Extracellular vesicle research in reproductive science— Paving the way for clinical achievements

Mammalian conception involves a multitude of reciprocal interactions via a molecular dialogue between mother and conceptus. Extracellular vesicles (EVs) are secreted membrane-encapsulated particles that mediate cell-to-cell communication in various contexts. EVs, which are present in seminal, follicular, oviductal, and endometrial fluids, as well as in embryo secretions, carry molecular constituents that impact gamete maturation, fertilization, early embryo development, and embryo-maternal communication. The distribution, concentration, and molecular cargo of EVs are regulated by steroid hormones and the health status of the tissue of origin, and thus are influenced by menstrual phase, stage of conception, and the presence of infertility-associated diseases. EVs have been recognized as a novel source of biomarkers and potential reproductive medicine therapeutics, particularly for assisted reproductive technology (ART). There are still many technological and scientific hindrances to be overcome before EVs can be used in clinical diagnostic and therapeutic ART applications. Issues to be resolved include the lack of standardized measurement protocols and an absence of absolute EV quantification technologies. Additionally, clinically suitable and robust EV isolation methods have yet to be developed. In this review, we provide an overview of EV-mediated interactions during the early stages of reproduction from gamete maturation to embryo implantation and then outline the technological progress that must be made for EV applications to be translated to clinical settings.

Contemporary Art in Applied Dimensions: A Reflective Review of Art as Therapeutic Process

A common perception about contemporary art is the perception that it excludes a majority of people as being its legitimate viewers or judges, by virtue of the fact that it contains exclusive or encrypted messages. A small, privileged group of experts grant value, acceptance and endow public popularity of such works for the market and media. In this research we seek to provide an insight into a cluster of contemporary abstract art forms and show how such art forms anticipate closer and more common sensory and hermeneutic experience. Art like that of Hamish Fulton is built on experiences that enables us to connect with them, thereby redefining the concepts and ideas of these arts through an alternative phenomenological experience of their methods and processes of making art. Fulton’s art is based on a visual translation of his experiences of healing walks through mountainous terrain. We may build a personal, general methodology of interpretation by building personal synergistic links with the methods of creation – that could in turn generate therapeutic effects both in the viewer or in the interpreter of such art, through self-reflection and re-construction of the concepts proposed in the framing. Likewise, we will reflect briefly on art therapeutic projects that we studied for patients with ADHD. We analyze the expressions and suggest a method of therapeutic art creation based on similar processes as in Fulton.

Pengembangan Scrapbook Sebagai Media Karya Kreatif dan Art Therapy

Pandemi virus Corona (COVID-19) yang berkepanjangan membuat masyarakat merasa jenuh dan bosan. Adanya kebijakan Work From Home (WFH) membuat masyarakat mau tidak mau membatasi ruang gerak mereka. Keadaan perekonomian masyarakat yang terpuruk juga membuat keadaan menjadi semakin sulit bagi kebanyakan orang. Satu per satu tren kreatif sebagai ungkapan menghibur diri bermunculan. Salah satunya scrapbook yang bukan hanya sebagai media pengasah kreatifitas, tetapi juga bisa menjadi media menulis (diary). Penelitian ini memiliki tujuan untuk membuat kreasi scrapbook sebagai media kreasi sekaligus sebagai alat art therapy. Penelitian yang dilakukan menggunakan metode pendekatan estetika dan metode penelitian Practice Based Research.The prolonged Corona virus (COVID-19) pandemic has made people feel bored and bored. The existence of the Work From Home (WFH) Policy has made people not want to limit their space. The deteriorating state of the community's economy also made things even more difficult for most people. One by one, creative trends as expressions of self-entertainment emerge. One of them is scrapbook, which is not only a creative media sharpener, but also a written media (diary). This research aims to make scrapbook creations as a creative medium as a therapeutic art tool. The research was conducted using an aesthetic approach and practical research based research methods.

Workshop Terapi Seni Ekspresif Pada Anak Pasien Kanker di Rumah Singgah Ykaki Bandung

<p>Art activities have been proven effective as psychological therapies that stimulate<br />children imagination in a positive way. A series of expressive art therapy workshops was conductedon children with cancer, who were temporarily stayed at Rumah Singgah YKAKI Bandung. The activities were integrated with fitness, music and dance. The aim was to stimulate the creative expression and spontaneity in children through the interactive and therapeutic art activities. The programwas expected to help reduce stress on children with cancer. Cancer patients were invited to create positive narratives, tell stories and imagine their current whereabouts also created works based on these narratives. At the end, their creative workswere exhibited to public as a form of achievement.</p><p>Kegiatan seni terbukti bermanfaat terapi psikologis yang mendorong anak untuk<br />berimajinasi ke arah yang positif. Sebuah serial workshop terapi seni ekspresif<br />dilaksanakan kepada anak-anak pasien kanker di rumah singgah YKAKI<br />Bandung. Kegiatan ini diintegrasikan dengan kegiatan lainnya, seperti olah tubuh, musik dan tari. Tujuannya untuk merangsang spontanitas berekspresi kreatif melalui kegiatan seni yang interaktif dan terapeutik. Program kegiatan seni rupa ini dapat membantu mereduksi stress pada anak pasien kanker. Dalam prosesnya pasien anak kanker diajak menciptakan narasi positif, bercerita dan berimajinasi tentang keberadaan mereka saat ini dan membuat karya berdasarkan narasi tersebut. Pada akhir sessi, karya kreatif mereka dipamerkan kepada publik sebagai wujud dari pencapaian.</p>

Kanchnar (Bauhinia Variegata Linn.) As A Thyroid Gland Protecting Drug

Ayurveda is a science of life or art of longevity which encompasses far more than mere therapeutic art. The paragon of beauty of Ayurveda is that it always emphasizes preventive over cure. Kanchnar mentioned as Gandmalanashak varga by Priyavrat Sharma in his book Dravyagun Vigyana part-2. Bauhinia variegata Linn (Family- Caesalpiniaceae) is the botanical name of Kanchnar or syn. Gandaari. Kanchnar is the Galgandnashka by Guna Prabhava. Nowadays, the use of herbal drugs for treatment of various diseases is developing all over the world. In Ayurveda Galganda and Gandmala are co-related with the disorder caused by Thyroid gland dysfunction. The diseases like Galganda and Gandamala are now days become more prevailing condition because of sedentary lifestyle, diet, stress and because of hormonal imbalance. In contemporary system of medicine advices Thyroxin and carbimazole for long standing, may lead to complication and adverse effect on the body. Hence it is necessary to explore safe treatment modalities. Kanchnar used as Ekala dravya in the treatment of thyroid gland dysfunction on the basis of its immunomodulator activity, anti-tumor and anti- cancer activity. Kanchnar is considered as drug of choice for all kind of Granthies. Ayurvedic medicine has the potential to make an important therapeutic contribution. This review article contain spectrum of information about Bauhinia variegata.

Presupuestos terapéuticos y pseudomorfosis en los trabajos Martyrs (2014) y Mary (2016) de Bill Viola

En 2014 Bill Viola completa su trabajo Martyrs, un encargo realizado por la Catedral de san Pablo, en Londres. Dos años después quedará concluida Mary, obra que complementa a Martyrs y que encuentra su ubicación, en esa misma catedral, en el extremo opuesto del ábside. Tomando como eje vertebrador la significación de los cuatro elementos (agua, tierra, aire, fuego) y el fenómeno de pseudomorfosis habitual en los trabajos de Viola, exploraremos los fundamentos de un arte terapéutico. La emergencia de contenidos profundos del imaginario permite la revitalización psicosomática del sujeto. In 2014 Bill Viola finished his work Martyrs, requested by Saint Paul’s Cathedral, in London. Two years later the American artist ended another work, Mary, that complements Martyrs. Mary is located, also in Saint Paul’s Cathedral, on the opposite side of the apse. Since the meaning of the four elements (water, earth, air and fire) and the idea of pseudomorphosis that normally structures Bill Viola’s works, we will explore the premises of a therapeutic art. The emergence of deep sediments buried in our imaginary, allows the psychosomatic revitalisation of the individual.

The Soul’s Virtue and the Health of the Body in Ancient Philosophy

This chapter undertakes a comparison between ancient philosophy and ancient medicine, showing that in Greek works and texts of the Roman period a parallel was drawn between the therapeutic art of medicine for the body and philosophy as a form of therapy in its own right. Attention is also paid to the epistemological dimension of medicine, with a variety of thinkers taking different stances on the kind of knowledge available to medicine and its sources. Do doctors have a mere “knack” for curing like rhetoricians with their art of persuasion, or is medicine a science in the full and proper sense? Authors and traditions covered include Plato, the Stoics, the Epicureans, and the Pyrrhonist Skeptics, as well as medical thinkers like Diocles and Herophilus.