Superposition of p-superharmonic functions

The dominative p-Laplace operator is introduced. This operator is a relative to the p-Laplacian, but with the distinguishing property of being sublinear. It explains the superposition principle in the p-Laplace equation.

Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness

Sexual transmission of HIV-1 is an inefficient process, with only one or few variants of the donor quasispecies establishing the new infection. A critical, and as yet unresolved, question is whether the mucosal bottleneck selects for viruses with increased transmission fitness. Here, we characterized 300 limiting dilution-derived virus isolates from the plasma, and in some instances genital secretions, of eight HIV-1 donor and recipient pairs. Although there were no differences in the amount of virion-associated envelope glycoprotein, recipient isolates were on average threefold more infectious (P= 0.0001), replicated to 1.4-fold higher titers (P= 0.004), were released from infected cells 4.2-fold more efficiently (P< 0.00001), and were significantly more resistant to type I IFNs than the corresponding donor isolates. Remarkably, transmitted viruses exhibited 7.8-fold higher IFNα2 (P< 0.00001) and 39-fold higher IFNβ (P< 0.00001) half-maximal inhibitory concentrations (IC50) than did donor isolates, and their odds of replicating in CD4+T cells at the highest IFNα2 and IFNβ doses were 35-fold (P< 0.00001) and 250-fold (P< 0.00001) greater, respectively. Interestingly, pretreatment of CD4+T cells with IFNβ, but not IFNα2, selected donor plasma isolates that exhibited a transmitted virus-like phenotype, and such viruses were also detected in the donor genital tract. These data indicate that transmitted viruses are phenotypically distinct, and that increased IFN resistance represents their most distinguishing property. Thus, the mucosal bottleneck selects for viruses that are able to replicate and spread efficiently in the face of a potent innate immune response.

Architecture of Vehicular Ad Hoc Network

Over the last few years Vehicular Ad hoc Networks (VANETs) have gained much attention within the automobile industry and the research applications. Vehicular Ad hoc networks (VANETs) are a subgroup of mobile adhoc networks (MANETs) with the distinguishing property that the nodes are vehicles like cars, trucks, buses and motorcycles. Nodes are expected to communicate by means of North American direct short-range communication (DSRC) standard [1] that employs the IEEE 802.11p standard for wireless communication and describes a MAC and PHY specifications for wireless connectivity. This chapter deals with the basic architecture of VANET and wired and wireless technology for intra-vehicular communication. Two prominent networking technologies such as Local Interconnect Network (LIN) and the Controller Area Network (CAN) for wired intra-vehicular communication have also been discussed. The objective of this chapter is to explain inter-vehicular communication and the components of a smart vehicle.

Stem cell concepts renew cancer research

Although uncontrolled proliferation is a distinguishing property of a tumor as a whole, the individual cells that make up the tumor exhibit considerable variation in many properties, including morphology, proliferation kinetics, and the ability to initiate tumor growth in transplant assays. Understanding the molecular and cellular basis of this heterogeneity has important implications in the design of therapeutic strategies. The mechanistic basis of tumor heterogeneity has been uncertain; however, there is now strong evidence that cancer is a cellular hierarchy with cancer stem cells at the apex. This review provides a historical overview of the influence of hematology on the development of stem cell concepts and their linkage to cancer.

Antimutator Mutants in Bacteriophage T4 and Escherichia coli

Antimutators are mutant strains that have reduced mutation rates compared to the corresponding wild-type strain. Their existence, along with mutator mutants that have higher mutation rates compared to the wild-type strain, are powerful evidence that mutation rates are genetically controlled. Compared to mutator mutants, antimutators have a very distinguishing property. Because they prevent normally occurring mutations, they, uniquely, are capable of providing insight into the mechanisms of spontaneous mutations. In this review, antimutator mutants are discussed in bacteriophage T4 and the bacterium Escherichia coli, with regard to their properties, possible mechanisms, and implications for the sources of spontaneous mutations in these two organisms.

X-Ray Variability in Active Galactic Nuclei: Two Things That Everybody Should Know

X-ray variability is a distinguishing property of Active Galactic Nuclei (AGN), and the energetics and time scales of the emission dictate that the X-rays must originate very close to the central engine. In this review I discuss two basic topics from AGN variability research. The first is the correlation of the variability time scale with the X-ray luminosity, and the second is the structure of the X-ray light curve. In each case, I first review the old results that have been known for approximately the last 10 years and then I discuss very new results which may force us to modify our ideas about the origin of AGN X-ray variability. Note that I am discussing the variability of non-blazar type AGN.

Ancient Banyan: an Inquiry into the Meaning of ‘Hinduness’

This paper suggests, against a comparative horizon and in broadly philosophical context, a fresh approach to the study of Hinduism. After indicating how religion in general and ‘Hinduism’ in particular are plural phenomena both internally and externally, the paper goes on to define a (if not, the) distinguishing property of Hinduness (or hindutā) in terms of an approach that is based on a re-centring system of equilibrating and interactive polarities called ‘polycentrism’. This is described further as a calculated paradoxicality, which is articulated in the light of possible objections.

Characterization of Ca(2+)-release channels in fetal and adult rat hearts

The goal of this study was to characterize the Ca(2+)-release channel in whole homogenates of left (LV) and right ventricles (RV) of fetal (22 days in gestation) and adult Sprague-Dawley rat hearts using [3H]ryanodine binding and 45Ca2+ fluxes. Although many features of the Ca(2+)-release channels were similar in fetal and adult hearts, biochemical assays revealed quantitative differences. Similar properties include 1) Ca(2+)-sensitive cooperative ryanodine binding to Ca(2+)-release channel, measured as Ca2+ concentration for half-maximal activation (fetal LV: 0.13 +/- 0.02 microM; adults LV: 0.15 +/- 0.02 microM) and Hill coefficient (fetal LV: 2.5 +/- 0.9; adult LV: 2.7 +/- 0.5), and 2) caffeine-sensitive ryanodine binding, measured as the percent increase in ryanodine binding induced by caffeine (fetal LV: 148.8 +/- 16.9% vs. adult LV: 171.4 +/- 34.9%). The distinguishing property was the lower Ca(2+)-release channel density in the fetal heart (LV: 0.22 +/- 0.03 pmol/mg protein) compared with adult heart (LV: 0.59 +/- 0.04 pmol/mg protein; P < 0.05), as determined by [3H]ryanodine binding. The lower density of Ca(2+)-release channel is supported by the finding that there is very low ryanodine-sensitive oxalate-supported 45Ca2+ uptake in the fetal heart. The tested characteristics of the Ca(2+)-release channel were similar between LV and RV in both fetal and adult rat hearts. Ou results indicate that expression of Ca2+-release channels in sarcoplasmic reticulum increases during postnatal growth in the rat heart. This is consistent with previous physiological reports that Ca2+ available for excitation-contraction coupling in the fetal heart is derived mainly from transsarcolemmal Ca2+ influx.