scholarly journals Impact of COVID-19 on the thyroid gland: an update

2020 ◽  
Author(s):  
Lorenzo Scappaticcio ◽  
Fabián Pitoia ◽  
Katherine Esposito ◽  
Arnoldo Piccardo ◽  
Pierpaolo Trimboli
Keyword(s):  
Thyroid Gland ◽  
Immune Responses ◽  
Literature Search ◽  
Host Cells ◽  
Complex Interplay ◽  
Nonthyroidal Illness ◽  
Current Review ◽  
Treatment Plans ◽  
Hpt Axis ◽  
The Relationship

AbstractCoronavirus disease 2019 (COVID-19) is the pandemic of the new millennium. COVID-19 can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. Data on the relationship between COVID-19 and thyroid have been emerging, and rapidly increasing since March 2020. The thyroid gland and the virus infection with its associated inflammatory-immune responses are known to be engaged in complex interplay. SARS-CoV-2 uses ACE2 combined with the transmembrane protease serine 2 (TMPRSS2) as the key molecular complex to infect the host cells. Interestingly, ACE2 and TMPRSS2 expression levels are high in the thyroid gland and more than in the lungs. Our literature search provided greater evidence that the thyroid gland and the entire hypothalamic–pituitary–thyroid (HPT) axis could be relevant targets of damage by SARS-CoV-2. Specifically, COVID-19-related thyroid disorders include thyrotoxicosis, hypothyroidism, as well as nonthyroidal illness syndrome. Moreover, we noticed that treatment plans for thyroid cancer are considerably changing in the direction of more teleconsultations and less diagnostic and therapeutical procedures. The current review includes findings that could be changed soon by new results on the topic, considering the rapidity of worldwide research on COVID-19.

Mesenchymal Stem Cells Differentiation: Mitochondria Matter in Osteogenesis or Adipogenesis Direction

2020 ◽  
Vol 15 (7) ◽  
pp. 602-606
Author(s):  
Kun Ji ◽  
Ling Ding ◽  
Xi Chen ◽  
Yun Dai ◽  
Fangfang Sun ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Potential ◽  
Mesodermal Cell ◽  
Cell Lineages ◽  
Current Review ◽  
Differentiation Factors ◽  
The Relationship ◽  
Msc Differentiation

Mesenchymal Stem Cells (MSCs) exhibit enormous therapeutic potential because of their indispensable regenerative, reparative, angiogenic, anti-apoptotic, and immunosuppressive properties. MSCs can best differentiate into mesodermal cell lineages, including osteoblasts, adipocytes, muscle cells, endothelial cells and chondrocytes. Specific differentiation of MSCs could be induced through limited conditions. In addition to the relevant differentiation factors, drastic changes also occur in the microenvironment to conduct it in an optimal manner for particular differentiation. Recent evidence suggests that the mitochondria participate in the regulating of direction and process of MSCs differentiation. Therefore, our current review focuses on how mitochondria participate in both osteogenesis and adipogenesis of MSC differentiation. Besides that, in our current review, we try to provide a further understanding of the relationship between the behavior of mitochondria and the direction of MSC differentiation, which could optimize current cellular culturing protocols for further facilitating tissue engineering by adjusting specific conditions of stem cells.

MHC and malaria: the relationship between HLA class II alleles and immune responses to Plasmodium falciprum

1992 ◽  
Vol 4 (9) ◽  
pp. 1055-1063 ◽  
Author(s):  
E. M. Riley ◽  
O. Olerup ◽  
S. Bennett ◽  
P. Rowe ◽  
S. J. Allen ◽  
...  
Keyword(s):  
Immune Responses ◽  
Class Ii ◽  
Hla Class Ii ◽  
The Relationship ◽  
Hla Class Ii Alleles

MIP-1α and MIP-1β differentially mediate mucosal and systemic adaptive immunity

Blood ◽  
2003 ◽  
Vol 101 (3) ◽  
pp. 807-814 ◽  
Author(s):  
James W. Lillard ◽  
Udai P. Singh ◽  
Prosper N. Boyaka ◽  
Shailesh Singh ◽  
Dennis D. Taub ◽  
...  
Keyword(s):  
T Cells ◽  
Immune Responses ◽  
Adaptive Immunity ◽  
Cd8 T Cells ◽  
Host Cells ◽  
Secretory Iga ◽  
Specific Cell ◽  
Cellular Immune Responses ◽  
Cc Chemokines ◽  
Cellular Immune

AbstractMacrophage inflammatory protein-1α (MIP-1α) and MIP-1β are distinct but highly homologous CC chemokines produced by a variety of host cells in response to various external stimuli and share affinity for CCR5. To better elucidate the role of these CC chemokines in adaptive immunity, we have characterized the affects of MIP-1α and MIP-1β on cellular and humoral immune responses. MIP-1α stimulated strong antigen (Ag)–specific serum immunoglobulin G (IgG) and IgM responses, while MIP-1β promoted lower IgG and IgM but higher serum IgA and IgE antibody (Ab) responses. MIP-1α elevated Ag-specific IgG1 and IgG2b followed by IgG2a and IgG3 subclass responses, while MIP-1β only stimulated IgG1 and IgG2b subclasses. Correspondingly, MIP-1β produced higher titers of Ag-specific mucosal secretory IgA Ab levels when compared with MIP-1α. Splenic T cells from MIP-1α– or MIP-1β–treated mice displayed higher Ag-specific Th1 (interferon-γ [IFN-γ]) as well as selective Th2 (interleukin-5 [IL-5] and IL-6) cytokine responses than did T cells from control groups. Interestingly, mucosally derived T cells from MIP-1β–treated mice displayed higher levels of IL-4 and IL-6 compared with MIP-1α–treated mice. However, MIP-1α effectively enhanced Ag-specific cell-mediated immune responses. In correlation with their selective effects on humoral and cellular immune responses, these chemokines also differentially attract CD4+ versus CD8+ T cells and modulate CD40, CD80, and CD86 expressed by B220+ cells as well as CD28, 4-1BB, and gp39 expression by CD4+ and CD8+ T cells in a dose-dependent fashion. Taken together, these studies suggest that these CC chemokines differentially enhance mucosal and serum humoral as well as cellular immune responses.

scholarly journals Hierarchy of Susceptibility of Dendritic Cell Subsets to Infection by Leishmania major: Inverse Relationship to Interleukin-12 Production

2002 ◽  
Vol 70 (7) ◽  
pp. 3874-3880 ◽  
Author(s):  
Sandrine Henri ◽  
Joan Curtis ◽  
Hubertus Hochrein ◽  
David Vremec ◽  
Ken Shortman ◽  
...  
Keyword(s):  
Immune Responses ◽  
Mhc Class Ii ◽  
Leishmania Major ◽  
Parasitophorous Vacuole ◽  
Class Ii ◽  
Host Cells ◽  
Interleukin 12 ◽  
Histocompatibility Complex ◽  
T Cell Immune Responses ◽  
Antigen Presenting

ABSTRACT Dendritic cells (DCs) are professional antigen-presenting cells which initiate and regulate T-cell immune responses. Here we show that murine splenic DCs can be ranked on the basis of their ability to phagocytose and harbor the obligately intracellular parasite Leishmania major. CD4+ CD8− DCs are the most permissive host cells for L. major amastigotes, followed by CD4− CD8− DCs; CD4− CD8+ cells are the least permissive. However, the least susceptible CD4− CD8+ DC subset was the best interleukin-12 producer in response to infection. Infection did not induce in any DC subset production of the proinflammatory cytokine gamma interferon and nitric oxide associated with the induction of Th1 responses. The number of parasites phagocytosed by DCs was low, no more than 3 organisms per cell, compared to more than 10 organisms per macrophage. In infected DCs, the parasites are located in a parasitophorous vacuole containing both major histocompatibility complex (MHC) class II and lysosome-associated membrane protein 1 molecules, similar to their location in the infected macrophage. The parasite-driven redistribution of MHC class II to this compartment indicates that infected DCs should be able to present parasite antigen.

Taste sensitivity in various strains of mice

1962 ◽  
Vol 202 (6) ◽  
pp. 1200-1204 ◽  
Author(s):  
Keiichiro Hoshishima ◽  
Sadasuke Yokoyama ◽  
Katsuo Seto
Keyword(s):  
Acetic Acid ◽  
Sodium Chloride ◽  
Thyroid Gland ◽  
Taste Sensitivity ◽  
The Relationship ◽  
Taste Thresholds

The present study was designed to elucidate the differences in taste sensitivity in various strains of mice, and to study the relationship between taste sensitivity and color of the fur. Taste thresholds for four kinds of taste substance, i.e., sodium chloride, saccharine, acetic acid, and phenylthiocarbamide (PTC), were measured with three black and three white strains of mice. Taste sensitivity in mice with hypofunction of the suprarenal body, thyroid gland, and liver was also studied to clarify the bearing of the functions of those organs on the sense of taste. The taste sensitivity of mice differed according to strain. A white strain (aa) showed the lowest taste thresholds for all substances tested, whereas a black strain (0–61) showed the highest. Other strains showed intermediate thresholds, the white strains showing lower ones except in the case of saccharine. Hypofunction of the suprarenal body, thyroid gland, and liver caused a rise in the taste thresholds: a) after cauterization of the suprarenal body, the threshold for acetic acid was raised, whereas those for other taste substances were unchanged; b) reduction of thyroid and hepatic functions resulted in a rise of the taste thresholds for saccharine, acetic acid, and PTC.

scholarly journals Extracellular Vesicles from Different Pneumococcal Serotypes Are Internalized by Macrophages and Induce Host Immune Responses

Pathogens ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1530
Author(s):  
Alfonso Olaya-Abril ◽  
Rafael Prados-Rosales ◽  
José A. González-Reyes ◽  
Arturo Casadevall ◽  
Liise-anne Pirofski ◽  
...  
Keyword(s):  
Immune Response ◽  
Biological Activity ◽  
Immune Responses ◽  
Extracellular Vesicles ◽  
Host Cells ◽  
Pneumococcal Serotypes ◽  
Human Pathogen ◽  
Host Immune Responses ◽  
Serotype 1 ◽  
Transient Loss

Bacterial extracellular vesicles are membranous ultrastructures released from the cell surface. They play important roles in the interaction between the host and the bacteria. In this work, we show how extracellular vesicles produced by four different serotypes of the important human pathogen, Streptococcus pneumoniae, are internalized by murine J774A.1 macrophages via fusion with the membrane of the host cells. We also evaluated the capacity of pneumococcal extracellular vesicles to elicit an immune response by macrophages. Macrophages treated with the vesicles underwent a serotype-dependent transient loss of viability, which was further reverted. The vesicles induced the production of proinflammatory cytokines, which was higher for serotype 1 and serotype 8-derived vesicles. These results demonstrate the biological activity of extracellular vesicles of clinically important pneumococcal serotypes.

scholarly journals The Relationship between Palatal Displacement of Upper Canines and Incisors Widths in a Syrian Sample of Patients with Uncrowded Arches

2015 ◽  
Vol 16 (11) ◽  
pp. 873-875 ◽  
Author(s):  
Luai Mahaini
Keyword(s):  
Orthodontic Treatment ◽  
Matched Control ◽  
Control Sample ◽  
Tooth Size ◽  
Orthodontic Patients ◽  
Treatment Plans ◽  
The Right ◽  
The Relationship ◽  
Mandibular Incisors ◽  
Dental Casts

ABSTRACT The aim of this study investigates mesiodistal crown size of the maxillary and mandibular incisors of patients with palatally impacted canines (PDC). Pretreatment dental casts of orthodontic patients with PDC of one or both maxillary canines (N: 33) were collected. This PDC sample was matched according to age and sex with pretreatment dental casts from unaffected orthodontic patients. For the PDC and matched control samples, maximum mesiodistal crown diameters were recorded for the four incisors on the right side only. The results showed that, on average, the mesiodistal crown diameters for the maxillary and mandibular incisors measured smaller in the PDC sample than in the control sample. These findings of statistically significant tooth-size reductions associated with PDC occurrence indicate a generalized pattern of reduced tooth size as a characteristic associated with the PDC anomaly. Further, the presence of generalized tooth-size reduction in cases with palatally displaced canines help explain why most orthodontic treatment plans for PDC patients are of the nonextraction type. How to cite this article Mahaini L. The Relationship between Palatal Displacement of Upper Canines and Incisors Widths in a Syrian Sample of Patients with Uncrowded Arches. J Contemp Dent Pract 2015;16(11):873-875

scholarly journals Digestive involvement in COVID-19: what we have learned in the past 12 months

2021 ◽  
Author(s):  
Vladimir Posmag ◽  
Liliana David ◽  
Dan L. Dumitrascu
Keyword(s):  
Observational Studies ◽  
Digestive System ◽  
Literature Search ◽  
Gastrointestinal Symptoms ◽  
Clinical Findings ◽  
Treatment Schedule ◽  
Gastrointestinal Involvement ◽  
Comprehensive Review ◽  
The Past ◽  
The Relationship

Background and aim. The year 2020 will remain in the medical history as the year of COVID-19 pandemic. Although COVID-19 is considered mainly a respiratory disease, it is well known now that SARS-CoV-2 can affect major organs including the digestive system. This is a comprehensive review on gastrointestinal involvement in the SARS-CoV-2 infection, also the digestive damage due to COVID-19. Methods. A literature search was undertaken in main databases of medical publications following the search items digestive or gastrointestinal or gastric or enteral and SARS-CoV-2 or COVID-19.  Data on gastrointestinal symptoms and alterations in this viral condition were collected and presented. Only observational studies were included. Results. In this review we discuss the recent information on the relationship between COVID-19 and the digestive system. The putative underlying pathogenic mechanisms of COVID-19 as well as the clinical findings in relation to gastrointestinal changes are presented. Conclusions. SARS-CoV-2 virus can affect any part of the digestive system. Patients with chronic diseases are at greatest risk of adverse out-comes. There is a considerable risk for drug-drug interactions in patients who require a large treatment schedule.

scholarly journals Control Study between CT Signs and Pathological Subtypes and Differentiation Degree in Lung Adenocarcinoma

2019 ◽  
Author(s):  
Lizhen Duan ◽  
Wenli Shan ◽  
Genji Bo ◽  
Guangming Lu ◽  
Lili Guo
Keyword(s):  
Lung Adenocarcinoma ◽  
Statistical Difference ◽  
The Other ◽  
Differentiation Degree ◽  
Treatment Plans ◽  
Poorly Differentiated ◽  
Tumor Types ◽  
The Relationship ◽  
Control Study ◽  
Pathological Subtypes

Abstract Background: To study the relationship between CT signs and pathological subtypes and differentiation degree in lung adenocarcinoma.Methods: We retrospectively reviewed 394 cases’ CT images of lung adenocarcinoma and compared the diversity of images among PIL, MIA and IAC, as well as differentiation degrees of IAC by Kruskal-Wall test and X2 test.Results: There was no statistical difference of CT sign between PIL and MIA (P＞0.05). There are statistical differences among size and density of PIL, MIA and IAC (P＜0.01); the incidences of pleura traction sign, spicule sign, lobulation sign, tumor vascular sign, bronchial cut-off sign, air bronchogram sign and cavity sign in IAC were higher than the other two groups (P＜0.05); there was no statistical difference of vacuole sign among PIL, MIA and IAC (P＞0.05). There are statistical differences among size and density of three differentiated subgroups (P＜0.01); the incidences of pleura traction sign, spicule sign, tumor vascular sign, bronchial cut-off sign and cavity sign in poorly differentiated subgroup were highest (P＜0.01); the incidence of air bronchogram sign in highly differentiated subgroup was higher than moderately and poorly differentiated subgroup while incidence of lobulation sign was the lowest in three subgroups above (P＜0.05) ; there was no statistical difference of vacuole sign among three differentiated subgroups (P＞0.05).Conclusions: CT signs of lung adenocarcinoma are closely related to pathological subtypes and differentiation degrees，which would have great value to help predict tumor types and make treatment plans in clinical.

scholarly journals Non-Suicidal Self-Injury in Those Dealing With Borderline Personality Disorder or Separation from Parents

2021 ◽  
Author(s):  
Janice Valencia ◽  
Frikson Christian Sinambela
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Literature Search ◽  
Borderline Personality ◽  
Physical Injury ◽  
Self Injury ◽  
Suicidal Intention ◽  
Separation From Parents ◽  
To Receive ◽  
The Relationship

Non-suicidal self-injury (NSSI) is a deliberate destruction of one’s own body tissue without suicidal intention that causes physical injury. NSSI is mostly found in adolescents or young adults (Paul, Tsypes, Eidlitz, Ernhout, & Whitlock, 2015). Borderline personality disorder (BPD) is one of the risk factors for developing NSSI. Individuals with borderline personality disorder also experience invalidation during their childhood, this can cause individuals with BPD to feel that they deserve to receive NSSI as a form of self-punishment (Sadeh et al., 2014). In addition, children who experience parental separation (through death, divorce or employment) have a higher risk factor for developing NSSI (Astrup, Pedersen, Mok, Carr, & Webb, 2017). A literature search was conducted in six databases, and a total of 20 relevant articles were found. The explanation of the relationship between non-suicidal self-injury, borderline personality disorder, and loss of or separation from a parent are explored in this study, in order to increase understanding of how NSSI behaviours can be prevented. Keywords: NSSI, Borderline Personality, Separation Parent

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