Application of lean manufacturing technology in a milk manufacturing company

This work presents the application of lean management principle in the area of waste elimination in a powder milk plant of a production company. The existing manufacturing procedure for the company’s plant was evaluated, and a lean manufacturing technique was developed for the plant. To achieve this, a time series analysis was carried out on the econometric data obtained, and a future forecast predicting losses and usage was predicted based on the practised manufacturing procedures. The econo­metric linear transfer function technique applied to the actual usage and actual loss data obtained filtered the waste in the production process and generated forecast values for actual loss and usage. This revealed that there had been poor manufacturing practices in the factory. The findings from this research can be used as a guide to managers on wastage control in a production system.

Implementation on a Preparation and Controlled Compaction Procedure for Waste-Fiber-Reinforced Raw Earth Samples

Earth bricks are a traditional eco-friendly construction material. In this study, harbor-dredged sediments were used along with hemp shiv to develop a brick manufacturing procedure and compaction techniques to produce durable earth bricks for the valorization of waste hemp shiv and dredged sediments. Prismatic specimens of size 4 × 4 × 16 cm3 were manufactured with Dunkirk sediments after analyzing their suitability for earth bricks according to the French standard for flexural strength test to observe the indirect tensile strength and impact of the compaction techniques on the strength of bricks. Crude bricks were manufactured with varying hemp shiv content from 0% to 5% by mass. Compaction techniques such as dynamic compaction, static compaction, and tamping were applied. The effect of hemp shiv content and compaction techniques was evaluated with a flexural strength test and the distribution of fibers in bricks. Grain size analysis of sediments with French and Spanish standards shows that the sediments granulometry is suitable for earth bricks. The flexural strength testing of bricks indicates that bricks with saturated hemp shiv have higher flexural strength. Earth bricks have maximum strength with dynamic compaction with 1% hemp shiv, which satisfies the adobe bricks tensile strength requirements that vary from 0.012 to 0.025 MPa (NZS 4298, 1998; NORMA E.080 (2017).

Influence of Powder Milling and Annealing Parameters on the Formation of Cubic Li7La3Zr2O12 Compound

Li-ion batteries are widely used as energy storage devices due to their excellent electrochemical performance. The cubic Li7La3Zr2O12 (c-LLZO) compound is regarded as a promising candidate as a solid-state electrolyte for lithium-ion batteries due to its high bulk Li-ion conductivity, excellent thermal performance, and chemical stability. The standard manufacturing procedure involves the high-temperature and lengthy annealing of powders. However, the formation of the tetragonal modification of LLZO and other undesired side phases results in the deterioration of electrochemical properties. The mechanical milling of precursor powders can enhance the powders’ reactivity and can result in an easier formation of c-LLZO. The aim of this work was to study the influence of selected milling and annealing parameters on c-LLZO compound formation. The starting powders of La(OH)3, Li2CO3, and ZrO2 were subjected to milling in various ball mills, under different milling conditions. The powders were then annealed at various temperatures for different lengths of times. These studies showed that the phase transformation processes of the powders were not very sensitive to the milling parameters. On the other hand, the final phase composition and microstructure strongly depended on heat treatment conditions. Low temperature annealing (750 °C) for 3 h produced 90% of c-LLZO in the powder structure.

Modeling Of Multi-Objective Process Plan, Its Optimization using Linear Modeling Technique

The Process planning is the procedure to opt for and schedule manufacturing procedure so as to attain one or more organizational goals and suit with a set of constraints. More specifically a Process planning in the reconfigurable manufacturing setup engages a sequence of all activities from raw material storage into the finished manufactured yield. In the current study a manufacturing setup of automotive industry is discussed. At the outset of papers, a basic process plan is modeled that includes design requirements after that it is mathematically modeled. Mathematically modeled process plan is then optimized in order to find optimal solution. Research then search the potential of linear programming optimization technique in handling optimization of process plan.

3D printing-directed flexible strain sensors of accordion-like architecture to achieve ultrastretchability with the assist of ultrasonic cavitation treatment

A new class of accordion-like cellular architecture with sinusoidal struts is designed to enhance the planar stretchability of cellular solids, aiming to fabricate flexible strain sensors with ultrastretchability. The combination manufacturing process of fused deposition modeling (FDM) 3D printing technique and ultrasonic cavitation-enabled treatment was introduced into the fabrication of flexible strain sensors made of thermoplastic polyurethane (TPU) substrate and carbon nanotubes (CNTs). A negative Poisson’s ratio (NPR) architecture made of TPU was firstly 3D-printed by FDM. The ultrasonic cavitation treatment was then conducted on the soft auxetic structure immersing in CNTs liquid, aiming to embed the CNTs into the surface layer of the flexible TPU substrate with NPR configurations. Instead of 3D printing the TPU matrix composite after hybridization inside the matrix material, the hybrid manufacturing procedure can ensure that the intrinsic excellent mechanical properties of TPU are not embrittled. Besides, the sinusoidal struts in accordion-like cellular architectures offer a design route to extend the material property chart to achieve ultrahigh stretchability in lightweight 3D printable flexible polymers for the applications that require combined stretchability, lightweight, and energy absorption such as soft robotics, stretchable electronics, and wearable protection shields.

Formulation, optimization, qualitative and quantitative analysis of new dosage form of corticosteroid

Background The objective of the present research work is to develop the entirely new drug product formulation (Ophthalmic Suspension) which belongs to the therapeutic class of steroids drugs (Corticosteroid). There are different dosage forms of Triamcinolone acetonide to treat different systemic as well as topical diseases as per patient symptomatic conditions. Due to non-availability of this active drug (Triamcinolone acetonide) ophthalmic dosage form in the national and international market research work is carried out to enter in this dosage form. Results In the formulation design and development, different inactive like polysorbate 30 mg/mL, PEG-12 glyceryl dimyristate 70 mg/mL, ethyl alcohol 10 µL/mL, citric acid 1 mg/mL, sodium citrate 3.5–4.0 mg/mL, BKC 0.15 mg/mL and water for injection have been used at different stages in different proportions during the manufacturing procedure. Gradient HPLC, C18 column, 5 µm, 100 A, 3.9 mm × 300 mm, detector UV/Vis @ 254 nm, column oven, auto-sampler, degasser, is used and this analytical testing method is validated to obtain the accurate results. The excipients play different roles including solvent, antioxidant, solubilizer, emulsifier, antibacterial, preservative, anticoagulant, antimicrobial agent, surfactant and buffers in the stability of active drug for its excellent therapeutic output results. Correlation coefficient factor is greater than 0.999 which indicates that the method has good linearity at proposed concentration against triamcinolone acetonide. Conclusions Excellent physical and chemical properties like physical appearance, pH, specific gravity, viscosity, re-suspendability, sedimentation volume is accomplished to meet the requirements of the eye treatment products. On the basis of experimental results achieved during validation process, it can be assumed that the current analysis method is more accurate, precise, specific, linear and consistency indicating in the range of 70 to 130% of the analyte concentration. From the physical, chemical behaviors and chemical assay of the newly developed drug formulation of corticosteroid (triamcinolone acetonide) it is concluded that it can be probably put for further clinical trial in different phases for human use.

Expansion of tumor-infiltrating lymphocytes with substantial stem cell properties from vulvar cancer

Tumor-infiltrating lymphocyte (TIL) therapy has been clinically proved as a promising therapeutic approach for patients with solid tumor. TIL therapy could effectively control tumor growth in cervical cancer as indicated by a phase 2 pivotal trial with an objective response rate of 44.4%. Vulvar cancer is believed to share a similar biological and immunological phenotype with cervical cancer. However, the therapeutic potential of TIL in vulvar cancer remains to be explored. In this study, we described a manufacturing procedure that can expand clinical-scale TILs from both vulvar cancer and cervical cancer with a high success rate. Characterization of the phenotype of TIL populations showed that TILs from vulvar cancer are prone to maintaining a higher percentage of progenitor-like phenotype and have stronger tumor-killing capacity compared to TILs from cervical cancer. TCR clonality analysis indicated that all TIL samples have more enriched TCR clones than PBMC, which might be expanded during anti-tumor responses and tend to be patient specific. Thus, our study provides a feasible method of TIL preparation from and a potential new therapeutic strategy for vulvar cancer patients.

Wetting-Induced Polyelectrolyte Pore Bridging

Active layers of ion separation membranes often consist of charged layers that retain ions based on electrostatic repulsion. Conventional fabrication of these layers, such as polyelectrolyte deposition, can in some cases lead to excess coating to prevent defects in the active layer. This excess deposition increases the overall membrane transport resistance. The study at hand presents a manufacturing procedure for controlled polyelectrolyte complexation in and on porous supports by support wetting control. Pre-wetting of the microfiltration membrane support, or even supports with larger pore sizes, leads to ternary phase boundaries of the support, the coating solution, and the pre-wetting agent. At these phase boundaries, polyelectrolytes can be complexated to form partially freestanding selective structures bridging the pores. This polyelectrolyte complex formation control allows the production of membranes with evenly distributed polyelectrolyte layers, providing (1) fewer coating steps needed for defect-free active layers, (2) larger support diameters that can be bridged, and (3) a precise position control of the formed polyelectrolyte multilayers. We further analyze the formed structures regarding their position, composition, and diffusion dialysis performance.

PHARMACEUTICO-ANALYTICAL STUDY OF DADIMAVALEHA

Background: Bhaishajyakalpana being a deep rooted science contains many unrevealed treasure of formulations. The present era demands scientific method and standardized protocol for any preparation. Here is an opportunity to revise the science using newer technologies in cost effective manner. Dadimavaleha, one of the most commonly used formulation in practice is least explored. Attempt has been made to study the pharmaceutico analytical parameters of Dadimavaleha and thereby establishing a standard operating procedure. Aim 1.To study the pharamaceutico-analytical aspects of Dadimavaleha 2.To set a standard manufacturing procedure of Dadimavaleha. Material And Methods: The preparation of Dadimavaleha was done according to the reference of YogaratnakarJwaratisaradhyay. All the procedure was done systematically and observations were noted. Discussion: The study is aimed at setting a standard manufacturing procedure for Dadimavalehaby thorough examination of pharmaceutico analytical characteristics of thethe same. The various analytical parameters like ph, total ash, acid insoluble ash, water soluble extractive, acid soluble extractive, specific gravity, sugar content were assessed. Conclusion: The detailed pharmaceutico-analytical study of Dadimavalehain a detailed stepwise description and documentation in scientific, logical, sequential manner helps in developing a Standard Manufacturing Procedure for Dadimavaleha.Since there is no standard protocol and comparable analytical parameters available at present, this study can prove to be a milestone towards setting a standard manufacturing procedure for Dadimavaleha.

Smart Inlays for Simultaneous Crack Sensing and Arrest in Multifunctional Bondlines of Composites

Disbond arrest features combined with a structural health monitoring system for permanent bondline surveillance have the potential to significantly increase the safety of adhesive bonds in composite structures. A core requirement is that the integration of such features is achieved without causing weakening of the bondline. We present the design of a smart inlay equipped with a micro strain sensor-system fabricated on a polyvinyliden fluorid (PVDF) foil material. This material has proven disbond arrest functionality, but has not before been used as a substrate in lithographic micro sensor fabrication. Only with special pretreatment can it meet the requirements of thin film sensor elements regarding surface roughness and adhesion. Moreover, the sensor integration into composite material using a standard manufacturing procedure reveals that the smart inlays endure this process even though subjected to high temperatures, curing reactions and plasma treatment. Most critical is the substrate melting during curing when sensory function is preserved with a covering caul plate that stabilizes the fragile measuring grids. The smart inlays are tested by static mechanical loading, showing that they can be stretched far beyond critical elongations of composites before failure. The health monitoring function is verified by testing the specimens with integrated sensors in a cantilever bending setup. The results prove the feasibility of micro sensors detecting strain gradients on a disbond arresting substrate to form a so-called multifunctional bondline.