Technology innovation creates value and competitive advantage. Blockchain has been used to resolve existing problems and offer efficient operations. Blockchain is applied in education, healthcare, automation, etc. Blockchain with permanence and reliability attributes has created trust in digital assets with high integrity and availability to leverage on innovative transactions. Indeed, a plethora of blockchain use cases and value propositions are documented. That notwithstanding, there is dearth of literature on transforming some legacy systems and creating value. To harness the potential, a deeper understanding of use cases and future opportunities is imperative. So, how can blockchain be harnessed for best value creation? What strategies could be adopted by SMEs to leverage? The study explicated on taxonomy of use cases in taxation, e-voting, AI and IoT, and analyzed some value creation perspectives to identify opportunities, in particular, smart contracts used to enforce regulatory compliance. It implies that blockchain use cases could create future opportunities for SMEs.