COVID 19 breakthrough infection risk: a simple physical model describing the dependence on antibody concentration

The empirically-observed dependence on blood IgG anti-receptor binding domain antibody concentration of SARS-CoV-2 vaccine efficacy against infection has a rational explanation in the statistics of binding of antibody to spike proteins on the virus surface: namely that the probability of protection is the probability of antibody binding to more than a critical number of the spike proteins protruding from the virus. The model is consistent with the observed antibody concentrations required to induce immunity and with the observed dependence of vaccine efficacy on antibody concentration and thus is a useful tool in the development of models to relate, for an individual person, risk of breakthrough infection given measured antibody concentration

Explanation and Understanding as Methods of Historical and Biographical Cognition

Traditionally, explanation is considered to be the method of natural sciences and understanding to be the method of humanities. However, this paper considers both to be methods of history. Namely, the author focuses on how explanation and understanding function in history in general and in biography in particular. Referring to biographical realm helps explicate the specifics of explanation and understanding as well as broaden the view about their uses in humanities. In the first part, the author refers to explanation and understanding in history as such. In particular, causal explanation (explanatory sketch by Karl Hempel) and rational explanation (history of ideas by Mark Bevir) are considered in the paper along with the relationship of hermeneutic notion of understanding with the two. The second part of the paper deals with the functioning of explanation and understanding in biographical research. Namely, it considers biographical understanding by Tilmann Habermas and Neşe Hatiboğlu as well as cases of causal and rational explanations in biographical research. In particular, it is shown that while causal explanation occurs in biography as explanatory sketch, it is not a separate distinct notion. It is also shown that rational explanation is used in biographical reconstructions in order to clarify the influence of particular events on beliefs of people. Based on the materials involved, the author demonstrates the specifics of explanation and understanding in biography compared to their usage in historical cognition in general.

COVID 19 breakthrough infection risk: a simple physical model describing the dependence on antibody concentration

The empirically-observed dependence on blood IgG anti-receptor binding domain antibody concentration of SARS-CoV-2 vaccine efficacy against infection has a rational explanation in the statistics of binding of antibody to spike proteins on the virus surface: namely that the probability of protection is the probability of antibody binding to more than a critical number of the spike proteins protruding from the virus. The model is consistent with the observed antibody concentrations required to induce immunity and with the observed dependence of vaccine efficacy on antibody concentration and thus is a useful tool in the development of models to relate, for an individual person, risk of breakthrough infection given measured antibody concentration

The Activity of Native Vacuolar Proton-ATPase in an Oscillating Electric Field – Demystifying an Apparent Effect of Music on a Biomolecule

The effect of an oscillating electric field generated from music on yeast vacuolar proton-ATPase (V-ATPase) activity in its native environment is reported. An oscillating electric field is generated by electrodes that are immersed into a dispersion of yeast vacuolar membrane vesicles natively hosting a high concentration of active V-ATPase. The substantial difference in the ATP hydrolysing activity of V-ATPase under the most stimulating and inhibiting music is unprecedented. Since the topic, i.e., an effect of music on biomolecules, is very attractive for non-scientific, esoteric mystification, we provide a rational explanation for the observed new phenomenon. Good correlation is found between changes in the specific activity of the enzyme and the combined intensity of certain frequency bands of the Fourier spectra of the music clips. Most prominent identified frequencies are harmonically related to each other and to the estimated rotation rate of the enzyme. These results lead to the conclusion that the oscillating electric field interferes with periodic trans-membrane charge motions in the working enzyme.

COVID 19 breakthrough infection risk: a simple physical model describing the dependence on antibody concentration

The empirically-observed dependence of SARS-CoV-2 vaccine efficacy on antibody concentration has a rational explanation in the statistics of binding of antibody to spike proteins on the virus surface: namely that the probability of protection is the probability of antibody binding to more than a critical number of the spike proteins protruding from the virus. The model is consistent with the observed antibody concentrations required to induce immunity.

Management Quality and Information Quality: Some Results of 2020 for the Post-Soviet Space

The foreign policy of some states does not always lend itself to rational explanation. The antithesis of the all-embracing rationality model was the model of incrementalism, first proposed by C. Lindblom, professor at Yale University. It was he who first noted that in the decision-making process there is a constant lack of knowledge, information, resources; and the role of uncertainty is great in the internal and external environment, which is difficult to control. However, even when ideally informed, politicians can make irrational decisions. Incrementalism as a theoretical approach draws attention to situations where decisions are not based on available and verified information. Political processes and relevant management decisions in Armenia and Belarus in 2020 indicate that the information quality and the management quality do not always correlate with each other.

Effect of Intravenous IgM-Enriched Immunoglobulins on Presepsin and Other Sepsis Biomarkers

Patients in septic shock with low IgG and IgM serum concentrations have higher mortality rates compared to those with normal immunoglobulin levels and, therefore, there is a rational explanation to administer intravenous IgM-enriched immunoglobulins to septic patients in ICU. Aim of this study is to evaluate the effectiveness of intravenous IgM-enriched immunoglobulins in decreasing several sepsis biomarker concentrations. 26 sepsis patients were enrolled in this observational cohort study and Nitric Oxide, Endocan, Pentraxin and presepsin serum levels were measured during their first 3 days of ICU stay. The use of intravenous IgM-enriched immunoglobulins did not influence the temporal evolution of SOFA, Nitric Oxide, Endocan, Pentraxin and Presepsin in the first 3 days of ICU stay in a statistically significant manner, even if Presepsin decreased of 25% from day 1 to day 2 in the Pentaglobin group. It seems possible that Pentaglobin infusion reduces the Presepsin level in a more effective way if it were administered to a younger population (p = 0.012). In conclusion, age modifies the response of Presepsin to Pentaglobin and is a critical variable when investigating the effect of intravenous IgM-enriched immunoglobulins on sepsis.

Books and Their Method

This chapter deals with the method of philosophical books during the sixth/twelfth century. It begins with an analysis of Abu l-Barakat al-Baghdadi’s method of i’tibar (careful consideration) and highlights its departure from al-Farabi’s and Avicenna’s (Ibn Sina’s) demonstrative method as the ideal of philosophical inquiry. The chapter looks at how Fakhr al-Din al-Razi describes his own method in his philosophical books and it analyzes the method of “probing and dividing” (sabr wa-taqsim) used therein. Finally, the chapter zooms in on the methodical differences between Fakhr al-Din’s philosophical books and his books of kalam and focuses on the principle of sufficient reason. This philosophical principle requires that every event must have a rational explanation of its cause(s). The principle is universally valid in al-Razi’s philosophical books, yet in his books on kalam only insofar as God’s will is excluded from this requirement. This difference has far-reaching effects on the teachings put forward in these two genres of books.

On Noble and Inherited Virtues: Discussions of the Semitic Race in the Levant and Egypt, 1876–1918

This article examines new notions about race, ethnicity and language current in modern movements of Arabic literary and cultural revival. I argue that the Arab print market before World War I adopted the racial category of the Semite as highly relevant to Arab ethnicity and language, but the philological and literary significations of the term subverted the negative constructions affiliated with the Semitic races in Western race theories. Combining elements from the study of linguistics, religion, and political philosophy, Arabic journals, books, and works of historical fiction, created a Semitic and Arab universe, populated by grand historical figures and mesmerizing literary and cultural artifacts. Such publications advanced the notion that the Arab races belonged to Semitic cultures and civilizations whose achievements should be a source of pride and rejuvenation. These printed products also conveyed the idea that the Arabic language and Arab ethnicity can create ecumenical and pluralistic conversations. Motivated by the desire to find a rational explanation to phenomena they identified with cultural and literary decline, Arab authors also hoped to reconstruct the modes with which their Semitic and Arab ancestors dealt with questions relating to community and civilization. By publishing scientific articles on philology, literature, and linguistics, the print media illustrated that Arabic itself was a language capable of expressing complex scientific concepts and arguments.