Comprehensive of N1-Methyladenosine Modifications Patterns and Immunological Characteristics in Ovarian Cancer

Backgroundrecently, many researches have concentrated on the relevance between N1-methyladenosine (m1A) methylation modifications and tumor progression and prognosis. However, it remains unknown whether m1A modification has an effect in the prognosis of ovarian cancer (OC) and its immune infiltration.MethodsBased on 10 m1A modulators, we comprehensively assessed m1A modification patterns in 474 OC patients and linked them to TME immune infiltration characteristics. m1Ascore computed with principal component analysis algorithm was applied to quantify m1A modification pattern in OC patients. m1A regulators protein and mRNA expression were respectively obtained by HPA website and RT-PCR in clinical OC and normal samples.ResultsWe finally identified three different m1A modification patterns. The immune infiltration features of these m1A modification patterns correspond to three tumor immune phenotypes, including immune-desert, immune-inflamed and immune-excluded phenotypes. The results demonstrate individual tumor m1A modification patterns can predict patient survival, stage and grade. The m1Ascore was calculated to quantify individual OC patient’s m1A modification pattern. A high m1Ascore is usually accompanied by a better survival advantage and a lower mutational load. Research on m1Ascore in the treatment of OC patients showed that patients with high m1Ascore showed marked therapeutic benefits and clinical outcomes in terms of chemotherapy and immunotherapy. Lastly, we obtained four small molecule drugs that may potentially ameliorate prognosis.ConclusionThis research demonstrates that m1A methylation modification makes an essential function in the prognosis of OC and in shaping the immune microenvironment. Comprehensive evaluation of m1A modifications improves our knowledge of immune infiltration profile and provides a more efficient individualized immunotherapy strategy for OC patients.

A Review of Principal Component Analysis Algorithm for Dimensionality Reduction

Big databases are increasingly widespread and are therefore hard to understand, in exploratory biomedicine science, big data in health research is highly exciting because data-based analyses can travel quicker than hypothesis-based research. Principal Component Analysis (PCA) is a method to reduce the dimensionality of certain datasets. Improves interpretability but without losing much information. It achieves this by creating new covariates that are not related to each other. Finding those new variables, or what we call the main components, will reduce the eigenvalue /eigenvectors solution problem. (PCA) can be said to be an adaptive data analysis technology because technology variables are developed to adapt to different data types and structures. This review will start by introducing the basic ideas of (PCA), describe some concepts related to (PCA), and discussing. What it can do, and reviewed fifteen articles of (PCA) that have been introduced and published in the last three years.

Iris-based human identity recognition with machine learning methods and discrete fast Fourier transform

One of the most important modules of computer systems is the one that is responsible for user safety. It was proven that simple passwords and logins cannot guarantee high efficiency and are easy to obtain by the hackers. The well-known alternative is identity recognition based on biometrics. In recent years, more interest was observed in iris as a biometrics trait. It was caused due to high efficiency and accuracy guaranteed by this measurable feature. The consequences of such interest are observable in the literature. There are multiple, diversified approaches proposed by different authors. However, neither of them uses discrete fast Fourier transform (DFFT) components to describe iris sample. In this work, the authors present their own approach to iris-based human identity recognition with DFFT components selected with principal component analysis algorithm. For classification, three algorithms were used—k-nearest neighbors, support vector machines and artificial neural networks. Performed tests have shown that satisfactory results can be obtained with the proposed method.

Hypoxia Molecular Characterization in Hepatocellular Carcinoma Identifies One Risk Signature and Two Nomograms for Clinical Management

Hypoxia is a universal feature in the tumor microenvironment (TME). Nonetheless, the heterogeneous hypoxia patterns of TME have still not been elucidated in hepatocellular carcinoma (HCC). Using consensus clustering algorithm and public datasets, we identified heterogeneous hypoxia subtypes. We also revealed the specific biological and clinical characteristics via bioinformatic methods. The principal component analysis algorithm was employed to develop a hypoxia-associated risk score (HARS). We identified the two hypoxia subtypes: low hypoxia pattern (C1) and high hypoxia pattern (C2). C1 was less sensitive to immunotherapy compared to C2, consistent with the lack of immune cells and immune checkpoints (ICPs) in C1, whereas C2 was the opposite. C2 displayed worse prognosis and higher sensitivity to obatoclax relative to C1, while C1 was more sensitive to sorafenib. The two subtypes also demonstrated subtype-specific genomic variations including mutation, copy number alteration, and methylation. Moreover, we developed and validated a risk signature: HARS, which had excellent performance for predicting prognosis and immunotherapy. We revealed two hypoxia subtypes with distinct biological and clinical characteristics in HCC, which enhanced the understanding of hypoxia pattern. The risk signature was a promising biomarker for predicting prognosis and immunotherapy.

Powerful processing to three-dimensional facial recognition using triple information

<p><span>Face Detection plays a crucial role in identifying individuals and criminals in Security, surveillance, and footwork control systems. Face Recognition in the human is superb, and pictures can be easily identified even after years of separation. These abilities also apply to changes in a facial expression such as age, glasses, beard, or little change in the face. This method is based on 150 three-dimensional images using the Bosphorus database of a high range laser scanner in a Bogaziçi University in Turkey. This paper presents powerful processing for face recognition based on a combination of the salient information and features of the face, such as eyes and nose, for the detection of three-dimensional figures identified through analysis of surface curvature. The Trinity of the nose and two eyes were selected for applying principal component analysis algorithm and support vector machine to revealing and classification the difference between face and non-face. The results with different facial expressions and extracted from different angles have indicated the efficiency of our powerful processing.</span></p>

A Robust Physical Exercise Recognition System Using Machine Learning Approach

Modern life is becoming more linked to our devices, and work is being done in a more regulated way. As life became more complicated, it is becoming challenging to keep track of human health and fitness, leading to unexpected illnesses and diseases. Moreover, a lack of activity monitoring and corresponding reminders is preventing the adoption of a healthier lifestyle. This research provides a practical approach for identifying Human Activity by using accelerometer data obtained from wearable devices. The model automatically finds patterns among 33 different physical exercises such as running, rowing, cycling, jogging, etc. and correctly identifies them. The principal component analysis algorithm was used on the statistical features to make the system more robust. Classification of the physical exercise was performed on the reduced features using WEKA. The overall accuracy of 85.51% was obtained using the 10-Fold Cross-Validation method and K nearest Neighbor Algorithm while 84% accuracy for Random Forest. The accuracy obtained was better than previous models and could improve recognition systems in monitoring user activity more precisely.

Using Principal Component Analysis for Factor Analysis in Indonesian Automotive Industries

Policies related to the automotive industry have become significant for the Ministry of Industry. The problem in determining these policies is the determination of important factors for the automotive industry so that the policies formulated are right on target. The search for these important factors can be done by using the factor analysis method. So far, no studies have been conducted to examine the factors that influence the growth of the automotive industry. In this study, factor analysis is performed on factors in the automotive industry using the principal component analysis algorithm. The algorithm seeks to describe independently the aspects that become the main factors in determining the automotive industry. Based on an analysis of factors in the automotive industry production, the most influential factors are foreign investment, vehicle ownership ratios, and at last the change in GDP.