Anthelmintic activity of pomegranate peel extract (Punica granatum) and synthetic anthelmintics against gastrointestinal nematodes in cattle, sheep, goats, and buffalos: in vivo study

Background: Funcionalized multi-walled carbon nanotubes (ox-MWCNTs) were used for the preparation of therapeutic nanoparticles for delivery of some bioactive compounds. Consequently, this work deals with the preparation of grafted MWCNTs with n-vinyl caprolactam in the presence of pomegranate peel extract (P. granatum), titanium dioxide (TiO2) and/or silver nanoparticeles and their toxic effects on male mice using in vivo biological examination (liver and kidney dysfunction biomarkers) and the histopathological analysis. Methods: P. granatum extract was immobilized onto functionalized MWCNTs using simple adsorption technique. Moreover, The prepared materials were analyzed by Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM). In vivo examination using liver and kidney dysfunction biomarkers was investigated. In addition, the histopathological study was carried out. Results: The ox-MWCNTs induced significant elevation in the liver enzymes including AST, ALT and ALP relative to the control group. While, the treatment with P. granatum extract only did not induce any change in the liver and kidney biomarkers. In other words, P. granatum extract loaded onto functionalized MWCNTs showed low effects on liver enzymes and kidney function biomarkers in the treated mice in comparison with ox-MWCNTs and extract separately. Moreover, histopathological analysis revealed that the P. granatum extract functionalized MWCNTs exhibited normal renal tissue with no histopathological alteration. Conclusion: The grafted MWCNTs with n-vinyl caprolactam in the presence of pomegranate peel extract (P. granatum), titanium dioxide (TiO2) and/or silver nanoparticeles were successfully prepared. SEM-micrographs showed complete coating of MWCNTs fiber with the extract. The prepared materials resulted in no toxic effects and the histopathological findings were confirmed by inflammation of the liver and kidney tissues.

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An aqueous pomegranate peel extract (Punica granatum) protect against Elastase-induced pulmonary emphysema in Sprague Dawley rats model

Brazilian Journal of Pharmaceutical Sciences ◽

10.1590/s2175-97902020000418972 ◽

2021 ◽

Vol 57 ◽

Author(s):

Zioud Fatma ◽

Martín-Barrasa Jose Luis ◽

Espinosa De Los Monteros Y Zaya Antonio ◽

Santana Reyes Laura ◽

Herráez Thomas Pherraez ◽

...

Keyword(s):

Pulmonary Emphysema ◽

Punica Granatum ◽

Sprague Dawley ◽

Pomegranate Peel ◽

Sprague Dawley Rats ◽

Pomegranate Peel Extract ◽

Peel Extract

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Antimicrobial Activity of Pomegranate (Punica granatum L.) Peel Extract, Physical, Mechanical, Barrier and Antimicrobial Properties of Pomegranate Peel Extract-incorporated Sodium Caseinate Film and Application in Packaging for Ground Beef

Packaging Technology and Science ◽

10.1002/pts.2145 ◽

2015 ◽

Vol 28 (10) ◽

pp. 869-881 ◽

Cited By ~ 25

Author(s):

Zahra Emam-Djomeh ◽

Arezoo Moghaddam ◽

Seyed Ali Yasini Ardakani

Keyword(s):

Antimicrobial Activity ◽

Antimicrobial Properties ◽

Ground Beef ◽

Sodium Caseinate ◽

Punica Granatum ◽

Pomegranate Peel ◽

Pomegranate Peel Extract ◽

Punica Granatum L ◽

Peel Extract ◽

Mechanical Barrier

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Krim ekstrak kulit delima merah (Punica granatum) menghambat peningkatan jumlah melanin sama efektifnya dengan krim hidrokuinon pada kulit marmut (Cavia porcellus) betina yang dipapar sinar UVB

JURNAL BIOMEDIK (JBM) ◽

10.35790/jbm.9.1.2017.15313 ◽

2017 ◽

Vol 9 (1) ◽

Author(s):

Eva R. Siahaan ◽

Wimpie Pangkahila ◽

A A G P Wiraguna

Keyword(s):

Guinea Pigs ◽

Punica Granatum ◽

Control Group ◽

Cavia Porcellus ◽

Pomegranate Peel ◽

Significant Difference ◽

Group 3 ◽

Group 2 ◽

Pomegranate Peel Extract ◽

Peel Extract

Abstract: As the outer organ of the body, skin becomes the main target of environmental influences, particularly the UVB rays. Based on analysis of phytochemicals, red pomegranate peel extract contains antioxidants such as flavonoids, phenols, tannins, and vitamin C which are able to prevent increased skin melanin by inhibiting the actions of tyrosinase. This study was aimed to prove that application of 8% red pomegranate peel extract (Punica granatum) cream could prevent the increase of skin melanin in female guinea pigs (Cavia porcellus) exposed to UVB as well as to prove that the 8% red pomegranate peel extract cream was as effective as 4% hydroquinone cream in preventing increased skin melanin. This was a true experimental study using post test only control group design. Subjects were divided into three groups, with 10 guinea pigs each group. Group 1, the control group, was treated with UVB exposure and basic cream. Group 2 was treated with UVB exposure and 4% hydroquinone cream. Group 3 was treated with UVB and 8% red pomegranate peel extract cream. A total of 390 mJ/cm UVB dosage was given for 2 weeks. Histopahtologic slides were stained with Masson-Fontana. The amount of melanin area colored in black was evaluated by the percentage of pixel areas of melanin compared with pixel areas of all epidermal tissues. The results showed that the highest amount of melanin was in group 1 (18.13±4.76%), followed by group 3 (1.876±0.73%), and group 2 as the lowest (0.67±0.291%). There was a significant difference between control group and group 2 as s well as group 3 (P <0.05). There was no significant difference between group 2 and group 3 (P >0.05). Conclusion: Application of 8% red pomegranate peel extract (Punica granatum) cream could prevent the increase of skin melanin in guinea pigs (Cavia porcellus) exposed to UVB. The 8% red pomegranate peel extract cream was as effective as 4% hydroquinone cream in preventing increased skin melanin.Keywords: red pomegranate peel extract, melanin, skin, UVBAbstrak: Sebagai organ terluar dari tubuh, kulit menjadi target utama dari pengaruh lingkungan, terutama oleh sinar UVB. Berdasarkan analisis fitokimia, ekstrak kulit delima merah memiliki kandungan antioksidan seperti flavonoid fenol, tanin, dan vitamin C yang mampu mencegah peningkatan jumlah melanin dengan cara menghambat kerja enzim tirosinase. Penelitian ini bertujuan untuk membuktikan efek pemberian krim ekstrak kulit delima merah (Punica granatum) 8% dalam menghambat peningkatan jumlah melanin pada kulit marmut (Cavia porcellus) betina yang dipapar sinar UVB dan krim ekstrak kulit delima merah (Punica granatum) 8% memiliki efektivitas yang sama dengan krim hidrokuinon 4% dalam menghambat peningkatan jumlah melanin tersebut. Jenis penelitian ialah eksperimental murni dengan post test only control group design. Subyek penelitian dibagi menjadi tiga kelompok, masing-masing berjumlah 10 ekor marmut betina. Kelompok 1 (kontrol) diberikan pajanan sinar UVB dan krim dasar; kelompok 2 diberikan paparan sinar UVB dan krim hidrokuinon 4%; dan kelompok 3diberikan pajanan sinar UVB dan krim ekstrak kulit delima merah 8%. Dosis total UVB 390 mJ/cm2 yang diberikan selama 2 minggu. Sediaan histopatologik jaringan kulit menggunakan pewarnaan Masson-Fontana. Jumlah melanin dihitung dengan persentase pixel luas area melanin dibandingkan pixel seluruh jaringan epidermis. Hasil penelitian menunjukkan bahwa jumlah melanin paling tinggi terdapat pada kelompok 1 (18,13±4,76%), diikuti kelompok 3 (1,876±0,73%), dan paling rendah pada kelompok 2 (0,67±0,291%). Terdapat perbedaan bermakna antara kelompok 1 dengan kelompok 2 dan 3 (P <0,05) sedangkan antara kelompok 2 dan 3 tidak berbeda bermakna dalam mencegah peningkatan jumlah melanin (P >0,05). Simpulan: Krim ekstrak kulit delima merah (Punica granatum) 8% dapat menghambat peningkatan jumlah melanin pada kulit marmut (Cavia porcellus) betina. Krim ekstrak kulit delima merah (Punica granatum) 8% sama efektif dengan krim hidrokuinon 4% dalam menghambat peningkatan jumlah melanin pada kulit marmut.Kata kunci: kulit delima merah, melanin, kulit, UVB, marmut betina.

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Pengaruh Polivinilpirolidon sebagai Polimer Mukoadhesif terhadap Sifat Fisik Patch Ekstrak Kulit Buah Delima (Punica granatum L.)

Lumbung Farmasi: Jurnal Ilmu Kefarmasian ◽

10.31764/lf.v1i2.2727 ◽

2020 ◽

Vol 1 (2) ◽

pp. 85

Author(s):

Rahmat A Hi Wahid

Keyword(s):

Active Substance ◽

Contact Time ◽

Punica Granatum ◽

Dosage Forms ◽

Pomegranate Peel ◽

Mucoadhesive Polymer ◽

Evaluation Test ◽

Pomegranate Peel Extract ◽

Punica Granatum L ◽

Peel Extract

ABSTRAKBuah delima (Punica granatum L.) secara empiris digunakan untuk mengobati masalah gigi dan mulut seperti sariawan. Pengembangan obat sariawan berbasis herbal dengan bentuk sediaan patch dilakukan untuk mempertahankan waktu kontak antara zat aktif dengan bagian sariawan. Polivinilpirolidon (PVP) digunakan sebagai polimer karena sifatnya mukoadhesif sehingga mampu berikatan pada mukosa mulut. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan PVP sebagai polimer mukoadhesif terhadap karakteristik fisik sediaan patch yang mengandung ekstrak kulit buah delima (EKBD). EKBD diperoleh dengan metode maserasi. Konsentrasi EKBD yang digunakan adalah 5% dan 10%. Sedangkan konsentrasi polimer PVP yang digunakan yaitu 30,29%, 33,04, 48,75%, dan 65,5%. Patch selanjutnya akan di evaluasi fisik yang meliputi keseragaman bobot dan dimensi ketebalan, pH permukaan, swelling, daya lekat, dan waktu lekat. Hasil menunjukkan bahwa patch yang mengandung ekstrak 10% dengan tambahan polimer konsentrasi 30,29% memiliki sifat yang cukup elastis disbanding dengan konsentrasi 48,75% dan 65,5%. Sedangkan uji evaluasi fisik menghasilkan keseragaman bobot dan dimensi yang seragam, pH 6,63, rata-rata indeks swelling 40,69% ± 16, dan rata-rata daya dan waktu lekat 13,50 ± 11,6. Dengan demikian dapat disimpulkan bahwa konsentrasi PVP terbukti berpengaruh pada sifat fisik patch yang dihasilkan. Kata kunci : Polivinilpirolidon; Ekstrak Kulit Buah Delima; Patch.ABSTRACTPomegranate (Punica granatum L.) is empirically used to treat dental and mouth problems such as reccurent aphthous stomatitis (RAS). The development of RAS therapy based on herbal with patches dosage forms is carried out to maintain the contact time between the active substance and the RAS. Polyvinylpyrrolidone (PVP) is used as a polymer because it is mucoadhesive, so it can bind to the oral mucosa. Aimed to determine the effect of the use of PVP as a mucoadhesive polymer on the physical characteristics of patches preparations containing pomegranate peel extract (PPE). PPE was obtained by maceration method. The PPE concentration used were 5% and 10%. PVP concentration used were 30.29%, 33.04%, 48.75%, and 65.5%. The patches properties such as uniformity of thickness, pH, swelling index, tensile and mucoadhesive strength. The results showed that patches containing 10% extract and PVP concentration of 30.29% had sufficient elastic properties compared to both concentration. While the physical evaluation test obtained uniform weights and dimensions that are uniform, pH 6.63, the average swelling index is 40.69% ± 16, and the tensile and mucoadhesive strength is 13.50 ± 11.6. Altogether, the concentration of PVP is proven to affect the physical properties of the resulting patch.Key word : Polyvinylpyrrolidone; Pomegranate Peel Extract; Patch.

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Effect of Sweet Orange and Pomegranate Peel Extract Combination on in Vivo Antidiabetic and Wound Healing Activity

Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021) ◽

10.2991/ahsr.k.210723.013 ◽

2021 ◽

Author(s):

Evi Sovia ◽

Rini Sundari Harjono ◽

R. J. Nurjatin ◽

Wisna Dirgahasari Asmara ◽

Aktiva Syifaaur Rohmah

Keyword(s):

Wound Healing ◽

Sweet Orange ◽

Pomegranate Peel ◽

Pomegranate Peel Extract ◽

Peel Extract ◽

Wound Healing Activity

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Anthelmintic activity of crude powder and crude aqueous extract of Trachyspermum ammi on gastrointestinal nematodes in donkey (Equus asinus): An in vivo study

Journal of Ethnopharmacology ◽

10.1016/j.jep.2019.112249 ◽

2020 ◽

Vol 248 ◽

pp. 112249 ◽

Cited By ~ 4

Author(s):

Abbas Imani-Baran ◽

Jalal Abdollahi ◽

Hamid Akbari ◽

Saeed Jafarirad ◽

Sajjad Moharramnejad

Keyword(s):

Aqueous Extract ◽

Anthelmintic Activity ◽

Gastrointestinal Nematodes ◽

In Vivo Study ◽

Equus Asinus ◽

Trachyspermum Ammi ◽

Crude Aqueous Extract ◽

Crude Powder

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Pomegranate (Punica granatum) Peel Extract as a Green Corrosion Inhibitor for Mild Steel in Hydrochloric Acid Solution

International Journal of Corrosion ◽

10.1155/2015/197587 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Habib Ashassi-Sorkhabi ◽

Shoja Mirzaee ◽

Taghi Rostamikia ◽

Robabeh Bagheri

Keyword(s):

Hydrochloric Acid ◽

Mild Steel ◽

Corrosion Inhibitor ◽

Chemical Compounds ◽

Punica Granatum ◽

Pomegranate Peel ◽

Inhibition Performance ◽

Pomegranate Peel Extract ◽

Peel Extract ◽

Hcl Solution

The inhibition effect of pomegranate peel extract (PPE) on the corrosion of mild steel in hydrochloric acid (HCl) solution was investigated. The polarization, mass loss, and electrochemical impendence techniques were used to evaluate the corrosion inhibition performance of the pomegranate peel extract. The results revealed that PPE acts as a corrosion inhibitor in HCl solution. The inhibition efficiency increased with the increase of extract concentration. The inhibition action was attributed to the adsorption of the chemical compounds present in the extract solution, on mild steel surface.

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