scholarly journals Is There Any Evidence of Premature, Accentuated and Accelerated Aging Effects on Neurocognition in People Living with HIV? A Systematic Review

2020 ◽  
Author(s):  
Htein Linn Aung ◽  
Maral Aghvinian ◽  
Hetta Gouse ◽  
Reuben N. Robbins ◽  
Bruce J. Brew ◽  
...  
Keyword(s):  
Interaction Effect ◽  
Test Performance ◽  
Cognitive Aging ◽  
Significant Interaction ◽  
People Living With Hiv ◽  
Hiv Status ◽  
Significant Interaction Effect ◽  
Cross Sectional ◽  
Neurocognitive Aging ◽  
Neurocognitive Test

Abstract Despite evidence of premature, accentuated and accelerated aging for some age-related conditions such as cardiovascular diseases in people living with HIV (PLHIV), the evidence for these abnormal patterns of aging on neurocognition remains unclear. Further, no systematic review has been dedicated to this issue. Using PRISMA guidelines, we searched standard databases (PubMed, EMBASE, CINAHL and PsycINFO). Articles were included if they analyzed and reported the effect of age on neurocognition among PLHIV as one of their major findings, if they were conducted in the combination anti-retroviral therapy era (after 1996) and published in a peer-reviewed journal in English. Quality appraisal was conducted using the Joanna Briggs Institute (JBI) appraisal tools. To systematically target the abnormal patterns of neurocognitive aging, we define premature cognitive aging as significant interaction effect of HIV status and age on cross-sectional neurocognitive test performance covering both the normal and abnormal performance range; accentuated cognitive aging as significant interaction effect of HIV status and age on cross-sectional neurocognitive impairment (NCI) rate, thus covering the abnormal performance range only; accelerated cognitive aging as significant interaction effect of HIV status and age on longitudinal neurocognitive test performance or incidence of NCI. Because these definitions require an age-comparable HIV-negative (HIV−) control group, when no controls were included, we determined the range of the age effect on neurocognitive test performance or NCI among PLHIV. A total of 37 studies originating from the US (26), UK (2), Italy (2), Poland (2), China (2), Japan (1), Australia (1), and Brazil (1) were included. Six studies were longitudinal and 14 included HIV- controls. The quality appraisal showed that 12/37 studies neither used an age-matched HIV- controls nor used demographically corrected cognitive scores. A meta-analysis was not possible because study methods and choice of neurocognitive measurement methods and outcomes were heterogeneous imposing a narrative synthesis. In studies with an HIV- control sample, premature neurocognitive aging was found in 45% of the cross-sectional analyses (9/20), while accelerated neurocognitive aging was found in 75% of the longitudinal analyses (3/4). There was no evidence for accentuated aging, but this was tested only in two studies. In studies without an HIV- control sample, the age effect was always present but wide (NCI OR = 1.18–4.8). While large sample size (> 500) was associated with abnormal patterns of cognitive aging, most of the studies were under powered. Other study characteristics such as longitudinal study design and higher proportion of older participants were also associated with the findings of abnormal cognitive aging. There is some support for premature and accelerated cognitive aging among PLHIV in the existing literature especially among large and longitudinal studies and those with higher proportion of older samples. Future HIV and cognitive aging studies need to harmonize neuropsychological measurement methods and outcomes and use a large sample from collaborative multi-sites to generate more robust evidences.

scholarly journals Complex Exercise Improves Anti-Inflammatory and Anabolic Effects in Osteoarthritis-Induced Sarcopenia in Elderly Women

Healthcare ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 711
Author(s):  
Jaeyong Park ◽  
Jongjin Bae ◽  
Jungchul Lee
Keyword(s):  
Interaction Effect ◽  
Significant Interaction ◽  
Elderly Women ◽  
Exercise Program ◽  
Interleukin 10 ◽  
Post Intervention ◽  
Significant Interaction Effect ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
The Impact

We investigated the effects of a 15-week complex exercise program on osteoarthritis and sarcopenia by analyzing anabolic effects and the impact on the activities of daily living (ADLs). Nineteen women aged ≥60 years with sarcopenia (SEG, n = 9) or diagnosed with osteoarthritis with sarcopenia (OSEG, n = 10) were enrolled and underwent an exercise program. Insulin-like growth factor 1 (IGF-1), irisin, myostatin, interleukin-10 (IL-10), and tumor necrosis factor alpha (TNF-a) levels were analyzed pre- and post-intervention. Thigh cross-sectional area (TCSA) was measured pre- and post-intervention via computed tomography. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Short Physical Performance Battery (SPBB) were assessed pre- and post-interventions to assess ADL. There was a significant interaction effect between SEG and OSEG at the IGF-1 level post-intervention. Irisin increased and myostatin decreased post-intervention in both groups. IL-10 increased and TNF-α decreased post-intervention with a significant interaction effect in the OSEG group. TCSAs increased post-intervention in both groups. There was a significant interaction between the two groups. OSEG showed a greater WOMAC decrease and SPPB increase post-intervention, and there was a significant interaction effect. Combined exercise may be effective in improving biochemical factors, anabolic effects, and ADL in elderly women with osteoarthritis and sarcopenia.

EFFECT OF SOWING DATE ON GRAIN YIELD OF CRAB GRASS

2001 ◽  
Vol 49 (3) ◽  
pp. 293-297
Author(s):  
S. O. Bakare ◽  
M. G. M. Kolo ◽  
J. A. Oladiran
Keyword(s):  
Grain Yield ◽  
Interaction Effect ◽  
Significant Interaction ◽  
Sowing Date ◽  
Yield Data ◽  
Significant Interaction Effect ◽  
Sowing Dates

There was a significant interaction effect between the variety and the sowing date for the number of productive tillers, indicating that the response to sowing date varied with the variety. A significant reduction in the number of productive tillers became evident when sowing was delayed till 26 June in the straggling variety as compared to sowing dates in May. Lower numbers of productive tillers were also recorded when the sowing of the erect variety was further delayed till 10 July. The grain yield data showed that it is not advisable to sow the straggling variety later than 12 June, while sowing may continue till about 26 June for the erect variety in the study area.

Family environment of eating disordered patients with and without self-injurious behaviors

2004 ◽  
Vol 19 (8) ◽  
pp. 494-498 ◽  
Author(s):  
Laurence Claes ◽  
Walter Vandereycken ◽  
Hans Vertommen
Keyword(s):  
Psychiatric Disorders ◽  
Family Environment ◽  
Interaction Effect ◽  
Significant Interaction ◽  
Family Context ◽  
Hair Pulling ◽  
Significant Interaction Effect ◽  
Eating Disordered ◽  
Significant Difference ◽  
The Family

AbstractObjective.– The family environment is known to be an important contributor to the course of psychiatric disorders. In this study, we examined the family context of eating disordered (ED) patients with and without self-injurious behaviors (SIB).Method.– A Dutch adaptation of the Family Environment Scale ‘Sci Eng 57(9-B):1997;5927’ was completed by 131 ED patients of whom 47% showed at least one form of SIB (e.g., cutting, burning, hair pulling, etc.).Results– Results showed a significant difference in family environment between patients with and without SIB. The family environment of self-injuring ED patients was less cohesive, expressive and socially oriented, and more conflictual and disorganized than the family environment of those without SIB. No significant differences in perceived family environment were found with respect to the number or form of SIB and the subtype of ED. Neither did we find a significant interaction effect between ED subtype and presence/absence of SIB.

scholarly journals PERFECCIONISMO INFANTIL: DIFERENCIAS EN FUNCIÓN DEL SEXO Y LA EDAD

2017 ◽  
Vol 3 (1) ◽  
pp. 15 ◽  
Author(s):  
María Vicent ◽  
M. P. Aparicio Flores ◽  
Cándido J. Inglés ◽  
Mª Isabel Gómez-Núñez ◽  
Aitana Fernández-Sogorb ◽  
...  
Keyword(s):  
Age Differences ◽  
Interaction Effect ◽  
Significant Interaction ◽  
Child And Adolescent ◽  
Practical Relevance ◽  
Education Students ◽  
Significant Interaction Effect ◽  
Socially Prescribed Perfectionism ◽  
Educación Primaria ◽  
Sex And Age Differences

Abstract. CHILD PERFECTIONISM: DIFFERENCES ACROSS SEX AND AGE The aim of this study was to analyze the sex and age differences in the levels of child perfectionism, considering the dimensions: Socially Prescribed Perfectionism (SPP), Self-Oriented Perfectionism Criticism (SOP-C) and Self-Oriented Perfectionism Strivings (SOP-S). The sample was composed by 804 Primary Education students from Spain, aged between 8 and 11 years old (Mage = 9.57; SD = 1.12). The Spanish version of the Child and Adolescent Perfectionism Scale was used to assess the perfectionist dimensions. The results of the variance analysis revealed statistically significant differences in favor of males for SOP-C and SOP-S dimensions. However, these differences had no practical relevance because their associated magnitude (d index) were below .20. Similarly, no statistically significant differences were observed across age for perfectionist dimensions. Moreover, a significant interaction effect (sex x age) was not found.Keywords: child perfectionism, sex, age, Child and Adolescent Perfectionism Scale, Primary Education.Resumen.El objetivo de este estudio consistió en analizar las diferencias en función del sexo y la edad en los niveles de perfeccionismo infantil, atendiendo a las dimensiones: Perfeccionismo Socialmente Prescrito (PSP), Perfeccionismo Auto-Orientado Críticas (PAO-C) y Perfeccionismo Auto-Orientado Esfuerzos (PAO-E). La muestra se compuso de 804 alumnos españoles de Educación Primaria con edades comprendidas entre 8 y 11 años (Medad = 9.57; SD = 1.12). Las dimensiones perfeccionistas fueron evaluadas a través de la versión española de la Child and Adolescent Perfectionism Scale. Los resultados del análisis de varianza revelaron diferencias estadísticamente significativas en favor de los varones para las dimensiones PAO-C y PAO-E. Sin embargo, dichas diferencias carecieron de relevancia práctica puesto que la magnitud asociada (índice d) fue inferior a .20. Similarmente, no se observaron diferencias estadísticamente significativas en función de la edad para ninguna de las dimensiones perfeccionistas ni se encontró un efecto de interacción (sexo x edad) significativo.Palabras clave: perfeccionismo infantil, sexo, edad, Child and Adolescent Perfectionism Scale, Educación Primaria

Personality and Students’ Knowledge about Ecosystem Related to Environmental Behavior of Grade XI Senior High School Students at SMA N 112, West Jakarta

2018 ◽  
Vol 3 (1) ◽  
pp. 44-59
Author(s):  
Agus Ramdani
Keyword(s):  
High School ◽  
High School Students ◽  
Interaction Effect ◽  
Significant Interaction ◽  
School Students ◽  
Significant Interaction Effect ◽  
Environmental Behaviour ◽  
Research Results ◽  
Significant Difference ◽  
Senior High School Students

The objective of this research is to find out the effect of Personality (P) and knowledge students about ecosystem (KS) on environmental behaviour (EB). An expost facto method has been used by selecting 8 sample for each cell. Reliability of P was  .964, KS was .937 and EB was .95. Data analyzed by two-way ANOVA. Research results revealed that there was environmental behaviour significant difference between those students who have most extraversion personality compared to introversion personality. Moreover, there was significant interaction effect between personality and knowledge students about ecosystem on environmental behaviour. 

scholarly journals The Effect of Competition on Risk Taking in Contests

Games ◽  
2018 ◽  
Vol 9 (3) ◽  
pp. 72 ◽  
Author(s):  
Lorenzo Spadoni ◽  
Jan Potters
Keyword(s):  
Risk Taking ◽  
Interaction Effect ◽  
Significant Interaction ◽  
Significant Interaction Effect ◽  
All Pay Auction ◽  
Level Of Risk

We investigate, theoretically and experimentally, the effect of competition on risk taking in a contest in which players only decide on the level of risk they wish to take. Taking more risk implies a chance of a higher performance, but also implies a higher chance of failure. We vary the level of competition in two ways: by varying the number of players (2 players versus 8 players), and by varying the sensitivity of the contest to differences in performance (lottery contest versus all-pay auction). Our results show that there is a significant interaction effect between the two treatments, suggesting that players are particularly prone to take more risks if both the number of players and the sensitivity to performance are higher.

The Impact of Amyloid-β or Tau on Cognitive Change in the Presence of Severe Cerebrovascular Disease

2020 ◽  
Vol 78 (2) ◽  
pp. 573-585
Author(s):  
Hyemin Jang ◽  
Hee Jin Kim ◽  
Yeong Sim Choe ◽  
Soo-Jong Kim ◽  
Seongbeom Park ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Interaction Effect ◽  
Significant Interaction ◽  
Amyloid Β ◽  
Cognitive Change ◽  
Significant Interaction Effect ◽  
The Impact

Background: As Alzheimer’s disease (AD) and cerebral small vessel disease (CSVD) commonly coexist, the interaction between two has been of the considerable interest. Objective: We determined whether the association of Aβ and tau with cognitive decline differs by the presence of significant CSVD. Methods: We included 60 subcortical vascular cognitive impairment (SVCI) from Samsung Medical Center and 82 Alzheimer’s disease-related cognitive impairment (ADCI) from ADNI, who underwent Aβ (florbetaben or florbetapir) and tau (flortaucipir, FTP) PET imaging. They were retrospectively assessed for 5.0±3.9 and 5.6±1.9 years with Clinical Dementia Rating-sum of boxes (CDR-SB)/Mini-Mental State Examination (MMSE). Mixed effects models were used to investigate the interaction between Aβ/tau and group on CDR-SB/MMSE changes. Results: The frequency of Aβ positivity (45% versus 54.9%, p = 0.556) and mean global FTP SUVR (1.17±0.21 versus 1.16±0.17, p = 0.702) were not different between the two groups. We found a significant interaction effect of Aβ positivity and SVCI group on CDR-SB increase/MMSE decrease (p = 0.013/p < 0.001), and a significant interaction effect of global FTP uptake and SVCI group on CDR-SB increase/MMSE decrease (p < 0.001 and p = 0.030). Finally, the interaction effects of regional tau and group were prominent in the Braak III/IV (p = 0.001) and V/VI (p = 0.003) not in Braak I/II region (p = 0.398). Conclusion: The association between Aβ/tau and cognitive decline is stronger in SVCI than in ADCI. Therefore, our findings suggested that Aβ positivity or tau burden (particularly in the Braak III/IV or V/VI regions) and CSVD might synergistically affect cognitive decline.

scholarly journals The Moderating Effects of Self-Referencing and Relational-Interdependent Self-Construal in Anti-Smoking Advertising for Adolescents

2020 ◽  
Vol 17 (22) ◽  
pp. 8481
Author(s):  
Hsiang-Ming Lee ◽  
Ya-Hui Hsu ◽  
Tsai Chen
Keyword(s):  
Factorial Design ◽  
Interaction Effect ◽  
Significant Interaction ◽  
Social Relationship ◽  
Significant Interaction Effect ◽  
Behavior Intention ◽  
Self Construal ◽  
Interdependent Self ◽  
Tobacco Epidemic ◽  
Advertising Appeal

The tobacco epidemic is one of the most serious public health issues in the world. Tobacco use starts and becomes established primarily during adolescence, and nearly 9 out of 10 cigarette smokers first tried smoking by age 18, with 99% first trying by age 26. This study employed a 2 (advertising appeal: emotional vs. rational) by 2 (self-referencing: analytical vs. narrative) factorial design in Study 1; and a 2 (relational-interdependent self-construal: high and low) by 3 (social relational cue: self, friend, and family) factorial design in Study 2. The behavior intention of anti-smoking acted as the measured dependent variable. Samples of 192 (Study 1) and 222 (Study 2) were collected from one of the biggest high schools in northern Taiwan. The results showed advertising appeal and self-referencing had a significant interaction effect on behavior intention (p = 0.040). The results also showed rational appealing advertising is suitable for analytical self-referencing (p = 0.022) and emotional appealing advertising is suitable for narrative self-referencing (p = 0.067). However, the social relationship cue and relational-interdependent self-construal had no significant interaction effect on behavior intention, and only relational-interdependent self-construal significantly affected behavior intention (p < 0.001). Regardless of whether the relational-interdependent self-construal is high or low, when the anti-smoking advertising is from the family perspective to persuade adolescents not to smoke, both influence the adolescent more than the other two social relationship cues (self and friend).

A Comparative Study on Parenting of Preschool Children Between the Chinese in China and Chinese Immigrants in the United States

2015 ◽  
Vol 38 (9) ◽  
pp. 1262-1287 ◽  
Author(s):  
Jennifer J. Chen ◽  
Peizhen Sun ◽  
Zuwei Yu
Keyword(s):  
United States ◽  
Preschool Children ◽  
Interaction Effect ◽  
Significant Interaction ◽  
Chinese Immigrants ◽  
The United States ◽  
Chinese Immigrant ◽  
Significant Interaction Effect ◽  
Chinese Mothers ◽  
And Gender

The goal of this questionnaire-based study was to compare the relative endorsement of specific parenting patterns among two ethnic Chinese groups rearing preschool children: Chinese parents in China ( N = 117) and first-generation Chinese immigrant parents in the United States ( N = 94). A significant interaction effect was found between country and gender on the nonreasoning/punitive dimension of authoritarian parenting, revealing that Chinese fathers endorsed this pattern more strongly than both Chinese immigrant fathers and Chinese mothers. There was also a significant interaction effect between country and gender on the practice of shaming/love withdrawal, indicating that Chinese fathers espoused this pattern more strongly than Chinese immigrant fathers and Chinese mothers, but Chinese immigrant mothers endorsed it more strongly than Chinese immigrant fathers. Furthermore, it was revealed that Chinese immigrants endorsed beliefs about maternal involvement more strongly than their Chinese counterparts. The results are discussed in the context of cultural and contextual influences.

Using MYSTAT to Analyze Simple Main Effects in Analysis of Variance

1994 ◽  
Vol 79 (1) ◽  
pp. 265-266
Author(s):  
Richard A. Hudiburg
Keyword(s):  
Analysis Of Variance ◽  
Interaction Effect ◽  
Significant Interaction ◽  
Significant Interaction Effect ◽  
Effect Factor ◽  
Research Designs ◽  
Main Effect ◽  
Two Factors ◽  
Main Effects

Research designs with two factors having a significant interaction effect are analyzed for simple main effects using MYSTAT. The coding used performs a series of one-way analyses of variance for each main-effect factor at only one level of the second factor.

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