Reduction of blood pressure fluctuations by telmisartan molecule especially in combination with calcium channel antagonist

1.28 billion people suffer from hypertension, and its complications cause 10 million deaths each year. Effective antihypertensive therapy is therefore one of the priority tasks of health care. Achieving good BP control depends on many factors, but one of the primary ones is the use of maximally effective therapy in the simplest possible regimen. Amlodipine in combination with telmisartan in the single-pill combination, through its high smoothness index, makes it possible to achieve a satisfactory hypotensive effect lasting 24 h when taken once daily. This combination is also a good alternative for cardiovascularly burdened patients who cannot use angiotensin-converting enzyme inhibitors and for elderly patients, especially after stroke

Approximation of Generalized Ovals and Lemniscates towards Geometric Modeling

This paper considers an approach towards the building of new classes of symmetric closed curves with two or more focal points, which can be obtained by generalizing classical definitions of the ellipse, Cassini, and Cayley ovals. A universal numerical method for creating such curves in mathematical packages is introduced. Specific aspects of the provided numerical data in computer-aided design systems with B-splines for three-dimensional modeling are considered. The applicability of the method is demonstrated, as well as the possibility to provide high smoothness of the curvature profile at the specified accuracy of modeling.

The Family of Multiparameter Quaternary Subdivision Schemes

In the field of subdivision, the smoothness increases as the arity of schemes increases. The family of high arity schemes gives high smoothness comparative to low arity schemes. In this paper, we propose a simple and generalized formula for a family of multiparameter quaternary subdivision schemes. The conditions for convergence of subdivision schemes are also presented. Moreover, we derive subdivision schemes after substituting the different values of parameters. We also analyzed the important properties of the proposed family of subdivision schemes. After comparison with existing schemes, we analyze that the proposed family of subdivision schemes gives better smoothness and approximation compared with the existing subdivision schemes.

Esthetic Rehabilitation With Nanohybrid Composite: Case Report Series

Composite resins represent the current state of the art in the field of restorative materials, for they present a standard aesthetic potential with satisfactory durability and are less cost-effective than a comparable ceramic restoration. The most recent addition to this is a nanohybrid direct composite that demonstrates exceptional handling properties and superior aesthetics. These series of case reports illustrate the three different scenarios where nanohybrid composite was used as a direct restorative material owing to its high smoothness and favorable mechanical properties; the first case being the fracture of an upper lateral incisor, second of Class IV caries in upper central incisors, and lastly the discolored restoration and Class III caries in upper central incisors. The nanohybrids used provided an acceptable color match in all the three cases with a conservative technique and were relatively easy to maintain.

Asymptotic estimates for the best uniform approximations of classes of convolution of periodic functions of high smoothness

We find two-sided estimates for the best uniform approximations of classes of convolutions of $2\pi$-periodic functions from a unit ball of the space $L_p, 1 \le p <\infty,$ with fixed kernels such that the moduli of their Fourier coefficients satisfy the condition $\sum\limits_{k=n+1}^\infty\psi(k)<\psi(n).$ In the case of $\sum\limits_{k=n+1}^\infty\psi(k)=o(1)\psi(n),$ the obtained estimates become the asymptotic equalities.

Analysis of starting in horse head system at optimal jerking mode of movement

This article presents the results of an analytical study of the kinematic and power parameters of the movement of the articulated boom system of the crane at the beginning of the movement. The study was carried out during the acceleration of the electric motor of the mechanism for changing the departure from the state of rest to the rotation frequency corresponding to the nominal operating speed of the load movement. In this case, the start of the electric motor occurs, provided that the entire boom system moves along with the load according to the law of jerking optimization. The using of this regularity allows you to completely smooth out the swinging of the load at the beginning of the movement. In addition, towards the end of the acceleration, the same speeds and accelerations are provided between the end point of the crane trunk and the load. This makes it possible to ensure high smoothness of movement of the boom system, and to avoid the load swinging after the rotor of the electric motor reaches the rated speed. Also, a study of static, dynamic and total force in the drive gear rack was carried out. These studies were carried out at different duration of the process of starting the electric motor according to the law of jerking optimization. This made it possible to establish the dependence of the studied kinematic and power parameters on the duration of the transient process. Based on the above, recommendations have been developed for choosing the duration of the acceleration of the electric motor in the mechanism for changing the departure. During of the study, graphs of changes in the studied parameters of the boom system in time were built. Graphical dependencies were obtained with the most acceptable duration of the acceleration mode from the point of view of reducing the dynamic loads on the links of the boom system, improving the technological process of the crane and its ergonomics.

A Genetic Algorithm Application in Planning Path Using B-Spline Model for Autonomous Underwater Vehicle (AUV)

This paper proposes a method of using the B-spline mathematical model to plan high smoothness curve trajectories with heading condition through given waypoints for autonomous underwater vehicles (AUVs) in particular and ships with rudder systems in general. In addition, this paper examines some of the physical limitations of this vehicle, which lead to some binding conditions of the trajectory. Besides, the paper applies B-spline approximation method to reduce the curvature of the trajectory, when waypoints are too close and we do not need to go through exactly these waypoints in the 2D plane. Finally, this paper also proposes the genetic algorithm application with some modifications to solve the optimization of B-spline path length with constraint in turning radius of the vehicle.

Some Features of Bearing Units’ Development Based on Sliding Friction Pairs for Precision Electrospindles

In mechanical engineering, various types of bearing units are used in moving connections and sliding pairs (sliding bearings, guides, bushings) are sufficiently widely used. This allows increasing the stiffness of the units, reducing their dimensions, improving heat dissipation, etc. But there are higher friction losses, probability in the increases of situations in which there is a jamming of friction surfaces for application of sliding friction pairs compared to the rolling bearings. These problems are even more important for application of sliding bearings in precision equipment, which typically operates under temperature and humidity stabilized conditions. The aim of the work is the development of methodological approaches to the creation and rational design and manufacture of sliding friction pairs based on the composite antifriction materials’ coatings for the application in vertical precision program-controlled electrospindles for high-speed machining. Questions of development and manufacturing of friction units for precision electrospindles with high rigidity on the basis of composite materials are considered. It is shown that acceptable cutting speed (750 m/min or more) for the quality standpoint of processing with a diamond-like tool can be achieved by placing the cutting edge of the tool on diameter of 200 mm. As a result, two tasks solved: the rigidity of the electrospindle for ultra-high accuracy of mechanical blade processing is achieved; high smoothness of work is provided, which allows achieving nanometric surface roughness with a decrease of deviations to 1 µm from the middle surface line. It is extremely important for a number of special applications.

Synthesis of Cerium Phosphate White Pigments from Cerium Oxalate

Catalytically active cerium dioxide is used as light reflection materials for cosmetic applications. Therefore, cosmetics containing this pigment too much cause oxidation of the skin. Therefore, the substitute for cerium dioxide is required to prepare the cosmetics without catalytic activity. Herein, as novel white pigments for use in cosmetics, cerium phosphates were prepared from cerium oxalate under various conditions. The chemical composition, powder properties, catalytic activity, color phase, and smoothness of the cerium phosphates were evaluated. All samples had weak unknown peaks in XRD patterns. Samples prepared at high temperature and for long time indicated the peaks of phosphate in IR spectra. Samples prepared in this work had no photo and oxidation catalytic activities. Samples prepared at high temperature and for long time indicated enough high whiteness and high smoothness.