Using SWOT Analysis for Defining Strategies of Mobile Learning

After exploring the concept of m-learning, this paper focuses on defining a SWOT analysis of mobile learning with detail discussion of each element. Finding important relationships by matching well know SWOT variables in a systematic fashion is a next step of research where using a algorithm which can provide a help in defining appropriate strategy. The result of our research is a conceptual framework for defining strategies for mobile learning, which will help primarily universities or other educational institutions in estimating their own position and creating the strategy for adopting m-learning into their curriculums which make a valuable contribution for the future research in this area.

Panning for gold: An annotated bibliography of treasures in Auckland Libraries’ special collections of children’s literature from 1880-1889

<p>The catalogue entries for much of the items housed within Auckland Libraries special collections of children’s literature contain many gaps and limitations. In order to illustrate these limitations this project has focused on the collection’s holdings of items dated from 1880-1889. As the collections are arranged in date order I was able to examine the selection of items in a systematic fashion with the help of special collections staff, working through the items as they appeared on the shelf, annotating each item and noting discrepancies with and gaps in the catalogued information as I went. It is hoped that this project will not only assist library staff in updating the records for the items contained herein, and act as a guide to researchers wishing to learn about and access the collection, but also highlight issues of access to and cataloguing of rare books for the profession. Addressing the issues of subject headings, publication dates, and call numbers, as well as the cataloguing issues across the wider collections would of course require further work, but would be of great benefit to the library, its staff, and its patrons.</p>

Panning for gold: An annotated bibliography of treasures in Auckland Libraries’ special collections of children’s literature from 1880-1889

<p>The catalogue entries for much of the items housed within Auckland Libraries special collections of children’s literature contain many gaps and limitations. In order to illustrate these limitations this project has focused on the collection’s holdings of items dated from 1880-1889. As the collections are arranged in date order I was able to examine the selection of items in a systematic fashion with the help of special collections staff, working through the items as they appeared on the shelf, annotating each item and noting discrepancies with and gaps in the catalogued information as I went. It is hoped that this project will not only assist library staff in updating the records for the items contained herein, and act as a guide to researchers wishing to learn about and access the collection, but also highlight issues of access to and cataloguing of rare books for the profession. Addressing the issues of subject headings, publication dates, and call numbers, as well as the cataloguing issues across the wider collections would of course require further work, but would be of great benefit to the library, its staff, and its patrons.</p>

A Parametric Framework to Generate Visual Illusions Using Python

Visual illusions are fascinating phenomena that have been used and studied by artists and scientists for centuries, leading to important discoveries about the neurocognitive underpinnings of perception, consciousness, and neuropsychiatric disorders such as schizophrenia or autism. Surprisingly, despite their historical and theoretical importance as psychological stimuli, there is no dedicated software, nor consistent approach, to generate illusions in a systematic fashion. Instead, scientists have to craft them by hand in an idiosyncratic fashion, or use pre-made images not tailored for the specific needs of their studies. This, in turn, hinders the reproducibility of illusion-based research, narrowing possibilities for scientific breakthroughs and their applications. With the aim of addressing this gap, Pyllusion is a Python-based open-source software (freely available at https://github.com/RealityBending/Pyllusion ), that offers a framework to manipulate and generate illusions in a systematic way, compatible with different output formats such as image files (.png, .jpg, .tiff, etc.) or experimental software (such as PsychoPy).

Case Report: Response to Regional Melphalan via Limb Infusion and Systemic PD1 Blockade in Recurrent Myxofibrosarcoma: A Report of 2 Cases

Treatment options for patients with advanced sarcoma remain limited. Promising responses to checkpoint inhibition have been observed, but responses to single-agent PD-1 inhibition are rare. We report on two patients with multiply recurrent myxofibrosarcoma treated with the combination of regionally administered melphalan (via isolated limb infusion) and pembrolizumab. Both patients had recurrent disease after multiple surgical resections and radiation. Analysis of primary tumors demonstrated microsatellite stable tumors with few mutations. After combination treatment, one patient had a significant partial response of 6 months duration, the second patient had a complete response of 2 years duration. Post treatment biopsies demonstrated immune infiltration into the tumor. These promising responses in patients with multiply recurrent myxofibrosarcoma have prompted the development of an investigator-initiated clinical trial to formally study the combination of regional melphalan and pembrolizumab in a systematic fashion (NCT04332874).

Condensed trajectory of the temporal correlation of diseases and mortality extracted from over 300,000 patients in hospitals

Understanding mortality, derived from debilitations consisting of multiple diseases, is crucial for patient stratification. Here, in systematic fashion, we report comprehensive mortality data that map the temporal correlation of diseases that tend toward deaths in hospitals. We used a mortality trajectory model that represents the temporal ordering of disease appearance, with strong correlations, that terminated in fatal outcomes from one initial diagnosis in a set of patients throughout multiple admissions. Based on longitudinal healthcare records of 10.4 million patients from over 350 hospitals, we profiled 300 mortality trajectories, starting from 118 diseases, in 311,309 patients. Three-quarters (75%) of 59,794 end-stage patients and their deaths accrued throughout 160,360 multiple disease appearances in a short-term period (<4 years, 3.5 diseases per patient). This overlooked and substantial heterogeneity of disease patients and outcomes in the real world is unraveled in our trajectory map at the disease-wide level. For example, the converged dead-end in our trajectory map presents an extreme diversity of sepsis patients based on 43 prior diseases, including lymphoma and cardiac diseases. The trajectories involving the largest number of deaths for each age group highlight the essential predisposing diseases, such as acute myocardial infarction and liver cirrhosis, which lead to over 14,000 deaths. In conclusion, the deciphering of the debilitation processes of patients, consisting of the temporal correlations of diseases that tend towards hospital death at a population-wide level is feasible.

Neurosarcoidosis

Although often regarded as a protean illness with myriad clinical and imaging manifestations, neurosarcoidosis typically presents as recognizable syndromes that can be approached in a rational, systematic fashion. Understanding of neurosarcoidosis has progressed significantly in recent years, including updated diagnostic criteria and advances in treatment. The diagnosis of neurosarcoidosis is established by the clinical syndrome, imaging and histopathological findings, and exclusion of other causes. Mounting evidence supports the use of tumor necrosis factor inhibitors as an important addition to the therapeutic armamentarium, along with glucocorticoids and steroid-sparing cytotoxic immunosuppressants. In this narrative review, we summarize recent advances in the diagnosis and treatment of neurosarcoidosis.

Impact of the menstrual cycle on commercial prognostic gene signatures in oestrogen receptor-positive primary breast cancer

Purpose Changes occur in the expression of oestrogen-regulated and proliferation-associated genes in oestrogen receptor (ER)-positive breast tumours during the menstrual cycle. We investigated if Oncotype® DX recurrence score (RS), Prosigna® (ROR) and EndoPredict® (EP/EPclin) prognostic tests, which include some of these genes, vary according to the time in the menstrual cycle when they are measured. Methods Pairs of test scores were derived from 30 ER-positive/human epidermal growth factor receptor-2-negative tumours sampled at two different points of the menstrual cycle. Menstrual cycle windows were prospectively defined as either W1 (days 1–6 and 27–35; low oestrogen and low progesterone) or W2 (days 7–26; high oestrogen and high or low progesterone). Results The invasion module score of RS was lower (− 10.9%; p = 0.098), whereas the ER (+ 16.6%; p = 0.046) and proliferation (+ 7.3%; p = 0.13) module scores were higher in W2. PGR expression was significantly increased in W2 (+ 81.4%; p = 0.0029). Despite this, mean scores were not significantly different between W1 and W2 for any of the tests and the two measurements showed high correlation (r = 0.72–0.93). However, variability between the two measurements led to tumours being assigned to different risk categories in the following proportion of cases: RS 22.7%, ROR 27.3%, EP 13.6% and EPclin 13.6%. Conclusion There are significant changes during the menstrual cycle in the expression of some of the genes and gene module scores comprising the RS, ROR and EP/EPclin scores. These did not affect any of the prognostic scores in a systematic fashion, but there was substantial variability in paired measurements.

Kinship terminologies reveal ancient contact zone in the Hindu Kush

The Hindu Kush, or the mountain region of northern Pakistan, north-eastern Afghanistan and the northern-most part of the Indian-administered Kashmir region, is home to approximately 50 languages belonging to six different genera: Indo-Aryan, Iranian, Nuristani, Sino-Tibetan, Turkic and the isolate Burushaski. Areality research on this region is only in its early stages, and while its significance as a convergence area has been suggested by several scholars, only a few, primarily phonological and grammatical, features have been studied in a more systematic fashion. Cross-linguistic research in the realms of semantics and lexical organization has been given considerably less attention. However, preliminary findings indicate that features are geographically bundled with one another, across genera, in significant ways, displaying semantic areality on multiple levels throughout the region or in one or more of its sub-regions. The present study is an areal-typological investigation of kinship terms in the region, in which particular attention is paid to a few notable polysemy patterns and what appears to be a significant geographical clustering of these. Comparisons are made between the geographical distribution of such patterns and those of some other linguistic features as well as with relevant non-linguistic factors related to shared cultural values or identities and a long history of small-scale cross-community interaction in different parts of the region.

When Palestinians Became Human Shields: Counterinsurgency, Racialization, and the Great Revolt (1936–1939)

This article examines the origins of human shielding—the practice of employing hostages on the battlefield—in Arab Palestine during the Great Revolt in the 1930s. The Palestinian rebellion vexed the British for over three years, and during its second phase (1937–1939), lightly armed rebels beat back the colonial authorities from broad stretches of the country, putting continued colonial control of the territory in serious jeopardy. Britain only defeated the insurgency through a harsh repertoire of collective punishments and “dirty war” tactics. British forces used Palestinians as human shields in a systematic fashion during the revolt's second phase, attempting thereby to stave off the insurgents’ consistent and effective attacks on transportation arteries. Beyond its battlefield rationale, this article contends that human shielding was critically tied to two other dynamic processes. The military's adoption of unauthorized tactics like human shielding was part of a broader pattern of rejecting its institutional subordination to civilian authorities and of seeking direct control over the Palestine government in order to assure its unfettered command over the revolt's suppression. At the same time, the conversion of colonized bodies into literal shields bespoke a process of deepening, corporeal racialization that had profound consequences for the Palestinians, stripping them of any figment of legal rights or protections and signaling the utter disposability of Arab life.