scholarly journals ECM and FGF-Dependent Assay of Embryonic SMG Epithelial Morphogenesis: Investigating Growth Factor/Matrix Regulation of Gene Expression During Submandibular Gland Development

2009 ◽  
pp. 319-330 ◽  
Author(s):  
Ivan T. Rebustini ◽  
Matthew P. Hoffman
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Submandibular Gland ◽  
Regulation Of Gene Expression ◽  
Epithelial Morphogenesis ◽  
Factor Matrix ◽  
Gland Development

scholarly journals EVOLUTION AND VARIATION OF RENIN GENES IN MICE

Genetics ◽  
1984 ◽  
Vol 108 (3) ◽  
pp. 651-667
Author(s):  
Douglas P Dickinson ◽  
Kenneth W Gross ◽  
Nina Piccini ◽  
Carol M Wilson
Keyword(s):  
Gene Expression ◽  
Submandibular Gland ◽  
Regulation Of Gene Expression ◽  
Inbred Strains ◽  
Duplication Event ◽  
Comparative Sequence Analysis ◽  
Chromosome 1 ◽  
Gene Encoding ◽  
Prior Estimate ◽  
Low Levels

ABSTRACT Inbred strains of mice carry Ren-1, a gene encoding the thermostable Renin-1 isozyme. Ren-1 is expressed at relatively low levels in mouse submandibular gland and kidney. Some strains also carry Ren-2, a gene encoding the thermolabile Renin-2 isozyme. Ren-2 is expressed at high levels in the mouse submandibular gland and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression. An investigation of renin genes and enzymatic activity in wild-derived mice identified several restriction site polymorphisms as well as putative variants in renin gene expression and protein structure. The number of renin genes carried by different subpopulations of wild-derived mice is consistent with the occurrence of a gene duplication event prior to the divergence of M. spretus (2.75-5.5 million yr ago). This conclusion is in agreement with a prior estimate based upon comparative sequence analysis of Ren-1 and Ren-2 from inbred laboratory mice.

scholarly journals Involvement of Heparin-Binding EGF-like Growth Factor and Its Processing by Metalloproteinases in Early Epithelial Morphogenesis of the Submandibular Gland

2001 ◽  
Vol 237 (1) ◽  
pp. 202-211 ◽  
Author(s):  
Yuko Umeda ◽  
Yuji Miyazaki ◽  
Hiroko Shiinoki ◽  
Shigeki Higashiyama ◽  
Yasuo Nakanishi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Submandibular Gland ◽  
Epithelial Morphogenesis ◽  
Heparin Binding

Extracellular-matrix gene expression during mouse submandibular gland development

1997 ◽  
Vol 42 (6) ◽  
pp. 443-454 ◽  
Author(s):  
Shawn P. Macauley ◽  
Roy W. Tarnuzzer ◽  
Gregory S. Schultz ◽  
Nasser Chegini ◽  
Gregory E. Oxford ◽  
...  
Keyword(s):  
Gene Expression ◽  
Extracellular Matrix ◽  
Submandibular Gland ◽  
Matrix Gene ◽  
Gland Development

scholarly journals Nuclear Functions of TOR: Impact on Transcription and the Epigenome

Genes ◽  
2020 ◽  
Vol 11 (6) ◽  
pp. 641 ◽  
Author(s):  
R. Nicholas Laribee ◽  
Ronit Weisman
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Protein Kinase ◽  
Neurological Disorders ◽  
Regulation Of Gene Expression ◽  
Clinical Implications ◽  
Biological Processes ◽  
The Core ◽  
Regulation Of Metabolism ◽  
Pharmacological Target

The target of rapamycin (TOR) protein kinase is at the core of growth factor- and nutrient-dependent signaling pathways that are well-known for their regulation of metabolism, growth, and proliferation. However, TOR is also involved in the regulation of gene expression, genomic and epigenomic stability. TOR affects nuclear functions indirectly through its activity in the cytoplasm, but also directly through active nuclear TOR pools. The mechanisms by which TOR regulates its nuclear functions are less well-understood compared with its cytoplasmic activities. TOR is an important pharmacological target for several diseases, including cancer, metabolic and neurological disorders. Thus, studies of the nuclear functions of TOR are important for our understanding of basic biological processes, as well as for clinical implications.

Thyroid hormone and androgen regulation of nerve growth factor gene expression in the mouse submandibular gland

1992 ◽  
Vol 84 (1-2) ◽  
pp. 145-154 ◽  
Author(s):  
Marsha A. Black ◽  
Fleur-Ange Lefebvre ◽  
Louise Pope ◽  
Yvonne A. Lefebvre ◽  
Peter Walker
Keyword(s):  
Gene Expression ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Thyroid Hormone ◽  
Submandibular Gland ◽  
Nerve Growth ◽  
Factor Gene ◽  
Growth Factor Gene ◽  
Androgen Regulation
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