of sudden sensorineural hearing loss

2013 ◽  
Vol 127 (10) ◽  
pp. 972-976 ◽  
Author(s):  
M Sagit ◽  
M Kavugudurmaz ◽  
S Guler ◽  
M A Somdas
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Mean Platelet Volume ◽  
Density Lipoprotein ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Healthy Controls ◽  
Platelet Volume ◽  
Volume Level ◽  
Loss Severity

AbstractObjective:We aimed to determine: (1) whether mean platelet volume was elevated in patients with sudden sensorineural hearing loss, compared with healthy controls; and (2) whether mean platelet volume level was related to hearing loss severity.Materials and methods:The study included 31 patients with sudden sensorineural hearing loss and 31 age- and sex-matched, healthy controls. Peripheral venous blood samples were taken from subjects and mean platelet volume and levels of glucose, total cholesterol, high-density lipoprotein, low-density lipoprotein and triglyceride were measured.Results:Mean platelet volume was significantly greater in the sudden sensorineural hearing loss group compared with the control group. However, there was no significant correlation between mean platelet volume level and hearing loss severity.Conclusion:Mean platelet volume, a determinant of platelet activation, is elevated in patients with sudden sensorineural hearing loss. To our knowledge, this is the first report investigating mean platelet volume levels in such patients. Our findings indirectly support the hypothesis of vascular impairment as a pathogenetic factor in sudden sensorineural hearing loss.

scholarly journals Mean platelet volume as an inflammation marker in active pulmonary tuberculosis

2014 ◽  
Vol 9 ◽  
Author(s):  
Gulsah Gunluoglu ◽  
Esra Ertan Yazar ◽  
Nurdan Simsek Veske ◽  
Ekrem Cengiz Seyhan ◽  
Sedat Altin
Keyword(s):  
Pulmonary Tuberculosis ◽  
Mean Platelet Volume ◽  
Inflammatory Diseases ◽  
Blood Platelet ◽  
Control Group ◽  
Healthy Controls ◽  
Inflammation Marker ◽  
Platelet Volume ◽  
Active Pulmonary Tuberculosis ◽  
Extent Of Disease

Background: The mean platelet volume (MPV) reflects the size of platelets. It has been shown to be inversely correlated with level of the inflammation in some chronic inflammatory diseases. This prospective study aims to show the usability of MPV as an inflammation marker in patients with active pulmonary tuberculosis (PTB) by comparison with healthy controls. In addition, its relationships with other inflammatory markers such as C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) as well as with the radiological extent of disease were examined. Methods: This study included 82 patients with active PTB and 95 healthy subjects (control group). Whole blood counts, CRP level, and ESR were compared between the two groups. In the PTB group, the relationships between the radiological extent of disease and the MPV and other inflammation markers were investigated. Results: The MPV was 7.74 ± 1.33/μL in the PTB group and 8.20 ± 1.13/μL in the control group (p = 0.005). The blood platelet count, CRP level, and ESR were significantly higher in the active PTB group than in the control group (p < 0.0001). In the PTB group, CRP levels (r = 0.26, p = 0.003) and ESR (r = 0.39, p = 0.003), but not MPV (p = 0.80), were significantly correlated with the radiologic extent of the disease. Conclusions: The MPV was lower in patients with PTB than in healthy controls, however, the difference was limited. The MPV does not reflect the severity of the disease. The use of MPV as an inflammation marker and a negative acute-phase reactant in PTB does not seem to be reliable.

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