Photodynamic reparative skin regeneration using application of photosensitizer gel based on chlorin e6

The results of a study of the clinical effectiveness of the correction of involutional changes in the skin by the method of photodynamic therapy (PDT) with the use of a photosensitizer gel (PS), the active substance of which is the trismeglumine salt of chlorin e6, are presented. The data of fluorescence spectroscopy for monitoring the level of PS fluorescence in order to determine the optimal time of its exposure are demonstrated. The study of the optimal exposure time involved 80 patients with different skin phototypes. The study of the effectiveness of PDT involved 42 patients aged 44–68 years with signs of chrono- and photoaging. The PDT procedure was performed by irradiating the entire surface treated with the PS with a power density of 100 mW/cm2, a light dose of 120–140 J/cm2, a laser radiation wavelength of 660 nm, and a light beam area of 400–800 cm2. It was found that exposure to PS for 10–20 min gives the highest fluorescence and does not depend on the skin phototype. The clinical effect of PDT was achieved in 85.7% of patients; there were no negative subjective sensations. Moisture metrics increased on the skin of the face by 53%, reaching the control values in young healthy volunteers, on the skin of the hands - by 64%. Elastometry indicators on the skin of the face and hands increased by 19% and 16%, respectively. Thus, the PDT procedure with PS based on chlorin e6 is an effective method for correcting involutional changes in the skin, leads to a pronounced clinical effect, improves the parameters of skin moisture measurement and elastometry, and passes without undesirable local reactions. Optical coherence tomography showed an increase in collagen ordering.

Нелинейное оптическое поглощение в GaSe при лазерном возбуждении

: Nonlinear light absorption in GaSe crystals at high levels of optical excitation have been investiqated experimentally. Nd:YAG laser (1st, 2nd harmonic-1064 nm, 532 nm) and a liquid laser (radiation wavelength tuning range of 594-643 nm) were used as radiation sources. It is shown that the observed features in the absorption, luminescence, and photoconductivity spectra in the exciton resonance region in GaSe crystals at high levels of optical excitation can be explained by the interaction of excitons and the screening of the Coulomb interaction by free carriers.

Limiting capabilities of self-mixing interferometry upon sawtooth modulation of a semiconductor laser wavelength

This paper discusses a self-mixing interferometry method for measuring distances upon sawtooth modulation of the wavelength of laser radiation. Conditions under which the distance obtained from the spectrum of the modeled autodyne signal coincides with the distance specified in computer simulation are determined. The limiting capabilities of the method are theoretically substantiated for the increased range of deviations of the laser wavelength. The estimation of the limiting capabilities of the distance measurement method on the spectrum of the autodyne signal gives 10 microns at a wavelength of 650 nm at a 5-nm deviation of laser radiation wavelength. We also discuss difficulties of attaining the limiting accuracy of distance measurements associated with the nonlinear dependence of the wavelength emitted by a laser diode on its supply current and the need to analyze the self-mixing signal at high frequencies.

On the impact of the laser radiation wavelength and the concentration of quantum dots on the luminescence spectra of colloid solution and QD-doped nanocomposites

The influence of the concentration and the laser excitation wavelength on the width and luminescence spectrum maximum of CdSe/CdS /ZnS quantum dots in the toluene solution and doped on the glass plate was studied. It was shown that the wavelength of the exciting laser does not affect the width and peak center of the luminescence spectrum of the samples under the study. Possible mechanisms of the quantum dots concentration influence on studied parameters are analyzed.

Лидарное зондирование смеси молекул сероводорода и метана в атмосфере с летающей платформы

The back scattering Raman lidar equation for the gas mixture of the hydrogen sulfide and the methane molecules numerical solution results are presented at the hydrogen sulfide and methane molecules remote sensing in the atmospheric boundary layer with the concentration in the range of 1010 cm-3 … 1016 cm-3 from the flying platform at the heights up to 500 m in the synchronous photon counting lidar mode. It has been shown that the studied hydrogen sulfide molecules concentration at the level of 1,4 1011 cm-3 can be registered during measurement time duration of 10 s and the methane molecules concentration of 7,6 1015 cm-3 - during measurement time of 1 ms for such a lidar variant at the 405 nm laser radiation wavelength and the platform flight altitude up to 500 m.

Non-invasive online wavelength measurements at FLASH2 and present benchmark

At FLASH2, the free-electron laser radiation wavelength is routinely measured by an online spectrometer based on photoionization of gas targets. Photoelectrons are detected with time-of-flight spectrometers and the wavelength is determined by means of well known binding energies of the target species. The wavelength measurement is non-invasive and transparent with respect to running user experiments due to the low gas pressure applied. Sophisticated controls for setting the OPIS operation parameters have been created and integrated into the distributed object-oriented control system at FLASH2. Raw and processed data can be stored on request in the FLASH data acquisition system for later correlation with data from user experiments or re-analysis. In this paper, the commissioning of the instrument at FLASH2 and the challenges of space charge effects on wavelength determination are reported. Furthermore, strategies for fast data reduction and online data processing are presented.

Newly Discovered Way of the Function of Cardio-Vascular System and the Latest Theory of the Development of Hypertension and Other Cardio-Vascular Diseases

Background: It is known that the power of the heart alone is about 3.3 W, and the length of the vessels is about 100,000 km. It made us doubt that with this power the heart can deliver blood to the capillary bed. Effects on the vascular wall of various modes of laser radiation (wavelength of 630-640 nm.) showed that if continuous radiation did not affect the parameters of blood pressure, frequency regimes had an impact. This leads us to the idea that the root cause of the development of different cardiovascular diseases is the system disturbance of the activity of the vascular pump leads to the increase of intra vascular pressure and the emergence of the hypertensive illness and the coronary heart disease. The local disturbances can cause various diseases depending on the organ where they develop. Rationale: According to our calculations - the length of the arterial bed is 29.1 - 504,6 km. Mathematical modeling showed that if the delivery of blood from the heart to the capillary bed, the required power ranges from 660 to 11942 W. Thus, the main load during transportation the blood to the capillary bed rests on the artery but not on the heart and the vascular pump plays the major role in transportation of blood. Even minor changes in the wall of the arteries, which disrupts vascular pump, lead to the emergence of various vascular diseases. The rationale for this idea I got Ming Chien Kao Awards 2015 [1]. The mortality from the diseases due to the affection of vessels came out now on the first place. The use of the Intravenous laser blood irradiation (ILBI) within the last 30 years showed its high efficiency in a treatment of diseases of vessels and heart, and other system diseases. Therefore ILBI, as the method of the system impact on the blood system, allows to lower the lethality and to increase the life expectancy [2]. The lasers used for treatment of various diseases, the waves having length of 630-640 nanometers are the most effective for the direct impact on the blood and the vascular wall. The energy of the waves of this length is absorbed by oxygen, improves the microcirculation in tissues, changes the viscosity of the blood and affects the wall of vessels [3].