scholarly journals Impact of Regular Physical Activity on Aortic Diameter Progression in Paediatric Patients with Bicuspid Aortic Valve

2021 ◽  
Author(s):  
Emanuele Monda ◽  
◽  
Adelaide Fusco ◽  
Alessandro Della Corte ◽  
Martina Caiazza ◽  
...  
Keyword(s):  
Physical Activity ◽  
Ascending Aorta ◽  
Regular Physical Activity ◽  
Aortic Diameter ◽  
Sinus Of Valsalva ◽  
Physically Active ◽  
The Impact ◽  
Aorta Diameter ◽  
Sedentary Subjects

AbstractPatients with bicuspid aortic valve (BAV) have an increased risk of aortic dilation and aortic dissection or rupture. The impact of physical training on the natural course of aortopathy in BAV patients remains unclear. The aim of this study was to evaluate the impact of regular physical activity on aortic diameters in a consecutive cohort of paediatric patients with BAV. Consecutive paediatric BAV patients were evaluated and categorized into two groups: physically active and sedentary subjects. Only the subjects with a complete 2-year follow-up were included in the study. To evaluate the potential impact of physical activity on aortic size, aortic diameters were measured at the sinus of Valsalva and mid-ascending aorta using echocardiography. We defined aortic diameter progression the increase of aortic diameter ≥ 10% from baseline. Among 90 BAV patients (11.5 ± 3.4 years of age, 77% males), 53 (59%) were physically active subjects. Compared to sedentary, physically active subjects were not significantly more likely to have > 10% increase in sinus of Valsalva (13% vs. 8%, p-value = 0.45) or mid-ascending aorta diameter (9% vs. 13%, p-value = 0.55) at 2 years follow-up, both in subjects with sinus of Valsalva diameter progression (3.7 ± 1.0 mm vs. 3.5 ± 0.8 mm, p-value = 0.67) and in those with ascending aorta diameter progression (3.0 ± 0.8 mm vs. 3.2 ± 1.3 mm, p-value = 0.83). In our paediatric cohort of BAV patients, the prevalence and the degree of aortic diameter progression was not significantly different between physically active and sedentary subjects, suggesting that aortic dilation is unrelated to regular physical activity over a 2-year period.

scholarly journals Is Exercise the Best Medicine during a COVID-19 Pandemic? Comment on Constandt, B.; Thibaut, E.; De Bosscher, V.; Scheerder, J.; Ricour, M.; Willem, A. Exercising in Times of Lockdown: An Analysis of the Impact of COVID-19 on Levels and Patterns of Exercise among Adults in Belgium. Int. J. Environ. Res. Public Health 2020, 17, 4144

2020 ◽  
Vol 17 (16) ◽  
pp. 5730
Author(s):  
Tamara Hew-Butler ◽  
Valerie Smith-Hale ◽  
Matthew Van Sumeren ◽  
Jordan Sabourin ◽  
Phillip Levy
Keyword(s):  
Public Health ◽  
Physical Activity ◽  
Physical Health ◽  
Regular Physical Activity ◽  
Intense Exercise ◽  
Social Distancing ◽  
Highly Active ◽  
The Impact ◽  
Mental And Physical Health

From Constandt et al.’s survey of 13,515 Belgium respondents, regular physical activity can be successfully initiated and sustained during a lockdown, with appropriate social distancing measures. Documentation that 77% of highly active people and 58% of low active people exercised as much or more following the institution of a nationwide lockdown was impressive, given that the cases of COVID-19 were accelerating at that time. The Belgian government’s central promotion of exercise, to boost both the mental and physical health of the population, likely contributed to the health, tolerance, and ultimate success of lockdown. In this commentary, we wish to pose a follow-up query which highlights the potential detrimental effects of intense exercise (competition) performed without social distancing measures. The proposed graphical abstract elucidates these possible risks, in contrast to the favorable results outlined in Constandt et al.’s study.

scholarly journals Regular Physical Activity Levels and Incidence of Restrictive Spirometry Pattern: A Longitudinal Analysis of 2 Population-Based Cohorts

2020 ◽  
Vol 189 (12) ◽  
pp. 1521-1528 ◽  
Author(s):  
Anne-Elie Carsin ◽  
Dirk Keidel ◽  
Elaine Fuertes ◽  
Medea Imboden ◽  
Joost Weyler ◽  
...  
Keyword(s):  
Physical Activity ◽  
Lower Risk ◽  
Heart Diseases ◽  
Population Based ◽  
Forced Expiratory Volume ◽  
Normal Weight ◽  
Regular Physical Activity ◽  
Activity Levels ◽  
Physically Active

Abstract We estimated the association between regular physical activity and the incidence of restrictive spirometry pattern. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and physical activity were assessed in 2 population-based European cohorts (European Community Respiratory Health Survey: n = 2,757, aged 39–67 years; and Swiss Study on Air Pollution and Lung and Heart Diseases in Adults: n = 2,610, aged 36–82 years) first in 2000–2002 and again approximately 10 years later (2010–2013). Subjects with restrictive or obstructive spirometry pattern at baseline were excluded. We assessed the association of being active at baseline (defined as being physically active at least 2–3 times/week for ≥1 hour) with restrictive spirometry pattern at follow-up (defined as a postbronchodilation FEV1/FVC ratio of at least the lower limit of normal and FVC of <80% predicted) using modified Poisson regression, adjusting for relevant confounders. After 10 years of follow-up, 3.3% of participants had developed restrictive spirometry pattern. Being physically active was associated with a lower risk of developing this phenotype (relative risk = 0.76, 95% confidence interval: 0.59, 0.98). This association was stronger among those who were overweight and obese than among those of normal weight (P for interaction = 0.06). In 2 large European studies, adults practicing regular physical activity were at lower risk of developing restrictive spirometry pattern over 10 years.

Abstract 2476: Regular Physical Activity Prevents the Development of Left Ventricular Hypertrophy in Young Stage 1 Hypertensive Subjects: Results of the Harvest Study

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Lucio Mos ◽  
Pier Alberto Visentin ◽  
Paolo Mormino ◽  
Francesca Dorigatti ◽  
Olga Vriz ◽  
...  
Keyword(s):  
Physical Activity ◽  
Ventricular Hypertrophy ◽  
Leisure Time ◽  
Left Ventricular ◽  
Regular Physical Activity ◽  
Competitive Sports ◽  
Physically Active ◽  
Young Stage ◽  
Stage 1

A beneficial effect of physical activity on left ventricular mass( LVM) in the short term has been described in hypertension. Aim of this study was to investigate the long-term effect of regular physical activity on development of left ventricular hypertrophy (LVH) in a cohort of young hypertensive subjects. We studied 454 participants (317 men, mean age 33±8 years) without LVH at baseline whose physical activity status was consistent throughout the follow-up. BP was 146±11/94±5 mm Hg at baseline and 141±/90±8 mmHg after 3 months of non-pharmacological measures. Subjects were divided into 3 categories of physical activity (sedentary, n=281;leisure-time activities, n=140; competitive sports, n=33). Patients were seen every six months until they developed hypertension. Echocardiographic LVM was measured at entry, every 5 years, and/or at the time of hypertension development. Active subjects were younger (31±8 versus 34±8 years, p=.000) and leaner (24.4±3.0 vs 25.2±3.7 Kg/m2, p=.006) than sedentary ones, and were more frequently male (45% versus 22%, p=.000). During a median follow-up of 8.2 years, 32 subjects(7.3%) developed LVH (sedentary=10.3%, leisure-time activities=2.1%, competitive sports= 0%, p=.002). In a logistic regression, physically active groups combined (n=173) were less likely to develop LVH than the sedentary group with a crude OR=0.16 (CI, 0.05– 0.55). After controlling for sex, age, family history for hypertension, body weight, smoking, alcohol and coffee use, blood pressure, LVM, and follow-up time, the OR was 0.22 (CI, 0.06 – 0.77). BP declined over time in physically active subjects (−5.1±17.0/−0.5±10.2 mmHg) and slightly increased in sedentary ones (0.0±15.3/0.9±9.7 mmHg, adjusted p versus active=0.04/0.06). Inclusion of changes in BP over time into the logistic model slightly decreased the strength of the association between physical activity status and LVH development (OR=0.24,CI, 0.07– 0.85). Regular physical activity prevents the development of LVH in young stage 1 hypertensive subjects. Leisure-time and competitive sports activities seem to have both a beneficial effect on LVM. This effect is only partially dependent on the reduction in BP caused by exercise.

scholarly journals Impact of an exercise programme on sustaining physical activity for recovering cancer patients: A qualitative study.

2016 ◽  
Vol 4 (1) ◽  
pp. 230
Author(s):  
Martyn Queen ◽  
Saul Bloxham ◽  
Phil Brown ◽  
Melissa Coyle ◽  
Ben Jane
Keyword(s):  
Physical Activity ◽  
Qualitative Study ◽  
Cancer Patients ◽  
Exercise Programme ◽  
Theory Approach ◽  
Physically Active ◽  
Physical Activity Programme ◽  
Number Of Patients ◽  
The Impact

Background Pedometers have been shown to improve adherence to exercise programmes. Evidence suggests that PA can improve physical function, wellbeing and reduce the negative impact of some cancer related side-effects. Yet, there are limited PA guidelines for cancer patients in the UK. The aim was to examine the impact of an 8-week exercise programme on sustaining physical activity (PA) at 3-month follow-up. Method A qualitative study with 12 mixed site cancer patients aged 43-70 (10 women, 2 men), involved in an 8-week exercise programme. The Programme took place at a University in the South West of England, UK. Semi-structured interviews with patients took place 3 times over 6 months. A grounded theory approach was used to analyse the data. Results We found that the number of patients perceived to be physically active prior to take-up of the physical activity programme were low (20%). At completion, most patients reported being physically active (84%), sustained but to a lesser extent (67%) at 3-month follow-up. Explanations for sustained PA at follow-up included application of knowledge gained from the Programme in relation to walking technique and use of pedometers and perceived health and fitness gains. Explanations for those not physically active included new diagnosis, reduced mobility following surgery and lack of clear exit route or progression to another structured opportunity. Conclusion Our study has provided valuable insight into how a supervised multi-modal physical activity programme can enable recovering cancer patients to develop a physically active lifestyle.

scholarly journals The Impact of sedentary behavior on health and the need for physical activity in children and adolescents

2018 ◽  
Vol 10 (1) ◽  
pp. 71 ◽  
Author(s):  
Mirela DAMIAN ◽  
Antoanela OLTEAN ◽  
Cosmin DAMIAN
Keyword(s):  
Physical Activity ◽  
Children And Adolescents ◽  
Sedentary Behavior ◽  
Healthy Lifestyle ◽  
Well Being ◽  
Regular Physical Activity ◽  
Physically Active ◽  
Important Health ◽  
Use Of The Internet ◽  
The Impact

Children and adolescents do not practice enough physical activity or have too much unbalanced nutrition, and the consequence of these unhealthy and bad habits is overweight that can lead to obesity, impairment of health and, implicitly, the quality of life.The objective of the study is to summarize the evidence of published literature on the impact of sedentary lifestyle on the health of children and adolescents, the benefits of regular physical activity, as well as recommendations for their correct performance.Results: All researched works combines regular physical activity with important health benefits. Children and adolescents aged 5-18 must be physically active for at least 60 minutes a day, with intense physical exercise being associated with the majority of authors with a better physical condition and well-being. The physical activity program should include exercises that address all fitness components: cardiorespiratory capacity, muscle strength / fitness, flexibility and body composition.Conclusions: Some action is needed to promote a healthy lifestyle and increase physical activity to at least 60 minutes a day, in order to reduce the sedentary behavior among children and adolescents due to excessive use of the Internet, social networks or audiovisual media. Implementation and support of programs to promote physical activity among them is necessary, given the increasing number of overweight and obese persons.

Cognitive Impairment and Physical Activity in Old Age: The Impact on All-Cause Mortality in a 15-Year Follow-Up of the Bambuí Cohort Study of Aging

2020 ◽  
Author(s):  
Erico Castro-Costa ◽  
Jerson Laks ◽  
Cecilia Godoi Campos ◽  
Josélia OA Firmo ◽  
Maria Fernanda Lima-Costa ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cohort Study ◽  
Cognitive Impairment ◽  
Old Age ◽  
All Cause Mortality ◽  
The Impact

scholarly journals POS1234 IMPACT OF THE CHANGE IN ADMINISTRATION ROUTE OF TOCILIZUMAB AND ABATACEPT, DUE TO THE COVID-19 LOCKDOWN ON DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 900.1-900
Author(s):  
L. Diebold ◽  
T. Wirth ◽  
V. Pradel ◽  
N. Balandraud ◽  
E. Fockens ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Physical Activity ◽  
Disease Activity ◽  
Univariate Analysis ◽  
Route Of Administration ◽  
Anxiety And Depression ◽  
Administration Route ◽  
Factors Associated ◽  
The Impact

Background:Among therapeutics used to treat rheumatoid arthritis (RA), Tocilizumab (TCZ) and Abatacept (ABA) are both biologic agents that can be delivered subcutaneously (SC) or intravenously (IV). During the first COVID-19 lockdown in France, all patients treated with IV TCZ or IV ABA were offered the option to switch to SC administration.Objectives:The primary aim was to assess the impact of changing the route of administration on the disease activity. The second aim was to assess whether the return to IV route at the patient’s request was associated with disease activity variation, flares, anxiety, depression and low physical activity during the lockdown.Methods:We conducted a prospective monocentric observational study. Eligibility criteria: Adult ≥ 18 years old, RA treated with IV TCZ or IV ABA with a stable dose ≥3 months, change in administration route (from IV to SC) between March 16, 2020, and April 17, 2020. The following data were collected at baseline and 6 months later (M6): demographics, RA characteristics, treatment, history of previous SC treatment, disease activity (DAS28), self-administered questionnaires on flares, RA life repercussions, physical activity, anxiety and depression (FLARE, RAID, Ricci &Gagnon, HAD).The primary outcome was the proportion of patients with a DAS28 variation>1.2 at M6. Analyses: Chi2-test for quantitative variables and Mann-Whitney test for qualitative variables. Factors associated with return to IV route identification was performed with univariate and multivariate analysis.Results:Among the 84 patients who were offered to switch their treatment route of administration, 13 refused to change their treatment. Among the 71 who switched (48 TCZ, 23 ABA), 58 had a M6 follow-up visit (13 lost of follow-up) and DAS28 was available for 49 patients at M6. Main baseline characteristics: female 81%, mean age 62.7, mean disease duration: 16.0, ACPA positive: 72.4%, mean DAS28: 2.01, previously treated with SC TCZ or ABA: 17%.At M6, the mean DAS28 variation was 0.18 ± 0.15. Ten (12.2%) patients had a DAS28 worsening>1.2 (ABA: 5/17 [29.4%] and TCZ: 5/32 [15.6%], p= 0.152) and 19 patients (32.8%) had a DAS28 worsening>0.6 (ABA: 11/17 [64.7%] and TCZ: 8/32 [25.0%], p= 0.007).At M6, 41 patients (77.4%) were back to IV route (26 TCZ, 15 ABA) at their request. The proportion of patients with a DAS28 worsening>1.2 and>0.6 in the groups return to IV versus SC maintenance were 22.5%, 42.5% versus 11.1% and 22.2% (p=0.4), respectively. The univariate analysis identified the following factors associated with the return to IV route: HAD depression score (12 vs 41, p=0.009), HAS anxiety score (12 vs 41, p=0.047) and corticosteroid use (70% vs 100%, p=0.021), in the SC maintenance vs return to IV, respectively.Conclusion:The change of administration route of TCZ and ABA during the first COVID-19 lockdown was infrequently associated with a worsening of RA disease. However, the great majority of the patients (77.4%) request to return to IV route, even without disease activity worsening. This nocebo effect was associated with higher anxiety and depression scores.Disclosure of Interests:None declared

scholarly journals Impact of Work and Recreational Physical Activity on Prediabetes Condition among U.S. Adults: NHANES 2015–2016

2021 ◽  
Vol 18 (4) ◽  
pp. 1378
Author(s):  
Lenin Pazmino ◽  
Wilmer Esparza ◽  
Arian Ramón Aladro-Gonzalvo ◽  
Edgar León
Keyword(s):  
Physical Activity ◽  
Protective Factor ◽  
Hemoglobin A1c ◽  
Physical Activities ◽  
Recreational Physical Activity ◽  
Physically Active ◽  
Hba1c Test ◽  
Health And Nutrition ◽  
The Impact

More minutes of physical activity (PA) accumulated during a day are associated with a lower risk of diabetes mellitus type 2. However, it is less known if distinct dimensions of PA can produce a different protective effect in the prevention of prediabetes. The aim of this study was to analyze the impact of work and recreational PA on prediabetes among U.S. adults during the period 2015–2016 using the National Health and Nutrition Examination Survey (NHANES) database. Individuals (n = 4481) with hemoglobin A1c (HbA1c) test values of 5.7% to 6.4% were included. A logistic regression multivariate-adjusted analysis was conducted to estimate the association between the odds ratios (ORs) and 95% confidence intervals (CIs) of prediabetes, with work and recreational PA. The prevalence of prediabetes among U.S. adults was lower in physically active individuals both at work (~24%) and recreational (~21%) physical activities compared to individuals who were not physically active (27 to 30%). Individuals lacking practice of recreational PA had a high risk of prediabetes (OR = 1.26, 95% CI: 1.080 to 1.466). PA may be a protective factor for prediabetes conditions depending on gender, age, ethnic group, waist circumference, and thyroid disease.

scholarly journals The Association between Physical Activity and Selected Parameters of Psychological Status and Dementia in Older Women

2021 ◽  
Vol 18 (14) ◽  
pp. 7549
Author(s):  
Angelika Cisek-Woźniak ◽  
Kinga Mruczyk ◽  
Rafał W. Wójciak
Keyword(s):  
Mental Health ◽  
Physical Activity ◽  
Cognitive Impairment ◽  
Cognitive Functioning ◽  
Cognitive Functions ◽  
Protective Factor ◽  
The Elderly ◽  
Regular Physical Activity ◽  
Psychological Status ◽  
The Impact

Physical activity has an unquestionable impact on broadly understood human health. One interesting issue related to this is the importance of movement on mental health and cognitive functioning. Research shows that regular physical activity improves the cognitive functioning of adults and people with mental disorders. Regular physical activity can be an important and powerful protective factor in cognitive impairment and dementia in the elderly, and exercise is an important non-pharmacological treatment for mild cognitive impairment or neurodegenerative diseases. This study aims to present the impact of physical activity on selected cognitive functions in physically active women over 60 years of age. The research was carried out in a group of 110 generally healthy women from the area of western Poland over 60 years of age, who were divided into four groups based on the intensity of their physical activity. A pedometer (sport watch) and a physical activity diary were used to measure physical activity. Body Mass Index was assessed. Selected cognitive functions were assessed using the MMSE test, motor and psychomotor skills were measured, and Luria’s auditory memory test and recall test, a clock drawing test, and a GDS test were performed. There were statistically significant relationships between the level of physical activity and the effectiveness of cognitive processes. These results show that about 5000 steps a day is enough to see a positive effect on the mental health and cognitive functioning of this group of the elderly population. The women had an average BMI of 28.1 ± 4.7. BMI, indicating an overweight condition (over 30 kg/m2), was observed in 31% of women. The results of this study lead the authors to conclude that physical activity positively influences cognitive function and can be recommended for all seniors who do not have other serious comorbidities that would prevent them from playing sports.

scholarly journals P181 Long-term improvement in axial spondyloarthritis clinical outcomes following 2-weeks of intensive education and rehabilitation: results from the Bath residential rehabilitation programme

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Rosie Barnett ◽  
Anita McGrogan ◽  
Matthew Young ◽  
Charlotte Cavill ◽  
Mandy Freeth ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Disease Activity ◽  
Axial Spondyloarthritis ◽  
Rehabilitation Programme ◽  
Spinal Mobility ◽  
The Impact

Abstract Background/Aims  Axial spondyloarthritis (axSpA) is a chronic rheumatic condition, characterised by inflammatory back pain - often associated with impaired function and mobility, sleep disturbance, fatigue, and reduced quality of life. Despite the vast advances in pharmacological treatments for axSpA over the last few decades, physical activity and rehabilitation remain vital for effective disease management. At the Royal National Hospital for Rheumatic Diseases in Bath (RNHRD), the 2-week inpatient axSpA rehabilitation programme has been integral to axSpA care since the 1970’s. Prior research has demonstrated significant short-term improvements in spinal mobility (BASMI), function (BASFI) and disease activity (BASDAI) following course attendance. However, the long-term outcomes are yet to be evaluated in this unique cohort. Methods  Since the early 1990’s, clinical measures of spinal mobility, function and disease activity have been routinely collected at the RNHRD at all clinical appointments through administration of the BASMI, BASFI and BASDAI, respectively. Dates of attending the axSpA course and standard clinical and treatment follow-up data were also collected. Multiple linear regression models were used to investigate the impact of course attendance on final reported BASMI, BASDAI and BASFI scores (final score=most recent). Length of follow-up was defined as time between first and last recorded BASMI. Results  Of the 203 patients within the Bath SPARC200 cohort, 77.8% (158/203) had attended at least one rehabilitation course throughout follow-up. 70.0% (140/203) of patients were male. The mean duration of follow-up was 13.5 years (range 0-35 years); 28.1% (57/203) of individuals with 20+ years of follow-up. Course attendance (yes versus no) significantly reduced final BASMI score by 0.84 (p = 0.001, 95%CI -1.31 to -0.37) and final BASDAI score by 0.74 (p = 0.018, 95%CI -1.34 to -0.13). Although course attendance reduced final BASFI by 0.45 (95%CI -1.17 to 0.28), this relationship did not reach significance (p = 0.225). Whilst minimally clinically important difference (MCID) is, to our knowledge, yet to be defined for BASMI, MCIDs were achieved long-term for both BASDAI and BASFI - defined by van der Heijde and colleagues in 2016 as 0.7 and 0.4 for BASDAI and BASFI, respectively. Conclusion  These results provide novel evidence to support the integral role of education, physical activity and rehabilitation in the management of axSpA. Future work should investigate additional outcomes of critical importance to patients and clinicians, such as fatigue, quality of life and work productivity. Furthermore, a greater understanding of the factors that confound these outcomes may provide insights into those patients who may most benefit from attending a 2-week rehabilitation course. In addition to facilitating identification of those patients who may require additional clinical support. Disclosure  R. Barnett: None. A. McGrogan: None. M. Young: None. C. Cavill: None. M. Freeth: None. R. Sengupta: Honoraria; Biogen, Celgene, AbbVie, Novartis, MSD. Grants/research support; Novartis, UCB.

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