Chemical Constituents of the Whole Plants of Houttuynia cordata

2017 ◽  
Vol 53 (2) ◽  
pp. 365-367 ◽  
Author(s):  
Dong Li ◽  
Jin-Ping Liu ◽  
Xue Han ◽  
Yue-Fei Wang ◽  
Chun-Hua Wang ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Houttuynia Cordata ◽  
Whole Plants

Chemical constituents from the whole plants of Sedum sarmentosum Bunge and their chemotaxonomic significance

2020 ◽  
Vol 93 ◽  
pp. 104180
Author(s):  
Tieqiang Zong ◽  
Zhe Jiang ◽  
Yi Zhou ◽  
Jinfeng Sun ◽  
Jingyue Guo ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Whole Plants

scholarly journals Chemical constituents and cytotoxicity of Aspidistra letreae

2020 ◽  
Vol 129 (1B) ◽  
pp. 31-39
Author(s):  
Duc Viet Ho ◽  
Hanh Nhu Thi Hoang ◽  
Khue Minh Vo ◽  
Anh Tuan Le ◽  
Hoai Thi Nguyen
Keyword(s):  
Human Cancer ◽  
Chemical Constituents ◽  
Hep G2 ◽  
Human Cancer Cell Lines ◽  
Phytochemical Investigation ◽  
Ic50 Values ◽  
Reported Data ◽  
Whole Plants ◽  
First Time

A phytochemical investigation of whole Aspidistra letreae plants led to the isolation of 2H-chromen-2-one (1), α-tocopherol (2), (E)-phytol (3), asparenydiol (4) and (25S)-spirost-1β,3α,5β-triol (5). Their structures were determined on the basis of NMR spectral evidences and in comparison with the reported data. Of these, asparenydiol (4) was isolated from the genus Aspidistra for the first time. This is also the first report on the separation and structural determination of (25S)-spirost-1β,3α,5β-triol (5) as a pure compound. The methanol extract from the whole plants of Aspidistra letreae exhibits moderate cytotoxicity against the LU-1, HeLa, MDA-MB-231, Hep-G2, and MKN-7 human cancer cell lines with IC50 values ranging from 52.58 ± 3.65 to 64.78 ± 4.89 μg/mL.

Chemical constituents from Houttuynia cordata

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
J Ahn ◽  
J Kim
Keyword(s):  
Chemical Constituents ◽  
Houttuynia Cordata

scholarly journals Sterol and triterpenoids from Hygrophila schulli Buch.-Ham.

2018 ◽  
Vol 44 (2) ◽  
pp. 319-321
Author(s):  
Md Abu Suflan ◽  
Fatema Begum ◽  
Mohammad Rashedul Haque ◽  
Choudhury Mamood Hasan ◽  
Mohammad Abdur Rashid
Keyword(s):  
1H Nmr ◽  
Chromatographic Separation ◽  
Methanol Extract ◽  
Chemical Constituents ◽  
Published Data ◽  
Separation And Purification ◽  
First Report ◽  
Spectral Evidence ◽  
Whole Plants

The methanol extract of whole plants of Hygrophila schulli Buch.-Ham. was subjected to repeated chromatographic separation and purification processes to isolate its chemical constituents. A total of three compounds were isolated which have been characterized as stigmasterol, lupeol and lup-20(29)-ene-3β,23- diol on the basis of 1H NMR spectral evidence and confirmed by comparing with published data, as well as co-TLC in case of stigmasterol and lupeol. This is the first report of lup-20(29)-ene-3β,23-diol from this plant.

Chemical Constituents from Houttuynia cordata

2010 ◽  
Vol 7 (6) ◽  
pp. 425-427 ◽  
Author(s):  
Wei QU ◽  
Jing-Yu LIANG ◽  
Meng-Ran LI
Keyword(s):  
Chemical Constituents ◽  
Houttuynia Cordata

Chemical Constituents of the Aerial Parts of Scoparia Dulcis and Anti-Cancer, Anti-Inflammatory Activities

2019 ◽  
Vol 814 ◽  
pp. 360-364
Author(s):  
Nguyen Ngoc Thanh Tin ◽  
Nguyen Dang Thanh Truc ◽  
Hoang Thi Thu Hang ◽  
Pham Thi Nhat Trinh ◽  
Long Giang Bach ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Chemical Constituents ◽  
Methanol Fraction ◽  
Scoparia Dulcis ◽  
Aerial Parts ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Whole Plants ◽  
Ethyl Acetate Extracts

In Vietnam, the medicinal plant Scoparia dulcis is used for the treatment of bronchitis, gastric disorders, antidiabetes, hypertension, hepatitis etc.1 In this paper, experiments was designed to evaluate in vitro anticancer and anti-inflammatory activities and isolate phytochemicals from methanol extracts of Scoparia dulcis whole plants. The chemical investigation of methanol fraction of Scoparia dulcis led to the isolation of benzoxazinone (1), phenylethanoid (2), flavone (3), and lignan (4) glycosides. The bioactivity results indicated that crude ethanol and ethyl acetate extracts had potent cytotoxic activity toward the HepG2 cancer cell with IC50 of 47.03 μg/mL and 36.04 μg/mL, respectively. Interestingly, crude ethanol and ethyl acetate extracts had the NO inhibitory activity, with inhibition of 56.9 % or 74.7 % at 30 μg/mL and 97.3% or 82.9 % at 100 μg/mL, respectively. In addition, the hexane extract at concentrations of 100 μg/ml demonstrated anti-inflammatory activity through the inhibition of nitric oxide production of 76.7%.

Chemical constituents from the whole plants of Pilea cavaleriei Levl subsp. cavaleriei

Fitoterapia ◽  
2017 ◽  
Vol 119 ◽  
pp. 100-107 ◽  
Author(s):  
Yong Zhou ◽  
Ling-Yu Li ◽  
Heng-Chun Ren ◽  
Ri-Dong Qin ◽  
Qin Li ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Whole Plants

Chemical constituents of the whole plants of Saussurea medusa

2009 ◽  
Vol 63 (3) ◽  
pp. 327-330 ◽  
Author(s):  
Zhuoma Dawa ◽  
Yang Bai ◽  
Yan Zhou ◽  
Suolang Gesang ◽  
Ping A ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Saussurea Medusa ◽  
Whole Plants

scholarly journals Evaluating the Therapeutic Mechanisms of Selected Active Compounds in Houttuynia cordata Thunb. in Pulmonary Fibrosis via Network Pharmacology Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
De-Wei Zhu ◽  
Qun Yu ◽  
Ji-Jia Sun ◽  
Yun-Hui Shen
Keyword(s):  
Protein Kinase ◽  
Pulmonary Fibrosis ◽  
Signaling Pathways ◽  
Chemical Constituents ◽  
A549 Cells ◽  
Mitogen Activated Protein Kinase ◽  
Network Pharmacology ◽  
Interleukin 17 ◽  
Upper Respiratory Tract ◽  
Houttuynia Cordata

Pulmonary fibrosis, a common outcome of pulmonary interstitial disease of various different etiologies, is one of the most important causes of respiratory failure. Houttuynia cordata Thunb. (family: Saururaceae) (H. cordata), as has been reported, is a Chinese herbal medicine commonly used to treat upper respiratory tract infection and bronchitis. Our previous study has proven that sodium houttuyfonate (an additional compound from sodium bisulfite and houttuynin) had beneficial effects in the prevention of pulmonary fibrosis (PF) induced by bleomycin (BLM) in mice. In the present study, network pharmacology was used to investigate the efficiency and potential mechanisms of H. cordata in PF treatment. Upon manual collection from the literature and databases such as TCMSP and TCM-ID, 10 known representative ingredients of H. cordata species were screened. Then, the prediction of the potential active ingredients, action targets, and signaling pathways were conducted through the Gene Ontology (GO), protein–protein interaction (PPI),and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. The results of network pharmacology prediction suggested that H. cordata may act through multiple signaling pathways to alleviate PF, including the phosphatidylinositol 3-kinase-protein kinase B (PI3K/AKT) pathways, mitogen-activated protein kinase (MAPK) pathways, the tumor necrosis factor (TNF) pathways, and interleukin-17 (IL-17) signaling pathways. Molecular docking experiments showed that the chemical constituents of H. cordata had good affinity with TNF, MAPK1, and AKT1, and using lipopolysaccharide (LPS)-induced A549 cells, a model was established to verify the anti-pulmonary fibrosis effects and related mechanisms of H. cordata–relevant constituents. Finally, these evidences collectively suggest H. cordata may alleviate PF progression via PI3K/Akt, MAPK, and TNF signaling pathways and provide novel insights to verify the mechanism of H. cordata in the treatment of PF.

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