Alcoholism is a commonest growing disease of today’s modern society and affected to millions of Indians. Living with an alcoholic parent can have significant impact on adolescent leaving them into risk. The adolescent of alcoholic parents develop a sort of negligence from their parent make them to be isolated. They grow up with low self esteem, dysfunctional family interaction, insecurity and maladaptive coping is higher risk for them become an alcoholic. The present study aimed to find the effectiveness of guidance programme on impact of parental alcoholism among adolescents in selected schools, Mangaluru, Karnataka. An evaluative approach with one group pre-test - post test design was used. Purposive sampling method was used to select the adolescents of alcoholics. Out of 1420 adolescents screened by CAST and a total of 350 adolescents aged 12 – 15 years were identified as adolescents of alcoholic parent/s. The instruments such as Rosenberg self esteem scale, family interaction pattern scale, security inventory rating scale and coping check list was used for the data collection. The computed inferential statistics revealed that the guidance programme has made significant improvement in the self esteem (t = 60.149), family interaction (t = 30.082), security feeling (t = 30.082), and in coping (t =11.679) of adolescents of alcoholic parents. Computed Karl Pearson’s coefficient of correlation revealed that there was a low negative correlation(r = -0.041) between self esteem and family interaction, low negative correlation (r = -0.068) between security feelings with family interaction and low positive correlation between the levels of security feeling with self esteem (r = 0.116). Computed Chi Square showed that there was significant association between the selected demographic variable religion ,self esteem, sex, type of family and incomes with pre test scores of family interaction. The study concluded that the guidance program was highly effective in improving the self esteem, family interaction pattern, security felling and coping of adolescents of alcoholic parents.