In this chapter, we will present our research on the patterns of physiological stress and disease among the infants and children in our three Nubian communities. The discussion will begin with the methods employed in the estimation of demographic variables, such as sex, age at death, and life expectancy. These variables will provide the context for our subsequent investigations of stress and mortality as a result of the nutritional and infectious disease challenges faced by infants and children at both Wadi Halfa and Kulubnarti. Conditions such as cribra orbitalia, enamel hypoplasia, and enamel microdefects will be the focus of the analyses. Comparisons of the conditions within and between these populations has provided us with important insight into the impact of gender, social status, and economic opportunity on the health and wellbeing of communities at large.