Cable Temperature Alarm Threshold Setting Method Based on Convolutional Neural Network

Power cable is used more and more in the power network, and its significance to the safety and stability of the power network is increasingly prominent. Especially in the urban power grid, the high voltage cable is related to the normal production and life of the city. Because of the particularity of the laying environment, it is very difficult to find and eliminate the fault points once the cable faults occur, which seriously affects the reliability of the power grid. Currently, 25% of cable faults are caused by elevated cable temperature, so it is important to set the cable temperature alarm threshold accurately. In this paper, a method of setting temperature alarm threshold using convolutional neural network is proposed. Experiments show that this method is 60% more accurate than other methods.

Taming the Monster: Arresting Excessive Sand Production Problem in ARAMU037

Chemical Sand Consolidation (SCON) has been used as a means of downhole sand control in Niger Delta since the early 70s. The countries where SCON has been used include Nigeria (Niger Delta), Gabon (Gamba) and UK (North Sea). SCON provides grain-to-grain cementation and locks formation fines in place through the process of adsorption of the sand grains and subsequent polymerization of the resin at elevated well temperatures. The polymerized resin serves to consolidate the surfaces of the sand grain while retaining permeability through the pore spaces. In a typical Niger Delta asset, over 30% of the wells may be completed with SCON. A high percentage are still producing without failure since installation from1970s. Where the original SCON jobs have failed, re-consolidation has also been carried out successfully. Chemical Sand Consolidation development has evolved over the years from: Eposand 112A and B, Eposand 212A and B, Wellfix 2000, Wellfix 3000, Sandstop (resin based), Sandtrap 225, 350 & 500 (resin based) and lately Sandtrap 225,350, 500 (solvent based) and Sandtrap ABC (aqueous based). There have been mixed results experienced with the deployment of either of the latest recipes of SCON. This was due to the fact that the conventional deployment work procedure was followed with the tendency for one-size-fits-all approach to the treatment. This paper details the challenges faced with sand production in ARAMU037, the previous interventions and how an integrated approach to the design and delivery of the most recent intervention restored the way to normal production. The well has now produced for about 2 years with minimal interruption with the activity paying out in less than 6 months. The paper also recommends the best practice for remedial sand control especially for wells in mature assets.

Collaboration of Districts in Fulfilling Rajangan Madura Tobacco National Production

This study aims to analyze the concept of collaboration between districts in fulfilling the national production of Rajangan Madura tobacco national and to know the factors causing the decline in Rajangan Madura tobacco production. The problems are focused on the decline in tobacco production and the area of agricultural land in each district, and the instability of the price of tobacco which causes anxiety for farmers. The production and area of Madura tobacco farming land has decreased since 2013 with the production produced is only 3.5 tons with an area of 8.4 ha. If the accumulated decline in production and the area of tobacco farming land per year has decreased by 15%of the total normal production per year as much as 29 thousand tons from a land area of 32 hectares in each district.To approach this problem, Wright's theoretical reference was used, there were five key elements in the implementation of intergovernmental relations, namely 1) the roles of government, 2) the interactions of public officials, 3) sustainability communication, 4) the roles administrators, and 5) focus attentions on the policy. The data were collected through observation and literature study and analyzed qualitatively and descriptively. This study concluded that collaboration between districts has shown good cooperation by dividing the roles and tasks of each region. The interaction of public officials had shown cooperation in behavior, beliefs, perceptions and preferences. With regard to the communication that was built from the four regions, looking for ways and solutions to increase Madura tobacco production and prevent instability in the price of Madurese tobacco in the harvest season. This collaboration had a target of achieving the fulfillment of Rajangan Madura tobacco production to increase by thirty percent, namely the production of Madura tobacco in each year was targeted at eighty tons. Three factors caused the decline in Rajangan Madura tobacco production, namely, first, the decline in tobacco prices was a major factor for farmers in producing tobacco. Second, climatic factors also influenced the maturation process of tobacco until it wasready for harvest. Third, the reduction of land owned by the government and the community due to the fulfillment of development in the infrastructure sector.

Role of OSCAR Signaling in Osteoclastogenesis and Bone Disease

Formation of mature bone-resorbing cells through osteoclastogenesis is required for the continuous remodeling and repair of bone tissue. In aging and disease this process may become aberrant, resulting in excessive bone degradation and fragility fractures. Interaction of receptor-activator of nuclear factor-κB (RANK) with its ligand RANKL activates the main signaling pathway for osteoclastogenesis. However, compelling evidence indicates that this pathway may not be sufficient for the production of mature osteoclast cells and that co-stimulatory signals may be required for both the expression of osteoclast-specific genes and the activation of osteoclasts. Osteoclast-associated receptor (OSCAR), a regulator of osteoclast differentiation, provides one such co-stimulatory pathway. This review summarizes our present knowledge of osteoclastogenesis signaling and the role of OSCAR in the normal production of bone-resorbing cells and in bone disease. Understanding the signaling mechanism through this receptor and how it contributes to the production of mature osteoclasts may offer a more specific and targeted approach for pharmacological intervention against pathological bone resorption.

Butyric acid (butyrate)

Бутановая кислота - одна из короткоцепочечных жирных кислот (КЖК). Присутствует в молочных продуктах и сливочном масле, поэтому имеет второе название - масляная (бутират). Как и другие КЖК, образуется в толстом кишечнике человека местной анаэробной флорой из грубой растительной пищи - пищевых волокон. Собственные пищеварительные механизмы человека не способны создавать КЖК. Эти кислоты - главный источник энергии для микрофлоры толстого кишечника и обеспечивают около 15% общих энергозатрат тела. Бутират проникает во многие среды организма, служит сигнальной молекулой множества физиологических и патологических процессов. Достаточная продукция бутирата толстым кишечником - свидетельство нормального состояния кишечной микробиоты, существенно влияющей и даже определяющей развитие (или не развитие) многих болезней, в том числе нейроиммунных: болезней Альцгеймера и Паркинсона, шизофрении, множественного склероза, аутизма и расстройств аутистического спектра. В арсенале современной медицины опосредованные микробиомом влияния могут быть наиболее выполнимыми и действенными способами профилактики и лечения. Butyric acid, also known as butyrate, is one of the short-chain fatty acids (SCFA). It is present in dairy products and, especially, in butter. Like other SCFA, butyrate is formed in the human large intestine from coarse, vegetable fiber by the local anaerobic flora. The digestive mechanisms are not capable of creating SCFA. These acids are the main source of energy for the microflora in the large intestine, and they also provide about 15% of the total energy consumed by the body. Butyrate penetrates many body environments, and it serves as a signaling molecule for many physiological and pathological processes. Normal production of butyrate by the large intestine is evidence of the normal state of the intestinal microbiota, which significantly affects and even determines the development, or not the development, of many diseases. Among these are neuroimmune diseases, including Alzheimer’s and Parkinson’s diseases, schizophrenia, multiple sclerosis, autism and autism spectrum disorders. In the arsenal of modern medicine, microbiome-mediated influences may be among the most feasible and effective preventive and therapeutic means.

Diagnosis of Pneumatic Systems on Basis of Time Series and Generalized Feature for Comparison with Standards for Normal Working Condition

Faults are unwanted events in any industrial production system. Early detection and diagnosis of faults in automated systems is important in order to prevent equipment damage, loss of performance and profits. For this purpose, more and more sophisticated and complex systems for observation and monitoring of basic characteristics in automated processes are being built. Preconditions for increasing their efficiency are processing and analysis of process information is obtained through a significant number of sensors. For pneumatic systems in addition to the identification of certain faults that may affect the normal production process, it is important to consider the possibilities to improve their energy efficiency. In this regards, the work focuses on the detection of leaks. The fault detection is based on the measurement of the compressed air consumption at the inlet of the pneumatic module and synchronization with signal from the PLC to the valve, and controlled the pneumatic cylinder. The experimental study aims to develop methods for automatic detection and classification of leaks that may be used in machine learning algorithms.

Targeting SHIP1 and SHIP2 in Cancer

Membrane-anchored and soluble inositol phospholipid species are critical mediators of intracellular cell signaling cascades. Alterations in their normal production or degradation are implicated in the pathology of a number of disorders including cancer and pro-inflammatory conditions. The SH2-containing 5′ inositol phosphatases, SHIP1 and SHIP2, play a fundamental role in these processes by depleting PI(3,4,5)P3, but also by producing PI(3,4)P2 at the inner leaflet of the plasma membrane. With the intent of targeting SHIP1 or SHIP2 selectively, or both paralogs simultaneously, small molecule inhibitors and agonists have been developed and tested in vitro and in vivo over the last decade in various disease models. These studies have shown promising results in various pre-clinical models of disease including cancer and tumor immunotherapy. In this review the potential use of SHIP inhibitors in cancer is discussed with particular attention to the molecular structure, binding site and efficacy of these SHIP inhibitors.

Non-deviant Causation

The problem of deviant causation has long vexed causalist accounts of action. This chapter argues that an account of non-deviant causation can be developed by leveraging insights from the author’s account of control. In order to understand what happens when non-deviant causation happens, it develops the notion of a comprehensive set of circumstances. This is a set of circumstances that is derived by building a causal model that includes an agent, a plan, and the agent’s location in a particular situation. What is special about the model is that it gets the causal parameters of the particular situation right. Non-deviant causation then turns out to be the normal production of behavior that is, for the agent, normal given the plan and across the comprehensive set of circumstances. After developing this account, this chapter discusses a range of problem cases for it, examines an alternative account due to Wayne Wu, and discusses how the account fares against some complaints drawn from relevant literature.

PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation

Cyclic GMP-AMP synthase (cGAS) plays a major role in detecting pathogenic DNA. It produces cyclic dinucleotide cGAMP, which subsequently binds to the adaptor protein STING and further triggers antiviral innate immune responses. However, the molecular mechanisms regulating cGAS enzyme activity remain largely unknown. Here, we characterize the cGAS-interacting protein Poly(rC)-binding protein 2 (PCBP2), which plays an important role in controlling cGAS enzyme activity, thereby mediating appropriate cGAS-STING signaling transduction. We found that PCBP2 overexpression reduced cGAS-STING antiviral signaling, whereas loss of PCBP2 significantly increased cGAS activity. Mechanistically, we showed that PCBP2 negatively regulated anti-DNA viral signaling by specifically interacting with cGAS but not other components. Moreover, PCBP2 inhibited cGAS enzyme activity by antagonizing cGAS condensation, thus ensuring the normal production of cGAMP and balancing cGAS-STING signal transduction. Collectively, our findings provide novel insight into mechanisms regulating cGAS-mediated antiviral innate immune signaling.