Cudraflavone C from Artocarpus hirsutus as a Promising Inhibitor of Pathogenic, Multidrug-Resistant S. aureus, Persisters, and Biofilms: A New Insight into a Rational Explanation of Traditional Wisdom

2021 ◽  
Author(s):  
Murugan Thulasi Meenu ◽  
Grace Kaul ◽  
Manjulika Shukla ◽  
Kokkuvayil Vasu Radhakrishnan ◽  
Sidharth Chopra
Keyword(s):  
Multidrug Resistant ◽  
Rational Explanation ◽  
Insight Into

Pathologic Physiology: Mechanisms of Disease

PEDIATRICS ◽  
1951 ◽  
Vol 8 (1) ◽  
pp. 162-162
Keyword(s):  
Internal Medicine ◽  
Signs And Symptoms ◽  
True Nature ◽  
Rational Explanation ◽  
Pathologic Physiology ◽  
Insight Into

While this timely volume, written by 25 well qualified contributors, is addressed primarily to those concerned with the problems of internal medicine, its contents are naturally of great interest and practical value to all physicians who are interested in a rational explanation for the manifestations of disease. Emphasis on the mechanisms involved in producing the signs and symptoms of disease provides a clearer insight into its true nature and leads thereby to more effective methods of therapy.

Enterokokken mit speziellen Resistenzen – Epidemiologie, Hygiene und Therapie

2019 ◽  
Vol 144 (08) ◽  
pp. 553-560 ◽  
Author(s):  
Alexander Mischnik ◽  
Guido Werner ◽  
Jennifer Bender ◽  
Nico Mutters
Keyword(s):  
Scientific Evidence ◽  
Bloodstream Infections ◽  
Multidrug Resistant ◽  
Vancomycin Resistant Enterococci ◽  
Resistance Patterns ◽  
Single Intervention ◽  
Vancomycin Resistant ◽  
Meta Analyses ◽  
Resistance Rates ◽  
Insight Into

AbstractEnterococci with special resistance patterns (mainly vancomycin-resistant enterococci) play an important role in everyday clinical practice. Rising resistance rates to linezolid, daptomycin or tigecycline are also increasingly reported. Therapeutically, linezolid and daptomycin are the most important substances mainly in infections due to vancomycin-resistant enterococci. Several systematic meta-analyses of bloodstream infections showed discrepant results in the comparison of mortality of linezolid and daptomycin-treated bacteraemias. The containment of enterococci with special resistance patterns is currently receiving great attention. The key hygienic issue in all recommendations for dealing with multidrug-resistant enterococci can be summarized very simply: current scientific evidence is often inconsistent and studies that have clearly tested a single intervention for efficacy are lacking. The present work gives an insight into the current epidemiology and therapeutic strategies. Furthermore, the recently published German KRINKO recommendations are presented.

scholarly journals Insight Into Resistance Phenotypes of Emergent Non 13-valent Pneumococcal Conjugate Vaccine Type Pneumococci Isolated From Invasive Disease After 13-valent Pneumococcal Conjugate Vaccine Implementation in France

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Claire Janoir ◽  
Agnès Lepoutre ◽  
Laurent Gutmann ◽  
Emmanuelle Varon
Keyword(s):  
Antibiotic Resistance ◽  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Pneumococcal Disease ◽  
Clonal Expansion ◽  
Invasive Disease ◽  
Multidrug Resistant ◽  
Antibiotic Resistance Profile ◽  
Vaccine Type ◽  
Insight Into

Abstract Background.  In 2010, the pneumococcal 13-valent conjugate vaccine (PCV13), containing 6 additional serotypes including the multidrug-resistant 19A, replaced the PCV7 in France. This study aimed at analyzing trends in antibiotic resistance in invasive pneumococcal disease (IPD) isolates in France after PCV13 introduction. Methods.  A total of 5243 pneumococci isolated from IPD in 2008–2009 (late PCV7 era) and 2011–2012 (PCV13 era) were studied according to their serotype and antibiotic resistance profile. Multilocus sequence typing analysis was performed on strains of the predominant serotypes (12F and 24F) isolated from young children. Results.  Overall, the prevalence of antibiotic resistance decreased in France (−21.5% for penicillin from 2008–2009 to 2011–2012), mainly driven by the decline of the 19A serotype. Among non-PCV13 serotypes that concomitantly emerged, serotypes 12F, 24F, 15A, and 35B were consistently associated with resistance to 1 or more antibiotics. In children under 2 years, serotypes 15A, 35B, and 24F accounted together for 37.8% and 31.9% of penicillin-nonsusceptible and erythromycin-resistant isolates, respectively. Chloramphenicol and cotrimoxazole resistance were mainly associated with serotypes 12F and 24F, respectively. Genetic analysis showed that although emergence of serotype 12F pneumococci resulted from the expansion of various pre-existing lineages, increase in serotype 24F was related to the clonal expansion of the ST162 penicillin-susceptible cotrimoxazole-resistant lineage. Conclusions.  We showed that decline of PCV13-related IPD was associated with a decline in antibiotic resistance in France, but that it likely favored the spread of several resistant nonvaccine serotypes. However, antibiotic resistance does not seem to be the only element that may drive this phenomenon.

Insight into multidrug-resistant microorganisms from microbial infected diabetic foot ulcers

2019 ◽  
Vol 13 (2) ◽  
pp. 1261-1270 ◽  
Author(s):  
Mohamed A. Hassan ◽  
Tamer M. Tamer ◽  
Asmaa A. Rageh ◽  
Alaa M. Abou-Zeid ◽  
Eman H.F. Abd El-Zaher ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Multidrug Resistant ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Insight Into

scholarly journals Novel IncR/IncP6 Hybrid Plasmid pCRE3-KPC Recovered from a Clinical KPC-2-Producing Citrobacter braakii Isolate

mSphere ◽  
2020 ◽  
Vol 5 (2) ◽  
Author(s):  
Dandan Dong ◽  
Ziqiang Mi ◽  
Dujun Li ◽  
Mingming Gao ◽  
Nan Jia ◽  
...  
Keyword(s):  
Bioinformatics Analysis ◽  
Multidrug Resistant ◽  
Genomic Diversity ◽  
Hybrid Plasmid ◽  
The Novel ◽  
Antimicrobial Susceptibility Test ◽  
Genetic Characteristics ◽  
Content Type ◽  
Carbapenemase Gene ◽  
Insight Into

ABSTRACT Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have become widespread in hospitals and the environment. Here, we describe a blaKPC-2-carrying plasmid called pCRE3-KPC, which was recovered from a clinical multidrug-resistant Citrobacter braakii CRE3 strain in China. The complete nucleotide sequence of pCRE3-KPC was determined by combining MiSeq and MinION sequencing and then compared with those of three related plasmids. Plasmid conjugal transfer and electroporation tests, modified carbapenem inactivation method, and bacterial antimicrobial susceptibility test were carried out. We compared this plasmid with three related plasmids to verify that the backbone of pCRE3-KPC was composed of the backbones of the IncR plasmid and IncP6 plasmid. Further bioinformatics analysis showed that pCRE3-KPC carried two resistance-related regions (the blaKPC-2 gene cluster and the aacC2-tmrB-related region). The aacC2-tmrB-related region included two novel insertion sequences (ISCfr28 and ISCfr16). IMPORTANCE Reports of human-pathogenic C. braakii strains, especially of strains showing resistance to carbapenems, are rare. To the best of our knowledge, our results represent the first detection of carbapenemase gene blaKPC-2 in C. braakii strains. In addition, we have studied detailed genetic characteristics of the novel IncR/IncP6 hybrid plasmid pCRE3-KPC, which was isolated from a clinical multidrug-resistant Citrobacter braakii CRE3 strain. Our results may provide further insight into the horizontal transfer of multidrug resistance genes in bacteria and into the genomic diversity and molecular evolution of plasmids.

scholarly journals Genome Sequences of Multidrug-Resistant Salmonella enterica subsp. enterica Serovar Infantis Strains from Broiler Chicks in Hungary

2016 ◽  
Vol 4 (6) ◽  
Author(s):  
Tímea Wilk ◽  
Móni Szabó ◽  
Ama Szmolka ◽  
János Kiss ◽  
Endre Barta ◽  
...  
Keyword(s):  
Genome Evolution ◽  
Salmonella Enterica ◽  
Broiler Chickens ◽  
Multidrug Resistant ◽  
Broiler Chicks ◽  
Genome Sequences ◽  
Insight Into

Three strains of Salmonella enterica serovar Infantis isolated from healthy broiler chickens from 2012 to 2013 have been sequenced. Comparison of these and previously published S . Infantis genome sequences of broiler origin in 1996 and 2004 will provide new insight into the genome evolution and recent spread of S . Infantis in poultry.

scholarly journals Complete Genetic Analysis of Plasmids Carried by Two Nonclonal bla NDM-5 - and mcr-1 -Bearing Escherichia coli Strains: Insight into Plasmid Transmission among Foodborne Bacteria

2021 ◽  
Author(s):  
Xiaobo Liu ◽  
Ruichao Li ◽  
Ning Dong ◽  
Lianwei Ye ◽  
Edward Wai-Chi Chan ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Genetic Analysis ◽  
Bacterial Pathogens ◽  
Multidrug Resistant ◽  
Content Type ◽  
Foodborne Bacteria ◽  
Clinical Pathogens ◽  
Insight Into

Carbapenem and colistin are last-resort antibiotics used to treat serious clinical infections caused by multidrug-resistant (MDR) bacterial pathogens. Plasmids encoding resistance to carbapenems and colistin have been reported in clinical pathogens in recent years, and yet few studies reported cocarriage of mcr and bla NDM genes in Escherichia coli strains of food origin.

scholarly journals On peroxide antimalarials

2007 ◽  
Vol 72 (12) ◽  
pp. 1181-1190 ◽  
Author(s):  
Igor Opsenica ◽  
Dejan Opsenica ◽  
Milka Jadranin ◽  
Kirsten Smith ◽  
Wilbur Milhous ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Natural Product ◽  
Antimalarial Activity ◽  
Multidrug Resistant ◽  
Activity Relationship ◽  
Similar Activity ◽  
Structure Activity ◽  
Relationship Of ◽  
Insight Into ◽  
Better Than

Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure-activity relationship of this kind of antimalarials. The tetraoxanes 2-5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. They have better than or similar activity to the corresponding desmethyl dicyclohexylidene derivatives. Two chimeric endoperoxides with superior antimalarial activity to the natural product ascaridole were also synthesized.

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