Injectable Optical System for Drug Delivery, Ablation, and Sampling in Deep Tissue

2021 ◽  
pp. 2101464
Author(s):  
Yingchao Ma ◽  
Yanji Chu ◽  
Shanzhi Lyu ◽  
Yonglin He ◽  
Yapei Wang
Keyword(s):  
Drug Delivery ◽  
Optical System ◽  
Deep Tissue

Near-infrared persistent luminescence hollow mesoporous nanospheres for drug delivery and in vivo renewable imaging

2016 ◽  
Vol 4 (48) ◽  
pp. 7845-7851 ◽  
Author(s):  
Junpeng Shi ◽  
Meng Sun ◽  
Xia Sun ◽  
Hongwu Zhang
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
High Sensitivity ◽  
Drug Carriers ◽  
Template Method ◽  
Persistent Luminescence ◽  
Deep Tissue ◽  
Large Capacity

Near-infrared persistent luminescence hollow mesoporous nanospheres have been synthesized via a template method. These nanospheres can be used as large capacity drug carriers and realize super long-term and high sensitivity tracking of drug delivery in deep tissue.

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

2014 ◽  
Vol 50 (58) ◽  
pp. 7824-7827 ◽  
Author(s):  
Minghui Zan ◽  
Junjie Li ◽  
Shizhong Luo ◽  
Zhishen Ge
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Lysosomal Ph ◽  
Tumor Acidity

The multistage polymeric nanogel delivery systems were constructed via host–guest interactions, which showed tumor acidity-triggered disassembly into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

scholarly journals Polymersomes and Wormlike Micelles Made Fluorescent by Direct Modifications of Block Copolymer Amphiphiles

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Karthikan Rajagopal ◽  
David A. Christian ◽  
Takamasa Harada ◽  
Aiwei Tian ◽  
Dennis E. Discher
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Transmission Electron Microscopy ◽  
Diblock Copolymers ◽  
Physicochemical Characteristics ◽  
Wormlike Micelles ◽  
Deep Tissue ◽  
Near Ir ◽  
Transmission Electron ◽  
Tissue Fluorescence

Wormlike micelles and vesicles prepared from diblock copolymers are attracting great interest for a number of technological applications. Although transmission electron microscopy has remained as the method of choice for assessing the morphologies, fluorescence microscopy has a number of advantages. We show here that when commercially available fluorophores are covalently attached to diblock copolymers, a number of their physicochemical characteristics can be investigated. This method becomes particularly useful for visualizing phase separation within polymer assemblies and assessing the dynamics of wormlike micelles in real time. Near-IR fluorophores can be covalently conjugated to polymers and this opens the possibility for deep-tissue fluorescence imaging of polymer assemblies in drug delivery applications.

scholarly journals One-step synthesis of amino-functionalized up-converting NaYF4:Yb,Er nanoparticles for in vitro cell imaging

RSC Advances ◽  
2018 ◽  
Vol 8 (48) ◽  
pp. 27429-27437 ◽  
Author(s):  
Lidija Mancic ◽  
Aleksandra Djukic-Vukovic ◽  
Ivana Dinic ◽  
Marko G. Nikolic ◽  
Mihailo D. Rabasovic ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Single Molecule ◽  
Cell Imaging ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
Single Molecule Tracking ◽  
Wide Range ◽  
Deep Tissue Imaging ◽  
One Step

The emerging up-conversion nanoparticles (UCNPs) offer a wide range of biotechnology applications, from biomarkers and deep tissue imaging, to single molecule tracking and drug delivery.

scholarly journals Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier

2014 ◽  
Vol 2014 ◽  
pp. 1-37 ◽  
Author(s):  
Ravi Kant Upadhyay
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Neurological Diseases ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Delivery Methods ◽  
Deep Tissue ◽  
Therapeutic Alternatives ◽  
Pharmaceutical Agents ◽  
Chimeric Peptides

Present review highlights various drug delivery systems used for delivery of pharmaceutical agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic substances through the endothelial capillaries (BBB) for CNS therapeutics. In addition, the use of ultrasound in delivery of therapeutic agents/biomolecules such as proline rich peptides, prodrugs, radiopharmaceuticals, proteins, immunoglobulins, and chimeric peptides to the target sites in deep tissue locations inside tumor sites of brain has been explained. In addition, therapeutic applications of various types of nanoparticles such as chitosan based nanomers, dendrimers, carbon nanotubes, niosomes, beta cyclodextrin carriers, cholesterol mediated cationic solid lipid nanoparticles, colloidal drug carriers, liposomes, and micelles have been discussed with their recent advancements. Emphasis has been given on the need of physiological and therapeutic optimization of existing drug delivery methods and their carriers to deliver therapeutic amount of drug into the brain for treatment of various neurological diseases and disorders. Further, strong recommendations are being made to develop nanosized drug carriers/vehicles and noninvasive therapeutic alternatives of conventional methods for better therapeutics of CNS related diseases. Hence, there is an urgent need to design nontoxic biocompatible drugs and develop noninvasive delivery methods to check posttreatment clinical fatalities in neuropatients which occur due to existing highly toxic invasive drugs and treatment methods.

scholarly journals Steerable Microinvasive Probes for Localized Drug Delivery to Deep Tissue

Small ◽  
2019 ◽  
Vol 15 (37) ◽  
pp. 1901459 ◽  
Author(s):  
Max J. Cotler ◽  
Erin B. Rousseau ◽  
Khalil B. Ramadi ◽  
Joshua Fang ◽  
Ann M. Graybiel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Deep Tissue ◽  
Localized Drug Delivery

A Field Emission System For Transmission Electron Microscopy

1973 ◽  
Vol 31 ◽  
pp. 298-299
Author(s):  
Michel Troyonal ◽  
Huei Pei Kuoal ◽  
Benjamin M. Siegelal
Keyword(s):  
Electron Microscope ◽  
Field Emission ◽  
Optical System ◽  
High Vacuum ◽  
Ultra High Vacuum ◽  
Objective Lens ◽  
Electron Optical System ◽  
Cross Sectional ◽  
Transmission Electron ◽  
Emission System

A field emission system for our experimental ultra high vacuum electron microscope has been designed, constructed and tested. The electron optical system is based on the prototype whose performance has already been reported. A cross-sectional schematic illustrating the field emission source, preaccelerator lens and accelerator is given in Fig. 1. This field emission system is designed to be used with an electron microscope operated at 100-150kV in the conventional transmission mode. The electron optical system used to control the imaging of the field emission beam on the specimen consists of a weak condenser lens and the pre-field of a strong objective lens. The pre-accelerator lens is an einzel lens and is operated together with the accelerator in the constant angular magnification mode (CAM).

Information and estimation in image processing

1987 ◽  
Vol 45 ◽  
pp. 14-17
Author(s):  
B. Roy Frieden
Keyword(s):  
Image Processing ◽  
Optical System ◽  
Large Amplitude ◽  
Communication Theory ◽  
Image Data ◽  
Direct Approach ◽  
Ill Posed

Despite the skill and determination of electro-optical system designers, the images acquired using their best designs often suffer from blur and noise. The aim of an “image enhancer” such as myself is to improve these poor images, usually by digital means, such that they better resemble the true, “optical object,” input to the system. This problem is notoriously “ill-posed,” i.e. any direct approach at inversion of the image data suffers strongly from the presence of even a small amount of noise in the data. In fact, the fluctuations engendered in neighboring output values tend to be strongly negative-correlated, so that the output spatially oscillates up and down, with large amplitude, about the true object. What can be done about this situation? As we shall see, various concepts taken from statistical communication theory have proven to be of real use in attacking this problem. We offer below a brief summary of these concepts.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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