scholarly journals imzML: Imaging Mass Spectrometry Markup Language: A Common Data Format for Mass Spectrometry Imaging

2010 ◽  
pp. 205-224 ◽  
Author(s):  
Andreas Römpp ◽  
Thorsten Schramm ◽  
Alfons Hester ◽  
Ivo Klinkert ◽  
Jean-Pierre Both ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Imaging Mass Spectrometry ◽  
Markup Language ◽  
Data Format

scholarly journals Distribution of Glycerophospholipids in the Adult Human Lens

Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 156 ◽  
Author(s):  
Jo Seng ◽  
Jessica Nealon ◽  
Stephen Blanksby ◽  
Todd Mitchell
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Imaging Mass Spectrometry ◽  
Human Lens ◽  
Limited Data ◽  
Outer Cortex ◽  
Adult Human ◽  
Cell Age ◽  
Human Lenses ◽  
The Relationship

In humans, the age of fibre cells differs across the ocular lens, ranging from those formed before birth in the core of the lens to those formed just prior to death in the outer cortex. The distribution of glycerophospholipids in the adult human lens should reflect this range; however, limited data currently exists to confirm this hypothesis. Accordingly, this study aimed to determine the distribution of glycerophospholipids in adult human lens using mass spectrometry imaging. To achieve this, 20-µm thick slices of two human lenses, aged 51 and 67 were analysed by matrix-assisted laser desorption ionisation imaging mass spectrometry. The data clearly indicate that intact glycerophospholipids such as phosphatidylethanolamine, phosphatidylserine, and phosphatidic acid are mainly present in the outer cortex region, corresponding to the youngest fibre cells, while lyso-phosphatidylethanolamine, likely produced by the degradation of phosphatidylethanolamine, is present in the nucleus (older fibre cells). This study adds further evidence to the relationship between fibre cell age and glycerophospholipid composition.

scholarly journals imzML — A common data format for the flexible exchange and processing of mass spectrometry imaging data

2012 ◽  
Vol 75 (16) ◽  
pp. 5106-5110 ◽  
Author(s):  
Thorsten Schramm ◽  
Zoë Hester ◽  
Ivo Klinkert ◽  
Jean-Pierre Both ◽  
Ron M.A. Heeren ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Imaging Data ◽  
Data Format

scholarly journals Raman2imzML converts Raman imaging data into the standard mass spectrometry imaging format

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Stefania Alexandra Iakab ◽  
Lluc Sementé ◽  
María García-Altares ◽  
Xavier Correig ◽  
Pere Ràfols
Keyword(s):  
Mass Spectrometry ◽  
Open Source ◽  
Open Source Software ◽  
Multimodal Imaging ◽  
Mass Spectrometry Imaging ◽  
Raman Imaging ◽  
Imaging Analysis ◽  
Imaging Data ◽  
Data Format ◽  
Computational Tools

Abstract Background Multimodal imaging that combines mass spectrometry imaging (MSI) with Raman imaging is a rapidly developing multidisciplinary analytical method used by a growing number of research groups. Computational tools that can visualize and aid the analysis of datasets by both techniques are in demand. Results Raman2imzML was developed as an open-source converter that transforms Raman imaging data into imzML, a standardized common data format created and adopted by the mass spectrometry community. We successfully converted Raman datasets to imzML and visualized Raman images using open-source software designed for MSI applications. Conclusion Raman2imzML enables both MSI and Raman images to be visualized using the same file format and the same software for a straightforward exploratory imaging analysis.

Robust Simulation Of Imaging Mass Spectrometry Data

2021 ◽  
Author(s):  
Anastasia Sarycheva ◽  
Anton Grigoryev ◽  
Evgeny N. Nikolaev ◽  
Yury Kostyukevich
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Mass Spectrometry Imaging ◽  
Imaging Mass Spectrometry ◽  
Real Data ◽  
Sample Surface ◽  
Mass Spectrometry Data ◽  
Ion Composition ◽  
Simulation Parameters ◽  
Imaging Mass Spectrometry Data

Mass spectrometry imaging (MSI) with high resolution in mass and space is an analytical method that produces distributions of ions on a sample surface. The algorithms for preprocessing and analysis of the raw data acquired from a mass spectrometer should be evaluated. To do that, the ion composition at every point of the sample should be known. This is possible via the employment of a simulated MSI dataset. In this work, we suggest a pipeline for a robust simulation of MSI datasets that resemble real data with an option to simulate the spectra acquired from any mass spectrometry instrument through the use of the experimental MSI datasets to extract simulation parameters.

scholarly journals Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging

2015 ◽  
Vol 6 (10) ◽  
pp. 5383-5393 ◽  
Author(s):  
Bence Paul ◽  
Dominic J. Hare ◽  
David P. Bishop ◽  
Chad Paton ◽  
Van Tran Nguyen ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Mouse Brain ◽  
Inductively Coupled Plasma ◽  
Mass Spectrometry Imaging ◽  
Imaging Mass Spectrometry ◽  
Metal Distribution ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
And Function

Studying the neuroanatomy of the mouse brain using imaging mass spectrometry and chemometric analysis.

Surface analysis by imaging mass spectrometry

2009 ◽  
Vol 74 (7-8) ◽  
pp. 1101-1116 ◽  
Author(s):  
Veronika Vidová ◽  
Michael Volný ◽  
Karel Lemr ◽  
Vladimír Havlíček
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Mass Spectrometry Imaging ◽  
Structural Information ◽  
Imaging Techniques ◽  
Imaging Mass Spectrometry ◽  
Molecular Surface ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Desorption Ionization

A review of four MS-based techniques available for molecular surface imaging is presented. The main focus is on the commercially available mass spectrometry imaging techniques: secondary ion mass spectrometry (SIMS), matrix assisted laser desorption ionization mass spectrometry (MALDI-MS), desorption electrospray ionization mass spectrometry (DESI-MS) and laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS). A short historical perspective is presented and traditional desorption ionization techniques are also briefly described. The four techniques are compared mainly with respect to their usage for imaging of biological surfaces. MALDI is evaluated as the most successful in life sciences and the only technique usable for imaging of large biopolymers. SIMS is less common but offers superior spatial lateral resolution and DESI is considered to be an emerging alternative approach in mass spectrometry imaging. LA-ICP ionization is unbeatable in terms of limits of detection but does not provide structural information. All techniques are considered extremely useful, representing a new wave of expansion of mass spectrometry into surface science and bioanalysis. A minireview with 121 references.

scholarly journals Imaging mass spectrometry imaging

2007 ◽  
Vol 260 (2-3) ◽  
pp. 89 ◽  
Author(s):  
Ron M.A. Heeren ◽  
Jonathan V. Sweedler
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Imaging Mass Spectrometry

Search for super early biomarker of multiple sclerosis using mass spectrometry imaging

Impact ◽  
2019 ◽  
Vol 2019 (8) ◽  
pp. 41-43
Author(s):  
Masaya Ikegawa
Keyword(s):  
Multiple Sclerosis ◽  
Mass Spectrometry ◽  
Central Nervous System ◽  
Mass Spectrometry Imaging ◽  
Imaging Mass Spectrometry ◽  
The Central Nervous System ◽  
Early Biomarker ◽  
Visual Problems ◽  
Muscle Spasms ◽  
Project Search

Multiple sclerosis (MS) is a disease that affects the central nervous system. It is a lifelong condition with no cure, but it can be managed with treatments and specialists. For example, treatment can focus on accelerating recovery from attacks, slowing disease progression and managing symptoms. Symptoms caused by MS include fatigue, visual problems, muscle spasms and stiffness, mobility problems, neuropathic pain and problems with thinking, learning and memory, among others. Professor Masaya Ikegawa is a researcher based in the Department of Medical Life Systems at Doshisha University, Japan. His latest research project ('Search for super early biomarker of multiple sclerosis using mass spectrometry imaging') involves identifying biomarkers and therapeutic targets of MS through imaging mass spectrometry. His research also encompasses a broader spectrum of intractable diseases, which are those that have mostly arisen through unidentifiable causes and lack established or curable treatments, including Alzheimer's disease, diabetic neuropathy and cancer, among others.

scholarly journals Imaging mass spectrometry : a new way to distinguish dermal contact from administration of cocaine, using a single fingerprint

The Analyst ◽  
2021 ◽  
Author(s):  
Catia Costa ◽  
Min Jang ◽  
Janella M. de Jesus ◽  
Rory T Steven ◽  
Chelsea J Nikula ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Drug Use ◽  
Mass Spectrometry Imaging ◽  
Imaging Mass Spectrometry ◽  
Application Area ◽  
Dermal Contact ◽  
Potential Use ◽  
Significant Application

Here we show a new and significant application area for mass spectrometry imaging. The potential use of for fingerprints to determine reveal drug use has been widely reported, with potential...

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