High prevalence of coronary calcifications and increased risk for coronary heart disease in adults with growth hormone deficiency

2011 ◽  
Vol 34 (1) ◽  
pp. 32-37 ◽  
Author(s):  
S. Cannavò ◽  
F. Marini ◽  
Lorenzo Curtò ◽  
M. L. Torre ◽  
C. de Gregorio ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Coronary Calcifications ◽  
Increased Risk ◽  
High Prevalence

scholarly journals Coronary artery calcification score in migraine patients

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Filipp M. Filippopulos ◽  
Florian Schoeberl ◽  
Hans-Christoph Becker ◽  
Sandra Becker-Bense ◽  
Ozan Eren ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Pathophysiological Mechanism ◽  
Coronary Artery Calcification Score ◽  
Coronary Calcifications ◽  
Calcification Score ◽  
Increased Risk

Abstract Epidemiological studies have shown an increased risk of cardiovascular events in migraineurs. The pathophysiological mechanisms of this observation remain largely unknown. Recent genetic and epidemiologic studies suggest, that atherosclerosis might be the overlapping pathophysiological mechanism in migraine and coronary heart disease. The aim of the present study was to evaluate if the increased cardiovascular risk in migraineurs is attributed to an increased coronary artery calcification. For this the coronary artery calcium score was assessed by computed tomography of the heart in 1.437 patients of which 337 were migraineurs. All patients had a similar cardiovascular risk profile, so that the risk for coronary calcifications could be considered similar between migraineurs and non-migraineurs. The results showed no significant differences in the amount of coronary calcifications in patients with or without migraine. This suggests that a more pronounced coronary artery calcification, as a surrogate marker of coronary atherosclerosis, does not underlie the increased cardiovascular risk in migraineurs. A distinct common pathophysiological mechanism in migraine and coronary heart disease such as endothelial dysfunction or vasospasm should be discussed instead. However, it has to be considered, that the coronary artery calcification score does not indicate the total risk of atherosclerotic changes in the coronary arteries.

scholarly journals Skin morphological changes in growth hormone deficiency and acromegaly

2001 ◽  
pp. 147-153 ◽  
Author(s):  
M Lange ◽  
J Thulesen ◽  
U Feldt-Rasmussen ◽  
NE Skakkebaek ◽  
N Vahl ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Morphological Changes ◽  
Hormone Deficiency ◽  
Sweat Glands ◽  
Gh Treatment ◽  
Sweat Secretion ◽  
Increased Risk ◽  
Significant Difference ◽  
Eccrine Sweat

OBJECTIVE: To evaluate the histomorphology of skin and its appendages, especially eccrine sweat glands, in patients with GH disorders, because reduced sweating ability in patients with growth hormone deficiency (GHD) is associated with increased risk of hyperthermia under stressed conditions. DESIGN AND METHODS: A skin biopsy was obtained from 17 patients with GHD treated with GH, five patients with untreated GHD, 10 patients with active acromegaly and 13 healthy controls. RESULTS: The sweat secretion rate (SSR) was significantly decreased in both the untreated (median 41 mg/30 min, range 9-79 mg/30 min) and the GH-treated (median 98 mg/30 min, range 28-147 mg/30 min) patients with GHD compared with that in controls (median 119 mg/30 min, range 90-189 mg/30 min; P=0.001 and 0.01 respectively). Epidermal thickness was significantly decreased in both untreated (median 39 microm, range 28-55 microm) and GH-treated patients with GHD (median 53 microm, range 37-100 microm), compared with that in controls (median 66 microm, range 40-111 microm; P<0.02). A statistically non-significant tendency towards thinner epidermis (median 59 microm, range 33-83 microm) was recorded in acromegalic patients (P=0.08) compared with controls. There was no significant difference in the area of the sebaceous glands in the biopsies between the three groups and the controls. The area of eccrine sweat gland glomeruli was significantly decreased in the untreated patients with GHD (median 16407 microm2, range 12758-43976 microm2) compared with that in controls (median 29446 microm2, range 13511-128661 microm2; P=0.03), but there was no significant difference between the GH-treated patients with GHD and controls. CONCLUSIONS: We conclude that GH, either directly or via IGF-I, may have both a structural and a functional effect on human skin and its appendages, and that patients with GHD have histomorphological changes in skin compared with controls. Importantly, these changes are not fully reversed despite long-term and adequate GH treatment in patients with childhood onset GHD.

scholarly journals Correlation of Significantly Decreased Serum Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Level With an Increased Risk of Future Cardiovascular Disease in Adult Patients With Growth Hormone Deficiency

2021 ◽  
Vol 12 ◽  
Author(s):  
Ziyu Ren ◽  
Yunting Wang ◽  
Qing Chen ◽  
Jiangchuan Long ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Disease ◽  
Growth Hormone ◽  
Lipid Metabolism ◽  
Growth Hormone Deficiency ◽  
Neurotrophic Factor ◽  
Hormone Deficiency ◽  
Control Group ◽  
Increased Risk ◽  
Normal Controls

ObjectiveAdult growth hormone deficiency (AGHD) is a rare chronic inflammatory disease caused by damage to the pituitary gland and is accompanied by disorders of multiple metabolic pathways. By examining the correlation between the serum mesencephalic astrocyte-derived neurotrophic factor (MANF) levels of AGHD patients and those of normal controls, we hope to elucidate the close relationship among MANF, lipid metabolism and insulin resistance in AGHD and discuss the potential therapeutic value of MANF.MethodsThis study included 101 AGHD patients and 100 healthy subjects matched for sex, age, height, and weight. Anthropometric parameters and biochemical indicators such as body mass index, waist circumference, hip circumference, serum MANF level, blood lipids and insulin level were measured. The above patients were also divided into several subgroups for correlation analysis based on indicators such as insulin resistance and BMI.ResultsThe serum circulating MANF content of AGHD patients was significantly lower than that of the normal control group (5.235 (0.507-17.62) ng/ml (n=101) vs. 10.30 (1.84-16.65) ng/ml (n=100); p&lt;0.0001), and circulating MANF levels were linearly correlated with HOMA-IR in the AGHD population (R=0.481, P=0.0041). When MANF was at pathological concentrations (lower than the mean circulating MANF of normal controls), the lowest concentration tertile (OR=21.429 p&lt;0.0001) had a significantly higher disease odds ratio, Framingham risk score and 10-year risk of atherosclerotic cardiovascular disease than the highest concentration tertile.ConclusionsMANF has a significant correlation with insulin resistance in the AGHD state. There is a strong correlation with abnormal glucose and lipid metabolism in the obese AGHD population. MANF is also a good assessment factor for the risk of cardiovascular disease in AGHD patients and has excellent therapeutic potential.

scholarly journals High Prevalence of Growth Hormone Deficiency in Severe Fibromyalgia Syndromes

2010 ◽  
Vol 95 (9) ◽  
pp. 4331-4337 ◽  
Author(s):  
G. Cuatrecasas ◽  
M. J. Gonzalez ◽  
C. Alegre ◽  
G. Sesmilo ◽  
J. Fernandez-Solà ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
High Prevalence

scholarly journals ANALYSIS OF THE VITAMIN D RECEPTOR BSMI GENE POLYMORPHISM IN CHILDREN WITH GROWTH HORMONE DEFICIENCY

2021 ◽  
Vol 74 (3) ◽  
pp. 498-503
Author(s):  
Elena V. Bolshova ◽  
Mariana A. Ryznychuk ◽  
Dmitry A. Kvacheniuk
Keyword(s):  
Growth Hormone ◽  
Vitamin D ◽  
Gene Polymorphism ◽  
Growth Hormone Deficiency ◽  
Vitamin D Receptor ◽  
Polymorphic Locus ◽  
Hormone Deficiency ◽  
Allele Carrier ◽  
Vdr Gene ◽  
Increased Risk

The aim: The objective of the study was to investigate the polymorphism of the vitamin D receptor (VDR) BsmI gene in children with growth hormone deficiency and the level of their vitamin D supply. Materials and methods: Sixteen children diagnosed with of growth hormone deficiency who were treated at the State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine» were examined. The patient’s gender and age, the anthropometric data, the vitamin D level in the blood, the bone age, the GH level, the IGF-1 levels, the level of calcium in the blood and VDR gene polymorphism were taken into account. Results: It was shown that in the presence of the G/A genotype, the risk of growth hormone deficiency development was increased OR = 1,096 (95% CI 0.39-3.02; p = 0.86). For BsmI, mean values of height, body mass, height SDS, serum 25(OH)D, in the studied population (16 children) were 123.49 ± 19.62 cm, 26.96 ± 11.11 kg, -2.25 ± 0.85, 48.86 ± 16.71 nmol/l, respectively; total calcium level consisted of 2.40 ± 0.12 mmol/l, serum phosphorus – 1.43 ± 0.11 mmol/l. Conclusions: The allele frequency of the VDR BsmI polymorphism was 62.5% for the G allele (n = 20) and 37.5% for the allele A (n = 12). The G allele carrier of the polymorphic locus BsmI rs1544410 of the VDR gene (rs11568820) is associated with an increased risk of growth hormone deficiency development OR = 1.31 (95% CI 0.62-2.75; p = 0.47).

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