A review of MEMS drug delivery in medical application

2007 ◽  
pp. 312-315 ◽  
Author(s):  
S. Karman ◽  
F. Ibrahim ◽  
N. Soin
Keyword(s):  
Drug Delivery ◽  
Medical Application

scholarly journals Control ofIn VivoTransport and Toxicity of Nanoparticles by Tea Melanin

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Yu-Shiun Chen ◽  
Yao-Ching Hung ◽  
Meng-Yeng Hong ◽  
Andrei Aleksandrovich Onischuk ◽  
Jin Chern Chiou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Cognitive Impairment ◽  
Raman Scattering ◽  
Therapeutic Approach ◽  
Medical Application ◽  
Toxic Materials ◽  
Cornu Ammonis ◽  
Novel Strategy

Nanoparticles are unfamiliar to researchers in toxicology. Toxicity may be generated simply due to the reduction in size. Compounds that prevent or cure toxic materials may not work on nanoparticles. Furthermore, as there are more and more applications of nanoparticles in drug delivery andin vivoimaging, controlling the transport and toxicity will be primary concerns for medical application of nanoparticles. Gold nanoparticles (GNPs) if injected intraperitoneally into mice can enter hippocampus and induce cognitive impairment. GNPs caused a global imbalance of monoamine levels, specifically affecting the dopaminergic and serotonergic neurons. Pretreatment of tea melanin significantly prevented the deposition of GNPs in mouse brains, especially in the hippocampus. Pretreatment of melanin completely alleviated GNP-induced impairment of cognition. Pre-administration of melanin stably maintained monoamines at normal profiles. Melanin completely prevented the invasion of GNPs into the Cornu Ammonis region of the hippocampus shown by coherent anti-Stoke Raman scattering microscopy. Here we show that the administration of tea melanin prevented the accumulation of Au in brain, the imbalance of monoamines, and the impairment of cognition in mice. The current study provides a therapeutic approach to toxicity of nanoparticles and a novel strategy to control the transport of GNP in mouse brain.

Nanoemulsions in drug delivery: formulation to medical application

Nanomedicine ◽  
2018 ◽  
Vol 13 (19) ◽  
pp. 2507-2525 ◽  
Author(s):  
Hossam H Tayeb ◽  
Frank Sainsbury
Keyword(s):  
Drug Delivery ◽  
Medical Application

scholarly journals Brief Review on Future of Medicine: Nanorobots

2021 ◽  
pp. 29-42
Author(s):  
Shravani Girigosavi ◽  
Payal Oak
Keyword(s):  
Drug Delivery ◽  
Medical Application ◽  
Cancer Tissue ◽  
Dental Surgery ◽  
Microscopic Scale ◽  
Control Power ◽  
Inorganic Systems ◽  
The World ◽  
Nano Medicine ◽  
Medicine Application

Nano-robots are the robots that are the technology of creating machines or robots close to the microscopic scale of a nanometre (10-9meters). These devices range from 0.1 – 10 micrometres. Nano-robots are the advances in technology. The technology has expanded our capability and potential to operate the world around us on above removing scale. Nano robots can be used in various application such as space and medicine technology. Nanos robots are device is used for motive of nourishing, keeping and protecting the human body opposing antibody, microorganisms, pathogens. Nano robots are instrumental by using various components such as actuators, sensors, control, power, conveying and by affiliating cross – marked scales between organic and inorganic systems. Nanotechnologies are quickly arising within the nation of medicine, and this subdivision has been termed Nano medicine. Application for nanorobotics in medicine including diagnosis and drug delivery for cancer, tissue engineering, pharmacokinetics, dental surgery, ophthalmology and others. This region of work is fulfilled with prospective and possible applications, many of like that recently animating researched and evolution. The objective of this paper is to introduce the expanding sector of nanorobotics inside in medicine and advancement in medical application.

scholarly journals pH-Sensitive Biomaterials for Drug Delivery

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5649
Author(s):  
Shijie Zhuo ◽  
Feng Zhang ◽  
Junyu Yu ◽  
Xican Zhang ◽  
Guangbao Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Medical Application ◽  
Ph Sensitive ◽  
Great Promise ◽  
Responsive Materials ◽  
And Personalized Medicine ◽  
Microenvironment Ph ◽  
Pathological Tissues

The development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads to the pathological tissues, producing enhanced therapeutic outcome and reduced side effects. As many diseased tissues are feathered with acidic characteristics microenvironment, pH-sensitive biomaterials for drug delivery present great promise for the purpose, which could protect the therapeutic payloads from metabolism and degradation during in vivo circulation and exhibit responsive release of the therapeutics triggered by the acidic pathological tissues, especially for cancer treatment. In the past decades, many methodologies, such as acidic cleavage linkage, have been applied for fabrication of pH-responsive materials for both in vitro and in vivo applications. In this review, we will summarize some pH-sensitive drug delivery system for medical application, mainly focusing on the pH-sensitive linkage bonds and pH-sensitive biomaterials.

scholarly journals Alginate Metal Complexes and Their Application

2021 ◽  
Author(s):  
Ghaidaa Alkhayer
Keyword(s):  
Drug Delivery ◽  
Metal Complexes ◽  
Drug Delivery System ◽  
Organic Synthesis ◽  
Delivery System ◽  
Main Idea ◽  
Medical Application ◽  
Chiral Drugs ◽  
Multivalent Metal

Alginate is a natural polymer that can form complexes in the presence of multivalent metal. In this chapter, we summarized the newest alginate metal complexes application in many fields; organic synthesis, environmental and medical application. The main idea was about alginate complexes’ role in the drug delivery system as a chiral excipient to reach the enantioselective release in the case of chiral drugs. We also present a case study about the ketoprofen enantioselective release investigation from alginate mixed beads with two ion metal types.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

Nanotheranostic agents for neurodegenerative diseases

2020 ◽  
Vol 4 (6) ◽  
pp. 645-675
Author(s):  
Parasuraman Padmanabhan ◽  
Mathangi Palanivel ◽  
Ajay Kumar ◽  
Domokos Máthé ◽  
George K. Radda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Cell Types ◽  
Specific Cell ◽  
Ageing Population ◽  
Target Tissue ◽  
Therapeutic Approaches ◽  
Surface Receptors ◽  
Theranostic Agents ◽  
Preclinical Animal Models

Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), affect the ageing population worldwide and while severely impairing the quality of life of millions, they also cause a massive economic burden to countries with progressively ageing populations. Parallel with the search for biomarkers for early detection and prediction, the pursuit for therapeutic approaches has become growingly intensive in recent years. Various prospective therapeutic approaches have been explored with an emphasis on early prevention and protection, including, but not limited to, gene therapy, stem cell therapy, immunotherapy and radiotherapy. Many pharmacological interventions have proved to be promising novel avenues, but successful applications are often hampered by the poor delivery of the therapeutics across the blood-brain-barrier (BBB). To overcome this challenge, nanoparticle (NP)-mediated drug delivery has been considered as a promising option, as NP-based drug delivery systems can be functionalized to target specific cell surface receptors and to achieve controlled and long-term release of therapeutics to the target tissue. The usefulness of NPs for loading and delivering of drugs has been extensively studied in the context of NDDs, and their biological efficacy has been demonstrated in numerous preclinical animal models. Efforts have also been made towards the development of NPs which can be used for targeting the BBB and various cell types in the brain. The main focus of this review is to briefly discuss the advantages of functionalized NPs as promising theranostic agents for the diagnosis and therapy of NDDs. We also summarize the results of diverse studies that specifically investigated the usage of different NPs for the treatment of NDDs, with a specific emphasis on AD and PD, and the associated pathophysiological changes. Finally, we offer perspectives on the existing challenges of using NPs as theranostic agents and possible futuristic approaches to improve them.

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