EARLY DIAGNOSIS BETWEEN BENIGN AND MALIGNANT NEOPLASMS OF THE LARYNX.

JAMA ◽  
1889 ◽  
Vol XIII (19) ◽  
pp. 671
Keyword(s):  
Early Diagnosis ◽  
Malignant Neoplasms

scholarly journals A systematic examination of the mucous membrane of the mouth (oral mucous membrane) – method of early diagnosis of precancerous diseases

2021 ◽  
Vol 2 (2) ◽  
pp. 32-37
Author(s):  
Irina K. Lutskaya ◽  
Keyword(s):  
Early Diagnosis ◽  
Oral Cavity ◽  
Malignant Transformation ◽  
Mucous Membrane ◽  
Malignant Neoplasms ◽  
Pathological Lesions ◽  
Systematic Survey ◽  
Membrane Method ◽  
Oral Mucous Membrane ◽  
Systematic Examination

The article presents information on the liability of the dentist for reducing the risk of development of pathological processes, including malignant neoplasms of the oral cavity. A thorough inspection of the oral mucous membrane, in accordance with WHO recommendations provides a systematic survey of all departments of the oral cavity and surrounding tissues. This tactic can significantly reduce the risk of development of pathological lesions of the oral cavity, to prevent malignant transformation or provide early diagnosis.

Use of Double Balloon Endoscopy for the Early Diagnosis of Small Intestinal Malignant Neoplasms

2009 ◽  
Vol 69 (5) ◽  
pp. AB200
Author(s):  
Tomoyoshi Shibuya ◽  
Taro Osada ◽  
Hiroki Mori ◽  
Kenshi Matsumoto ◽  
Kazuko Beppu ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Malignant Neoplasms ◽  
Double Balloon Endoscopy ◽  
Double Balloon ◽  
Small Intestinal

Technologies for early diagnosis and screening in the early detection of malignant neoplasms

2018 ◽  
Vol 7 (1) ◽  
pp. 34 ◽  
Author(s):  
A. D. Kaprin ◽  
L. M. Aleksandrova ◽  
V. V. Starinsky ◽  
A. S. Mamontov
Keyword(s):  
Early Detection ◽  
Early Diagnosis ◽  
Malignant Neoplasms

scholarly journals Immunodiagnosis and Immunotherapeutics Based on Human Papillomavirus for HPV-Induced Cancers

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhen Dong ◽  
Renjian Hu ◽  
Yan Du ◽  
Li Tan ◽  
Lin Li ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Early Diagnosis ◽  
Hpv Infection ◽  
Research Progress ◽  
Immunological Methods ◽  
Malignant Neoplasms ◽  
Single Chain ◽  
Induced Tumors ◽  
Antibody Mimics ◽  
E6 And E7

Infection with human papillomavirus (HPV) is one of the main causes of malignant neoplasms, especially cervical, anogenital, and oropharyngeal cancers. Although we have developed preventive vaccines that can protect from HPV infection, there are still many new cases of HPV-related cancers worldwide. Early diagnosis and therapy are therefore important for the treatment of these diseases. As HPVs are the major contributors to these cancers, it is reasonable to develop reagents, kits, or devices to detect and eliminate HPVs for early diagnosis and therapeutics. Immunological methods are precise strategies that are promising for the accurate detection and blockade of HPVs. During the last decades, the mechanism of how HPVs induce neoplasms has been extensively elucidated, and several oncogenic HPV early proteins, including E5, E6, and E7, have been shown to be positively related to the oncogenesis and malignancy of HPV-induced cancers. These oncoproteins are promising biomarkers for diagnosis and as targets for the therapeutics of HPV-related cancers. Importantly, many specific monoclonal antibodies (mAbs), or newly designed antibody mimics, as well as new immunological kits, devices, and reagents have been developed for both the immunodiagnosis and immunotherapeutics of HPV-induced cancers. In the current review, we summarize the research progress in the immunodiagnosis and immunotherapeutics based on HPV for HPV-induced cancers. In particular, we depict the most promising serological methods for the detection of HPV infection and several therapeutical immunotherapeutics based on HPV, using immunological tools, including native mAbs, radio-labelled mAbs, affitoxins (affibody-linked toxins), intracellular single-chain antibodies (scFvs), nanobodies, therapeutical vaccines, and T-cell-based therapies. Our review aims to provide new clues for researchers to develop novel strategies and methods for the diagnosis and treatment of HPV-induced tumors.

scholarly journals Digital technologies in prostate cancer prevention and early diagnosis

2020 ◽  
Vol 25 (6) ◽  
pp. 192-199
Author(s):  
A. F. Lazarev ◽  
Valentina D. Petrova ◽  
V. P. Pokornyak ◽  
S. A. Lazarev ◽  
V. A. Marchkov ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Early Diagnosis ◽  
Cancer Registry ◽  
Cancer Detection ◽  
Group Formation ◽  
Digital Technologies ◽  
Malignant Neoplasms ◽  
Prostate Cancer Detection ◽  
Prostate Cancer Prevention

Background. Prostate cancer is one of the most common malignant neoplasms in males. The Russian Federation observed the same patterns: the incidence of prostate cancer is steadily growing, without the tendency to decrease. Currently, no effective methods are available for prostate cancer early diagnosis and screening. Aim. To improve the effectiveness of prostate cancer prevention and early diagnosis with new digital technologies for high-risk cancer group formation Material and methods. Data from the Cancer Registry population in the Altai regional cancer center, Barnaul City was used. The Cancer Registry includes information about 253,000 patients with malignant neoplasms, including 14,482 males suffering from prostate cancer. Based on the targeted prevention method of A.F. Lazarev, Method for determining the risk of prostate cancer (Patent 2692987) and Automated program for early diagnosis of prostate cancer (certificate of state registration of the computer program No. 2019663514) was developed, which simplifies the stage of forming groups of precancerous high oncorisk and increases prostate cancer detection, as well as develops personalized targeted preventive measures for each patient. Results. The study formed a group of 328 patients with precancerous high oncorisk for prostate cancer in the Cancer Registry, wherein an in-depth examination revealed 26 patients with prostate cancer, which was 7.9%. Stages I and II were established in 97.8%. Conclusion. The web application Automated program for early diagnosis of prostate cancer allows the group formation of high-risk patients who are a targeted search for prostate cancer. The testing process allows a large number of patients to be examined in a short time. The automated program for the early diagnosis of prostate cancer allows a statistically significant increased prostate cancer detection, as well as personalized preventive measure suggestions for each patient.

Recurrent Adenoid Cystic Carcinoma of The Trachea: Intraluminal Radiotherapy

1979 ◽  
Vol 87 (5) ◽  
pp. 614-623 ◽  
Author(s):  
John C. Price ◽  
Bernard Percarpio ◽  
Patrick W. Murphy ◽  
Robert L. Henderson
Keyword(s):  
Early Diagnosis ◽  
Adenoid Cystic Carcinoma ◽  
Tumor Response ◽  
Malignant Neoplasms ◽  
Comprehensive Plan ◽  
Adenoid Cystic ◽  
Iridium 192 ◽  
Primary Radiotherapy ◽  
Methods Of Treatment ◽  
Outer Circumference

Malignant neoplasms of the trachea are rare lesions, of which adenoid cystic carcinoma constitutes 30%. A case of extensive tumor recurrent after primary radiotherapy is presented. Surgical resection and radioisotope implantation were impossible. A method was devised for placement of intraluminal iridium 192 by casting six small hollow plastic tubes to the outer circumference of a Silastic endotracheal tube. This was an easy, safe, and effective method of delivering radiation to the trachea while sparing other vital structures and organs. Excellent tumor response and palliation were achieved. The literature is reviewed and the problems in diagnosis of this tumor are discussed. A comprehensive plan for early diagnosis is presented. All current methods of treatment are discussed, and the need for aggressive surgical management is stressed.

scholarly journals Modern prostate cancer biomarkers. Prospects for EN2 in the prostate cancer diagnosis

2020 ◽  
Vol 16 (3) ◽  
pp. 165-173
Author(s):  
A. S. Tarabayeva ◽  
A. B. Zhubanturliyeva ◽  
I. M. Okhas
Keyword(s):  
Prostate Cancer ◽  
Early Diagnosis ◽  
Cancer Diagnosis ◽  
Cancer Biomarkers ◽  
Malignant Neoplasms ◽  
Prostate Cancer Diagnosis ◽  
Non Invasive ◽  
Diagnostic Capabilities ◽  
Risk Of Relapse ◽  
Tissue Biomarkers

Prostate cancer is one of the most common forms of malignant neoplasms in men. In this regard, it is relevant to search for diagnostic markers that allow the creation of inexpensive, effective tests for early diagnosis of the disease, predicting the risk of relapse and assessing the effectiveness of the therapy. Existing invasive methods for diagnosing prostate cancer present some difficulties for patients. This article discusses the diagnostic capabilities of tissue biomarkers of prostate cancer obtained by non-invasive methods.

scholarly journals How to improve the early diagnosis of oral cancer?

2017 ◽  
Vol 20 (4) ◽  
pp. 25
Author(s):  
Estela Kaminagakura Tango ◽  
Celso Muller Bandeira ◽  
Adriana Ávila De Almeida ◽  
Celina Faig Lima Carta ◽  
Janete Dias Almeida
Keyword(s):  
Public Health ◽  
Oral Cancer ◽  
Early Diagnosis ◽  
Health System ◽  
Squamous Cell ◽  
Public Health System ◽  
Delayed Diagnosis ◽  
Mouth Neoplasms ◽  
Malignant Neoplasms ◽  
Carcinoma Squamous Cell

<p> </p><p><strong>Purpose</strong>: Oral squamous cell carcinoma (OSCC) is one of the most common malignant neoplasms, with 300,000 new cases annually diagnosed in the world. Although it appears in the fifth position among men in Brazil, late diagnosis continues to be a leading cause of poor prognosis. We reviewed the literature to evaluate factors that contribute to diagnostic delay in oral cancer considering aspects related to the patient, health team and public health system. <strong>Material</strong> <strong>and</strong> <strong>Methods</strong>: The Medline (PubMed), Scopus, Web of Science and Embase databases were searched in the last 5 years using the following MeSH descriptors: carcinoma, squamous cell; mouth neoplasms; delayed diagnosis. The articles should contain in their objectives factors contributing to the delayed diagnosis of OSCC related to the patient, healthcare professionals and public health system in general. <strong>Results</strong>: One hundred twenty articles were retrieved and 27 on the delayed diagnosis of oral cancer were eligible. <strong>Conclusion</strong>: The literature showed that the delay in the diagnosis and treatment of patients with oral cancer could be minimized by providing health information, particularly about risk factors, by improving the training and retraining of physicians and dentists and by improving access to the health system. The communication technologies such as telemedicine, can play a key role in the early diagnosis of oral cancer.</p><p> </p><p><strong>Keywords</strong></p><p>Carcinoma; Squamous Cell; Mouth Neoplasms; Delayed Diagnosis.</p>

scholarly journals The role of the pediatrician in the early diagnosis of malignant neoplasms in children

2020 ◽  
Vol 65 (1) ◽  
pp. 94-99
Author(s):  
M. Yu. Rykov ◽  
O. A. Manerova ◽  
I. A. Turabov ◽  
V. V. Kozlov ◽  
V. A. Reshetnikov
Keyword(s):  
Early Diagnosis ◽  
Medical Care ◽  
Survival Time ◽  
Malignant Neoplasms ◽  
Specialized Treatment ◽  
Arkhangelsk Region ◽  
Pediatric Oncologist ◽  
Group 2 ◽  
The Moment

Malignant neoplasms prevail in the structure of mortality in children all over the world, while most patients are diagnosed at the common stages; the second place is taken by external causes. It determines a particular relevance of developing new approaches to strengthen the role of district pediatricians in the early diagnosis of malignant neoplasms in children.Material and methods. The Algorithm for determining the appropriateness of referring a patient to a pediatric oncologist was introduced in the medical organizations of the Arkhangelsk region in 2016. To evalute the effectiveness of the Algorithm, we compared two groups of patients with histologically verified solid malignant neoplasms: Group 1: 49 patients who received medical care in the Arkhangelsk region in 2011–2015 (prior to the experiment); Group 2: 51 patients who received medical care in the Department of Pediatric Oncology of the Arkhangelsk region in 2016–2018. Results. The average survival time was significantly increased in Group 2016–2018 (30.3 ± 1.57 months) as compared with the survival time of patients receiving treatment in 2011–2015 (25.04 ± 2.05 months) (p=0.045). The following time parameters were reduced: from the moment of contacting the pediatric oncologist to the verification of the diagnosis – from 9.0 to 7.0 days; from verification of the diagnosis to the start of specialized treatment – from 12.0 to 8.0 days; from the moment of contacting the local pediatrician to the referral to the pediatric oncologist – from 11.0 to 2.0 days; from the moment of contacting the local pediatrician to the start of specialized treatment – from 23.0 to 9.0 days. Conclusion: The organizational experiment confirmed the effectiveness of the Algorithm and the expediency of its implementation in the medical organizations. 

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