Systems engineering focuses on design, development, and implementation of complex systems. Not only does the Industry 4.0 concept consist of various technical components that need to be properly set and interconnected, but it is also tied to various managerial aspects. Thus, systems engineering approach can be used for its successful deployment. Overemphasis of technological aspects of Industry 4.0 represents the main starting point of this chapter. Then, collocation analysis, word clusters identification, selection and exemplification of selected domain in the business management realm, and frequency analysis are used in order to develop a holistic framework of Industry 4.0. This framework comprises six levels – physical, activity, outcome, content, triggers, and context. Moreover, the information and control level is integrated. The new holistic framework helps to consider Industry 4.0 from the complex systems engineering perspective – design and deployment of a complex system with required parameters and functionality.