Classical Geometry and Target Space Duality

1997 ◽  
pp. 1-18
Author(s):  
Orlando Alvarez
Keyword(s):  
Target Space ◽  
Classical Geometry

Nanostructured Hyaluronic Acid-based Materials for the Delivery of siRNA

2018 ◽  
Vol 24 (23) ◽  
pp. 2678-2691 ◽  
Author(s):  
Keval Shah ◽  
Sunita Chawla ◽  
Anuradha Gadeval ◽  
Goutham Reddy ◽  
Rahul Maheshwari ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Rna Interference ◽  
Sirna Delivery ◽  
Treatment Strategies ◽  
Aqueous Solubility ◽  
Micro Rna ◽  
Target Space ◽  
Significant Progress ◽  
Gene Therapies ◽  
Future Potential

Background: The search for the effective treatment strategies to combat a disease that is characterized by abnormal cell growth and known as cancer is still required to reach its destiny. To address the problem, recently several gene therapies based on novel RNA interference (RNAi) have been proposed such as siRNA, micro RNA, shRNA, etc. out of which, siRNAs (silencing RNA) promises to show significant progress in pharmacotherapy, including considerable expansion of the druggable target space and the possibility of treating cancer. Methods: This review aims to uncover the hyaluronic acid (HA) and HA-hybridized nanoplatforms for siRNA delivery systems with a particular focus on the discussion of available reports while addressing the future potential of HA-based treatment strategies. Results: HA modified siRNA delivery, as promised, provided better targeting potential in many types of cancers. In addition, it was able to modify the release of siRNA as well. Toxicity of HA is well mentioned however, the loophole is yet to be filled by exploring various remedies for overcoming toxicity. Conclusion: To overcome the problems associated with these emerging genetic tools, investigators have employed glycosaminoglycan HA-based biopolymers. This biopolymer offers a variety of properties such as biodegradability, biocompatibility, aqueous solubility, viscoelasticity, and non-immunogenicity.

Decoding Protein-protein Interactions: An Overview

2020 ◽  
Vol 20 (10) ◽  
pp. 855-882
Author(s):  
Olivia Slater ◽  
Bethany Miller ◽  
Maria Kontoyianni
Keyword(s):  
Drug Discovery ◽  
Protein Interactions ◽  
Drug Repurposing ◽  
Protein Docking ◽  
Target Space ◽  
Protein Protein Interactions ◽  
X Ray Crystallography ◽  
Protein Protein Interaction ◽  
Interaction Sites ◽  
Long Time

Drug discovery has focused on the paradigm “one drug, one target” for a long time. However, small molecules can act at multiple macromolecular targets, which serves as the basis for drug repurposing. In an effort to expand the target space, and given advances in X-ray crystallography, protein-protein interactions have become an emerging focus area of drug discovery enterprises. Proteins interact with other biomolecules and it is this intricate network of interactions that determines the behavior of the system and its biological processes. In this review, we briefly discuss networks in disease, followed by computational methods for protein-protein complex prediction. Computational methodologies and techniques employed towards objectives such as protein-protein docking, protein-protein interactions, and interface predictions are described extensively. Docking aims at producing a complex between proteins, while interface predictions identify a subset of residues on one protein that could interact with a partner, and protein-protein interaction sites address whether two proteins interact. In addition, approaches to predict hot spots and binding sites are presented along with a representative example of our internal project on the chemokine CXC receptor 3 B-isoform and predictive modeling with IP10 and PF4.

scholarly journals Competition and convergence between auditory and cross-modal visual inputs to primary auditory cortical areas

2011 ◽  
Vol 105 (4) ◽  
pp. 1558-1573 ◽  
Author(s):  
Yu-Ting Mao ◽  
Tian-Miao Hua ◽  
Sarah L. Pallas
Keyword(s):  
Auditory Cortex ◽  
Multisensory Processing ◽  
Sensory Deprivation ◽  
Target Space ◽  
Target Cells ◽  
Auditory Input ◽  
Visual Neurons ◽  
Cortical Areas ◽  
Visual Inputs ◽  
Medial Geniculate

Sensory neocortex is capable of considerable plasticity after sensory deprivation or damage to input pathways, especially early in development. Although plasticity can often be restorative, sometimes novel, ectopic inputs invade the affected cortical area. Invading inputs from other sensory modalities may compromise the original function or even take over, imposing a new function and preventing recovery. Using ferrets whose retinal axons were rerouted into auditory thalamus at birth, we were able to examine the effect of varying the degree of ectopic, cross-modal input on reorganization of developing auditory cortex. In particular, we assayed whether the invading visual inputs and the existing auditory inputs competed for or shared postsynaptic targets and whether the convergence of input modalities would induce multisensory processing. We demonstrate that although the cross-modal inputs create new visual neurons in auditory cortex, some auditory processing remains. The degree of damage to auditory input to the medial geniculate nucleus was directly related to the proportion of visual neurons in auditory cortex, suggesting that the visual and residual auditory inputs compete for cortical territory. Visual neurons were not segregated from auditory neurons but shared target space even on individual target cells, substantially increasing the proportion of multisensory neurons. Thus spatial convergence of visual and auditory input modalities may be sufficient to expand multisensory representations. Together these findings argue that early, patterned visual activity does not drive segregation of visual and auditory afferents and suggest that auditory function might be compromised by converging visual inputs. These results indicate possible ways in which multisensory cortical areas may form during development and evolution. They also suggest that rehabilitative strategies designed to promote recovery of function after sensory deprivation or damage need to take into account that sensory cortex may become substantially more multisensory after alteration of its input during development.

scholarly journals The Volume of the Quiver Vortex Moduli Space

2021 ◽  
Author(s):  
Kazutoshi Ohta ◽  
Norisuke Sakai
Keyword(s):  
Gauge Theory ◽  
Moduli Space ◽  
Riemann Surfaces ◽  
Gauge Theories ◽  
Target Space ◽  
Contour Integral ◽  
Quiver Gauge Theory ◽  
Volume Formula ◽  
Volume Operator ◽  
Space Volume

Abstract We study the moduli space volume of BPS vortices in quiver gauge theories on compact Riemann surfaces. The existence of BPS vortices imposes constraints on the quiver gauge theories. We show that the moduli space volume is given by a vev of a suitable cohomological operator (volume operator) in a supersymmetric quiver gauge theory, where BPS equations of the vortices are embedded. In the supersymmetric gauge theory, the moduli space volume is exactly evaluated as a contour integral by using the localization. Graph theory is useful to construct the supersymmetric quiver gauge theory and to derive the volume formula. The contour integral formula of the volume (generalization of the Jeffrey-Kirwan residue formula) leads to the Bradlow bounds (upper bounds on the vorticity by the area of the Riemann surface divided by the intrinsic size of the vortex). We give some examples of various quiver gauge theories and discuss properties of the moduli space volume in these theories. Our formula are applied to the volume of the vortex moduli space in the gauged non-linear sigma model with CPN target space, which is obtained by a strong coupling limit of a parent quiver gauge theory. We also discuss a non-Abelian generalization of the quiver gauge theory and “Abelianization” of the volume formula.

scholarly journals On the quantization of folded strings in non-critical dimensions

2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
Jacob Sonnenschein ◽  
Dorin Weissman
Keyword(s):  
Scalar Curvature ◽  
Space Dimension ◽  
Massive Particle ◽  
Open String ◽  
Closed String ◽  
Target Space ◽  
Critical Dimensions ◽  
Complete Set ◽  
Rotating String ◽  
Folding Point

Abstract Classical rotating closed string are folded strings. At the folding points the scalar curvature associated with the induced metric diverges. As a consequence one cannot properly quantize the fluctuations around the classical solution since there is no complete set of normalizable eigenmodes. Furthermore in the non-critical effective string action of Polchinski and Strominger, there is a divergence associated with the folds. We overcome this obstacle by putting a massive particle at each folding point which can be used as a regulator. Using this method we compute the spectrum of quantum fluctuations around the rotating string and the intercept of the leading Regge trajectory. The results we find are that the intercepts are a = 1 and a = 2 for the open and closed string respectively, independent of the target space dimension. We argue that in generic theories with an effective string description, one can expect corrections from finite masses associated with either the endpoints of an open string or the folding points on a closed string. We compute explicitly the corrections in the presence of these masses.

scholarly journals Target space entanglement in quantum mechanics of fermions and matrices

2021 ◽  
Vol 2021 (8) ◽  
Author(s):  
Sotaro Sugishita
Keyword(s):  
Mutual Information ◽  
Ground State ◽  
Entanglement Entropy ◽  
Algebraic Approach ◽  
Upper Bounds ◽  
Wave Functions ◽  
Target Space ◽  
Single Interval ◽  
Area Law ◽  
Formula Expression

Abstract We consider entanglement of first-quantized identical particles by adopting an algebraic approach. In particular, we investigate fermions whose wave functions are given by the Slater determinants, as for singlet sectors of one-matrix models. We show that the upper bounds of the general Rényi entropies are N log 2 for N particles or an N × N matrix. We compute the target space entanglement entropy and the mutual information in a free one-matrix model. We confirm the area law: the single-interval entropy for the ground state scales as $$ \frac{1}{3} $$ 1 3 log N in the large N model. We obtain an analytical $$ \mathcal{O}\left({N}^0\right) $$ O N 0 expression of the mutual information for two intervals in the large N expansion.

scholarly journals Long way to Ricci flatness

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Jin Chen ◽  
Chao-Hsiang Sheu ◽  
Mikhail Shifman ◽  
Gianni Tallarita ◽  
Alexei Yung
Keyword(s):  
Sigma Model ◽  
Ultra Violet ◽  
The Other ◽  
Target Space ◽  
Linear Sigma Model ◽  
Close Relative ◽  
Two Dimensional ◽  
World Sheet ◽  
Ricci Flat ◽  
The World

Abstract We study two-dimensional weighted $$ \mathcal{N} $$ N = (2) supersymmetric ℂℙ models with the goal of exploring their infrared (IR) limit. 𝕎ℂℙ(N,$$ \tilde{N} $$ N ˜ ) are simplified versions of world-sheet theories on non-Abelian strings in four-dimensional $$ \mathcal{N} $$ N = 2 QCD. In the gauged linear sigma model (GLSM) formulation, 𝕎ℂℙ(N,$$ \tilde{N} $$ N ˜ ) has N charges +1 and $$ \tilde{N} $$ N ˜ charges −1 fields. As well-known, at $$ \tilde{N} $$ N ˜ = N this GLSM is conformal. Its target space is believed to be a non-compact Calabi-Yau manifold. We mostly focus on the N = 2 case, then the Calabi-Yau space is a conifold. On the other hand, in the non-linear sigma model (NLSM) formulation the model has ultra-violet logarithms and does not look conformal. Moreover, its metric is not Ricci-flat. We address this puzzle by studying the renormalization group (RG) flow of the model. We show that the metric of NLSM becomes Ricci-flat in the IR. Moreover, it tends to the known metric of the resolved conifold. We also study a close relative of the 𝕎ℂℙ model — the so called zn model — which in actuality represents the world sheet theory on a non-Abelian semilocal string and show that this zn model has similar RG properties.

scholarly journals Gauged sigma-models with nonclosed 3-form and twisted Jacobi structures

2020 ◽  
Vol 2020 (11) ◽  
Author(s):  
Athanasios Chatzistavrakidis ◽  
Grgur Šimunić
Keyword(s):  
Sigma Models ◽  
Sigma Model ◽  
Target Space ◽  
Two Dimensional ◽  
Courant Algebroids ◽  
Dirac Structures ◽  
Courant Algebroid ◽  
Abelian Case ◽  
Jacobi Manifolds ◽  
Jacobi Structure

Abstract We study aspects of two-dimensional nonlinear sigma models with Wess-Zumino term corresponding to a nonclosed 3-form, which may arise upon dimensional reduction in the target space. Our goal in this paper is twofold. In a first part, we investigate the conditions for consistent gauging of sigma models in the presence of a nonclosed 3-form. In the Abelian case, we find that the target of the gauged theory has the structure of a contact Courant algebroid, twisted by a 3-form and two 2-forms. Gauge invariance constrains the theory to (small) Dirac structures of the contact Courant algebroid. In the non-Abelian case, we draw a similar parallel between the gauged sigma model and certain transitive Courant algebroids and their corresponding Dirac structures. In the second part of the paper, we study two-dimensional sigma models related to Jacobi structures. The latter generalise Poisson and contact geometry in the presence of an additional vector field. We demonstrate that one can construct a sigma model whose gauge symmetry is controlled by a Jacobi structure, and moreover we twist the model by a 3-form. This construction is then the analogue of WZW-Poisson structures for Jacobi manifolds.

A UV complete picture of black hole conforming to low energy effective field theory

2018 ◽  
Vol 33 (36) ◽  
pp. 1850219
Author(s):  
Biplab Paik
Keyword(s):  
Field Theory ◽  
Black Hole ◽  
Effective Field Theory ◽  
Effective Field ◽  
Radiation Process ◽  
Quantum Black Hole ◽  
Classical Geometry ◽  
Characteristic Radius ◽  
Hole Geometry ◽  
Principle Of Causality

In this paper, we propose a UV complete, quantum improved picture of a black hole geometry that conforms to the IR gravity of effective field theory. Our work builds on identifying an effective space-distributed notion of black hole fluid in quantum improved regular Einstein gravity and its theoretical correspondence with a cosmology inspired power law fluctuation of matter. Hence, we make use of phenomenological asymptotic scales of matter fluctuation in static space to consequently derive a UV complete line-element of black hole space–time. In this appraisal, it gets explicit how principle of causality is preserved even while there is an effective spread of black hole fluid across horizon(s). Gravity changes from its conventional classical geometry-state to a quantum masked profile across a hypersurface of characteristic radius [Formula: see text]. We make analyses that probe the newly proposed quantum improved gravity in the contexts of regularity of Einstein fields, complete predictability of Hawking radiation process, and first law of black hole thermodynamics. It emerges that quantum black hole geometry self-regulates a regular timelike core that is abide by every quantum theoretical constraint while being flat around its center.

scholarly journals ON TARGET SPACE DUALITY IN p-BRANES

1995 ◽  
Vol 10 (05) ◽  
pp. 441-450 ◽  
Author(s):  
R. PERCACCI ◽  
E. SEZGIN
Keyword(s):  
Dimensional Space ◽  
Target Space ◽  
Field Equations ◽  
Parameter Group ◽  
Duality Transformations ◽  
World Volume ◽  
The World ◽  
Dimensional Space Time ◽  
Background Fields ◽  
Two Parameter

We study the target space duality transformations in p-branes as transformations which mix the world volume field equations with Bianchi identities. We consider an (m+p+1)-dimensional space-time with p+1 dimensions compactified, and a particular form of the background fields. We find that while a GL (2) = SL (2) × R group is realized when m = 0, only a two-parameter group is realized when m > 0.

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