Hardness Prediction of AA 2024-T3 FSW Weld

The hardness of AA 2024 is mainly dependent of the precipitation state in the material. This one will vary through the process of friction stir welding (FSW) which generates heat and deformations. The most important effect will be the thermal excursion which greatly affects the nature and the distribution of precipitates and so the mechanical properties of the material. Three Myhr & Grong-type submodels have been used in this study in order to simulate the variation of hardness in AA 2024-T3 FSW welds. These models allowed to simulate the hardening by growth of S-precipitates and the softening by coarsening and dissolution of GPB zones / co-clusters or S-precipitates. Finally, the natural ageing was taken into account following the Robson model. The complete model has been calibrated with isothermal data found in the literature and still has to be optimised. Nevertheless, preliminary results show the coherence of the model when performed on isothermal data. The model has been also applied to predict FSW hardness profiles that are compared to those found in the literature.

Local rapid exhumation and fast cooling in a long-lived Paleoproterozoic orogeny

The exhumation and cooling rates of high-grade metamorphic rocks are crucial for inferring orogenic processes and understanding the regimes of heat transport in Earth's crust. Quantification of these rates remains challenging for Precambrian terranes, because the temporal resolution of geochronology becomes coarser in deeper geologic time. This limitation is partly reflected by a striking lack of Proterozoic or older short-duration events (<10 Myr), most documented cases of fast metamorphism are confined to the Phanerozoic. In this study, we use garnet geospeedometry to explore the metamorphic rates of Paleoproterozoic high-grade rocks from two representative areas within the long-lived (1.95–1.80 Ga) Jiao-Liao-Ji orogenic belt, North China Craton. The pelitic granulites in the Taipingzhuang area record high-pressure granulite-facies (HPG) metamorphism of ∼12 kbar and ∼800 °C, followed by a fast decompression-cooling to ∼5 kbar and ∼600 °C within ∼5 Myr, at ca. 1.87 Ga. The pelitic granulites in the Rizhuang area document a brief (<1 Myr) thermal excursion to ultra-high-temperature (UHT) metamorphism of ∼8 kbar and ∼940 °C at ca. 1.85 Ga, followed by a fast cooling to ∼600 °C within 1–5 Myr. In light of available geological data, the fast decompression-cooling of HPG granulites is interpreted as the syn-collisional exhumation of thickened lower crustal segments at ca. 1.87 Ga, most likely through tectonic extrusion. The thermal excursion transiently reaching UHT conditions is inferred to be triggered by localized syn-metamorphic mafic intrusions in association with magmatic underplating during post-collisional extension at ca. 1.85 Ga. These metamorphic pulses were interspersed within the protracted Paleoproterozoic orogenesis and require geodynamic processes resembling modern plate tectonics. Notably, these ancient rapid events are beyond the temporal resolution of commonly-used in-situ geochronology that tends to yield apparent longer durations given errors and uncertainties. We therefore note that most ancient metamorphic rates might be underestimated using geochronological data, and recommend garnet geospeedometry as a promising alternative approach. The largely similar rates recorded by Paleoproterozoic and Phanerozoic orogens, as well as high-pressure metamorphism at 1.9–1.8 Ga, support the operation of modern plate tectonics in Paleoproterozoic time.

Physicochemical stability study of MYL-1401O, a biosimilar of trastuzumab, following a transient temperature excursion

Introduction The extended stability of the trastuzumab biosimilar Ogivri™ (MYL-1401O; trastuzumab-dkst) was studied under different storage conditions, including following reconstitution of the lyophilized powder (21 mg/mL) but undiluted and stored in vials at 4°C; after dilution at two concentrations (0.8 and 2.4 mg/mL) in polyolefin bags and stored at 4°C; and following a three-day thermal excursion to 25°C. Methods Several methods were utilized to assess the physical and chemical stability of the drug under different storage conditions. Results At all storage conditions tested, there was no change in the tertiary structure of MYL-1401O as assessed by second-derivative ultraviolet and fluorescence-derived spectral analysis, and no evidence of oligomer formation or fragmentation was observed as assessed by gel exclusion chromatography and dynamic light scattering, confirmed by assessment of quinary structures using size-exclusion chromatography. Ion-exchange chromatography showed no significant changes in the distribution of ionic variants, particularly deamidations. Thermal denaturation curves indicated no destabilization of the three-dimensional structure after 90 days at 4°C or after thermal excursion for 72 h at 25°C. Conclusion The trastuzumab biosimilar MYL-1401O maintained its physical and chemical stability for at least 90 days at 4°C or after thermal excursion to 25°C, supporting the safe use of MYL-1401O in several real-world settings, including advanced preparation for administration or when a break in the cold cycle occurs.

Depth and Lateral Variation of Machining-Induced Residual Stress for a Nickel Base Superalloy

This paper investigates the variation of residual stress with depth and radial location in a nickel base superalloy, RR1000, introduced by face finish turning. X-ray diffraction stress measurement has revealed that the hoop stress at the surface becomes less tensile towards the centre of the face, whilst the level of radial sub-surface compression increases. The unstrained lattice spacing d0 and the diffraction peak width (FWHM) were used to make inferences regarding the thermal excursion and the plastic work, respectively. It was found the increase in the compressive stress from the outer towards the inner radius was associated with an increase in thermal excursion.

Stress gradients observed in Cu thin films induced by capping layers

Glancing-incidence x-ray diffraction (GIXRD) has been applied to the investigation of depth-dependent stress distributions within electroplated Cu films due to overlying capping layers. Cu films, 0.65 μm thick, plated on conventional barrier and seed layers received a chemical vapor deposited (CVD) SiCxNyHz cap, an electrolessly deposited CoWP layer, or a CoWP layer followed by a SiCxNyHz cap. GIXRD and conventional x-ray diffraction measurements revealed that strain gradients were created in Cu films possessing a SiCxNyHz cap, where a greater in-plane tensile stress of approximately 180 MPa was generated near the film/cap interface as a result of constraint imposed by the SiCxNyHz layer during cooling from the cap deposition temperature. Although Cu films possessing a CoWP cap without a SiCxNyHz layer did not exhibit depth-dependent stress distributions, subsequent annealing introduced stress gradients and increased the bulk Cu stress. However, a thermal excursion to liquid-nitrogen temperatures significantly reduced tensile stresses in the Cu films.

Shock-Wave Synthesis of Nanoparticles During Ion Sputtering

We report electron microscopy studies of nanoparticles ( 500 ≤ n ≤ 104, where n is the number of atoms in a given cluster) that are sputtered from the surface by high-energy ion impacts. Measurements of the sizes of these clusters yielded an inverse power-law distribution with an exponent of –2 that is independent of irradiating ion species and total sputtering yield. This inverse-square dependence indicates that these nanoclusters are produced when shock waves, generated by sub-surface displacement cascades, impact and ablate the surface. Such nanoparticles consist of simple fragments of the original surface, i.e., ones that have not undergone any large thermal excursion. As discussed below, this “ion ablation” technique should therefore be useful for synthesizing nanoparticles of a wide variety of alloy compositions and phases.

Curvature Measurements of Tri-Material Structures Under Thermal Excursion

The bending curvatures of tri-material plates have been measured using in situ laser reflection technique at temperatures ranging from 20°C to 160°C. The tri-material structures are formed by attaching silicon wafers to ceramic substrates with die-attach adhesives from solder-like (elastic modulus ≈ 24 GPa) to gel-like (elastic modulus ≈ 0.003 GPa) characteristics. The temperature dependence of curvature as a result of the thermal expansion mismatch is measured. The structure bonded by the gel-like adhesive has substantially lower, about a factor of ten less, bending than the structures attached by the other two types of adhesives. We found good agreements between the measurements and the theoretical derivations by Suhir[1] for the bending curvature of finite tri-material assembly.