Prototype observation and finite element analysis were carried out on a weld seam between a spiral case and a penstock of #6 generator in a certain power plant. According to the observation data and finite element calculated results, deformation and stress were analyzed for the weld seam in continuous operating stage (power generation, EL. 206.00). The results show that in the normal operation power generation stage, the strengths of the penstock, the spiral case and the weld seam are all satisfied; Even if the inlet water level reaches to EL. 275.00, the three parts are all safe (when the residual stress isn’t considered, the stress is far lower than the strength allowed values). However, the stress at point E is obviously higher, it is necessary to make further testing inspection. Finally the following suggestions are given: (1) the strain gauges should be arranged both circumferentially and axially, this is because the circumferential stress of weld seam is greater than axial stress; (2) the stiffener rings should be moved left by 50mm, thus the axial stress can be minimized and the circumferential stress can also be reduced.