Bringing Arts Integration to Youth (BRAINY) at Colorado State University

In this chapter, the authors demonstrate how a university Art Education program assists the university art museum and trains students to lead tours for BRAINY (BRinging Arts INtegration to Youth), the museum's educational program for Title I schools. The authors present how they guide student educators to develop tours for BRAINY by applying different interpretive strategies. The impacts that BRAINY creates for the visiting students and local communities include 1) the enhancement of civic engagement for young citizens, 2) high-quality art experiences for Title I schools, 3) the extended community program—Family Day. The impacts on student art educators are 1) knowing how to teach art in different learning contexts that are outside of the classroom, 2) applying the questioning strategies to their classroom teaching for probing art dialogues with students, 3) learning to be prepared but also flexible for unexpected situations. This chapter provides a practical and positive example to address a wonderful collaboration between an art museum, community members, and higher education.

High-resolution NWP forecast precipitation comparison over complex terrain of the Sierras de Córdoba during RELAMPAGO-CACTI.

Sierras de Córdoba (Argentina) is characterized by the occurrence of extreme precipitation events during the austral warm season. Heavy precipitation in the region has a large societal impact, causing flash floods. This motivates the forecast performance evaluation of 24-hour accumulated precipitation and vertical profiles of atmospheric variables from different numerical weather prediction (NWP) models with the final aim of helping water management in the region. The NWP models evaluated include the Global Forecast System (GFS) which parameterizes convection, and convection-permitting simulations of the Weather Research and Forecasting Model (WRF) configured by three institutions: University of Illinois at Urbana–Champaign (UIUC), Colorado State University (CSU) and National Meteorological Service of Argentina (SMN). These models were verified with daily accumulated precipitation data from rain gauges and soundings during the RELAMPAGO-CACTI field campaign. Generally all configurations of the higher-resolution WRFs outperformed the lower-resolution GFS based on multiple metrics. Among the convection-permitting WRF models, results varied with respect to rainfall threshold and forecast lead time, but the WRFUIUC mostly performed the best. However, elevation dependent biases existed among the models that may impact the use of the data for different applications. There is a dry (moist) bias in lower (upper) pressure levels which is most pronounced in the GFS. For Córdoba an overestimation of the northern flow forecasted by the NWP configurations at lower levels was encountered. These results show the importance of convection-permitting forecasts in this region, which should be complementary to the coarser-resolution global model forecasts to help various users and decision makers.

Synthesis of small molecule inhibitors for the treatment of disease

<p>Three aspects of the protecting-group-free (PGF) synthesis of small molecules have been described in this thesis. In the first part, the PGF azasugar synthesis methodology was applied to 2-deoxy-D-glucose with the intention of selectively forming the six-membered azasugar 5-epi-fagomine. Surprisingly, four products were formed in the key I2-mediated carbamate annulation step, with a pyrrolidine being the major product after optimisation. This was formed in 15% yield. A mechanism that explains the formation of the four carbamates was proposed, which was supported by an investigation into related halocyclisation reactions. The next part of this thesis describes the development of a new PGF methodology for the synthesis of conduramines, another class of biologically interesting molecules. Conduramines are amino polyhydroxy cyclohexenes and some conduramines have glycosidase inhibitory activity. These molecules are also useful precursors to a variety of biologically useful molecules including aminocyclitols and azasugars. The key steps in the PGF synthesis of conduramines are a Vasella-Barbier amination, a reaction that forms new C-C and C-N bonds concomitantly, and a ring closing metathesis in the presence of free hydroxyl and amine groups. To this end, a 4-deoxy 3-conduramine was prepared in just four steps and in 27% yield. Finally, the preparation of an amine library and its biological testing for the identification of a new anti-tuberculosis drug is described. Two short syntheses were used to prepare alkenylamines and amines from the corresponding sugar, with various lipophilic groups attached to the amine. A 20-member amine library was prepared, and the compounds were tested for anti-mycobacterial activity in a mycobacterial growth inhibition assay. The most active compounds were subjected to further biological testing to determine their general cytotoxic properties. Two amines, arabinohexadecylamine and arabinohexadecylmethylamine, were identified as having the best potential for use as anti-tuberculosis drugs, and have been sent to Colorado State University for subsequent in vivo testing in a mouse model of tuberculosis.</p>

Synthesis of small molecule inhibitors for the treatment of disease

<p>Three aspects of the protecting-group-free (PGF) synthesis of small molecules have been described in this thesis. In the first part, the PGF azasugar synthesis methodology was applied to 2-deoxy-D-glucose with the intention of selectively forming the six-membered azasugar 5-epi-fagomine. Surprisingly, four products were formed in the key I2-mediated carbamate annulation step, with a pyrrolidine being the major product after optimisation. This was formed in 15% yield. A mechanism that explains the formation of the four carbamates was proposed, which was supported by an investigation into related halocyclisation reactions. The next part of this thesis describes the development of a new PGF methodology for the synthesis of conduramines, another class of biologically interesting molecules. Conduramines are amino polyhydroxy cyclohexenes and some conduramines have glycosidase inhibitory activity. These molecules are also useful precursors to a variety of biologically useful molecules including aminocyclitols and azasugars. The key steps in the PGF synthesis of conduramines are a Vasella-Barbier amination, a reaction that forms new C-C and C-N bonds concomitantly, and a ring closing metathesis in the presence of free hydroxyl and amine groups. To this end, a 4-deoxy 3-conduramine was prepared in just four steps and in 27% yield. Finally, the preparation of an amine library and its biological testing for the identification of a new anti-tuberculosis drug is described. Two short syntheses were used to prepare alkenylamines and amines from the corresponding sugar, with various lipophilic groups attached to the amine. A 20-member amine library was prepared, and the compounds were tested for anti-mycobacterial activity in a mycobacterial growth inhibition assay. The most active compounds were subjected to further biological testing to determine their general cytotoxic properties. Two amines, arabinohexadecylamine and arabinohexadecylmethylamine, were identified as having the best potential for use as anti-tuberculosis drugs, and have been sent to Colorado State University for subsequent in vivo testing in a mouse model of tuberculosis.</p>

Hydraulic Tests and Interpretation of Test Data for Reno Mattresses in Open Channel Flow

The efficacy of erosion control systems depends on preventing soil loss underneath and maintaining its integrity under the effects of the water flow. The paper presents the research results at the Colorado State University on the performance of double twisted wire mesh products, known as Reno Mattresses, used as soil erosion control systems. Mattresses were subjected to various flow conditions on a 10 m long flume placed on a soil layer. The performance against erosion was evaluated by assessing the effect of the stone motion inside the mattress combined with the condition of incipient soil erosion underneath, in relationship to the mattress thickness, the filling stone properties, and under variable hydraulic flow regimes. At the same time, confirming the stability obtained using the conventional tractive force design approach, the research results allowed to introduce a new performance limit based on incipient soil erosion underneath the revetment. Based on the research results, the authors propose to express the shear resistance of mattresses used as soil erosion control systems as a function of the filling stones’ size, uniformity, unit weight, mattress thickness, and the presence of vertical strengthening elements.

Neoplasia and Proliferative Lesions of New World Camelids: A Systematic Literature Review and Retrospective Study of Cases Submitted to Colorado State University From 1995 to 2020

Camelid pathology submissions to veterinary diagnostic laboratories are on the rise given the increasing popularity and population of llamas and alpacas especially in the western United States. When compared to other animals, the field of camelid neoplasia has a relative paucity of cases reported in the literature. The Colorado State University Veterinary Diagnostic Laboratories (CSU-VDL) has had a steady increase in the numbers of camelid pathology submissions allowing for a robust review of diagnoses of neoplasia in new world camelids. Here we present a retrospective analysis of camelid neoplastic and proliferative lesions diagnosed at the CSU-VDL from 1995 to 2020, followed by an extensive literature review. Results show increasing incidence of camelid neoplasia reported in the literature, therefore becoming a common diagnosis in llamas and alpacas. Proliferative and neoplastic lesions were diagnosed in 8.8% of new world camelid submissions to CSU-VDL with the most common tumors being lymphomas, squamous cell carcinomas, fibromas, and adenocarcinomas. Risk factors are female sex and increased age except in the case of lymphoma, which tends to occur in younger camelids. Lymphomas, melanomas, and adenocarcinomas (especially of gastrointestinal tract) carry an increased risk of multiple-organ system involvement often with widespread metastases. Conditions described in camelids for the first time include osteosarcoma, cutaneous hemangiosarcoma, myxosarcoma, pilomatricoma, ovarian theca cell tumor, congenital nevus with malignant transformation, and various other neoplasia. This article will provide an operational guide for camelid neoplasia to further assist veterinary laboratory diagnosticians, researchers, and practicing veterinarians in the field of camelid medicine and pathology.

The Coaxium® Wheat Production System: A New Herbicide-Resistant System for Annual Grass Weed Control and Integrated Weed Management

The authors discuss the importance of wheat as a global food source and describe a novel multi-institutional, public-private partnership between Colorado State University, the Colorado Wheat Research Foundation, and private chemical and seed companies that resulted in the development of a new herbicide-resistant wheat production system.

Time-dependent scour processes on granular beds at large scale

A theoretical framework, based on the phenomenological theory of turbulence applied to scour-related processes due to plunging jets on cohesionless beds, is considered in this paper. More specifically, its predictive capability is assessed herein for large-scale domains, after it was developed for small scales elsewhere. The analysis focuses on both the time-evolution process and the equilibrium configuration for a wide range of hydraulic structures. After revisiting the theory for the temporal evolution of the scour processes, the scour for large-scale tests is investigated using unpublished experiments performed at Colorado State University by the last author. These tests confirm the existence of two stages in the scour hole development, namely the developing and developed phases. Thus, the scour dynamics at large scales is shown to be consistent with that at smaller scales. Then, the theory recently introduced by the first three authors is used to predict the time evolution of scour, corroborating that the very same equations, together with the same coefficients, provide successful predictions, regardless of scale and granulometric distribution. Finally, the theory is again verified against laboratory data on PK weirs obtained at the University of Pisa. Overall, the work described in the paper offers a tool with general validity.

THE COUPLING BET WEEN CONVECTIVE VARIABILITY AND LARGE-SCALE FLOW PATTERNS OBSERVED DURING PISTON 2018-2019

The Propagation of Intraseasonal Oscillations (PISTON) field campaign took place in the waters of the western tropical North Pacific during the late-summer and early-fall of 2018 and 2019. During both research cruises, the Colorado State University SEA-POL polarimetric C-Band weather radar obtained continuous 3D measurements of oceanic precipitation systems. This study provides an overview of the variability in convection observed during the PISTON cruises, and relates this variability to large-scale atmospheric conditions. Using an objective classification algorithm, precipitation features are identified and labeled by their size (isolated/sub-MCS/MCS) and degree of convective organization (nonlinear/linear). It is shown that although large mesoscale convective systems (MCS’s) occurred infrequently (present in 13% of radar scans), they contributed a disproportionately large portion (56%) of the total rain volume. Conversely, small isolated features were present in 91% of scans, yet these features contributed just 11% of the total rain volume, with the bulk of the rainfall owing to warm rain production. Convective rain rates and 30-dBZ echo top heights increased with feature size and degree of organization. MCS’s occurred more frequently in periods of low-level southwesterly winds, and when low-level wind shear was enhanced. By compositing radar and sounding data by phases of easterly waves (of which there were several in 2018), troughs are shown to be associated with increased precipitation and a higher relative frequency of MCS feature occurrence, while ridges are shown to be associated with decreased precipitation and a higher relative frequency of isolated convective features.