Evaluation of Genotoxicity of Perchlozone, Antituberculous Drug

2020 ◽  
Vol 169 (1) ◽  
pp. 48-52
Author(s):  
L. M. Sosedova ◽  
V. A. Vokina ◽  
E. A. Kapustina ◽  
E. S. Bogomolova
Keyword(s):  
Antituberculous Drug

Pseudomonas laryngeal perichondritis: unexpected diagnosis

2020 ◽  
Vol 13 (12) ◽  
pp. e237129
Author(s):  
Siti Salwa Zainal Abidin ◽  
Thean Yean Kew ◽  
Mawaddah Azman ◽  
Marina Mat Baki
Keyword(s):  
Diabetes Mellitus ◽  
Pseudomonas Aeruginosa ◽  
Vocal Fold ◽  
Histopathological Examination ◽  
Thyroid Cartilage ◽  
Tracheal Aspirate ◽  
Good Recovery ◽  
Antituberculous Drug ◽  
False Vocal ◽  
Oral Ciprofloxacin

A 57-year-old male chronic smoker with underlying diabetes mellitus presented with dysphonia associated with cough, dysphagia and reduced effort tolerance of 3 months’ duration. Videoendoscope finding revealed bilateral polypoidal and erythematous true and false vocal fold with small glottic airway. The patient was initially treated as having tuberculous laryngitis and started on antituberculous drug. However, no improvement was observed. CT of the neck showed erosion of thyroid cartilage, which points to laryngeal carcinoma as a differential diagnosis. However, the erosion was more diffuse and appeared systemic in origin. The diagnosis of laryngeal perichondritis was made when the histopathological examination revealed features of inflammation, and the tracheal aspirate isolated Pseudomonas aeruginosa. The patient made a good recovery following treatment with oral ciprofloxacin.

TREATMENT OF TUBERCULOUS PLEURAL EFFUSIONS WITH PARTICULAR REFERENCE TO ADRENAL CORTICOSTEROIDS

PEDIATRICS ◽  
1958 ◽  
Vol 22 (6) ◽  
pp. 1074-1087
Author(s):  
Margaret H. D. Smith ◽  
Nicholas Matsaniotis
Keyword(s):  
Tuberculin Test ◽  
Bed Rest ◽  
Tuberculous Infection ◽  
Pleural Effusions ◽  
Pleural Biopsy ◽  
Extensive Experience ◽  
Antituberculous Drug ◽  
Time Of Admission ◽  
General Care ◽  
Test Cultures

On the basis of our own experience with tuberculous pleural effusions in children as well as on the more extensive experience of other clinicians working with adult patients, we believe that adrenal corticosteroids, given simultaneously with adequate antituberculous drug therapy, not only exert no deleterious effect on the underlying tuberculous infection, but frequently hasten clinical and roentgenographic improvement. Six consecutive patients with tuberculous pleural effusions are here presented. Diagnosis was established with the aid of tuberculin test, cultures of gastric washings and pleural fluid, and pleural biopsy. Treatment included administration of INH, PAS and prednisone. The clinical and roentgenographic response was unusually prompt in the five patients with early effusions. On the basis of this experience we recommend the following treatment: INH (20 mg/kg/24 hr) for a period of at least a year, PAS (0.5 gm/kg/24 hr) for the same length of time; and prednisone (1.0 mg/kg/24 hr) for a period of about 4 to 6 weeks, with diminishing doses during the ensuing 2 weeks. The general care should be that given to any child with early active tuberculosis, including bed rest during the febrile period but rarely beyond it. If such treatment can be instituted early, the incidence of pleural adhesions, with ventilatory impairment and development of scoliosis, is probably lessened. The sixth patient, who was suffering from fibrocaseous pleurisy at the time of admission to our hospital, recovered slowly; in this case adrenal corticosteroid therapy appeared to exert no effect on the course of the disease.

scholarly journals Novel drug–drug cocrystals of carbamazepine with para-aminosalicylic acid: screening, crystal structures and comparative study of carbamazepine cocrystal formation thermodynamics

CrystEngComm ◽  
2017 ◽  
Vol 19 (30) ◽  
pp. 4273-4286 ◽  
Author(s):  
Ksenia V. Drozd ◽  
Alex N. Manin ◽  
Andrei V. Churakov ◽  
German L. Perlovich
Keyword(s):  
Comparative Study ◽  
Crystal Structures ◽  
Anticonvulsant Drug ◽  
Aminosalicylic Acid ◽  
Antituberculous Drug ◽  
Novel Drug ◽  
Formation Thermodynamics

The cocrystal formation of the anticonvulsant drug carbamazepine (CBZ) with para-aminosalicylic acid (PASA, antituberculous drug) has been studied by varying methods.

scholarly journals Molecular Investigation of Resistance to the Antituberculous Drug Ethionamide in Multidrug-Resistant Clinical Isolates ofMycobacterium tuberculosis

2010 ◽  
Vol 55 (1) ◽  
pp. 355-360 ◽  
Author(s):  
F. Brossier ◽  
N. Veziris ◽  
C. Truffot-Pernot ◽  
V. Jarlier ◽  
W. Sougakoff
Keyword(s):  
Cell Wall ◽  
Mycobacterium Tuberculosis ◽  
Drug Targets ◽  
Nadh Dehydrogenase ◽  
Multidrug Resistant ◽  
Clinical Isolates ◽  
Cell Wall Biosynthesis ◽  
Molecular Investigation ◽  
Antituberculous Drug ◽  
Resistant Cells

ABSTRACTEthionamide (ETH) needs to be activated by the mono-oxygenase EthA, which is regulated by EthR, in order to be active againstMycobacterium tuberculosis. The activated drug targets the enzyme InhA, which is involved in cell wall biosynthesis. Resistance to ETH has been reported to result from various mechanisms, including mutations altering EthA/EthR, InhA and its promoter, the NADH dehydrogenase encoded byndh, and the MshA enzyme, involved in mycothiol biosynthesis. We searched for such mutations in 87 clinical isolates: 47 ETH-resistant (ETHr) isolates, 24 ETH-susceptible (ETHs) isolates, and 16 isolates susceptible to ETH but displaying an intermediate proportion of resistant cells (ETHSip; defined as ≥1% but <10% resistant cells). In 81% (38/47) of the ETHrisolates, we found mutations inethA,ethR, orinhAor its promoter, which mostly corresponded to new alterations inethAandethR. The 9 ETHrisolates without a mutation in these three genes (9/47, 19%) had no mutation inndh, and a single isolate had a mutation inmshA. Of the 16 ETHSipisolates, 7 had a mutation inethA, 8 had no detectable mutation, and 1 had a mutation inmshA. Finally, of the 24 ETHsisolates, 23 had no mutation in the studied genes and 1 displayed a yet unknown mutation in theinhApromoter. Globally, the mechanism of resistance to ETH remained unknown for 19% of the ETHrisolates, highlighting the complexity of the mechanisms of ETH resistance inM. tuberculosis.

scholarly journals Tuberculosis and Trimethoprim-Sulfamethoxazole

2009 ◽  
Vol 53 (11) ◽  
pp. 4789-4793 ◽  
Author(s):  
Pierre Forgacs ◽  
Nancy L. Wengenack ◽  
Leslie Hall ◽  
Sarah K. Zimmerman ◽  
Mark L. Silverman ◽  
...  
Keyword(s):  
Immunocompromised Patient ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Mycobacterium Kansasii ◽  
Drug Resistant Tuberculosis ◽  
Rapidly Growing Mycobacteria ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
Antituberculous Drug ◽  
Widespread Belief

ABSTRACT The sulfonamides were the first drugs with antituberculous effects. Their use was abandoned and basically forgotten with the advent of streptomycin and isoniazid combination treatment. There is a widespread belief, apparently based on testing a single isolate on questionable media, that Mycobacterium tuberculosis is resistant to trimethoprim-sulfamethoxazole (TMP-SMX). We saw a complex immunocompromised patient with tuberculosis who was initially treated with TMP-SMX without antituberculous drugs and defervesced on this treatment. An isolate of M. tuberculosis from this patient was found to be sensitive to TMP-SMX. We examined how frequently M. tuberculosis is sensitive to TMP-SMX. Isolates were tested for susceptibility to TMP-SMX on supplemented Middlebrook 7H10 plates. We found that 43 of 44 (98%) isolates of M. tuberculosis were susceptible to the combination of ≤1 μg/ml of TMP and 19 μg/ml of SMX (≤1/19 μg/ml). Thus, the vast majority of our M. tuberculosis isolates were susceptible to TMP-SMX at an MIC similar to that for Mycobacterium kansasii, Mycobacterium marinum, and sensitive rapidly growing mycobacteria, organisms successfully treated with TMP-SMX as part of the treatment regimen. It is possible that TMP-SMX may be useful in treating patients with multiple-drug-resistant and extended drug-resistant tuberculosis. We feel that a clinical trial looking at the effectiveness of TMP-SMX as an antituberculous drug is worthwhile.

scholarly journals Drug delivery system on the base of phospholipid nanoparticles for rifampicin

2013 ◽  
Vol 59 (5) ◽  
pp. 585-590 ◽  
Author(s):  
M.A. Sanzhakov ◽  
V.N. Prozorovskyi ◽  
O.M. Ipatova ◽  
E.G. Tikhonova ◽  
N.V. Medvedeva ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Sodium Oleate ◽  
Fold Increase ◽  
Phospholipid Nanoparticles ◽  
Antituberculous Drug

Low bioavailability of rifampicin, one of the main antituberculous drug, stimulates searches of its new optimized formulations. The present study has showen possibility of rifampicin embedding into nanoparticles from plant phosphatidylcholine (diameter of 20-30 nm). Addition of sodium oleate to the phospholipid system caused a 2-fold increase of the percent of rifampicin incorporation. After oral administration to rats, the maximal drug observed in plasma one hour after was 0.5 and 4.2 mkg/ml for free rifampicin for rifampicin in phospholipids-oleate nanoparticles, respectively. These levels were maintained for more than two hours of the experiment. High rifampicin bioavailability in the oleate containing phospholipid nanosystem suggests prospectivity of its pharmaceutical elaboration.

scholarly journals Mesenchymal stem cells of the bone marrow in treatment of genital tuberculosis in rabbits (experimental research with morphological control)

2017 ◽  
Vol 15 (2) ◽  
pp. 47-55
Author(s):  
Boris M Ariel ◽  
Faina M Guseinova ◽  
Tatiana I Vinogradova ◽  
Natalia V Zabolotnykh ◽  
Dariko A Niaury ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Experimental Research ◽  
Specific Treatment ◽  
Fallopian Tubes ◽  
Genital Tuberculosis ◽  
Specific Therapy ◽  
Morphological Control ◽  
Antituberculous Drug

The aim of this study was to evaluate a therapeutic efficacy of allogenic mesenchymal bone marrow stem cells (MSCs) (5 million / ml dose) in combination with specific therapy in experimental female genital tuberculosis (20 female “Chinchilla” rabbits). It has been shown that on the background of specific therapy the injection of MSCs actively affects reparative processes and promotes reepithelialization of the fallopian tubes 2 months after the inoculation. An active position of myofibroblasts differentiating from the MSC in the reparative reaction and promoting a normalization of epithelium and connective tissue relations was registered. At the same time, the introduction of a new antituberculous drug - tioureidoiminomethylpyridinium perhlorate (perhlozon) to the specific treatment, was contributed to a restoration of structural and functional integrity of the fallopian tubes, by reinforcing the effect of etiotropic substances and by accelerating abacillation. (For citation: Ariel BM, Guseinova FM, Vinogradova TI, et al. Mesenchymal stem cells of the bone marrow in treatment of genital tuberculosis in rabbits (experimental research with morphological control). Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(2):47-55. doi: 10.17816/RCF15247-55).

scholarly journals A prospective study of antituberculous drug-induced hepatotoxicity in an area endemic for liver diseases

2008 ◽  
Vol 2 (3) ◽  
pp. 353-360 ◽  
Author(s):  
Hoda A. Makhlouf ◽  
Ahmed Helmy ◽  
Ehab Fawzy ◽  
Madiha El-Attar ◽  
Hebat Alla G. Rashed
Keyword(s):  
Prospective Study ◽  
Liver Diseases ◽  
Drug Induced ◽  
Antituberculous Drug ◽  
A Prospective Study

scholarly journals Medical versus Surgical Treatment of a Primary Tuberculous Pleural Peel

2001 ◽  
Vol 8 (6) ◽  
pp. 449-453 ◽  
Author(s):  
Richard Long ◽  
Anne Fanning ◽  
Ciaran McNamee ◽  
James Barrie ◽  
Lakshmi Puttagunta
Keyword(s):  
Computed Tomography ◽  
Drug Therapy ◽  
Surgical Treatment ◽  
Pulmonary Function ◽  
Present Report ◽  
Pulmonary Function Tests ◽  
Response To Treatment ◽  
Lung Expansion ◽  
Computed Tomography Scans ◽  
Antituberculous Drug

The role and timing of surgical decortication in the management of a primary tuberculous pleural peel remains controversial. The present report describes the case of a young man with an extensive primary tuberculous pleural peel that responded dramatically to medical therapy. A serious attempt at surgical decortication three weeks into antituberculous drug therapy may have removed some compressive aspects of the peel, facilitating lung expansion. However, it had almost no measurable impact on the size of peel and was technically very difficult. Response to treatment was measured anatomically (computed tomography scans) and physiologically (pulmonary function tests).

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