A case of acute spontaneous gangrenous balanoposthitis

Gangrenous and phagedenic balanoposthitis are in most cases a complication of ulcers of venereal origin: ulcus durum, ulcus molle and ulcus mixtum. Occasionally they appear after a perverted coitus, with diseases of the oral cavity (stomatitis, angina Vincenti), after coitus per rectum (with a disease of the rectum). In some cases, the reasons can be traumatic, thermal, chemical, inappropriate therapy. Often, with unclean maintenance of the genitals, partners after coitus may experience vulgar erosions, which cause balanoposthitis. But often gangrenous and phagedenic balanoposthitis can occur completely independently (spontaneously), when none of the above reasons can be found, even without previous coitus. Such spontaneous gangrenous balanoposthitis was first described in 1883 by Fournier; it is characterized by the fact that it occurs in full health and is extremely intense.

Keeping your finger on the pulse of your business: now is the time for a practice health check

Gilly Dickons details the steps that clinics should take to carry out a full health check and ensure that they are making the most of their business moving out of the COVID-19 pandemic

EQ-5D-3L full health state discriminates between drug and placebo in clinical trials of systemic lupus erythematosus

Objectives To investigate the discriminative ability of EQ-5D-3L full health state (FHS) in clinical trials of SLE, and identify factors associated with FHS after treatment. Methods Data from the BLISS-52 (NCT00424476) and BLISS-76 (NCT00410384) trials of belimumab (N = 1684) were utilised. FHS was defined as a response of no problems in all five EQ-5D-3L dimensions, yielding an index score of 1. The Pearson’s chi-square or Fisher’s exact test was employed for comparisons, and logistic regression for adjustments and assessment of independence. Results We demonstrated higher EQ-5D-3L FHS frequencies among patients given standard therapy (ST) plus the licensed belimumab dose versus ST alone (26.1% versus 19.4%; P = 0.001; week 52), and within SRI-4 responders versus non-responders (27.0% versus 19.8%; P < 0.001; week 52) from week 36 to 52. In multivariable regression analysis, SLEDAI-2K (OR: 0.90; 95% CI: 0.87 − 0.94; P < 0.001) and SLICC/ACR Damage Index (OR: 0.79; 95% CI: 0.69 − 0.91; P = 0.001) scores were independently associated with lower FHS frequencies at week 52, while adding monthly infusions of belimumab 10 mg/kg to ST favoured FHS perception (OR: 1.60; 95% CI: 1.15 − 2.24; P = 0.006). Add-on belimumab 10 mg/kg yielded higher FHS frequencies in antimalarial users versus non-users (29.9% versus 20.1%; P = 0.011), and in anti-dsDNA and anti-Sm positive versus negative patients (31.4% versus 13.4%; P < 0.001 and 33.0% versus 22.6%; P = 0.010, respectively), whereas no significant differences were observed in patients given ST alone. Conclusion EQ-5D-3L FHS distinguished belimumab from placebo and responders from non-responders, and exhibited known-group validity in subgroup analysis. FHS may prove a useful patient-reported outcome in SLE studies.

Politics of Care

This chapter traces the life of architectural objects at the Canadian Centre of Architecture (CCA) and the conservation lab, which creates the impression of being the most isolated place at the CCA. It describes the objects on trial, experiments in progress, protocols, tests results, a giant microscope, and the lingering smell of unknown chemicals inside the conservation lab. It also emphasizes how objects in the conservation lab are treated like patients in need of special care as the objects get a full health and security check. The chapter analyses reports of each object's experiences and reactions, which allow the objects to be inspected during an exhibition to ensure that they have not changed. It reviews the work of conservators Karen Potje and David Stevenson in order to follow how the affected objects are treated amidst the fear of time and hazards of climates and environments.

Editorial for Special Issue “Heavy Minerals”

This special volume, published 13 years after the monumental volume “Heavy Minerals in Use” edited by Maria Mange and David Wright, demonstrates that the use of heavy minerals as provenance tracers is alive and in full health [...]

Sheehans syndrome: the hidden nemesis

Sheehan’s syndrome is the name given to postpartum hypopituitarism, usually precipitated by massive uterine haemorrhage and hypovolemic shock during or after childbirth resulting into pituitary injury in varying degrees. Most cases are diagnosed very late in life and the first presentation may be a life-threatening situation like shock or cardiorespiratory collape. This hidden nemesis in women compromises their quality of life and may result into mortality if not suspected early. In this article we present 3 patients who presented in the ICU in a state of complete cardio-respiratory collapse and later discharged in full health.

What patients wish you understood

Learning medicine has traditionally meant a strong focus on acute medicine—diagnosing, treating, curing, and concentrating on one part of the body at a time. Traditionally, the doctor has always been the expert, the person we come to when something is wrong, to help make our bodies healthy again. Those skills are still vital, but things are changing in several key ways. This chapter is written from a personal viewpoint on how helping patients manage chronic conditions requires a different set of skills from those used in acute medicine. Diagnosis becomes only a tiny part of the story, because people can live with a long-term condition for a lifetime, and restoring people to full health is often impossible. Dividing the body up into textbook chapters becomes less and less relevant because chronic illnesses can impact on many body parts at once.

Zarys pojęcia świętości w życiu człowieka – patroni i orędownicy od chorób wszelakich

The creator of the cosmos and the human race has made the world perfect and lasting in perfect harmony. God made man in paradise to live forever and then remain healthy in any sphere. Deficiencies, martyrdom, melancholy, suffering appeared at the time of the fall of man and falling into sin (sin of the forefathers). All religious practices are a bridge between the empirical world of matter and the transcendent spiritual world. In order to achieve full health, the coexistence of the spiritual and bodily sphere, and their coexistence, is extremely important. Man converts ontologically, turning away from the opposite pathological condition and returns to God, regaining the health of his nature. Initially, the spiritual heals, that is, the soul, then the psyche and somatics. Among the many saints, doctors have their patrons, while their patients - many advocates in all sorts of diseases. Everyday many patients and doctors ask saints for support during the fight against diseases. The lives of many saints and often their martyrdom and death can be an example of living and resisting problems. The text presents a list of nearly a hundred holy advocates in many diseases. Everyone pleads before Christ and presents our prayers and pleas to God. Prayer, especially with a request for the intercession of saints, can be extremely helpful when trying to restore health.

Factors contributing to the ceiling effect of the EQ-5D-5L: an analysis of patients with prostate cancer judged “no-problems”

Purpose The goal of the present study was to determine factors related to a ceiling effect (CE) on the EQ-5D-5L among Japanese patients with prostate cancer (PC). Methods An existent cross-sectional observational study dataset was used. Patients were ≥ 20 years of age and diagnosed with PC. For CE determinants on the EQ-5D-5L, we excluded possible “full-health” patients flagged by the EQ-VAS (score = 100) and/or FACT-P (score = 156) instruments. We then divided them into binary variables: A CE group (EQ-5D-5L score = 1) and others (< 1). The associations between CE, sociodemographic and medical characteristics, and FACT-P subscale scores were examined using a multivariate LASSO selection followed by a binomial logistic regression analysis performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results A total of 362 patients were analyzed. The LASSO selection variables, including all obtained variables, were as follows: age, palliative treatment, FACT-P physical well-being, and PC subscale score. Statistically significant variables predicting CE were palliative treatment (OR 0.23; 95% CI 0.09–0.60), physical well-being (OR 1.54; 95% CI 1.34–1.76), and PC subscale (OR 1.08; 95% CI 1.03–1.14). Conclusions This study revealed that palliative treatment and two FACT-P physical well-being and PC subscale scores were positively related to CE on the EQ-5D-5L. To our knowledge, this is the first study to examine predictors of CE on the EQ-5D-5L. The present results may be helpful for facilitating the consideration of “bolt-on” studies from the standpoint of PC patients.

CONCEPT OF MANAGEMENT FOR FORMING OF FULL HEALTH OF HUMAN

Concepts of managing the formation of complete human health based on the creation of models of creative management. Research methods. The study used such research methods as system-logical method, attributive and hierarchical methods, analysis, induction and deduction, comparisons and key components. Research results. To date, scientists have failed to formulate a single theoretical and methodological framework for a comprehensive assessment of basic health, so it is necessary to only partially consider its individual types. Depending on the field of knowledge, there are several types of health: physical, mental, mental, spiritual, moral, social, etc., which together form a healthy health. The authors justify the need to reduce the complexity of the Conceptual Decimal Model by reducing the number of types of good health. To address this issue, it is taken into account that mental and spiritual health belong to the category of "faith", moral and social - have common features and are characterized by a certain specificity, and sexual health is not fully adequate because it is absent in preschool children and most of the elderly. In its updated form, the concept of managing the formation of full-fledged human health is represented by five components: physical, physiological, financial, mental and occupational health. Studies have shown that the first level of the hierarchical model of managing the formation of complete human health occupies physical health as a state of physical well-being of the human body, which is characterized by its functional readiness to perform the main activities, including professional. Physiological, financial and mental health are located according to the second, third and fourth levels of the five-element hierarchical model of good health and their functions also consist in ensuring the performance of the person in the conditions of his professional activity. Conclusions. The proposed concept of managing the formation of full-fledged human health is a universal, high-performance, five-element hierarchical management model of physical, physiological, financial, mental and occupational health that has a comprehensive impact and provides effective management of the formation of full health and financial health. Human well-being in any social environment that may be the subject of further scientific research.