An in situ silicone–silicone interpenetrating polymer network (IPN) with higher mechanical property, higher hydrophilicity, and lower protein adsorption

2018 ◽  
Vol 53 (12) ◽  
pp. 9325-9339 ◽  
Author(s):  
Yang Xie ◽  
Li Wang ◽  
Yan Zhang ◽  
Houbin Li ◽  
Ronghua Huang
Biomaterials ◽  
2018 ◽  
Vol 170 ◽  
pp. 12-25 ◽  
Author(s):  
Hamid Sadeghi Abandansari ◽  
Mohammad Hossein Ghanian ◽  
Fahimeh Varzideh ◽  
Elena Mahmoudi ◽  
Sarah Rajabi ◽  
...  

2020 ◽  
Vol 32 (12) ◽  
pp. 5208-5216 ◽  
Author(s):  
Fang Chen ◽  
Peter Le ◽  
Krystal Lai ◽  
Gabriella M. Fernandes-Cunha ◽  
David Myung

Author(s):  
Saruchi Sharma ◽  
VANEET KUMAR

Objective: This study involves the synthesis of Gum tragacanth (gt) based interpenetrating polymer network (ipn) and its utilization for sustained release of anti-ulcerative drug i.e. pantoprazole sodium. Methods: IPN was synthesized from Gum tragacanth, polyacrylic acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in distilled water. Further, acryamide (aam) and methylmethacrylate (mma) was added and then kept for overnight. Later on, lipase and glutaraldehyde were added. Homopolymers and the unreacted monomers were removed using acetone. Synthesized IPN was dried at 50 °C for further study. Synthesized ipn was swelled in water and the drug was added to it. The drug was entrapped in the pores of the synthesized ipn and then drug release behavior was studied using uv-vis spectrophotometer. Results: Gt, paa and mma based crosslinked IPN were synthesized using lipase-glutaraldehyde as initiator-crosslinker system. The synthesized IPN was pH sensitive and possessed the desired swelling capacity required for the controlled and systematic liberation of pantoprazole sodium at 37 °C. The kinetic of drug release was studied and found that lateral diffusion (DL) of drug was higher as compared to the initial diffusion (DI). The prepared IPN can be used as prospective carrier for prolonged drug delivery. Conclusion: A novel pH sensitive and colon targeted IPN was synthesized. It acts as an effective device for the controlled release of drug pantoprazole sodium.


2011 ◽  
Vol 306-307 ◽  
pp. 220-223
Author(s):  
Xiao Ping Fan ◽  
An Ning Zhou

Semi-interpenetrating polymer network of coal/polyaniline (PANI) composite material were prepared by in situ polymerization. Raw coal was oxidized in different conditions by H2O2 and HNO3, respectively. The total acidic groups analysis, Fourier transform infrared (FTIR) spectrum, and conductivity test of the raw coal and the oxidized coal/PANI composite material were conducted. The results showed that the increases of the carboxyl groups and the hydroxyl groups were mainly attributed to the hydrolysis of the weak ether link and the transform from the carboxylate to carboxylic acid. These increases were benefit to the reaction of coal and PANI, and consequently enhanced the conductivity of the composite material. The maximum conductivity of oxidized coal/PANI reached 4.72×10‑1 S/cm.


RSC Advances ◽  
2014 ◽  
Vol 4 (75) ◽  
pp. 39822-39829 ◽  
Author(s):  
Saruchi Saruchi ◽  
B. S. Kaith ◽  
Rajeev Jindal ◽  
Vaneet Kumar ◽  
Manpreet S. Bhatti

The present study proposes the development and optimization of a new interpenetrating polymer network (IPN), consisting of Gum tragacanth, poly(acrylic acid) (PAA), and poly(acrylamide) (PAAm), for the in situ controlled release of losartan potassium under different pH conditions at 37 °C.


RSC Advances ◽  
2016 ◽  
Vol 6 (54) ◽  
pp. 49101-49112 ◽  
Author(s):  
Abbas Tanver ◽  
Mu-Hua Huang ◽  
Yunjun Luo

Novel energetic interpenetrating polymer network (EIPN) nanocomposite comprised of fMWCNTs covalently attached to HTPB and GAP by facile in situ polymerization technique.


2011 ◽  
Vol 675-677 ◽  
pp. 481-484 ◽  
Author(s):  
Shao Yun Shan ◽  
Qing Ming Jia ◽  
Li Hong Jiang ◽  
Ya Ming Wang

Epoxy/polyurethane interpenetrating polymer network coatings(EP/PU IPNs) modified by organic montmorillonite(oMMT)were prepared by interpenetrating polymer technology and in situ intercalative polymerization methods. TEM analysis showed that there is interaction between the oMMT and EP, PU phase, and the oMMT plays a role of "cross-linking point", changing the EP/PU matrix microstructure. Electrochemical analysis showed that oMMT and IPNs of EP and PU exhibits synergistic effect on improving anticorrosive properties of pure EP. When PU content is 30%, oMMT content is 3%, the EP/PU IPNs coatings has the best corrosion resistance.


RSC Advances ◽  
2021 ◽  
Vol 11 (37) ◽  
pp. 22544-22555
Author(s):  
Atefeh Safaei-Yaraziz ◽  
Shiva Akbari-Birgani ◽  
Nasser Nikfarjam

The interlacing of biopolymers and synthetic polymers is a promising strategy to fabricate hydrogel-based tissue scaffolds to biomimic a natural extracellular matrix for cell growth.


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