This chapter described the intimate processes of the informational system of the human body and cells and their effect on the mind in order to understand how information is received/operated and integrated in the genetic structure of the organism by epigenetic mechanisms. Individual education/learning are the basic processes allowing the knowledge/judgement of mediated reality, and for the formation of decision criteria, beliefs, and mentality. The contributive role of media in education/behavior is highlighted, revealing the positive/negative effects of the persuasive messages in interaction with individual/collective beliefs and mentality. The inoculation techniques applied in various fields of media are discussed from the informational perspective, emphasizing the implication of the cognitive centers on such processes. Big data analysis and predictive conclusions on the social effects are used nowadays as feedback support, helping the optimization of the relation between audience and media products.