The early Mississippian Period in the midwestern United States was a time of great religious, social, economic, and political change. Several models and theories have been proposed for understanding changes in regional interactions associated with the rise of Cahokia, the largest Mississippian city. However, the later dissolution of Cahokia and other Mississippian centers during the twelfth through fourteenth centuries and their impacts on regional interactions are poorly understood. This chapter assesses the utility of the Cross-Cultural Interaction Model for Mississippian Period during the late twelfth through fourteenth centuries in the Midwest. Additionally, this chapter proposes the addition of a third dimension to the model in order to account for indigenous ontological perspectives with regard to entanglements between political reorganization and cosmological realms. Particular attention is given to the Common Field site, a political and religious center located in a region that had been sparsely populated prior to AD 1200.