Quality of cosmetics with active caffeine in cream and gel galenic bases prepared by compounding pharmacies

As there is a great scarcity of studies on the importance of good compounding practices in the preparation of cosmetics, this study aimed to evaluate the quality control of cosmetics with active ingredient caffeine for the treatment of cellulite prepared by magistrals pharmacies. Microbiological analyzes, pH determination, color measurement, quantification of the percentage of the active ingredient caffeine and viscosity in creams and gels with 5% of the active ingredient caffeine were performed. In the microbiological analysis, the presence of molds and yeasts was verified above the permitted level according to the Brazilian pharmacopoeia. The pH decreased over time, contributing to the formulations becoming more acidic. In the color parameters, it was found that pharmacy F4 showed a brownish color, both for the gel and for the cream. The percentage of caffeine was within specifications in all formulations and the viscosity remained unchanged during the shelf life of the samples. It is important that the compounding pharmacies demand more effectively the commitment of the team, as well as the analysis of the raw material according to the microbiological control regulations to translate into the quality of the products prepared by the pharmacies and favor the consumer in the effective objective that the product you want to achieve.

Case Report: Paradoxical Inflammatory Response Syndrome in a Previously Healthy, HIV-Negative, Pediatric Patient With Cryptococcus gatii Meningitis

The immunological response of patients with cryptococcal meningitis (CM), particularly those not known to be immunocompromised, has generated an increased interest recently. Although CM is an infection with significant rates of morbidity and mortality, its sequelae may also include a post-infectious inflammatory response syndrome (PIIRS) in patients who have already achieved microbiological control. PIIRS can cause substantial immune-mediated damage to the central nervous system resulting in long-term neurological disability or even death. Steroids have been used successfully in the management of PIIRS in adults. In this report, we present the case of a previously healthy adolescent male with Cryptococcus gattii meningitis who experienced neurological deterioration due to PIIRS after the initiation of antifungal therapy. Immunological workup did not demonstrate any frank underlying immunodeficiencies, and genetic primary immunodeficiency screening was unremarkable. He was treated with steroids and recovered clinically; however, intermittent inflammatory episodes needed to be managed through several flares of symptoms. In the setting of the current literature, we discuss the management and monitoring of PIIRS in a pediatric patient, along with considerations of targeted future therapies.

Sanitary condition of soil in the territory of Astrakhan state technical university and nearby territories of higher educational institutions

Objective. The authors of this article studied and analyzed the sanitary condition of the soil in the territory of Astrakhan State Technical University and the nearby territories of higher educational institutions. Materials and methods. The study was carried out in May June 2019 on the basis of the laboratory of the Department of Infectious Diseases and Epidemiology of Astrakhan State Medical University and the laboratory of the Department of Applied Biology and Microbiology of Astrakhan State Technical University. Thirty soil samples were taken from these territories. The studies of soil samples for parasitological indicators were performed according to the guidelines "Control Methods. Biological and Microbiological Factors. Methods of Sanitary and Parasitological Research", for microbiological indicators "Methods of Soil Microbiological Control". Results. The following results were obtained: the sanitary-parasitological condition of the soil in parks near higher educational institutions in Astrakhan remains very tense as evidenced by positive findings of geohelminthoses; when assessing the degree of epidemic hazard of soil, there were identified nematode eggs and adult worm Strongyloids, that corresponds to the indicators of moderately hazard soil; the presence of live strongylid larvae in the studied samples indicates contamination of the soil with feces of infested animals, and the presence of Ascaris eggs indicates contamination of the soil with sewage or feces of infested children walking and resting in these territories; the total microbial number on average gave indicators for evaluating the selected soil samples as a slightly polluted soil. Conclusions. The sanitary and parasitological state of soil in parks of Astrakhan higher educational institutions remains rather tense as evidenced by positive findings of geohelminthoses.

Microbiological Control: A New Age of Maize Production

Maize is one of the world’s most widely grown and consumed cereal. It is known for its multipurpose use; it provides food and fuel to humans, feeds to animals and used as raw material in manufacturing industries. Globally, maize production is a large and significant market which produced 1,116.41 million tons in year 2020 and it’s expected to increase by 1.57% in year 2021. Pests and disease of maize cause significant damage to maize thereby reducing its’s yield and quality. There are many methods of controlling maize disease and pests; they include cultural, biological and chemical methods etc. Recent research studies have discovered an alternative agricultural practices that are sustainable and safe as compared to chemical control of pests and disease. However, biological control has gained large acceptance and its believed to yield positive outcome as compared to chemical control. Various microorganisms are used to control pathogens of maize and thus, there is a need to understand better their interactions with plants. Furthermore, microorganism known as entomopathogens are used to control arthropods. They are biopesticides that play integral role in Pest Management. This section focuses on microbiological control of pathogens and arthropods, their mechanisms of action, applications and the future of entomopathogenic microorganisms and microbiological control of pathogens.

Management tools applied to milk quality in cattle farming in the Western Amazon

This study aimed to analyze the applicability of management tools such as SWOT matrix, GUT matrix, Brainstorming, PDCA, Ishikawa diagram, and 5W2H in improving milk quality in rural properties for family labor. The survey was conducted in 18 properties in the municipality of Senador Guiomard, State of Acre, Brazil, during the period from January to December 2019. The properties were divided into two groups (treatment group-TG and control group-CG) and the data obtained through a form with 255 questions for diagnosis and analysis (LQL-GO) for somatic cell count (SCC) and total bacterial count (TBC) were tabulated in spreadsheets (Excel®) and subjected to statistical analysis by the Wilcoxon test. Nineteen weaknesses were obtained through the GUT matrix. The implementation of milking practices using tools obtained an average reduction of 31.4% for SCC and 63% for TBC in TG and a reduction of 39.3% for SCC and an increase of 33.7% for TBC in CG. Thus, the management tools applied to milk quality are capable of generating positive results (p < 0.05) in microbiological control, facilitating quick decision-making, aiming at the correction of weaknesses, and, consequently, an increase in profitability.

Safety Analysis of Freshwater Fish

The results presented in this paper demonstrate that the microbial population in the hydroecosystem has seasonal variations. The bacterial contamination of water and fish in November was 140 and 11 times less than in July respectively. It was found that fish caught in natural reservoirs in the autumn-winter period had different dynamics in the development of postmortem changes in comparison with those caught in the summer period. Postmortem secretion of mucus was not as pronounced in autumn-winter as in summer. Postmortem rigidity on the contrary was pronounced; gill covers were tightly fitting; and spinal muscles were tensed and of dense texture. Storing fresh river fish at a temperature of 3-5°C for 24 hours did not lead to a change in sensory evaluation. Physic-chemical indicators corresponded to the values characterizing fresh, healthy fish. During storage, the bacterial contamination of fish increased by more than 100 times, while the maximum permissible number of microorganisms (5.0 × 104 CFU / g) was not exceeded. Keywords: fish, microbiological control, organoleptic and physic-chemical indicators