Preparation of chlorin e6–monoclonal antibody conjugate and its effect for photodynamic therapy
2001 ◽
Vol 05
(05)
◽
pp. 486-489
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Keyword(s):
Chlorin e6 ( Ce 6) was conjugated with anti-tumor monoclonal antibody ( IgG 2 b ) to increase its binding affinity for tumors. The Ce 6 was activated by N -hydroxysuccinimide and directly conjugated with IgG 2 b ( IgG 2 b – Ce 6) via peptide bonds. An average of 11 Ce 6 molecules were coupled to each IgG2b molecule. IgG 2 b – Ce 6 showed high cellular uptake in tumor cells and high photocytotoxicity. These results indicate IgG 2 b – Ce 6 is a good photosensitizer with high binding affinity to tumor cells.
2005 ◽
Vol 09
(02)
◽
pp. 138-141
◽
1993 ◽
Vol 36
(4)
◽
pp. 260-266
◽
Keyword(s):
2018 ◽
Vol 1
(4)
◽
pp. e00063
◽
Keyword(s):
2011 ◽
Vol 83
(4)
◽
pp. 733-748
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Keyword(s):