scholarly journals Sugammadex in systemic mastocytosis

2021 ◽  
Author(s):  
A. Becerra-Bolaños ◽  
V. Muiño-Palomar ◽  
S. Cabrera-Doreste ◽  
A. Rodríguez-Pérez
Keyword(s):  
Systematic Review ◽  
Case Report ◽  
Search Strategy ◽  
Perioperative Management ◽  
Systemic Mastocytosis ◽  
Case Reports ◽  
Anesthetic Management ◽  
Google Scholar ◽  
Current Evidence

AbstractPerioperative management in patients suffering from systemic mastocytosis is challenging. Most recommendations regarding anesthetic management in these patients are based on clinical reports, and there are controversies about the use of rocuronium and sugammadex. We present a case report of a patient with systemic mastocytosis who was given sugammadex for rocuronium reversal. Tryptase levels were monitored during the first postoperative 24 h, without evidence of elevation. We also performed a systematic review to provide an overview of current evidence regarding the safety of using sugammadex in patients suffering from systemic mastocytosis. The search strategy included PubMed and Google Scholar. All studies published up to and including January 2021 concerning anesthetic management in systemic mastocytosis were included. Of the 122 articles located, 9 articles were included: 2 reviews and 7 case reports. Data from reviewed studies confirm that sugammadex can safely be administered in patients suffering from systemic mastocytosis.

scholarly journals COVID-19 in Patients with Solid Organ Transplantation: A Systematic Review

2020 ◽  
Vol 1 (1) ◽  
pp. 1-15 ◽  
Author(s):  
René Hage ◽  
Carolin Steinack ◽  
Christian Benden ◽  
Macé M. Schuurmans
Keyword(s):  
Systematic Review ◽  
Social Life ◽  
Case Reports ◽  
Solid Organ Transplantation ◽  
Organ Transplant ◽  
Case Series ◽  
Google Scholar ◽  
Current Evidence ◽  
Solid Organ ◽  
Increased Risk

The novel coronavirus, SARS-CoV-2, is causing a pandemic of unknown precedent, with huge healthcare challenges and worldwide disruptions to economic and social life. Lung transplant recipients and other solid organ transplant (SOT) recipients are immunosuppressed, and therefore are generally considered at an increased risk for severe infections. Given the current gap in knowledge and evidence regarding the best management of these patients, we conducted a systematic review of studies on SARS-CoV-2 infections and Coronavirus Disease 2019 (COVID-19) in SOT recipients, to evaluate the association between immunosuppression in these patients, SARS-CoV-2 infection and COVID-19 outcomes. The focus was the severity of the disease, the need for mechanical ventilation and intensive care unit (ICU) admissions, and rate of death. The literature search was conducted repeatedly between 16 March and 8 April 2020. We searched original papers, observational studies, case reports, and meta-analyses published between 2019 and 2020 using two databases (PubMed, Google Scholar) with the search terms: [transplant OR immunosuppression] AND [COVID-19 OR SARS-CoV-2]. Further inclusion criteria were publications in English, French, German and Italian, and reference to humans. We also searched the reference lists of the studies encountered. From an initial search of PubMed and Google Scholar, 19 potential articles were retrieved, of which 14 were excluded after full-text screening (not being case reports or case series), leaving 5 studies for inclusion. No further studies were identified from the bibliographies of retrieved articles. Based on the limited research, no firm conclusions can be made concerning SOT recipients, but the current evidence suggests that immunosuppression is most likely associated with a better outcome of SARS-CoV-2 infection and COVID-19 because it prevents hyperinflammation (cytokine storm) in this particular population. There is a need for further research that would allow results to be adjusted for other factors potentially impacting COVID-19 severity and outcome.

Reticular erythematous mucinosis: Literature review and case report of a 24-year-old patient with systemic erythematosus lupus

Lupus ◽  
2020 ◽  
pp. 096120332096570
Author(s):  
Juliana P Ocanha-Xavier ◽  
Camila O Cola-Senra ◽  
Jose Candido C Xavier-Junior
Keyword(s):  
Systematic Review ◽  
Case Report ◽  
Literature Review ◽  
English Language ◽  
Case Reports ◽  
Histopathological Diagnosis ◽  
Skin Disorders ◽  
Histopathological Findings ◽  
Inflammatory Skin

Reticular erythematous mucinosis (REM) was first described 50 years ago, but only around 100 case reports in English have been published. Its relation with other inflammatory skin disorders is still being debated. We report a case of REM, including the clinical and histopathological findings. Also, a systematic review of 94 English-language reported cases is provided. The described criteria for clinical and histopathological diagnosis are highlighted in order to REM can be confidently diagnosed.

scholarly journals COVID‐19 complicating perioperative management of LVAD implantation: A case report and systematic review

2021 ◽  
Author(s):  
Deborah de Sá Pereira Belfort ◽  
Bruno Biselli ◽  
Mônica Samuel Ávila ◽  
Maria Tereza Sampaio de Sousa Lira ◽  
Filomena Regina Barbosa Gomes Galas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Report ◽  
Perioperative Management

scholarly journals Systematic review of Kabuki Syndrome’s phenotype with KMT2D gene mutation

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Leonardo Bonini Fischetti ◽  
Julia Zaccarelli Magalhães ◽  
André Rinaldi Fukushima ◽  
Paula Waziry ◽  
Esther Lopes Ricci
Keyword(s):  
Systematic Review ◽  
Differential Diagnosis ◽  
Case Report ◽  
Animal Models ◽  
Case Reports ◽  
Accurate Diagnosis ◽  
Kabuki Syndrome ◽  
Live Births ◽  
Comparative Review ◽  
Secondary Phenotypes

Kabuki Syndrome is rare and poorly documented, initially mentioned by Niikawa and Kuroki in 1981. The prevalence of the syndrome among live births is 1:32,000. Case reports are now available, which correlates to improved techniques for accurate diagnosis. This study focused on a systematic comparative review of the phenotypes of individuals with Kabuki Syndrome, with the purpose to facilitate diagnosis. The systematic review was done with a bibliographic survey of case studies using the following databases: Pubmed, Science Direct and Google Scholar, in conjunction with the following key-words: Kabuki syndrome, phenotype, KMT2D and case report. The literature shows that patients with this syndrome present five main characteristics, besides several types of secondary phenotypes. These characteristics present variations in permeability as well as expressivity of some genes in individuals, therefore, a characterization through phenotype alone becomes limited, making it necessary to perform genetic analysis for differential diagnosis. In order to increase the knowledge and elucidate mechanisms of Kabuki syndrome, we suggest further studies that utilize animal models.

scholarly journals Is Non-Chlamydial Non-Gonococcal Urethritis Associated with Significant Clinical Complications in Men? A Systematic Review

2020 ◽  
Vol 14 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Cassandra E.L. Fairhead ◽  
Alexander Hampson ◽  
Louis Dwyer-Hemmings ◽  
Nikhil Vasdev
Keyword(s):  
Systematic Review ◽  
Reactive Arthritis ◽  
Case Reports ◽  
Case Series ◽  
Current Evidence ◽  
Future Research ◽  
Qualitative Synthesis ◽  
Cross Sectional ◽  
Gonococcal Urethritis ◽  
Clinical Complications

Background: It is estimated that between 50 and 89% of non-gonococcal urethritis is not caused by Chlamydia trachomatis. Associations between non-chlamydial non-gonococcal urethritis (NCNGU) with balanoposthitis, epididymo-orchitis and reactive arthritis have been suggested, but evidence to support these often-theoretical relationships is sparse and further investigation is called for. Concerns over increasing antimicrobial resistance has rendered the need for clarity over this question ever more pressing in recent years. A review of the current evidence on the complications of NCNGU in men is therefore urgently warranted. Objective: This systematic review summarizes and evaluates the available evidence that NCNGU, whether symptomatic or asymptomatic, causes the significant complications that are already well-recognized to be associated with non-gonococcal urethritis. These significant complications are epididymo-orchitis, balanoposthitis, and sexually-acquired reactive arthritis (Reiter's syndrome) including arthritis or conjunctivitis. Summary: We conducted a systematic review and qualitative synthesis using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis framework. Five databases (PubMed, EMBASE, Cumulative Index to Nursing and Allied Health Literature, PsycINFO, and British Nursing Index) were searched. We included studies that measured clinical outcome after diagnosis of NCNGU in men. Bias was assessed using variations of the Newcastle-Ottawa scale. Data were extracted and entered into a pre-written data abstraction proforma. Seven peer-review studies were included. This included 2 retrospective cohort studies, 1 case series, 2 case reports and 2 cross-sectional studies. The studies described and analyzed 3 types of complication: balanitis, posthitis and/or meatitis; reactive arthritis and/or conjunctivitis; and epididymitis. All studies reported one or more complications. Key Messages: This review identifies an important avenue for future research: while the available evidence suggests that NCNGU has the potential to cause significant complications in men, with the strongest evidence existing for balanitis, posthitis and/or meatitis, the nature and significance of these relationships is far from clear. The findings of this review suggest that prospective, adequately powered research into whether there is a causal link between NCNGU and significant clinical complications in men would be highly worthwhile. The findings of this review raise important questions about the utility of the term NCNGU in research and clinical practice.

Would you use novel oral anticoagulants (NOACs) for thromboprophylaxis in patients with an underlying hypercoagulable state? A literature review through a case report

2020 ◽  
Vol 13 (10) ◽  
pp. e237238
Author(s):  
Bhavika Kakadia ◽  
Giselle Alexandra Suero-Abreu ◽  
Rrita Daci ◽  
Ryna Karina Then
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Arterial Thrombosis ◽  
Case Reports ◽  
Oral Anticoagulants ◽  
Novel Oral Anticoagulants ◽  
Current Evidence ◽  
Multiple Drug ◽  
Autoimmune Condition ◽  
Randomised Controlled

Antiphospholipid syndrome (APLS) is an autoimmune condition that predisposes to venous and arterial thrombosis. Warfarin is the agent of choice for anticoagulation. However, a need for routine international normalised ratio (INR) checks and multiple drug interactions are some of the difficulties with warfarin. Currently, there is mixed evidence for and against the use of novel oral anticoagulants (NOACs) for thromboprophylaxis. We present a case report of a patient with APLS on a NOAC for secondary thromboprophylaxis who developed a stroke and discuss current evidence regarding the use of NOACs in patients with APLS. The patient was switched to warfarin for secondary thromboprophylaxis with an INR goal of 2–3. Literature review revealed mixed case reports for and against NOACs for secondary prevention of thrombotic events in patients with APLS. There needs to be further randomised controlled trials to evaluate the efficacy of NOACs for thromboprophylaxis in patients with APLS.

scholarly journals Current evidence for anesthesia management during endovascular stroke therapy: updated systematic review and meta-analysis

2018 ◽  
Vol 11 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Nitin Goyal ◽  
Konark Malhotra ◽  
Muhammad F Ishfaq ◽  
Georgios Tsivgoulis ◽  
Christopher Nickele ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Outcomes ◽  
Meta Analysis ◽  
Anesthetic Management ◽  
Functional Independence ◽  
Sensitivity Analyses ◽  
Current Evidence ◽  
Vessel Occlusion ◽  
Random Effects Models ◽  
Randomized Studies

IntroductionDebate continues about the optimal anesthetic management for patients undergoing endovascular treatment (ET) of acute ischemic stroke due to emergent large vessel occlusion.ObjectiveTo compare, using current evidence, the clinical outcomes and procedural characteristics among patients undergoing general anesthesia (GA) and local or monitored anesthesia (non-GA).MethodsWe performed a systematic review and meta-analysis of all available studies that involved the use of stent retrievers for ET (stentriever group). Additionally, we included studies that were published in 2015 and later, and compared the clinical outcomes among the studies using stentrievers or no stentrievers (pre-stentriever group). Outcome variables included functional independence (FI; modified Rankin Scale scores of 0–2), symptomatic hemorrhage, mortality, procedure duration, and vascular and respiratory complications. We calculated pooled odds ratios and 95% CIs using random-effects models.ResultsSixteen studies (three randomized controlled clinical trials (RCTs) and 13 non-randomized studies) were identified comprising 5836 patients. Although non-GA was associated with higher odds of 3-month FI (OR=1.57; 95% CI 1.17 to 2.10; P=0.003) and lower odds of 3-month mortality (OR=0.62; 95% CI 0.47 to 0.82; P=0.0006, substantial heterogeneity was noted across included trials. Sensitivity analyses of RCTs showed that non-GA was inversely associated with FI (OR=0.55; 95% CI 0.34 to 0.89; P=0.01; I2=15%), while no association was noted with mortality (OR=1.36; 95% CI 0.79 to 2.34; P=0.27; I2=0%).ConclusionOur updated meta-analysis demonstrates favorable results with non-GA, probably owing to inclusion of non-randomized studies. Recent single-center RCTs indicate that GA is associated with higher odds of FI at 3 months, while other outcomes are similar between the two groups.

Systemic Mastocytosis, Kounis Syndrome and Coronary Intervention: Case Report and Systematic Review

2017 ◽  
Vol 26 (8) ◽  
pp. 772-778 ◽  
Author(s):  
Elizabeth D. Paratz ◽  
Nancy Khav ◽  
Andrew T. Burns
Keyword(s):  
Systematic Review ◽  
Case Report ◽  
Systemic Mastocytosis ◽  
Coronary Intervention ◽  
Kounis Syndrome

scholarly journals Dental Findings in Kabuki Syndrome: A Systematic Review for Dentistry

2020 ◽  
Vol 22 (2) ◽  
pp. 61-69
Author(s):  
Ricardo Barbosa-Lima ◽  
Amanda Lopes ◽  
Juliely N. F. De Moura ◽  
Sabrina N. Ribeiro ◽  
Matheus S. N. T. Cardoso
Keyword(s):  
Systematic Review ◽  
Clinical Case ◽  
Search Strategy ◽  
Case Reports ◽  
Kabuki Syndrome ◽  
Inclusion Criteria ◽  
Qualitative Synthesis ◽  
Genetic Condition ◽  
Language Data ◽  
Eleven Case

Kabuki syndrome consists in a series of congenital anomalies involving intellectual disability, hypotonia, and facial and body dysmorphism. In addition to these cardinal signs, craniofacial and dental changes are frequently observed, although they are not fully understood. Thus, the aim of this article is to present the dental findings in patients with Kabuki syndrome. This is a systematic review developed according to the PRISMA protocol. A search strategy with descriptors ("kabuki syndrome" AND "dentistry") was applied to six databases. As inclusion criteria, we selected clinical case reports that addressed dental findings in one or more patients with Kabuki syndrome between 1999 and 2019, without restrictions regarding gender, age or language. Data collection in all databases was performed by a calibrated evaluator and titles, abstracts and full-text studies were systematically analyzed. Eleven case reports that fit the proposed inclusion criteria were found. After the qualitative synthesis, teeth absence or agenesis were the most reported findings, being observed by nine authors. Less frequent dental findings in patients with this syndrome are taurodontism, microdontia, fusion, gemination and conical or screwdriver-shaped teeth. In fact, when any syndrome or genetic condition is related to manifestations of dental interest, the dental surgeon should be able to investigate them, especially teeth agenesis or absence. For this reason, the dentist should be aware of the manifestations of Kabuki syndrome, contributing to patients' understanding and management.

scholarly journals Use of Simulation in Newborn Resuscitation Education: Systematic Review

2021 ◽  
Author(s):  
Süreyya Sarvan ◽  
Emine Efe
Keyword(s):  
Systematic Review ◽  
Health Care Professionals ◽  
Neonatal Resuscitation ◽  
Google Scholar ◽  
Current Evidence ◽  
Knowledge And Skills ◽  
Newborn Resuscitation ◽  
Study Results ◽  
Resuscitation Training ◽  
Academic Search

Objective: Every year, millions of newborns around the world need the help of health professionals to take their first breath. Healthcare professionals need to have comprehensive knowledge and skills of specified in the neonatal resuscitation algorithm to perform life-saving interventions quickly and accurately. However, since neonatal resuscitation is a rather complicated task, deviations from this algorithm are common. In this article, it is aimed to review the current evidence of simulation used to improve neonatal resuscitation training. Methods: This research is the systematic review design and is a qualitative research based on document analysis of the articles. The universe of the study consisted of 116 articles from 2015-2020, accessed from databases such as Medline Complete, Academic Search Complete, Academic Search Ultimate, CINAHL Complete, Directory of Open Access Journals, Google Scholar and Google Scholar. Nine articles that satisfy the criteria for inclusion in this study were evaluated within the scope of the study. Results: Eight of the nine studies included in the study were reported to be in use high reality simulations. In all studies, educational content ranging from theoretical lessons based on neonatal resuscitation guidance and simulated resuscitation training to scenario-based practices were reported. In simulations to evaluate skill performances Megacode scenario was used in five studies, simulator software in one study, and a standard evaluation form in three studies. Conclusion: In the current studies, despite the improvement in knowledge and skill performance immediately after neonatal resuscitation training, the protection of knowledge and skills in the long term is controversial. For this reason, it may be recommended to conduct refresher trainings for the protection of newborn resuscitation knowledge and skills of health care professionals.

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