scholarly journals Investigating the Microchannel Architectures Inside the Subchondral Bone in Relation to Estimated Hip Reaction Forces on the Human Femoral Head

2021 ◽  
Author(s):  
Shahed Taheri ◽  
Takashi Yoshida ◽  
Kai O. Böker ◽  
Robert H. Foerster ◽  
Lina Jochim ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Subchondral Bone ◽  
Regional Differences ◽  
Reaction Force ◽  
Joint Reaction Force ◽  
Load Bearing ◽  
Circularity Index ◽  
Reaction Forces ◽  
Healthy Cohort ◽  
Ct Data

AbstractThe interplay between articular cartilage (AC) and subchondral bone (SB) plays a pivotal role in cartilage homeostasis and functionality. As direct connective pathways between the two are poorly understood, we examined the location-dependent characteristics of the 3D microchannel network within the SB that connects the basal cartilage layer to the bone marrow (i.e. cartilage-bone marrow microchannel connectors; CMMC). 43 measuring points were defined on five human cadaveric femoral heads with no signs of osteoarthritis (OA) (age ≤ 60), and cartilage-bone cylinders with diameters of 2.00 mm were extracted for high-resolution scanning (n = 215). The micro-CT data were categorized into three groups (load-bearing region: LBR, n = 60; non-load-bearing region: NLBR, n = 60; and the peripheral rim: PR, n = 95) based on a gait analysis estimation of the joint reaction force (young, healthy cohort with no signs of OA). At the AC-SB interface, the number of CMMC in the LBR was 1.8 times and 2.2 times higher compared to the NLBR, and the PR, respectively. On the other hand, the median Feret size of the CMMC were smallest in the LBR (55.2 µm) and increased in the NLBR (73.5 µm; p = 0.043) and the PR (89.1 µm; p = 0.043). AC thickness was positively associated with SB thickness (Pearson's r = 0.48; p < 1e-13), CMMC number. (r = 0.46; p < 1e-11), and circularity index (r = 0.61; p < 1e-38). In conclusion, our data suggest that regional differences in the microchannel architecture of SB might reflect regional differences in loading.

Mechanism Analysis Using Implicit Constraints

2008 ◽  
Author(s):  
George H. Sutherland
Keyword(s):  
Equations Of Motion ◽  
Reaction Force ◽  
Mechanism Analysis ◽  
Kinematic Parameters ◽  
Joint Reaction Force ◽  
Dynamic Mechanisms ◽  
Joint Reaction Forces ◽  
Reaction Forces ◽  
Mechanism Kinematic ◽  
Joint Reaction

This paper introduces an approach to kinematic and dynamic mechanisms analysis where one or more joints are modeled using joint component relative displacements that approximate real joint behavior. This approach allows for the simultaneous nonrecursive solution for both mechanism kinematic parameters and selected dynamic joint reaction forces. Also, for closed loop mechanisms, the approach eliminates the need for forming explicit loop closure constraint equations, so that the dynamic equations of motion, derived using either the Newtonian or Lagrangian method, have a simplified unconstrained form. The key element underlying the approach is the formation of axioms for the standard mechanism joint types that describe the form of the joint reaction force and/or moment in terms of a virtual (or real) displacement between the joint components.

Are sound dogs mechanically symmetric at trot?

2008 ◽  
Vol 21 (03) ◽  
pp. 294-301 ◽  
Author(s):  
G. R. Colborne
Keyword(s):  
Hind Limb ◽  
Reaction Force ◽  
Joint Mechanics ◽  
Joint Reaction Force ◽  
Stifle Joint ◽  
Joint Reaction Forces ◽  
Reaction Forces ◽  
The Right ◽  
Vertical Joint ◽  
Joint Reaction

SummaryA two-year-old, sound Labrador Retriever was determined to be ’right hind limb dominant’ by comparison of total hind limb moments of support using inverse dynamics. Net joint moments at the hip, tarsal and metatarsophalangeal joints were larger on the right side. Vertical joint reaction forces at the stifle were larger on the right, and horizontal stifle joint reaction forces were smaller on the right. The crus segment was more cranially inclined on the right side through most of stance, but the angle of the resultant stifle joint reaction force vector against the long axis of the crus segment was identical between the right and left sides. The cranially inclined crus segment orientation on one side, coupled with the larger vertical joint reaction force, may result in an internal asymmetry in stifle joint mechanics, although the effects of this on cruciate ligament stresses remain to be determined.

Recovery of Joint Reaction Force for Real-Time Recursive Multibody Dynamics

1997 ◽  
Author(s):  
Fuh-Feng Tsai ◽  
Masoud Mirtaheri
Keyword(s):  
Parallel Algorithm ◽  
Multibody Dynamics ◽  
Lagrange Multipliers ◽  
Reaction Force ◽  
Joint Reaction Force ◽  
Component Design ◽  
Vehicle Component ◽  
Joint Reaction Forces ◽  
Reaction Forces ◽  
Joint Reaction

Abstract This paper proposes a formulation and parallel algorithm for the computation of all joint reaction forces in the recursive multibody dynamics. First, the Lagrange Multipliers associated with cut joints in each decoupled loop of a mechanical system are recovered. Then the joint reaction forces for the cut joints are computed directly using the obtained Lagrange Multipliers. After that, joint reaction forces associated with uncut joints are computed in backward computational paths, using synchronization in all junction nodes. A parallel algorithm for recovering reaction forces and torques for all cut joints and uncut joints is proposed. For validation, a space slider 3-D model is illustrated to compare the simulation results with those obtained from a commercial code DADS. Finally, A passenger car 14-body model is generated and simulated to obtain the joint reaction forces for the purpose of vehicle component design purpose.

scholarly journals Running ground reaction forces across footwear conditions are predicted from the motion of two body mass components

2019 ◽  
Vol 126 (5) ◽  
pp. 1315-1325 ◽  
Author(s):  
Andrew B. Udofa ◽  
Kenneth P. Clark ◽  
Laurence J. Ryan ◽  
Peter G. Weyand
Keyword(s):  
Ground Reaction Force ◽  
Lower Limb ◽  
Reaction Force ◽  
Ground Reaction Forces ◽  
Vertical Ground Reaction Force ◽  
Time Patterns ◽  
Foot Strike ◽  
Reaction Forces ◽  
Vertical Ground ◽  
Force Time

Although running shoes alter foot-ground reaction forces, particularly during impact, how they do so is incompletely understood. Here, we hypothesized that footwear effects on running ground reaction force-time patterns can be accurately predicted from the motion of two components of the body’s mass (mb): the contacting lower-limb (m1 = 0.08mb) and the remainder (m2 = 0.92mb). Simultaneous motion and vertical ground reaction force-time data were acquired at 1,000 Hz from eight uninstructed subjects running on a force-instrumented treadmill at 4.0 and 7.0 m/s under four footwear conditions: barefoot, minimal sole, thin sole, and thick sole. Vertical ground reaction force-time patterns were generated from the two-mass model using body mass and footfall-specific measures of contact time, aerial time, and lower-limb impact deceleration. Model force-time patterns generated using the empirical inputs acquired for each footfall matched the measured patterns closely across the four footwear conditions at both protocol speeds ( r2 = 0.96 ± 0.004; root mean squared error  = 0.17 ± 0.01 body-weight units; n = 275 total footfalls). Foot landing angles (θF) were inversely related to footwear thickness; more positive or plantar-flexed landing angles coincided with longer-impact durations and force-time patterns lacking distinct rising-edge force peaks. Our results support three conclusions: 1) running ground reaction force-time patterns across footwear conditions can be accurately predicted using our two-mass, two-impulse model, 2) impact forces, regardless of foot strike mechanics, can be accurately quantified from lower-limb motion and a fixed anatomical mass (0.08mb), and 3) runners maintain similar loading rates (ΔFvertical/Δtime) across footwear conditions by altering foot strike angle to regulate the duration of impact. NEW & NOTEWORTHY Here, we validate a two-mass, two-impulse model of running vertical ground reaction forces across four footwear thickness conditions (barefoot, minimal, thin, thick). Our model allows the impact portion of the impulse to be extracted from measured total ground reaction force-time patterns using motion data from the ankle. The gait adjustments observed across footwear conditions revealed that runners maintained similar loading rates across footwear conditions by altering foot strike angles to regulate the duration of impact.

scholarly journals Finite element modeling of multiple density materials of bone specimens for biomechanical behavior evaluation

2021 ◽  
Vol 3 (9) ◽  
Author(s):  
Sebastián Irarrázaval ◽  
Jorge Andrés Ramos-Grez ◽  
Luis Ignacio Pérez ◽  
Pablo Besa ◽  
Angélica Ibáñez
Keyword(s):  
Finite Elements ◽  
Computational Models ◽  
Reaction Force ◽  
Elastic Stiffness ◽  
Finite Elements Method ◽  
Mechanical Resistance ◽  
Assessment Procedure ◽  
Axial Tomography ◽  
Biomechanical Behavior ◽  
Ct Data

AbstractThe finite elements method allied with the computerized axial tomography (CT) is a mathematical modeling technique that allows constructing computational models for bone specimens from CT data. The objective of this work was to compare the experimental biomechanical behavior by three-point bending tests of porcine femur specimens with different types of computational models generated through the finite elements’ method and a multiple density materials assignation scheme. Using five femur specimens, 25 scenarios were created with differing quantities of materials. This latter was applied to computational models and in bone specimens subjected to failure. Among the three main highlights found, first, the results evidenced high precision in predicting experimental reaction force versus displacement in the models with larger number of assigned materials, with maximal results being an R2 of 0.99 and a minimum root-mean-square error of 3.29%. Secondly, measured and computed elastic stiffness values follow same trend with regard to specimen mass, and the latter underestimates stiffness values a 6% in average. Third and final highlight, this model can precisely and non-invasively assess bone tissue mechanical resistance based on subject-specific CT data, particularly if specimen deformation values at fracture are considered as part of the assessment procedure.

Ultrapurified Alginate Gel Containing Bone Marrow Aspirate Concentrate Enhances Cartilage and Bone Regeneration on Osteochondral Defects in a Rabbit Model

2021 ◽  
pp. 036354652110141
Author(s):  
Liang Xu ◽  
Atsushi Urita ◽  
Tomohiro Onodera ◽  
Ryosuke Hishimura ◽  
Takayuki Nonoyama ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Marrow ◽  
Cell Transplantation ◽  
Cartilage Repair ◽  
Subchondral Bone ◽  
Bone Repair ◽  
Bone Marrow Aspirate ◽  
Defect Group ◽  
The Other ◽  
Osteochondral Defects

Background: Ultrapurified alginate (UPAL) gel implantation has been demonstrated as effective in cartilage repair for osteochondral defects; however, cell transplantation within UPAL gels would be required to treat larger defects. Hypothesis: The combination of UPAL gel and bone marrow aspirate concentrate (BMAC) would enhance cartilage repair and subchondral bone repair for large osteochondral defects. Study Design: Controlled laboratory study. Methods: A total of 104 osteochondral defects (1 defect per knee) of 52 rabbits were randomly divided into 4 groups (26 defects per group): defects without any treatment (Defect group), defects treated using UPAL gel alone (UPAL group), defects treated using UPAL gel containing allogenic bone marrow mesenchymal stromal cells (UPAL-MSC group), and defects treated using UPAL gel containing BMAC (UPAL-BMAC group). At 4 and 16 weeks postoperatively, macroscopic and histologic evaluations and measurements of repaired subchondral bone volumes of reparative tissues were performed. Collagen orientation and mechanical properties of the reparative tissue were assessed at 16 weeks. Results: The defects in the UPAL-BMAC group were repaired with hyaline-like cartilage with well-organized collagen structures. The histologic scores at 4 weeks were significantly higher in the UPAL-BMAC group (16.9 ± 2.0) than in the Defect group (4.7 ± 1.9; P < .05), the UPAL group (10.0 ± 3.3; P < .05), and the UPAL-MSC group (12.2 ± 2.9; P < .05). At 16 weeks, the score in the UPAL-BMAC group (24.4 ± 1.7) was significantly higher than those in the Defect group (9.0 ± 3.7; P < .05), the UPAL group (14.2 ± 3.9; P < .05), and the UPAL-MSC group (16.3 ± 3.6; P < .05). At 4 and 16 weeks, the macroscopic evaluations were significantly superior in the UPAL-BMAC group compared with the other groups, and the values of repaired subchondral bone volumes in the UPAL-BMAC group were significantly higher than those in the Defect and UPAL groups. The mechanical properties of the reparative tissues were significantly better in the UPAL-BMAC group than in the other groups. Conclusion: The implantation of UPAL gel containing BMAC-enhanced hyaline-like cartilage repair and subchondral bone repair of osteochondral defects in a rabbit knee model. Clinical Relevance: These data support the potential clinical application of 1-step treatment for large osteochondral defects using biomaterial implantation with cell transplantation.

scholarly journals Ground Reaction Forces and Kinematics of Ski Jump Landing Using Wearable Sensors

Sensors ◽  
2019 ◽  
Vol 19 (9) ◽  
pp. 2011 ◽  
Author(s):  
Bessone ◽  
Petrat ◽  
Schwirtz
Keyword(s):  
Wearable Sensors ◽  
Reaction Force ◽  
Ground Reaction Forces ◽  
Inertial Motion ◽  
Jump Landing ◽  
The Past ◽  
Landing Biomechanics ◽  
Reaction Forces ◽  
The Hill ◽  
Kinematics And Kinetics

In the past, technological issues limited research focused on ski jump landing. Today, thanks to the development of wearable sensors, it is possible to analyze the biomechanics of athletes without interfering with their movements. The aims of this study were twofold. Firstly, the quantification of the kinetic magnitude during landing is performed using wireless force insoles while 22 athletes jumped during summer training on the hill. In the second part, the insoles were combined with inertial motion units (IMUs) to determine the possible correlation between kinematics and kinetics during landing. The maximal normal ground reaction force (GRFmax) ranged between 1.1 and 5.3 body weight per foot independently when landing using the telemark or parallel leg technique. The GRFmax and impulse were correlated with flying time (p < 0.001). The hip flexions/extensions and the knee and hip rotations of the telemark front leg correlated with GRFmax (r = 0.689, p = 0.040; r = −0.670, p = 0.048; r = 0.820, p = 0.007; respectively). The force insoles and their combination with IMUs resulted in promising setups to analyze landing biomechanics and to provide in-field feedback to the athletes, being quick to place and light, without limiting movement.

Modification of the contact area of a standard force platform and runway for small breed dogs

2014 ◽  
Vol 27 (04) ◽  
pp. 257-262 ◽  
Author(s):  
J. Y. W. Kim ◽  
T. C. Garcia-Nolan ◽  
S. Y. Kim ◽  
K. Hayashi ◽  
P. L. Hitchens ◽  
...  
Keyword(s):  
Reaction Force ◽  
Force Plate ◽  
Force Platform ◽  
Standard Size ◽  
Plate Size ◽  
Propulsion Force ◽  
In Series ◽  
Reaction Forces ◽  
Wood Frame ◽  
Clinically Significant

SummaryObjectives: To develop a platform that used standard size force plates for large breed dogs to capture ground reaction force data from any size dog.Methods: A walkway platform was constructed to accommodate two force plates (60 cm x 40 cm) positioned in series to a variety of smaller sizes. It was constructed from a custom wood frame with thick aluminium sheet force plate covers that prevented transfer of load to the force plate, except for rectangular windows of three different dimensions. A friction study was performed to ensure plates did not translate relative to one another during gait trials. A prospective, observational, single crossover study design was used to compare the effect of force platform configuration (full plate size [original plate], half plate size [modified plate]) on ground reaction forces using eight adult healthy Labrador Retriever dogs.Results: Slippage of the steel plate on the force plate did not occur. Peak propulsion force was the only kinetic variable statistically different between the full size and half sized platforms. There were no clinically significant differences between the full and half force platforms for the variables and dogs studied.Discussion and conclusion: The modified force platform allows the original 60 x 40 cm force plate to be adjusted effectively to a 30 x 40 cm, 20 x 40 cm and 15 x 40 cm sized plate with no clinically significant change in kinetic variables. This modification that worked for large breed dogs will potentially allow kinetic analysis of a large variety of dogs with different stride lengths.

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