The Story of how Vladimir Sergeevich Took Offense at Faivel Bentsilovich. An Unpublished V.S. Solovyov’s Letter to F.B. Getz

An analysis of the manuscript legacy of V.S. Solovyov is of the greatest importance for the study of his views, creativity, and biography, especially in connection with the ongoing pro-ject of publishing a complete collection of his works and letters. Even well-known and al-ready published texts, including those that appeared in newspapers and journals, need careful comparison with the manuscripts that have come down to us. This is particularly true of Solovyov's correspondence that at the time were carefully selected and, in some cases, edited before publication. This is demonstrated by the example of one of the philosopher’s letters that was intentionally published in a noticeably shortened form. The letter to his friend F.B. Getz was written in the summer of 1891 and reflects a dramatic episode in the lives of both and led to a break between Solovyov and the editorial board of the Petersburg newspaper Novosti. The article also presents a short story about Faivel Getz (1853–1932), a journalist, social activist, and the addressee of the letter with whom Solovyov engaged on the Jewish issue. This article also analyzes at length the events of 1891, which led to a small scandal that served as the reason for writing this letter. V.S. Solovyov could be suspected of cheating and self-promotion as a result of a misunderstanding that arose from the fact that two different authors published in the same newspaper at that time under the same pseudonym. The appendix contains the full text of Solovyov's letter to Getz with the necessary commentary.

Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies

Gene editing technologies hold great potential to enhance our ability to model inheritable neurodegenerative diseases. Specifically, engineering multiple amyotrophic lateral sclerosis (ALS) mutations into isogenic cell populations facilitates determination of whether different causal mutations cause pathology via shared mechanisms, and provides the capacity to separate these mechanisms from genotype-specific effects. As gene-edited, cell-based models of human disease become more commonplace, there is an urgent need to verify that these models constitute consistent and accurate representations of native biology. Here, commercially sourced, induced pluripotent stem cell-derived motor neurons from Cellular Dynamics International, edited to express the ALS-relevant mutations TDP-43M337V and TDP-43Q331K were compared with in-house derived lines engineered to express the TDP-43Q331K mutation within the WTC11 background. Our results highlight electrophysiological and mitochondrial deficits in these edited cells that correlate with patient-derived cells, suggesting a consistent cellular phenotype arising from TDP-43 mutation. However, significant differences in the transcriptomic profiles and splicing behavior of the edited cells underscores the need for careful comparison of multiple lines when attempting to use these cells as a means to better understand the onset and progression of ALS in humans.

Chlamydia spreads to the large intestine lumen via multiple pathways

Chlamydia in the genital tract is known to spread via the blood circulation system to the large intestinal lumen to achieve long-lasting colonization. However, the precise pathways for genital Chlamydia to access to the large intestinal lumen remain unclear. The spleen was recently reported to be critical for the chlamydial spreading. In the current study, it was found that following intravaginal inoculation with Chlamydia , mice with or without splenectomy both produced infectious Chlamydia in the rectal swabs, indicating that spleen is not essential for genital Chlamydia to spread to the gastrointestinal tract. This conclusion was validated by the observation that intravenously inoculated Chlamydia was also detected in the rectal swabs of mice regardless of splenectomy. Careful comparison of the tissue distribution of live chlamydial organisms following intravenous inoculation revealed redundant pathways for Chlamydia to reach the large intestine lumen. The intravenously inoculated Chlamydia was predominantly recruited to the spleen within 12h and then detected in the stomach lumen by 24h, the intestinal lumen by 48h and rectal swabs by 72h. These observations suggest a potential spleen-to-stomach pathway for hematogenous Chlamydia to reach the large intestine lumen. This conclusion was supported by the observation made in mice under coprophagy-free condition. However, in the absence of spleen, hematogenous Chlamydia was predominantly recruited to the liver and then simultaneously detected in the intestinal tissue and lumen, suggesting a potential liver-to-intestine pathway for Chlamydia to reach the large intestine lumen. Thus, genital/hematogenous Chlamydia may reach the large intestinal lumen via multiple redundant pathways.

Family Law Trends in Ukraine

The paper provides the results of the analysis of the current state of legal regulation of family relations in Ukraine, and summarises the main problems of the legislation that establishes general principles of regulation of family relations. Particular attention is devoted to the research into the basic principles of family law, and how they are reflected in the Constitution of Ukraine and the Family Code of Ukraine. To assess the compliance of the Family Code of Ukraine with current societal developments, a careful comparison of its provisions with the principles developed by the Commission on European Family Law (cefl) is needed. The family legislation of Ukraine requires detailed monitoring, factoring in the provisions of a questionnaire developed by the Commission. There is a need to introduce a system of national planning, development and adoption by the Verkhovna Rada of Ukraine of the concept of national legal policy.

Legalism: a turn to history in the anthropology of law

Notorious definitional debates have characterized the anthropology of law, and scholars have not reached consensus over how “law” is to be distinguished from other social phenomena. This article suggests that light can be shed upon this issue by combining the insights of anthropologists and historians. Careful comparison among empirical examples highlights the importance of texts and the legal form. Case studies from Tibet are used to illustrate these points and draw attention to the phenomenon of legalism, that is, the use of generalizing rules and abstract categories to describe and organise the world. This provides a basis for exploring the nature and significance of law, both in the modern world and societies of the past.

Why Tolbachik Diamonds Cannot be Natural

Taking into account recent publications, we provide additional comprehensive evidence that type Ib cuboctahedral diamonds and some other microcrystalline diamonds from Kamchatka volcanic rocks and alluvial placers cannot be natural and undoubtedly represent synthetic materials, which appear in the natural rocks by anthropogenic contamination. The major arguments provided in favor of the natural origin of those diamonds can be easily disproved. They include the coexistence of diamond and deltalumite from Koryaksky volcano; coexistence with super-reduced corundum and moissanite, Mn-Ni silicide inclusions, F-Cl enrichment and F/Cl ratios, and carbon and nitrogen isotopes in Tolbachik diamonds, as well as microtwinning, Mn-Ni silicides, and other inclusions in microcrystalline diamond aggregates from other Kamchatka placers. We emphasize the importance of careful comparison of unusual minerals found in nature, which include type Ib cuboctahedral diamonds and super-reduced phase assemblages resembling industrial slags, with synthetic analogs. The cavitation model proposed for the origin of Tolbachik diamonds is also unreliable since cavitation has only been shown to cause the formation of nanosized diamonds only.

Complex Characterization of Fine Fraction and Source Contribution to PM2.5 Mass at an Urban Area in Central Europe

It is well documented that Southern Poland is one of the most polluted areas in Europe due to the highest airborne concentrations of particulate matter (PM). Concentrations of fine particles are especially high in winter. Apart from detailed number concentrations, it is essential to accurately identify and quantify specific particulate pollution sources. Only a few Polish research centers are involved in such experiments—among them is Krakow research group. For the most part, research focuses on collecting 24-h average samples from stationary PM samplers at ambient monitoring sites and quantifying the specific elements and chemical constituents in PM. This approach includes modeling methods that can use the variability in physical and chemical PM characteristics as an input dataset to identify possible sources of the particles. The objective of this paper is to provide research results based on data collected from June 2018 to May 2019 from a single monitoring station at a central urban site. Careful comparison of data obtained prior to a 2019 law prohibiting solid fuel burning in the city of Krakow with data (2019–2020) when a regulation went into effect should indicate progress by noting lower PM levels. This work has shown that the method applied and Krakow results might be of interest to the broader community in regions of high PM concentration.

The Scrambling Paradox

It has been commonly observed that scrambling and wh-movement share sensitivity to strong movement constraints ( Webelhuth 1989 , Saito 1992 , Bailyn 1995 ). At the same time, the two processes clearly differ in certain other respects, such as wh-island sensitivity, a finding that has inspired a range of analyses of scrambling as entirely distinct from better-understood movement processes ( Müller and Sternefeld 1993 , Bošković and Takahashi 1998 , among many others). Careful comparison of Ā-scrambling and overt wh-movement in a language that shows both (Russian) reveals that this seemingly paradoxical behavior can be captured effectively in a probe-goal theory of scrambling that obeys a form of Relativized Minimality defined across feature classes, following Rizzi 2004 . The resulting analysis exposes the distinct nature of strong and weak islands, with consequences for our understanding of the core architecture of syntactic movement.

Deletion in the Bardet–Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs

In golden retriever dogs, a 1 bp deletion in the canine TTC8 gene has been shown to cause progressive retinal atrophy (PRA), the canine equivalent of retinitis pigmentosa. In humans, TTC8 is also implicated in Bardet–Biedl syndrome (BBS). To investigate if the affected dogs only exhibit a non-syndromic PRA or develop a syndromic ciliopathy similar to human BBS, we recruited 10 affected dogs to the study. The progression of PRA for two of the dogs was followed for 2 years, and a rigorous clinical characterization allowed a careful comparison with primary and secondary characteristics of human BBS. In addition to PRA, the dogs showed a spectrum of clinical and morphological signs similar to primary and secondary characteristics of human BBS patients, such as obesity, renal anomalies, sperm defects, and anosmia. We used Oxford Nanopore long-read cDNA sequencing to characterize retinal full-length TTC8 transcripts in affected and non-affected dogs, the results of which suggest that three isoforms are transcribed in the retina, and the 1 bp deletion is a loss-of-function mutation, resulting in a canine form of Bardet–Biedl syndrome with heterogeneous clinical signs.