The THP-1 cell toolbox: a new concept integrating the key events of skin sensitization

2019 ◽  
Vol 93 (4) ◽  
pp. 941-951
Author(s):  
Elodie Clouet ◽  
Rami Bechara ◽  
Chloé Raffalli ◽  
Marie-Hélène Damiens ◽  
Hervé Groux ◽  
...  
Keyword(s):  
Skin Sensitization ◽  
Key Events

The THP-1 Toolbox: A new method that integrates the 4 key events of skin sensitization

2018 ◽  
Vol 295 ◽  
pp. S120
Author(s):  
E. Clouet ◽  
C. Raffalli ◽  
M.-H. Damiens ◽  
M. Pallardy ◽  
P.-J. Ferret ◽  
...  
Keyword(s):  
New Method ◽  
Skin Sensitization ◽  
Key Events

scholarly journals Applicability of amino acid derivative reactivity assay for prediction of skin sensitization by combining multiple alternative methods to evaluate key events

2019 ◽  
Vol 44 (9) ◽  
pp. 585-600 ◽  
Author(s):  
Yusuke Yamamoto ◽  
Masaharu Fujita ◽  
Sayaka Wanibuchi ◽  
Ayako Sato ◽  
Miyuki Akimoto ◽  
...  
Keyword(s):  
Amino Acid ◽  
Acid Derivative ◽  
Alternative Methods ◽  
Amino Acid Derivative ◽  
Skin Sensitization ◽  
Multiple Alternative ◽  
Key Events

scholarly journals In silico Prediction of Skin Sensitization: Quo vadis?

2021 ◽  
Vol 12 ◽  
Author(s):  
Giang Huong Ta ◽  
Ching-Feng Weng ◽  
Max K. Leong
Keyword(s):  
In Silico ◽  
Human Cell Line ◽  
Skin Area ◽  
Skin Sensitization ◽  
Animal Data ◽  
Cosmetic Ingredients ◽  
Quo Vadis ◽  
Allergic Contact ◽  
Key Events

Skin direct contact with chemical or physical substances is predisposed to allergic contact dermatitis (ACD), producing various allergic reactions, namely rash, blister, or itchy, in the contacted skin area. ACD can be triggered by various extremely complicated adverse outcome pathways (AOPs) remains to be causal for biosafety warrant. As such, commercial products such as ointments or cosmetics can fulfill the topically safe requirements in animal and non-animal models including allergy. Europe, nevertheless, has banned animal tests for the safety evaluations of cosmetic ingredients since 2013, followed by other countries. A variety of non-animal in vitro tests addressing different key events of the AOP, the direct peptide reactivity assay (DPRA), KeratinoSens™, LuSens and human cell line activation test h-CLAT and U-SENS™ have been developed and were adopted in OECD test guideline to identify the skin sensitizers. Other methods, such as the SENS-IS are not yet fully validated and regulatorily accepted. A broad spectrum of in silico models, alternatively, to predict skin sensitization have emerged based on various animal and non-animal data using assorted modeling schemes. In this article, we extensively summarize a number of skin sensitization predictive models that can be used in the biopharmaceutics and cosmeceuticals industries as well as their future perspectives, and the underlined challenges are also discussed.

Applicability of ADRA (4 mM) for the prediction of skin sensitization by combining multiple alternative methods to evaluate key events

2022 ◽  
Author(s):  
Mika Imamura ◽  
Yusuke Yamamoto ◽  
Masaharu Fujita ◽  
Sayaka Wanibuchi ◽  
Natsumi Nakashima ◽  
...  
Keyword(s):  
Alternative Methods ◽  
Skin Sensitization ◽  
Multiple Alternative ◽  
Key Events

Revising Plants, man and life: Edgar Anderson reshapes a classic book

2003 ◽  
Vol 30 (1) ◽  
pp. 85-96 ◽  
Author(s):  
Kim Kleinman
Keyword(s):  
Twentieth Century ◽  
Evolutionary Theory ◽  
Evolutionary Synthesis ◽  
Ernst Mayr ◽  
Active Participant ◽  
Evolutionary Mechanism ◽  
Popular Work ◽  
Scientific Attention ◽  
Key Events ◽  
Jesup Lectures

On at least four occasions, Edgar Anderson (1897–1969) began revising his book Plants, man and life (1952). Given both its place in Anderson's career and his place in the development of evolutionary theory in the mid-twentieth century, the emendations are noteworthy. Though a popular work, Plants, man and life served as the distillation of Anderson's ideas on hybridization as an evolutionary mechanism, the need for more scientific attention on domesticated and semi-domesticated plants, and the opportunities such plants provided for the study of evolution. Anderson was an active participant in several key events in what historians have come to call the Evolutionary Synthesis. For example, he and Ernst Mayr shared the 1941 Jesup Lectures on “Systematics and the origin of species”. Anderson's proposed revisions to his book reflect both an attempt to soften certain acerbic comments as well as an attempt to recast the book as a whole.

How to Define the Czechoslovak Underground

2018 ◽  
Vol 56 (3) ◽  
pp. 42-46
Author(s):  
Barbara Bothová
Keyword(s):  
Significant Influence ◽  
The State ◽  
Way Of Life ◽  
The West ◽  
State Security ◽  
The Third ◽  
Key Events

What is an underground? Is it possible to embed this particular way of life into any definition? After all, even underground did not have the need to define itself at the beginning. The presented text represents a brief reflection of the development of underground in Czechoslovakia; attention is paid to the impulses from the West, which had a significant influence on the underground. The text focuses on the key events that influenced the underground. For example, the “Hairies (Vlasatci)” Action, which took place in 1966, and the State Security activity in Rudolfov in 1974. The event in Rudolfov was an imaginary landmark and led to the writing of a manifesto that came into history as the “Report on the Third Czech Musical Revival.”

An archaeological analysis to trace the emergence and transformation of qualified physical education teachers in Singapore primary schools

2019 ◽  
Vol 41 (2) ◽  
pp. 69-84
Author(s):  
Ho Jin Chung ◽  
Muhammad Sufri ◽  
Chee Keng John Wang
Keyword(s):  
Physical Education ◽  
Primary Schools ◽  
Physical Education Teachers ◽  
National Archives ◽  
The Future ◽  
The Status ◽  
Archaeology Of Knowledge ◽  
Archaeological Analysis ◽  
Key Events ◽  
Underlying Processes

This study explored the underlying processes associated with the policy of increasing qualified physical education teachers (QPETs) in Singapore primary schools. Data were collected from the National Archives of Singapore, Newslink, NewpaperSG and documents. An ‘archaeological analysis’ by Foucault (1972) was used to trace the discursive conditions which enabled and facilitated the policy. Three distinct elements were borrowed from ‘The Archaeology of Knowledge and the Discourse on Language’, namely: the status – as reflected in the positions of individuals influencing the PE policies and initiatives; the institutional sites – as in the locations of the decisions being exercised, and; the situation – identified by the key events leading to the decision to increase QPETs in primary schools. The conclusions based on the analysis of these elements offer a clearer understanding of the various contributions to the adoption of the policy and serve to provide an insightful lens to policymakers who might seek to redesign the future shape of Physical Education.

Reform oder Papstwahl: das Konzil in der Zerreißprobe. Eine innerkonziliare Auseinandersetzung zwischen ‘Mehrheit’ und ‘Minderheit’ auf dem Konstanzer Konzil

2020 ◽  
Vol 49 (2) ◽  
pp. 281-308
Author(s):  
Ansgar Frenken
Keyword(s):  
Limited Extent ◽  
Long Time ◽  
Key Events ◽  
The Church ◽  
Broad Consensus ◽  
National Borders

Abstract Reform or Papal Election – the Council and its Ordeal: An Inner-Conciliar Dispute between ‘Majority’ and ‘Minority’ at the Council of Constance. The broad consensus that prevailed among the Fathers at the beginning of the Council of Constance gave way to a climate of tension, at the latest after the resurgence of the English-French conflict in mid-1415, which made the inner tensions among the participants of the Council more and more apparent. The front that arose between ‘majority’ and ‘minority’ only followed ‘national’ borders to a limited extent, and for a long time it had not been firmly established, hence shifts and overlaps were still possible. The arrival of the Spaniards – first the Aragonese, later the Castilians – and the outbreak of the conflict of nations can be interpreted as key events in this development, which led to the formation of the two blocs. The national tensions between the English and the French were overlaid by the question of how the Council should proceed further: to proceed to the election of a new Pope first or to prioritize the reform of the church. For a long time both sides were in balance, but after the Castilians’ accession to the Council in the summer of 1417, the situation changed rapidly. The predominance of a coalition of Cardinals, Italica, Gallicana and the Castilians grew, while the group assembled around Sigmund, Germanica, Anglicana and the Aragonese increasingly eroded and became a ‘minority’. A finally negotiated compromise, in which both sides were able to save face, rendered a successful conclusion of the council possible.

The Evaluation of Potential Skin Sensitization and Collagen Synthesis of Rats Receiving Proteoglycan Serum

2018 ◽  
Vol 14 (01) ◽  
pp. 1-4
Author(s):  
Wannara Chuenwattana ◽  
Wichai Chatthanawaree ◽  
Sitthiphon Bunman ◽  
Hiroshi Yoshikawa
Keyword(s):  
Collagen Synthesis ◽  
Skin Sensitization
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