scholarly journals Effects of Alkaline-Reduced Water on Gastrointestinal Diseases

Processes ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 87
Author(s):  
Johny Bajgai ◽  
Cheol-Su Kim ◽  
Md. Habibur Rahman ◽  
Eun-Sook Jeong ◽  
Hong-Young Jang ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Healthy Lifestyle ◽  
Acid Reflux ◽  
Gastrointestinal Diseases ◽  
Review Article ◽  
The Body ◽  
Bowel Diseases ◽  
Inducing Factors ◽  
Reduced Water

Living a healthy lifestyle is the most important need in the world today. However, oxidative stress (OS) is caused by several stress-inducing factors such as smoking, alcohol consumption, chronic diseases, and inflammatory responses, oxygen-free radicals are produced in excess and can damage major organs in the body. This phenomenon has been implicated in the pathogenesis of several gastrointestinal (GI) diseases, including gastritis, constipation, and inflammatory bowel diseases, which include Crohn’s disease, ulcerative colitis, functional dyspepsia, acid reflux, diverticular disease, and irritable bowel syndrome. In this review article, we provide a brief overview of the role of OS in the pathogenesis of GI disorders. Additionally, we discuss the therapeutic role of alkaline-reduced water (ARW) on GI diseases and existing studies on ARW related to GI diseases. Furthermore, we believe that findings from this review article will enhance the knowledge of the readers on the role of ARW on OS and inflammation-based GI diseases.

The role of macrophages in inflammatory bowel diseases

2009 ◽  
Vol 11 ◽  
Author(s):  
Sigrid E.M. Heinsbroek ◽  
Siamon Gordon
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Inflammatory Responses ◽  
Intestinal Flora ◽  
The Body ◽  
Intestinal Immunity ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Intestinal Macrophage ◽  
Small And Large Intestine

The small and large intestine contain the largest number of macrophages in the body and these cells are strategically located directly underneath the epithelial layer, enabling them to sample the lumen. Such intestinal macrophages have a different phenotype from other tissue macrophages in that they ingest and may kill microbes but they do not mediate strong pro-inflammatory responses upon microbial recognition. These properties are essential for maintaining a healthy intestine. It is generally accepted that tolerance to the intestinal flora is lost in inflammatory bowel diseases, and genes involved in microbial recognition, killing and macrophage activation have already been associated with these diseases. In this review, we shed light on the intestinal macrophage and how it influences intestinal immunity.

scholarly journals Modulation of Macrophages M1/M2 Polarization Using Carbohydrate-Functionalized Polymeric Nanoparticles

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 88
Author(s):  
Raquel G. D. Andrade ◽  
Bruno Reis ◽  
Benjamin Costas ◽  
Sofia A. Costa Lima ◽  
Salette Reis
Keyword(s):  
Inflammatory Responses ◽  
Polymeric Nanoparticles ◽  
Interaction Mechanism ◽  
Mannose Receptor ◽  
The Body ◽  
Receptor Expression ◽  
Production Methods ◽  
Polymeric Nanocarriers ◽  
Efficient Delivery

Exploiting surface endocytosis receptors using carbohydrate-conjugated nanocarriers brings outstanding approaches to an efficient delivery towards a specific target. Macrophages are cells of innate immunity found throughout the body. Plasticity of macrophages is evidenced by alterations in phenotypic polarization in response to stimuli, and is associated with changes in effector molecules, receptor expression, and cytokine profile. M1-polarized macrophages are involved in pro-inflammatory responses while M2 macrophages are capable of anti-inflammatory response and tissue repair. Modulation of macrophages’ activation state is an effective approach for several disease therapies, mediated by carbohydrate-coated nanocarriers. In this review, polymeric nanocarriers targeting macrophages are described in terms of production methods and conjugation strategies, highlighting the role of mannose receptor in the polarization of macrophages, and targeting approaches for infectious diseases, cancer immunotherapy, and prevention. Translation of this nanomedicine approach still requires further elucidation of the interaction mechanism between nanocarriers and macrophages towards clinical applications.

scholarly journals Prevailing role of mucosal immunoglobulins and B cells in teleost skin immune responses to bacterial infection

2020 ◽  
Author(s):  
Xiao-Ting Zhang ◽  
Yong-Yao Yu ◽  
Hao-Yue Xu ◽  
Zhen-Yu Huang ◽  
Xia Liu ◽  
...  
Keyword(s):  
B Cells ◽  
Bacterial Infection ◽  
Inflammatory Responses ◽  
The Body ◽  
Innate Immune ◽  
Flavobacterium Columnare ◽  
First Line ◽  
Skin Mucus ◽  
Skin Mucosa

AbstractThe skin of vertebrates is the outermost organ of the body and serves as the first line of defense against external aggressions. In contrast to mammalian skin, that of teleost fish lacks keratinization and has evolved to operate as a mucosal surface containing a skin-associated lymphoid tissue (SALT). Thus far, IgT representing the prevalent immunoglobulin (Ig) in SALT have only been reported upon infection with a parasite. However, very little is known about the types of B cells and Igs responding to bacterial infection in the teleost skin mucosa, as well as the inductive or effector role of the SALT in such responses. To address these questions, here we analyzed the immune response of trout skin upon infection with one of the most widespread fish skin bacterial pathogens, Flavobacterium columnare. This pathogen induced strong skin innate immune and inflammatory responses at the initial phases of infection. More critically, we found that the skin mucus of fish having survived the infection contained significant IgT-but not IgM- or IgD-specific titers against the bacteria. Moreover, we demonstrate the local proliferation and production of IgT+ B-cells and specific IgT titers respectively within the SALT upon bacterial infection. Thus, our findings represent the first demonstration that IgT is the main Ig isotype induced by the skin mucosa upon bacterial infection, and that because of the large surface of the skin, its SALT probably represents a prominent IgT inductive site in fish.

Role of autopsy in COVID-19 patients

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1517-1523
Author(s):  
Vriti Pursnani ◽  
Amit Reche ◽  
Gaurav Majumdar ◽  
Prerna Gautam ◽  
Kumar Gaurav Chhabra ◽  
...  
Keyword(s):  
Respiratory System ◽  
Review Article ◽  
The Body ◽  
Personal Hygiene ◽  
Treatment Modalities ◽  
Shortness Of Breath ◽  
Human Waste ◽  
Entire Country ◽  
Indian Scenario

Coronavirus disease 2019 had caused a pandemic leading to over 6M positive cases worldwide out of which 3.73 lac are demised (until when the article was written). Its first outbreak was seen in Wuhan, China. In the Indian scenario, we have a total of 2 lac cases out of which 5,679 have been deceased (until when the article was written). Due to the high transmissibility of this disease, the entire country is under lockdown to prevent the spread of the virus. The main etiology of this virus is the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2). This affects the respiratory system leading to cough, shortness of breath, and fever. There have been cases with mild or no symptoms reported, but the cause of death is due to the virus. This helps us understand the diagnosis, epidemiology, symptoms, and pathophysiology about the virus, which can help in treatment modalities. An autopsy is one of the methods by which we can understand the systematic involvement other than the respiratory system. Various pathological, microbiological changes can occur in the other organs. Even though the person is deceased, the virus is highly infectious can cause the spread through body fluids. Proper care must be taken while handling the body and performing the procedure. This review article aims to focus on the autopsy findings found in various cases to study the disease pathophysiology of the SARS-CoV-2. This article also helps us understand the guidelines that have been put forward by WHO and CDC must be followed regarding the specification required in the autopsy room; PPE’s to be worn, human waste and fluid disposal, body transportation. Proper personal hygiene must be maintained while handling the COVID-19 patients; this can lead to less susceptibility of acquiring the disease.

HUMAN PELVIS BUTTRESS SYSTEM AND THE ROLE OF SKELETAL MUSCLES IN ITS FORMATION (REVIEW ARTICLE)

2020 ◽  
pp. 93-100
Author(s):  
Иван Васильевич Гайворонский ◽  
А. А. Родионов ◽  
Геннадий Иванович Ничипорук ◽  
Инга Александровна Горячева ◽  
Мария Георгиевна Гайворонская
Keyword(s):  
Lower Limb ◽  
Skeletal Muscles ◽  
Bone Structure ◽  
Review Article ◽  
The Body ◽  
Vertical Position ◽  
Abdominal Pressure ◽  
Mechanical Forces ◽  
Bone Structures

В связи с вертикальным положением тела на таз человека действуют такие механические силы, как масса тела, внутренностей, внутрибрюшное давление, тяга мышц, связочного аппарата. Под воздействием этих сил происходит моделирование костных структур - внутренних пластинок губчатого вещества и замыкательных пластинок компактного вещества, наибольшая концентрация которых происходит в местах воздействия сил сжатия и растяжении. Указанные места повышенной плотности костной ткани в составе костного таза являются его контрфорсами. Связующим фундаментом контрфорсной системы таза является крестец, воспринимающий воздействия механических сил и передающих их на тазовые кости. Авторами выделены следующие костные контрфорсы: 1 - пояснично-крестцово-подвздошно-бедренный; 2 - пояснично-крестцово-подвздошно-седалищный; 3 - крестцово-седалищный; 4 - крестцово-бедренный; 5 - крестцово-подвздошнолобковый. Рассматривать контрфорсы таза необходимо с позиций арочных конструкций с обязательным взаимодействием контралатеральных сторон. Арочные конструкции, образованные пояснично-крестцово-подвздошно-бедренным, крестцовобедренным и крестцово-подвздошно-лобковыми контрфорсами, функционируют при вертикальном положении тела, а пояснично-крестцово-подвздошно-седалищные и крестцово-седалищные контрфорсы - при сидячем положении тела. Важнейшую роль в формировании и поддержании костных контрфорсов также играют скелетные мышцы, прикрепляющиеся к костям таза. Они не только изменяют его костную структуру, но и передают напряжение при своем сокращении на другие кости, формируя мышечные контрфорсные системы. В работе доказано наличие следующих костно-мышечных контрфорсов: 1 - наружного и внутреннего подвздошно-бедренного; 2 - наружного и внутреннего запирательнобедренного; 3 - лобково-седалищно-бедренно-большеберцового; 4 - седалищно-большеберцово-малоберцового контрфорсов. Показано, что таз является важнейшей частью опорно-двигательного аппарата человека и стабилизационным кольцом для свободной нижней конечности. In connection with the vertical position of the body, such mechanical forces as body weight, viscera, intra-abdominal pressure, traction of muscles, tendons and ligament apparatus act on the human pelvis. The bone structures - the internal plates of the spongy substance and the end plates of the compact substance, the highest concentration of which occurs at the sites of compression and tension - are modeled under the influence of these forces. The aforementioned places of increased bone density in the composition of the bone pelvis are its buttresses. The connecting foundation of the buttress system of the pelvis is the sacrum, perceiving the effects of mechanical forces and transmitting them to the pelvic bones. The authors distinguished the following bone buttresses: 1 - lumbo-sacral-iliac-femoral; 2 - lumbo-sacral-iliac-sciatic; 3 - sacro-sciatic; 4 - sacro-femoral; 5 - sacro-iliac-pubical. It is necessary to consider buttresses of the pelvis from the position of arched structures, with the obligatory interaction of the contralateral sides. Arched structures formed by the lumbo-sacral-iliac-femoral, sacro-femoral and sacro-iliac-pubic buttresses function when the body is in vertical position, and the lumbo-sacral-iliac-sciatic and sacroiliac buttresses when the body is in seated position. Skeletal muscles attached to the bones of the pelvis also play an important role in the formation and maintenance of bone buttresses. They not only change its bone structure, but during their contraction also transmit tension to other bones, forming muscle buttress systems. In the work, the presence of the following musculoskeletal buttresses is proved: 1 - the external and internal ileo-femoral; 2 - external and internal obturator-femoral; 3 - pubic-sciaticfemoral-tibial; 4 - sciatic-tibial-fibular buttresses. It is shown that the pelvis is the most important part of the human musculoskeletal system and the stabilization ring for the free lower limb.

Role of Diet and Nutrition in Pregnancy – An Ayurvedic Perspective

2017 ◽  
Vol 1 (4) ◽  
Author(s):  
Jyoti M. Ganer ◽  
Umapati C. Baragi
Keyword(s):  
Antenatal Care ◽  
Review Article ◽  
Great Emphasis ◽  
The Body ◽  
Pregnant Mother ◽  
Optimum Amount ◽  
Healthy State ◽  
State Of Mind ◽  
Mind And Body

Women have special dietary needs during each stage of her lives, including adolescence, pregnancy, breast feeding and menopause. During pregnancy the mother’s nutrition bears a great impact on the foetus’s growth and its future. Ayurveda lays great emphasis on ensuring holistic nutrition. A combination of Ahara (diet), Vihara (regimen), Vichara (emotions/thoughts) and Aushadha (medications) have been given great significance in Ayurveda in antenatal care called as Garbhini Paricharya (Antenatal care). Diet comprises the most important component of Garbhini Paricharya. Ayurveda advises congenital diet and regimen throughout the pregnancy. It also stresses on the healthy state of mind and body to beget healthy progeny. Milk and ghee stand out as the most common in the pregnant diet that Ayurveda advises. The idea of this is to provide optimum amount of protein and fat to the body. In addition, it provides right amount of calcium and vitamins for the pregnant mother helping in sustaining a comfortable lactation. In this review article a designed protocol of the month wise diet advised by various ancient Ayurvedic physicians, which can be modified according to the age, season, place, constitution and the digestive fire of the pregnant woman has been presented.

scholarly journals Obesity and tooth wear among American adults: the role of sugar-sweetened acidic drinks

2019 ◽  
Vol 24 (4) ◽  
pp. 1379-1385 ◽  
Author(s):  
Yousaf Kamal ◽  
Saoirse O’Toole ◽  
Eduardo Bernabé
Keyword(s):  
Daily Intake ◽  
Tooth Wear ◽  
Acid Reflux ◽  
Sociodemographic Factors ◽  
The Body ◽  
Obese Adults ◽  
Hurdle Models ◽  
Health And Nutrition ◽  
Adult Participants

Abstract Background To explore the association between obesity and tooth wear among American adults and the role of sugar-sweetened acidic drinks consumption in explaining that association. Methods We analyzed data from 3541 adult participants in the National Health and Nutrition Examination Survey. Obesity was determined using the body mass index and tooth wear was assessed using the modified tooth wear index. Daily intake of four categories of drinks was estimated as the average (drinks/day) of two consecutive 24-h dietary recalls. The association between obesity and number of surfaces with moderate-to-severe tooth wear was assessed in hurdle models adjusting for sociodemographic factors, acid reflux medication, and dental insurance. Results Overweight and obese adults had more surfaces with moderate-to-severe tooth wear than those with normal body size, after adjusting for confounders. The consumption of sugar-sweetened acidic drinks explained part, but not all the above association. More specifically, the estimate for obesity was fully attenuated, whereas the estimate for overweight was slightly attenuated but remained significant. Conclusion Obesity was positively associated with tooth wear in American adults. This association was only partially accounted for by the consumption of sugar-sweetened acidic drinks, a common risk factor for both conditions. Practical implications Dentists must be aware of the health consequences of sugar-sweetened acidic drinks and advocate for reduction in consumption and/or substitution with healthier alternatives.

scholarly journals The Role of IL-33 in Gut Mucosal Inflammation

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Luca Pastorelli ◽  
Carlo De Salvo ◽  
Maurizio Vecchi ◽  
Theresa T. Pizarro
Keyword(s):  
Intestinal Inflammation ◽  
Inflammatory Responses ◽  
Experimental Models ◽  
Conclusive Evidence ◽  
The Body ◽  
Lymphoid Cells ◽  
Mucosal Inflammation ◽  
Inflammatory Bowel ◽  
Chronic Intestinal Inflammation

Interleukin (IL)-33 is a recently identified cytokine belonging to the IL-1 family that is widely expressed throughout the body and has the ability to induce Th2 immune responses. In addition, IL-33 plays a key role in promoting host defenses against parasites through the expansion of a novel population of innate lymphoid cells. In recent years, a growing body of evidence has shown that the proinflammatory properties displayed by IL-33 are detrimental in several experimental models of inflammation; in others, however, IL-33 appears to have protective functions. In 2010, four different research groups consistently described the upregulation of IL-33 in patients with inflammatory bowel disease (IBD). Animal models of IBD were subsequently utilized in order to mechanistically determine the precise role of IL-33 in chronic intestinal inflammation, without, however, reaching conclusive evidence demonstrating whether IL-33 is pathogenic or protective. Indeed, data generated from these studies suggest that IL-33 may possess dichotomous functions, enhancing inflammatory responses on one hand and promoting epithelial integrity on the other. This review focuses on the available data regarding IL-33/ST2 in the physiological and inflammatory states of the gut in order to speculate on the possible roles of this novel IL-1 family member in intestinal inflammation.

scholarly journals Role of TGF-Beta and Smad7 in Gut Inflammation, Fibrosis and Cancer

Biomolecules ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 17
Author(s):  
Carmine Stolfi ◽  
Edoardo Troncone ◽  
Irene Marafini ◽  
Giovanni Monteleone
Keyword(s):  
Transforming Growth Factor ◽  
Cell Types ◽  
Mucosal Immune Response ◽  
The Body ◽  
Mucosal Cell ◽  
Gut Inflammation ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Tgf Β1

The human gastrointestinal tract contains the largest population of immune cells in the body and this is a reflection of the fact that it is continuously exposed to a myriad of dietary and bacterial antigens. Although these cells produce a variety of inflammatory cytokines that could potentially promote tissue damage, in normal conditions the mucosal immune response is tightly controlled by counter-regulatory factors, which help induce and maintain gut homeostasis and tolerance. One such factor is transforming growth factor (TGF)-β1, a cytokine produced by multiple lineages of leukocytes, stromal cells and epithelial cells, and virtually targets all the gut mucosal cell types. Indeed, studies in animals and humans have shown that defects in TGF-β1 production and/or signaling can lead to the development of immune-inflammatory pathologies, fibrosis and cancer in the gut. Here, we review and discuss the available evidence about the role of TGF-β1 and Smad7, an inhibitor of TGF-β1 activity, in gut inflammation, fibrosis and cancer with particular regard to the contribution of these two molecules in the pathogenesis of inflammatory bowel diseases and colon cancer.

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