scholarly journals Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts

2019 ◽  
Vol 19 (2) ◽  
pp. 713-722 ◽  
Author(s):  
Sjeng Quicken ◽  
Yeshi de Bruin ◽  
Barend Mees ◽  
Jan Tordoir ◽  
Tammo Delhaas ◽  
...  
Keyword(s):  
Mechanical Loading ◽  
Mechanical Performance ◽  
Computational Study ◽  
Neointimal Hyperplasia ◽  
Von Mises Stress ◽  
Patient Specific ◽  
Eptfe Graft ◽  
Flow Disturbances ◽  
Highly Oscillatory ◽  
Von Mises

Abstract Compliance mismatch between an arteriovenous dialysis graft (AVG) and the connected vein is believed to result in disturbed haemodynamics around the graft–vein anastomosis and increased mechanical loading of the vein. Both phenomena are associated with neointimal hyperplasia development, which is the main reason for AVG patency loss. In this study, we use a patient-specific fluid structure interaction AVG model to assess whether AVG haemodynamics and mechanical loading can be optimised by using novel electrospun polyurethane (ePU) grafts, since their compliance can be better tuned to match that of the native veins, compared to gold standard, expanded polytetrafluoroethylene (ePTFE) grafts. It was observed that the magnitude of flow disturbances in the vein and the size of anastomotic areas exposed to highly oscillatory shear ($$\hbox {OSI} >0.25$$OSI>0.25) and very high wall shear stress ($$>40 \hbox { Pa}$$>40Pa) were largest for the ePTFE graft. Median strain and von Mises stress in the vein were similar for both graft types, whereas highest stress and strain were observed in the anastomosis of the ePU graft. Since haemodynamics were most favourable for the ePU graft simulation, AVG longevity might be improved by the use of ePU grafts.

scholarly journals Effects of intracorneal ring segments implementation technique and design on corneal biomechanics and keratometry in a personalized computational analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Niksa Mohammadi Bagheri ◽  
Mahmoud Kadkhodaei ◽  
Shiva Pirhadi ◽  
Peiman Mosaddegh
Keyword(s):  
Clinical Data ◽  
Three Dimensional ◽  
Element Model ◽  
Von Mises Stress ◽  
Patient Specific ◽  
Average Error ◽  
Constant Thickness ◽  
Arc Length ◽  
Implementation Techniques ◽  
Von Mises

AbstractThe implementation of intracorneal ring segments (ICRS) is one of the successfully applied refractive operations for the treatment of keratoconus (kc) progression. The different selection of ICRS types along with the surgical implementation techniques can significantly affect surgical outcomes. Thus, this study aimed to investigate the influence of ICRS implementation techniques and design on the postoperative biomechanical state and keratometry results. The clinical data of three patients with different stages and patterns of keratoconus were assessed to develop a three-dimensional (3D) patient-specific finite-element model (FEM) of the keratoconic cornea. For each patient, the exact surgery procedure definitions were interpreted in the step-by-step FEM. Then, seven surgical scenarios, including different ICRS designs (complete and incomplete segment), with two surgical implementation methods (tunnel incision and lamellar pocket cut), were simulated. The pre- and postoperative predicted results of FEM were validated with the corresponding clinical data. For the pre- and postoperative results, the average error of 0.4% and 3.7% for the mean keratometry value ($$\text {K}_{\text{mean}}$$ K mean ) were predicted. Furthermore, the difference in induced flattening effects was negligible for three ICRS types (KeraRing segment with arc-length of 355, 320, and two separate 160) of equal thickness. In contrast, the single and double progressive thickness of KeraRing 160 caused a significantly lower flattening effect compared to the same type with constant thickness. The observations indicated that the greater the segment thickness and arc-length, the lower the induced mean keratometry values. While the application of the tunnel incision method resulted in a lower $$\text {K}_{\text{mean}}$$ K mean value for moderate and advanced KC, the induced maximum Von Mises stress on the postoperative cornea exceeded the induced maximum stress on the cornea more than two to five times compared to the pocket incision and the preoperative state of the cornea. In particular, an asymmetric regional Von Mises stress on the corneal surface was generated with a progressive ICRS thickness. These findings could be an early biomechanical sign for a later corneal instability and ICRS migration. The developed methodology provided a platform to personalize ICRS refractive surgery with regard to the patient’s keratoconus stage in order to facilitate the efficiency and biomechanical stability of the surgery.

scholarly journals Evaluation of Bone–Implant Interface Stress and Strain Using Heterogeneous Mandibular Bone Properties Based on Different Empirical Correlations

2021 ◽  
Author(s):  
Mostafa Omran Hussein ◽  
Mohammed Suliman Alruthea
Keyword(s):  
Finite Element ◽  
Group Iv ◽  
Von Mises Stress ◽  
Patient Specific ◽  
Dental Arch ◽  
Stress And Strain ◽  
Bone Implant ◽  
Bone Properties ◽  
Group I ◽  
Von Mises

Abstract Objective The purpose of this study was to compare methods used for calculating heterogeneous patient-specific bone properties used in finite element analysis (FEA), in the field of implant dentistry, with the method based on homogenous bone properties. Materials and Methods In this study, three-dimensional (3D) computed tomography data of an edentulous patient were processed to create a finite element model, and five identical 3D implant models were created and distributed throughout the dental arch. Based on the calculation methods used for bone material assignment, four groups—groups I to IV—were defined. Groups I to III relied on heterogeneous bone property assignment based on different equations, whereas group IV relied on homogenous bone properties. Finally, 150 N vertical and 60-degree-inclined forces were applied at the top of the implant abutments to calculate the von Mises stress and strain. Results Groups I and II presented the highest stress and strain values, respectively. Based on the implant location, differences were observed between the stress values of group I, II, and III compared with group IV; however, no clear order was noted. Accordingly, variable von Mises stress and strain reactions at the bone–implant interface were observed among the heterogeneous bone property groups when compared with the homogenous property group results at the same implant positions. Conclusion Although the use of heterogeneous bone properties as material assignments in FEA studies seem promising for patient-specific analysis, the variations between their results raise doubts about their reliability. The results were influenced by implants’ locations leading to misleading clinical simulations.

scholarly journals Mechanical Strength Study of a Cranial Implant Using Computational Tools

2022 ◽  
Vol 12 (2) ◽  
pp. 878
Author(s):  
Pedro O. Santos ◽  
Gustavo P. Carmo ◽  
Ricardo J. Alves de Sousa ◽  
Fábio A. O. Fernandes ◽  
Mariusz Ptak
Keyword(s):  
Structural Integrity ◽  
Mechanical Performance ◽  
Skull Fracture ◽  
Human Head ◽  
Element Model ◽  
Von Mises Stress ◽  
Cranial Implant ◽  
Von Mises ◽  
Two Parameters ◽  
The Brain

The human head is sometimes subjected to impact loads that lead to skull fracture or other injuries that require the removal of part of the skull, which is called craniectomy. Consequently, the removed portion is replaced using autologous bone or alloplastic material. The aim of this work is to develop a cranial implant to fulfil a defect created on the skull and then study its mechanical performance by integrating it on a human head finite element model. The material chosen for the implant was PEEK, a thermoplastic polymer that has been recently used in cranioplasty. A6 numerical model head coupled with an implant was subjected to analysis to evaluate two parameters: the number of fixation screws that enhance the performance and ensure the structural integrity of the implant, and the implant’s capacity to protect the brain compared to the integral skull. The main findings point to the fact that, among all tested configurations of screws, the model with eight screws presents better performance when considering the von Mises stress field and the displacement field on the interface between the implant and the skull. Additionally, under the specific analyzed conditions, it is observable that the model with the implant offers more efficient brain protection when compared with the model with the integral skull.

Altered Load Transfer in the Pelvis in the Presence of Periprosthetic Osteolysis

2014 ◽  
Vol 136 (11) ◽  
Author(s):  
Jacob T. Munro ◽  
Justin W. Fernandez ◽  
James S. Millar ◽  
Cameron G. Walker ◽  
Donald W. Howie ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Load Transfer ◽  
Von Mises Stress ◽  
Patient Specific ◽  
Fe Model ◽  
Stress Concentrations ◽  
Periprosthetic Osteolysis ◽  
Total Hip ◽  
Long Term Follow Up ◽  
Von Mises

Periprosthetic osteolysis in the retroacetabular region with cancellous bone loss is a recognized phenomenon in the long-term follow-up of total hip replacement. The effects on load transfer in the presence of defects are less well known. A validated, patient-specific, 3D finite element (FE) model of the pelvis was used to assess changes in load transfer associated with periprosthetic osteolysis adjacent to a cementless total hip arthroplasty (THA) component. The presence of a cancellous defect significantly increased (p < 0.05) von Mises stress in the cortical bone of the pelvis during walking and a fall onto the side. At loads consistent with single leg stance, this was still less than the predicted yield stress for cortical bone. During higher loads associated with a fall onto the side, highest stress concentrations occurred in the superior and inferior pubic rami and in the anterior column of the acetabulum with larger cancellous defects.

scholarly journals Numerical investigation of stent designs for wireless access to integrated sensors

2019 ◽  
Vol 5 (1) ◽  
pp. 497-499
Author(s):  
Swen Großmann ◽  
Robert Ott ◽  
Richard Kosub ◽  
Klaus-Peter Schmitz ◽  
Stefan Siewert ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Mechanical Performance ◽  
Short Circuit ◽  
Pressure Sensors ◽  
Wireless Access ◽  
Von Mises Stress ◽  
Stent Design ◽  
Resonance Frequencies ◽  
Von Mises

AbstractIn recent years, a progressive interest in the implementation of wireless access to cardiovascular implants has been established. This manifests in new devices, such as arterial pressure sensors, or additional functionalities added to established implants like stents. However, common stent designs, possessing highly optimized mechanical properties, often consist of cylindrically arranged struts with connections in-between which can be considered as short-circuited inductive coils. As a consequence, the small inductance raises the resonance frequency, which may decrease the in vivo performance of the wireless connection between the stent and the external readout device. Thus, new designs were developed to overcome this limitation, for example by avoiding the short-circuit due to a helical arrangement of the struts. Within this work we compare the performance of a common stent design and a helical design by means of numerical simulations. We are using two designs which only differ in the arrangement of the struts. The electromagnetic and mechanical properties are investigated using a finitedifference time-domain algorithm and finite element method, respectively. We will show that a common stent design exhibits resonance frequencies in the gigahertz regime, much higher than the frequencies of comparable helical designs. Furthermore, we compare the mechanical performance of the two designs and reveal individual distinctions in the radial stiffness, bending stiffness, and the von Mises stress.

Numerical Investigations of the Long Blade Performance Using RANS Solution and FEA Method Coupled With One-Way and Two-Way Fluid-Structure Interaction Models

2017 ◽  
Author(s):  
Minyan Yin ◽  
Jun Li ◽  
Liming Song ◽  
Zhenping Feng
Keyword(s):  
Rotor Blade ◽  
Mechanical Performance ◽  
Fluid Structure Interaction ◽  
Interaction Model ◽  
Leading Edge ◽  
Von Mises Stress ◽  
Maximum Displacement ◽  
Fluid Structure ◽  
Structure Interaction ◽  
Von Mises

The aerodynamic and mechanical performance of the last stage was numerically investigated using three-dimensional Reynolds-Averaged Navier-Stokes (RANS) solution and Finite Element Analysis (FEA) coupled with the one-way and two-way fluid-structure interaction models in this work. The part-span damping snubber and tip damping shroud of the rotor blade and aerodynamic pressure on rotor blade mechanical performance was considered in the one-way model. The two-way fluid-structure interaction model coupled with the mesh deformation technology was conducted to analyze the aerodynamic and mechanical performance of the last stage rotor blade. One-way fluid-structure interaction model numerical results show that the location of nodal maximum displacement moves from leading edge of 85% blade span to the trailing edge of 85% blade span. The position of nodal maximum Von Mises stress is still located at the first tooth upper surface near the leading edge at the blade root of pressure side. The two-way fluid-structure interaction model results show that the variation of static pressure distribution on long blade surface is mostly concentrated at upper region, absolute outflow angle of long blade between the 40% span and 95% span reduces, the location of nodal maximum displacement appears at the trailing edge of 85% blade span. Furthermore, the position of nodal maximum Von Mises stress remains the same and the value decreases compared to the oneway fluid-structure model results.

Trans-Thrombus Blood Pressure Effects in Abdominal Aortic Aneurysms

2010 ◽  
Vol 132 (7) ◽  
Author(s):  
Clark A. Meyer ◽  
Carine Guivier-Curien ◽  
James E. Moore
Keyword(s):  
Wall Stress ◽  
Aortic Aneurysms ◽  
Pressure Effects ◽  
Von Mises Stress ◽  
Patient Specific ◽  
Aneurysm Wall ◽  
Abdominal Aortic ◽  
Histopathological Studies ◽  
Von Mises ◽  
Von Mises Stresses

How much and how the thrombus supports the wall of an abdominal aortic aneurysm (AAA) is unclear. While some previous studies have indicated that thrombus lacks the mechanical integrity to support much load compared with the aneurysm wall, others have shown that removing thrombus in computational AAA models drastically changes aneurysm wall stress. Histopathological studies have shown that thrombus properties vary through the thickness and it can be porous. The goal of this study is to explore the variations in thrombus properties, including the ability to isolate pressure from the aneurysm wall, incomplete attachment, and their effects on aneurysm wall stress, an important parameter in determining risk for rupture. An analytical model comprised of cylinders and two patient specific models were constructed with pressurization boundary conditions applied at the lumen or the thrombus/aneurysm wall interface (to simulate complete transmission of pressure through porous thrombus). Aneurysm wall stress was also calculated in the absence of thrombus. The potential importance of partial thrombus attachment was also analyzed. Pressurizing at either surface (lumen versus interface) made little difference to mean von Mises aneurysm wall stress values with thrombus completely attached (3.1% analytic, 1.2% patient specific) while thrombus presence reduced mean von Mises stress considerably (79% analytic, 40–46% patient specific) in comparison to models without it. Peak von Mises stresses were similarly influenced with pressurization surface differing slightly (3.1% analytic, 1.4% patient specific) and reductions in stress by thrombus presence (80% analytic, 28–37% patient specific). The case of partial thrombus attachment was investigated using a cylindrical model in which there was no attachment between the thrombus and aneurysm wall in a small area (10 deg). Applying pressure at the lumen resulted in a similar stress field to fully attached thrombus, whereas applying pressure at the interface resulted in a 42% increase in peak aneurysm wall stress. Taken together, these results show that the thrombus can have a wall stress reducing role even if it does not shield the aneurysm wall from direct pressurization—as long as the thrombus is fully attached to the aneurysm wall. Furthermore, the potential for porous thrombus to transmit pressure to the interface can result in a considerable increase in aneurysm wall stress in cases of partial attachment. In the search for models capable of accurately assessing the risk for rupture, the nature of the thrombus and its attachment to the aneurysm wall must be carefully assessed.

Dynamic Analysis of Three Types of Bioprosthetic Heart Valves

2011 ◽  
Vol 71-78 ◽  
pp. 2683-2688
Author(s):  
Xin Ye ◽  
Quan Yuan ◽  
Hua Cong ◽  
Hai Bo Ma ◽  
Dong Liang Wei
Keyword(s):  
Stress Distribution ◽  
Heart Valve ◽  
Computer Aided Design ◽  
Heart Valves ◽  
Mechanical Performance ◽  
Bioprosthetic Valve ◽  
Von Mises Stress ◽  
Element Analysis ◽  
Diastolic Phase ◽  
Von Mises

This paper constructs three types of bioprosthetic valve leaflets’ parametric model via computer aided design, a series of accurate parameters of the bioproshtetic heart valve, such as radius of the sutural ring, height of the supporting stent and inclination of the supporting stent, are determined. Numerical simulation is used to determine the effect of different shape designs on the mechanical performance of the bioprosthetic valve leaflet. The dynamic behavior of the valve during diastolic phase is analyzed. The finite element analysis results show the stress distribution of the ellipsoidal and spherical valve leaflets are comparatively reasonable. The ellipsoidal and spherical valve leaflets have the following advantages over the cylindrical leaflet valve, lower peak von-Mises stress, smaller stress concentration area, and relatively uniform stress distribution. The ellipsoidal and spherical valve leaflets may contribute to the long term durability of the valve. This work is very helpful to manufacture valvular leaflets with reasonable shapes and to prolong the lifetime of the bioprosthetic heart valve.

scholarly journals Patient-Specific Static Structural Analysis of Femur Bone of different lengths

2018 ◽  
Vol 12 (1) ◽  
pp. 108-114 ◽  
Author(s):  
K.N. Chethan ◽  
Shyamasunder N. Bhat ◽  
Mohammad Zuber ◽  
Satish B. Shenoy
Keyword(s):  
Body Weight ◽  
Structural Analysis ◽  
Anatomical Variation ◽  
The Body ◽  
Von Mises Stress ◽  
Patient Specific ◽  
Element Analysis ◽  
Load Bearing ◽  
Femur Bone ◽  
Von Mises

Background:The femur bone is an essential part of human activity, providing stability and support in carrying out our day to day activities. The inter-human anatomical variation and load bearing ability of humans of different heights will provide the necessary understanding of their functional ability.Objective:In this study, femur bone of two humans of different lengths (tall femur and short femur) were subjected to static structural loading conditions to evaluate their load-bearing abilities using Finite Element Analysis.Methods:The 3D models of femur bones were developed using MIMICS from the CT scans which were then subjected to static structural analysis by varying the load from 1000N to 8000N. The von Mises stress and deformation were captured to compare the performance of each of the femur bones.Results:The tall femur resulted in reduced Von-Mises stress and total deformation when compared to the short femur. However, the maximum principle stresses showed an increase with an increase in the bone length. In both the femurs, the maximum stresses were observed in the medullary region.Conclusion:When the applied load exceeds 10 times the body weight of the person, the tall femur model exceeded 134 MPa stress value. The short femur model failed at 9 times the body weight, indicating that the tall femur had higher load-bearing abilities.

scholarly journals A Finite Element Modeling and Simulation of Human Temporomandibular Joint with and Without TM Disorders: An Indian Experience

2021 ◽  
Vol 8 (3) ◽  
pp. 347-355
Author(s):  
Mehak Sharma ◽  
Manoj Soni
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Temporomandibular Joint ◽  
Computational Study ◽  
3D Models ◽  
Von Mises Stress ◽  
Element Analysis ◽  
Stress Studies ◽  
Jaw Joint ◽  
Von Mises

Temporomandibular joint (TMJ) is anatomically the most intricate joint which connects the lower jaw to the upper jaw and regulates jaw movements. It significantly deals with mastication and speech. It is hence imperative to study the mechanics and functioning of the jaw joint to devise alternative solutions for its replacement whenever required. Further, human skulls are anthropologically categorized into three types – African, Asian and European. Out of these, the Indian skull is also a bit different than its Asian counterparts because of its osteology and skeletal biology. Hence, a comprehensive biomechanical and computational study is essential to provide customized solutions. For the present study, four different loading conditions are selected to perform finite element analysis on the human skull, Anonymized and unidentifiable CT scan data sets from open-source web platforms are converted to STL and then 3D models using 3D slicer. Finite element analysis of jaw joint is carried out. Results based on Von Mises stress studies show significant behavioral differences under varying load conditions. Hence, it is crucial to identify solutions for TMJ disorders of the Indian population.

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