Acknowledgement to Reviewers of OBM Integrative and Complementary Medicine in 2021

The editors of OBM Integrative and Complementary Medicine would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2021. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the service Publons (https://publons.com) to receive recognition. Of course, in these initiatives we are careful not to compromise reviewer confidentiality. Many reviewers see their work as a voluntary and often unseen part of their role as researchers. We are grateful to the time reviewers donate to our journals and the contribution they make.

Laser Watch—New Generation 2021: Modern Integrative Photomedicine Equipment for Photobiomodulation

In the recent past, laser therapy has made immense progress as it is known to change microcirculation, modulate vegetative parameters, and stimulate mitochondrial activity in the human body. This editorial briefly describes a new laser watch prototype (generation 2021), which can be used to perform continuous and simultaneous blood irradiation at the radial and/or ulnar artery of the wrist with different wavelengths of laser light. In a preliminary measurement, the increase in regional oxygen saturation at the crook of the elbow during laser light stimulation with the watch was observed using near-infrared spectroscopy. Apart from this, laser stimulation applied via a newly designed laser watch can modulate biological parameters (photobiomodulation). However, presently, the possible long-term effects are not known, as there are no studies on this topic available to date.

COVID on the Brain: Anxiety Sensitivity and Mindful Awareness Mediate the Relationship between COVID-19 Obsession and Anxiety

The coronavirus (COVID-19) pandemic has produced a global mental health crisis and many individuals have obsessive thoughts and worry about COVID-19 which may, both directly and indirectly, relate to more general anxiety. This study explored anxiety sensitivity and mindful awareness as mediators in the relationship between COVID-19 obsession and general anxiety. College student participants (N = 172) completed the Obsession with COVID-19 scale, the Anxiety Sensitivity Index, the awareness subscale of the Five Factor Mindfulness Questionnaire, and the Generalized Anxiety Disorder Scale. Process was used to test a mediational model. We found both anxiety sensitivity and mindful awareness to be significant mediators such that COVID-19 obsession predicted increased anxiety sensitivity which predicted decreased mindful awareness which, in turn, predicted increased general anxiety. These results demonstrate that anxiety about COVID-19 increases awareness and worry surrounding one’s physical and mental state which lead to a decrease in mindful awareness. Our findings identify mechanisms by which worry about COVID-19 may be leading to increased general anxiety and can be used to inform mindfulness interventions to help prevent these negative effects.

Photobiomodulation for Complex Regional Pain Syndrome: A Case Report and Literature Summary

Complex Regional Pain Syndrome (CRPS) is a highly debilitating chronic pain condition characterized by continuous regional pain disproportionate to duration and intensity of the initial damaging stimulus. In CRPS, abnormal perception, transmission, and modulation of pain by nerve cells and the autonomic nervous system induces extreme increases in perceived pain that may be accompanied by swelling, temperature sensitivity, color fluctuations, and/or skin changes. CRPS most commonly affects the extremities but may spread to other limbs or bodily locations. Since there is currently no cure for the underlying processes that play a role in causing this debilitating condition, therapeutic options seek to mitigate some of the symptoms of CRPS to improve quality of life. A recent systematic review found low-quality evidence of efficacy for all currently available CRPS treatments as well as a lack of consensus about first-line treatments. The pathophysiological complexity of CRPS, in addition to the lack of non-invasive, efficacious therapies for this extremely burdensome pain condition, highlights the vital need to explore novel therapeutic options in both research and clinical practice. Photobiomodulation through the repeated application of high-intensity laser therapy in a clinical setting has been shown to modulate nociception, minimize inflammation, and reduce different types of chronic and acute pain. The present case report describes a clinical protocol using laser therapy for CRPS, presents longitudinal pain scores, and summarizes mechanisms of action supporting the subsequent reduction of CRPS symptoms. After a series of laser treatments, the patient showed marked improvement in range of movement, hypersensitivity, pain, and function. Photobiomodulation through high-intensity laser therapy may represent a promising therapy for individuals affected by CRPS, although further randomized, controlled trials are recommended to evaluate efficacy on different disease-affected areas, assess dose-response relationships, and refine optimal treatment frequency.

Effects of the Phytochemical Combination PB123 on Nrf2 Activation, Gene Expression, and the Cholesterol Pathway in HepG2 Cells

There has been a long history of human usage of the biologically-active phytochemicals in Salvia rosmarinus, Zingiber officinale, and Sophora japonica for health purposes, and we recently reported on a combination of those plant materials as the PB123 dietary supplement. In the present work we extended those studies to evaluate activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factor and differential gene expression in cultured HepG2 (hepatocellular carcinoma) cells treated with PB123. We determined transcriptome changes using mRNA-seq methods, and analyzed the affected pathways using Ingenuity Pathway Analysis and BioJupies, indicating that primary effects included increasing the Nrf2 pathway and decreasing the cholesterol biosynthesis pathway. Pretreatment of cultured HepG2 cells with PB123 upregulated Nrf2-dependent cytoprotective genes and increased cellular defenses against cumene hydroperoxide-induced oxidative stress. In contrast, pretreatment of cultured HepG2 cells with PB123 downregulated cholesterol biosynthesis genes and decreased cellular cholesterol levels. These findings support the possible beneficial effects of PB123 as a healthspan-promoting dietary supplement.

Developing Self-Compassion Online: Assessing the Efficacy and Feasibility of a Brief Online Intervention

The aim of the study was to assess the efficacy and feasibility of a newly designed online self-compassion training programme for the general public. Two hundred and forty-nine participants were randomly assigned to have either immediate or delayed access to a four-week online self-compassion training programme. This programme was based on Compassionate Mind Training and was made up of psychoeducational sessions and in-between session practices and readings. Out of the 179 participants who completed the pre-intervention measures, 81 participants completed the waiting list control design (45.25%; 52 participants from the waiting list group and 29 from the intervention group) and 50 participants went on to complete the intervention (27.9%; i.e., combining the 21 participants from the waiting list group that completed the intervention with the 29 from the intervention group). Compared to the control group, participants in the intervention group showed statistically significant increases in self-compassion and well-being and significant decreases in uncompassionate attitude towards self, shame, self-criticism, depression, anxiety, stress, levels of fear of compassion and attachment avoidance and anxiety. These effects remained at a one month follow up (based on data from 31 participants who completed these measures). The number of sessions completed was significantly predicted by baseline levels of well-being. This study provides promising results for the use of online self-compassion interventions to improve the mental wellbeing of the general public. However, further research is now needed to help understand the barriers to engagement and to help tailor its format to better suit participants who disengaged.

‘A Way of Being in the World’: An Exploration of the Experience of Developing Self-Compassion through Online Training

Compassion Focused Therapy (CFT) has increasingly been shown to have a positive impact for people experiencing a range of difficulties, and online self-help formats could provide a way of increasing its accessibility and scalability. This study explored adult participants’ subjective experiences of engaging with online self-compassion training drawn from Compassionate Mind Training (CMT) and CFT. Semi-structured interviews were conducted with 15 participants who had completed online self-compassion training, and the interview data was analysed using reflexive thematic analysis. The analysis generated four main themes and 17 sub-themes. The four main themes generated were ‘A way of being in the world’, ‘Old habits die hard’, The learning process, and Context and resources. These themes showed that while the process of developing self-compassion was often challenging, most participants described experiencing positive changes in their ways of relating to themselves and others. Participants identified many facilitators and barriers to change, including factors related to the training format and their wider social contexts. These findings support previous research into CMT and CFT, particularly in relation to some common positive changes people experience and some of the difficulties with this process (e.g. fears of compassion). Participants’ descriptions offer promise that approaches based on CMT and the CFT model can be experienced as acceptable and helpful by people engaging through an online self-help format as well as through individual and group-based interventions. The facilitators and barriers to change described by participants indicate the strong influence of people’s contexts and the need for these to be carefully considered when designing and implementing approaches.

Dance/Movement Therapy and Schizophrenia Spectrum Disorders: A Reflection of Clinical Practices and History

Dance/movement therapy (DMT) is a strengths-based approach to psychotherapy that uses dance and movement as the primary form of communication, while emphasizing the movement relationship in addition to verbal dialogue. Positive and negative symptomatology of a diagnosis on the schizophrenia spectrum often disrupt organized thinking, orientation to reality, overall functioning, communication, and healthy relationships. Therefore, a body-based psychotherapeutic approach can be a pragmatic way to support, join, and process with people who have a diagnosis of a schizophrenia spectrum disorder (SSD). This paper explores the positive and negative symptoms of SSD, bodily manifestations of these symptoms, and particular ways to use DMT as a psychosocial treatment option. The use of creativity with this population can support a psychotherapeutic relationship focused on personal strengths, individuality, community development, and unconditional acceptance. This paper is grounded in the historical framework of DMT, particularly considering the theoretical work of Marian Chace and Trudi Schoop. The work is also substantiated anecdotally through the authors’ respective clinical practice with individuals diagnosed on the schizophrenia spectrum and through individual research focused on working with individuals experiencing acute and chronic manifestations of SSD. A brief overview of the current research has been included.

Diabetes and Obesity

Obesity and Diabetes are leading causes of cardiovascular disease and mortality. They are closely linked because of insulin resistance. Hypertension and dyslipidaemia together with poor exercise drive atherosclerosis. Early treatment of blood sugar, dyslipidaemia and hypertension reverse the atherosclerosis process. Bariatric surgery and low calorie diets have in recent years been shown to reverse or improve blood sugars lipids and blood pressure. The risk of premature myocardial infarction and death should no longer be the desired outcome.